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Abstract Background Blood pressure is relevant to the diagnosis and management of many medical, cardiovascular and critical diseases. The accuracy of many commonly used noninvasive blood pressure (NIBP) monitors and the accuracy of NIBP measurements in hypo- and hypertensive standing horses has not been determined. Hypothesis/Objectives The objective of this study was to investigate the accuracy of an oscillometric BP monitor in standing horses before and during pharmacologically induced hyper- and hypotension and to compare results in standing and anesthetized horses. Animals Eight standing mares from a research herd (SG) and eight anesthetized horses from a hospital population (AG). Methods Prospective experimental and observational studies. Invasive blood pressure (IBP) and NIBP, corrected to heart level, were measured simultaneously. In the SG hyper- and hypotension were induced by administration of phenylephrine (3 μg/kg/min IV for 15 minutes) and acepromazine (0.05 mg/kg IV), respectively. In the AG NIBP and IBP were recorded during regular hospital procedures. Results There was a significant correlation between mean NIBP and IBP in standing (R = 0.88, P < .001) and anesthetized horses (R = 0.81, P < .001). The mean bias (lower, upper limit of agreement) was 16.4(−16.1, 48.9) mmHg for mean BP in the SG and 0.5(−22.3, 23.2) mmHg in the AG. The NIBP device was capable of identifying the increase and decrease in BP in all horses, but in the SG significant correlation between NIBP and IBP was only detected for the normotensive phase. Conclusion and Clinical Importance While the evaluated oscillometric BP device allowed estimation of BP and adequately differentiated marked trends, the accuracy and precision were low in standing horses.

To investigate the usability of the SedLine® monitor in anaesthetized pigs. Five juvenile healthy pigs underwent balanced isoflurane-based general anaesthesia for surgical placement of a subcutaneous jugular venous port. The SedLine® was applied to continuously monitor electroencephalographic (EEG) activity and its modulation during anaesthesia. Computer tomography and magnetic resonance were performed to investigate the relationship between electrodes’ positioning and anatomical structures. The pediatric SedLine® EEG-sensor could be easily applied and SedLine®-generated variables collected. An EEG Density Spectral Array (DS) was displayed over the whole procedure. During surgery, the EEG signal was dominated by elevated power in the delta range (0.5–4 Hz), with an underlying broadband signal (where power decreased with increasing frequency). The emergence period was marked by a decrease in delta power, and a more evenly distributed power over the 4–40 Hz frequency range. From incision to end of surgery, mean SedLine®-generated values (± standard deviation) were overall stable [23.0 (± 2.8) Patient State Index (PSI), 1.0% (± 3.8%) Suppression Ratio (SR), 8.8 Hz (± 2.5 Hz) Spectral Edge Frequency 95% (SEF) left, 7.7 Hz (± 2.4 Hz) SEF right], quickly changing during emergence [75.3 (± 11.1) PSI, 0.0 (± 0.0) SR, 12.5 (± 6.6) SEF left 10.4 (± 6.6) SEF right]. Based on the imaging performed, the sensor does not record EEG signals from the same brain areas as in humans. SedLine®-DSA and -generated variables seemed to reflect variations in depth of anaesthesia in pigs. Further studies are needed to investigate this correlation, as well as to define the species-specific brain structures monitored by the EEG-sensor.

The thin-layer chromatographic (TLC) separation of rare earths has been studied using di(2-ethylhexyl)dithiophosphoric acid as complexing agent in the mobile phase. Silica gel H and silica gel H impregnated with 2.5 M NH4NO3 were investigated as stationary phases. The TLC behavior of rare earths on these adsorbents was compared using different mixed mobile phases. The best results were obtained by use of ethyl methyl ketone—tetrahydrofuran—di(2-ethylhexyl)dithiophosphoric acid (1 M), 6.8 + 3.2 + 0.4 (v/v), as mobile phase. Double development was used to achieve better separation of consecutive rare earths.

Abstract Negative pressure pulmonary edema, a well-recognized phenomenon, is the formation of pulmonary edema after an acute upper airway obstruction, but pulmonary hemorrhage associated with negative-pressure pulmonary edema is rare. The patient required short-term ventilation with continuous positive airway pressure (12 cm H2O) by face mask with rapid resolution of clinical and radiological findings. The negative intrathoracic pressure increases right-sided cardiac filling, raising pulmonary arterial pressure and thereby pulmonary capillary pressure with transudation into the interstitial and alveolar spaces [1,5-7].

While solid mechanics codes are now conventional tools both in industry and research, the increasingly more exigent requirements of both sectors are fuelling the need for more computational power and more advanced algorithms. For obvious reasons, commercial codes are lagging behind academic codes often dedicated either to the implementation of one new technique, or the upscaling of current conventional codes to tackle massively large scale computational problems. Only in a few cases, both approaches have been followed simultaneously. In this article, a solid mechanics simulation strategy for parallel supercomputers based on a hybrid approach is presented. Hybrid parallelization exploits the thread-level parallelism of multicore architectures, combining MPI tasks with OpenMP threads. This paper describes the proposed strategy, programmed in Alya, a parallel multi-physics code. Hybrid parallelization is specially well suited for the current trend of supercomputers, namely large clusters of multicores. The strategy is assessed through transient non-linear solid mechanics problems, both for explicit and implicit schemes, running on thousands of cores. In order to demonstrate the flexibility of the proposed strategy under advance algorithmic evolution of computational mechanics, a non-local parallel overset meshes method (Chimera-like) is implemented and the conservation of the scalability is demonstrated.

The threshold velocity ≥200 cm/s at transcranial Doppler (TCD) evaluation is a useful cut-off for preventing the stroke (STOP trial) in pediatric patients with sickle cell disease (SCD), term including different types of sickle genotypes. Scanty data are available for adult SCD patients. We compared intracranial blood flow velocities between adult SCD patients and controls using transcranial color Doppler (TCCD), measuring the peak of systolic velocity (PSV) with the insonation angle correction and the pulsatility index (PI), an indicator of endothelial elasticity. Fifty-three adult SCD patients (aged >18 years) were enrolled (15 sickle cell anemia, 26 sickle cell thalassemia, and 12 HbS/HbC). None of the patients presented neurological signs. PSVs in middle cerebral artery (MCA) were higher in SCD patients than in controls ( p  = 0.001). In sickle cell anemia patients, PSVs were higher when compared to HbS/βThal ( p  < 0.0060) and HbS/HbC patients ( p  < 0.0139). PI was within the lower range of normality in SCD patients compared to controls. Moreover, MCA-PSV was higher with lower Hb levels and higher HbS%; PI did not change with variation of Hb levels and HbS%. PSV and PI in SCD adult patients could be a relevant index to indicate the abnormal cerebral blood flow and to detect the sickle endothelial damage, in order to prevent cerebrovascular accidents.

Background. Transbronchial lung biopsy (TBLB) is a valuable procedure used to obtain a parenchymal specimen in the evaluation of diffuse lung infiltrates. Large forceps are expected to result in larger specimens and improve diagnostic yield. Aim. The objective of this study was to evaluate diagnostic yield of TBLB using large modified flexible gastroenterological forceps (€œJumbo forceps€) compared with €˜normal' flexible forceps via rigid bronchoscopy in patients with diffuse parenchymal lung disease (DPLD). Methods. The study was a prospective alysis of 95 patients who underwent fluoroscopy guided TBLB over a two year period. Patients with a lung mass or solitary lung nodule undergoing TBLB were excluded. The larger and small forceps were used in a random sequence to avoid a reduction in diagnostic yield of the second series of biopsies related to possible bleeding by first series of biopsies. To minimize the consequence of haemorrhage, we performed every rigid bronchoscopy, placing a non inflated Fogarty balloon and a rigid aspirator (diameter 4 mm) in lobar bronchus near the biopsy segment. The Fogarty balloon has been inflated in case of bleeding. After the bleeding was controlled we continued to operate up to the biopsy segment. Results. Diagnostic yield of TBLB using Jumbo forceps was significantly higher than using normal flexible forceps via rigid bronchoscopy in patients with DPLD (p=0.001). In 74 out of 95 patients (78%) the diagnosis was placed with Jumbo forcep while the smaller forcep was diagnostic in 62 out of 95 patients (65%). Large forceps obtained significantly more tissue than the small forceps; the biopsy specimen taken with normal forcep measured in average 1.4 x 1.0 mm and the larger biopsy taken with jumbo forcep measured in average 2.5 x 1.9 mm (p < 0.005). Conclusion. The use of large biopsy forceps to perform TBLB via rigid bronchoscope can significantly increase diagnostic yield in the pathological diagnosis of diffuse infiltrative lung disease.

Study design: Observational prospective population-based incidence study. Objectives: The main objective of this study was to assess the incidence of traumatic spinal cord injuries (TSCIs) and incidence rates, in order to provide estimates by age, gender, characteristics and cause. Setting: This study was conducted at acute-care spinal cord injury (SCI) hospitals and SCI centers from 11 Italian regions, between 1 October 2013 and 30 September 2014. Methods: Data of all consecutive patients with acute TSCI who met the inclusion criteria were obtained through case reporting by clinicians. The data were collected into a web database. Incidence rates and incidence rate ratios were calculated and stratified by age, gender, cause, level and completeness. Results: From 50% of the entire population of Italy, 445 new cases of TSCI were included. The crude incidence rate of TSCI was 14.7 cases per million per year (95% CI: 13.4–16.4); the overall male to female ratio was 4:1 and the mean age was 54. Complete information was available in 85% of the sample and revealed tetraplegia in 58% and incomplete lesion in 67% of cases. The leading cause of TSCI was falls (40.9%) followed by road traffic accidents (33.5%). The leading cause was falls for patients over 55 and road traffic accidents for patients under 55. Conclusion: The changing trend of TSCI epidemiology concerns the increase in the average age of TSCI people and the increase of both cervical and incomplete lesions. The etiology shows the primacy of falls over road traffic accidents and suggests the need for a change in prevention policies.

This paper is the design of a Radio Environment Map (REM) with a real-time tool to sense the radiofrequency spectrum and optimally places with Surrogate Modelling and Sequential Experimental Design tools a total of 72 SDR sensors in the selected area, using LoRa and/or NB-IoT technologies for networking. It permits the regulatory body to check the correct use of the assigned spectrum and constitutes a communication alternative in case of a catastrophic event, such as a hurricane or an earthquake, where radio and TV broadcasting play an important role in keeping people informed after such meteorological event. The radiobroadcast services use large antennas and high towers, making them vulnerable to such events. Regardless of the chosen technology, the IoT monitoring network will be more robust, since it uses small antennas and lower towers, and often a given area is covered by multiple base stations. The tool can be used to deploy new services in the nonserved area (e.g., 4G in the 700 MHz band at a lower cost or using TVWS techniques to provide communications and internet connection) and optimal interference management.