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"Castoro, Laura"
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Chick lit grows up
Amy Einhorn, vice president and editor in chief of hardcovers at Warner Books, answers, I don't necessarily think this is a new phenomenon. \"Harlequin launched NEXT, an imprint dedicated to the woman who's been there, done that, and is ready to conquer what's next,\" says Margaret O'Neill Marbury, the executive editor of MIRA Books and Red Dress Ink. It's become a ubiquitous crossroads for baby boomers.
Magazine Article
Gastric Leiomyoma: Intraoperative Ultrasound (IOUS)-Guided Mini-invasive Laparoscopic Enucleation
Leiomyomas are rare benign mesenchymal tumors that can arise at any age and location in the gastrointestinal tract. Gastric leiomyomas are often detected incidentally, and they account for 14 to 30% of all gastrointestinal leiomyomas. Open surgical resection is considered the standard of care for gastric leiomyomas. However, in selected cases, minimally invasive resection is both feasible and safe. We present the case of a 52-year-old previously healthy man with a gastric leiomyoma. Echoendoscopy revealed a subepithelial neoformation in the subcardial region. Histological examination of the biopsy was consistent with a leiomyoma. The video shows the laparoscopic resection of the tumor with the aid of laparoscopic ultrasound to localize the lesion. The postoperative course was regular and free from complications. The histological examination of the excised lesion confirmed the diagnosis of leiomyoma. Intraoperatieve ultrasound-guided laparoscopic resection was performed with a reasonable operation time, low blood loss, and no adverse events. Therefore, this approach can be considered safe and feasible for resecting gastric leiomyoma.
Journal Article
Early miR-223 Upregulation in Gastroesophageal Carcinogenesis
Abstract
Objectives: To test miR-223 upregulation during gastric (intestinal-type) and Barrett esophageal carcinogenesis.
Methods: miR-223 expression was assessed by quantitative reverse transcription polymerase chain reaction in a series of 280 gastroesophageal biopsy samples representative of the whole spectrum of phenotypic changes involved in both carcinogenetic cascades. The results were further validated by in situ hybridization on multiple tissue specimens obtained from six surgically treated gastroesophageal adenocarcinomas. miR-223 expression was also assessed in plasma samples from 30 patients with early stage (ie, stages I and II) gastroesophageal adenocarcinoma and relative controls.
Results: In both gastric and esophageal models, miR-223 expression significantly increased along with the severity of the considered lesions (analysis of variance, P < .001). Among atrophic gastritis and long-segment Barrett esophagus samples, miR-223 overexpression was significantly associated with the score of intestinal metaplasia. miR-223 plasma levels were significantly upregulated in patients with cancer compared with controls (t test, both P < .001).
Conclusions: miR-223 early upregulation observed in tissue samples and its diagnostic value in discriminating patients with early adenocarcinoma by plasma testing provide a solid rationale for further exploring the diagnostic reliability of this microRNA as a novel biomarker in gastroesophageal adenocarcinoma secondary prevention strategies.
Journal Article
Positron emission tomography/computed tomography and esophageal cancer in the clinical practice: How does it affect the prognosis?
Aims: The aim of this study was to assess the diagnostic value of positron emission tomography/computed tomography (PET/CT) in staging of esophageal cancer and to evaluate the prognostic role of metabolic parameters before and after neo-adjuvant treatment.
Settings and Design: Mono-institutional retrospective study.
Materials and Methods: We retrospectively evaluated 29 patients who underwent PET/CT at initial staging and after neo-adjuvant therapy. Metabolic parameters were calculated: mean, average, maximum standardized uptake value (SUVmax), and total lesion glycolysis (TLG). Diagnostic advantages of PET/CT over conventional imaging (CI) were determined. The relationships between baseline and after-therapy SUVmax and TLG, change in SUV and TLG (reported as ∆) for the primary tumor and prognosis were assessed.
Statistical Analysis Used: Non-parametric statistic (e.g. Wilcoxon test and chi-square test).
Results: Twenty-nine patients were eligible for the initial staging. Thirteen patients were incorrectly staged based on CI; PET/CT was able to identify distant lymph nodes in seven patients (59%) and distant metastases in four (31%). The median SUVmax before and after neoadjuvant therapy was 10.38 and 3.53 (P = 0.0005), respectively. Only few semi-quantitative parameters obtained by PET/CT after neoadjuvant therapy seemed to have a prognostic value. TLG and ∆TLG were significantly different between disease-free and died patients (0.49 versus 15.51 and 100% versus 94%, respectively; all P = <0.05).
Conclusions: PET/CT is confirmed as being able to detect distant metastases and to avoid unnecessary surgery. Although not routinely reported, post-neoadjuvant TLG and ∆TLG might be considered as useful prognostic parameters and should be further evaluated prospectively.
Journal Article