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The objective of the experiment was to determine the effects of fat supplementation on embryo quality of dairy cows and the subsequent success of embryo transfer into recipient heifers fed the same sources of fat. A total of 30 lactating Holstein cows were allotted on d 18 postpartum to 2 groups of 15 donor cows blocked for similar calving dates. Total mixed diets based on silage and fat supplements were fed for ad libitum intake. On a dry matter basis, diets fed to donor cows contained 7.9% whole flaxseed or 2.8% calcium salts of palm oil and those fed to recipient heifers contained 11.4% whole flaxseed or 4.2% calcium salts of palm oil. The experiment with donor cows was carried out between d 18 and 109 of lactation. The experimental diets were fed to 121 recipient heifers from wk 8 before estrus synchronization and superovulation to d 50 of gestation. Dietary fat fed to donor cows had no effect on the number of viable embryos per cow (3.7 ± 0.5), the number of degenerated embryos per cow (1.8 ± 0.4), or the number of unfertilized oocytes per cow (2.1 ± 0.8). But feeding flaxseed decreased fertilization rate (64.3 vs. 78.4%) and the percentage of grade 1 to 2 embryos (56.5 vs. 74.1%) and increased the embryo degeneration percentage (27.4 vs. 18.2%) compared with feeding calcium salts of palm oil. There was no effect of diets fed to donor cows and those fed to recipient heifers for pregnancy rate of heifers. Supplementation with a rich source of n-3 fatty acids decreased quality of embryos from donor lactating dairy cows compared with feeding calcium salts of palm oil, but had no effect on the subsequent pregnancy rate of heifers receiving frozen grade-1 embryos.

The objective of the experiment was to determine the effects of fat supplementation on embryo quality of dairy cows and the subsequent success of embryo transfer into recipient heifers fed the same sources of fat. A total of 30 lactating Holstein cows were allotted on d 18 postpartum to 2 groups of 15 donor cows blocked for similar calving dates. Total mixed diets based on silage and fat supplements were fed for ad libitum intake. On a dry matter basis, diets fed to donor cows contained 7.9% whole flaxseed or 2.8% calcium salts of palm oil and those fed to recipient heifers contained 11.4% whole flaxseed or 4.2% calcium salts of palm oil. The experiment with donor cows was carried out between d 18 and 109 of lactation. The experimental diets were fed to 121 recipient heifers from wk 8 before estrus synchronization and superovulation to d 50 of gestation. Dietary fat fed to donor cows had no effect on the number of viable embryos per cow (3.7±0.5), the number of degenerated embryos per cow (1.8±0.4), or the number of unfertilized oocytes per cow (2.1±0.8). But feeding flaxseed decreased fertilization rate (64.3 vs. 78.4%) and the percentage of grade 1 to 2 embryos (56.5 vs. 74.1%) and increased the embryo degeneration percentage (27.4 vs. 18.2%) compared with feeding calcium salts of palm oil. There was no effect of diets fed to donor cows and those fed to recipient heifers for pregnancy rate of heifers. Supplementation with a rich source of n-3 fatty acids decreased quality of embryos from donor lactating dairy cows compared with feeding calcium salts of palm oil, but had no effect on the subsequent pregnancy rate of heifers receiving frozen grade-1 embryos.

Although possible implications of nitric oxide in the pathophysiology of liver cirrhosis have been extensively studied, until now few articles have addressed the assessment of nitric oxide production in primary biliary cirrhosis. This study was directed to evaluate circulating nitrosyl-hemoglobin levels as well as neutrophil elastase and soluble adhesion molecule concentrations in this condition, by assuming these parameters as possible markers of either inflammatory response or neutrophil activation. Laboratory investigations were performed in 30 patients with primary biliary cirrhosis, in 13 patients with postviral and/or alcoholic cirrhosis, and in a group of eight subjects with chronic hepatitis. Although no difference was detected with respect to chronic hepatitis subjects, higher levels of nitrosyl-hemoglobin adducts were found in primary biliary cirrhosis patients than in postviral or alcoholic cirrhotics and in normal subjects (3.55 ± 1.75 arbitrary units vs 1.95 ± 0.57 and 0.84 ± 0.34, p = 0.0004 and p < 0.0001, respectively). Similarly, more elevated concentrations of neutrophil elastase (213.7 ± 192.0 μg/L vs 51.1 ± 34.3 and 38.0 ± 11.5, p < 0.0001 and p < 0.0001, respectively) as well as of soluble forms of intercellular adhesion molecule 1 and endothelial-leukocyte adhesion molecule 1 were shown in primary biliary cirrhosis patients than in subjects with cirrhosis of other etiologies and in controls. Highly enhanced nitric oxide production in primary biliary cirrhosis could be related to the development of strong inflammation and at least partially to neutrophil activation, thus suggesting a putative role of these cellular mediators in the development of liver damage owing to their ability to synthesize and release a wide variety of important factors, including elastase and nitric oxide.

While moral perfectionists rank conscious beings according to their cognitive abilities, Paola Cavalieri launches a more inclusive defense of all forms of subjectivity. In concert with Peter Singer, J. M. Coetzee, Harlan B. Miller, and other leading animal studies scholars, she expands our understanding of the nonhuman in such a way that the derogatory category of \"the animal\" becomes meaningless. In so doing, she presents a nonhierachical approach to ethics that better respects the value of the conscious self. Cavalieri opens with a dialogue between two imagined philosophers, laying out her challenge to moral perfectionism and tracing its influence on our attitudes toward the \"unworthy.\" She then follows with a roundtable \"multilogue\" which takes on the role of reason in ethics and the boundaries of moral status. Coetzee, Nobel Prize winner for Literature and author ofThe Lives of Animals, emphasizes the animality of human beings; Miller, a prominent analytic philosopher at Virginia Polytechnic Institute, dismantles the rationalizations of human bias; Cary Wolfe, professor of English at Rice University, advocates an active exposure to other worlds and beings; and Matthew Calarco, author ofZoographies: The Question of the Animal from Heidegger to Derrida, extends ethical consideration to entities that traditionally have little or no moral status, such as plants and ecosystems. As Peter Singer writes in his foreword, the implications of this conversation extend far beyond the issue of the moral status of animals. They \"get to the heart of some important differences about how we should do philosophy, and how philosophy can relate to our everyday life.\" From the divergences between analytical and continental approaches to the relevance of posthumanist thinking in contemporary ethics, the psychology of speciesism, and the practical consequences of an antiperfectionist stance,The Death of the Animalconfronts issues that will concern anyone interested in a serious study of morality.

See how they run Electrons move in solids at very high speed — traversing atomic layers and interfaces within tens to hundreds of attoseconds (an attosecond is a billionth of a billionth of a second). These astonishingly brief travel times will ultimately limit the speed of the electronics of the future. Physicists have now experimentally probed such electron dynamics in real time. The cover illustrates the first attosecond spectroscopic measurement in a solid, revealing a 110-attosecond difference in the travel time of two different types of electrons following photoexcitation in a tungsten crystal. The ability to time electrons moving in solids over merely a few interatomic distances makes it possible to probe the solid-state electronic processes occurring at the ultimate speed limit and thus helps to advance technologies such as computation, data storage and photovoltaics, which all rely on exquisite control of electron transport in ever smaller structures of solid matter. When exposing a tungsten crystal to intense light, the travel times of emitted electrons differ by 110 attoseconds, depending on whether they were originally tightly bound to one atom in the crystal or delocalized over many atoms. This ability to directly probe fundamental aspects of solid-state electron dynamics could aid the further development of modern technologies such as electronics, information processing and photovoltaics. Comprehensive knowledge of the dynamic behaviour of electrons in condensed-matter systems is pertinent to the development of many modern technologies, such as semiconductor and molecular electronics, optoelectronics, information processing and photovoltaics. Yet it remains challenging to probe electronic processes, many of which take place in the attosecond (1 as = 10 -18  s) regime. In contrast, atomic motion occurs on the femtosecond (1 fs = 10 -15  s) timescale and has been mapped in solids in real time 1 , 2 using femtosecond X-ray sources 3 . Here we extend the attosecond techniques 4 , 5 previously used to study isolated atoms in the gas phase to observe electron motion in condensed-matter systems and on surfaces in real time. We demonstrate our ability to obtain direct time-domain access to charge dynamics with attosecond resolution by probing photoelectron emission from single-crystal tungsten. Our data reveal a delay of approximately 100 attoseconds between the emission of photoelectrons that originate from localized core states of the metal, and those that are freed from delocalized conduction-band states. These results illustrate that attosecond metrology constitutes a powerful tool for exploring not only gas-phase systems, but also fundamental electronic processes occurring on the attosecond timescale in condensed-matter systems and on surfaces.

Linearisation of the Navier–Stokes equations about the mean of a turbulent flow forms the foundation of popular models for energy amplification and coherent structures, including resolvent analysis. While the Navier–Stokes equations can be equivalently written using many different sets of dependent variables, we show that the properties of the linear operator obtained via linearisation about the mean depend on the variables in which the equations are written prior to linearisation, and can be modified under nonlinear transformation of variables. For example, we show that using primitive and conservative variables leads to differences in the singular values and modes of the resolvent operator for turbulent jets, and that the differences become more severe as variable-density effects increase. This lack of uniqueness of mean-flow-based linear analysis provides new opportunities for optimising models by specific choice of variables while also highlighting the importance of carefully accounting for the nonlinear terms that act as a forcing on the resolvent operator.

We present an experimental study of reactive control of turbulent jets, in which we target axisymmetric coherent structures, known to play a key role in the generation of sound. We first consider a forced jet, in which coherent structures are amplified above background levels, facilitating their detection, estimation and control. We then consider the more challenging case of an unforced jet. The linear control targets coherent structures in the region just downstream of the nozzle exit plane, where linear models are known to be appropriate for description of the lowest-order azimuthal modes of the turbulence. The control law is constructed in frequency space, based on empirically determined transfer functions. And the Wiener–Hopf formalism is used to enforce causality and to provide an optimal controller, as opposed to the sub-optimal control laws provided by simpler wave-cancellation methods. Significant improvements are demonstrated in the control of both forced and unforced jets. In the former case, order-of-magnitude reductions are achieved; and in the latter, turbulence levels are reduced by up to 60 %. The results open new perspectives for the control of turbulent flow at high Reynolds number.

We investigate source mechanisms for subsonic jet noise using experimentally obtained datasets of high-Reynolds-number Mach 0.4 and 0.6 turbulent jets. The focus is on the axisymmetric mode which dominates downstream sound radiation for low polar angles and the frequency range at which peak noise occurs. A linearized Euler equation (LEE) solver with an inflow boundary condition is used to generate single-frequency hydrodynamic instability waves, and the resulting near-field fluctuations and far-field acoustics are compared with those from experiments and linear parabolized stability equation (LPSE) computations. It is found that the near-field velocity fluctuations closely agree with experiments and LPSE computations up to the end of the potential core, downstream of which deviations occur, but the LEE results match experiments better than the LPSE results. Both the near-field wavepackets and the sound field are observed directly from LEE computations, but the far-field sound pressure levels (SPLs) obtained are more than an order of magnitude lower than experimental values despite close statistical agreement of the near hydrodynamic field up to the potential core region. We explore the possibility that this discrepancy is due to the mismatch between the decay of two-point coherence with increasing distance in experimental flow fluctuations and the perfect coherence in linear models. To match the near-field coherence, experimentally obtained coherence profiles are imposed on the two-point cross-spectral density (CSD) at cylindrical and conical surfaces that enclose near-field structures generated with LEEs. The surface pressure is propagated to the far field using boundary value formulations based on the linear wave equation. Coherence matching yields far-field SPLs which show improved agreement with experimental results, indicating that coherence decay is the main missing component in linear models. The CSD on the enclosing surfaces reveals that the application of a decaying coherence profile spreads the hydrodynamic component of the linear wavepacket source on to acoustic wavenumbers, resulting in a more efficient acoustic source.