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In 1842, the pioneering French photographer Joseph-Philibert Girault de Prangey (1804-1892) set out eastward across the Mediterranean with a custom-built camera to explore ancient lands that were largely unknown to the Western world. This book is the first to fully consider the hundreds of daguerreotypes that resulted from his three-year journey, many of which were made using innovative techniques that fascinate photographers to this day. The images, including the first-known photographic documentation of significant locations, offer tangible evidence of historic sites, many of which have since been destroyed, in places such as Greece, Italy, Egypt, Turkey, Syria, and Jerusalem. They are remarkable and unparalleled portraits of a world gone by. Copiously illustrated and featuring a geographic glossary of the sites and images, Monumental Journey sheds new light on the arc of Girault's career, the vibrant orientalist milieu of 19th-century France that shaped his work, and his inventive contributions to the nascent field of photography. It introduces modern audiences to a brilliant yet enigmatic talent, as well as the stunning images, many published here for the time, that make a major contribution to the histories of both photography and eastern Mediterranean.--Exhibition: The Metropolitan Museum of Art, New York (30.10-12.05.2019); Musâee d'Orsay, Paris, France (17.06-13.10.2019).

Brain‐computer interfaces (BCIs) can provide sensory feedback of ongoing brain oscillations, enabling stroke survivors to modulate their sensorimotor rhythms purposefully. A number of recent clinical studies indicate that repeated use of such BCIs might trigger neurological recovery and hence improvement in motor function. Here, we provide a first meta‐analysis evaluating the clinical effectiveness of BCI‐based post‐stroke motor rehabilitation. Trials were identified using MEDLINE, CENTRAL, PEDro and by inspection of references in several review articles. We selected randomized controlled trials that used BCIs for post‐stroke motor rehabilitation and provided motor impairment scores before and after the intervention. A random‐effects inverse variance method was used to calculate the summary effect size. We initially identified 524 articles and, after removing duplicates, we screened titles and s of 473 articles. We found 26 articles corresponding to BCI clinical trials, of these, there were nine studies that involved a total of 235 post‐stroke survivors that fulfilled the inclusion criterion (randomized controlled trials that examined motor performance as an outcome measure) for the meta‐analysis. Motor improvements, mostly quantified by the upper limb Fugl‐Meyer Assessment (FMA‐UE), exceeded the minimal clinically important difference (MCID=5.25) in six BCI studies, while such improvement was reached only in three control groups. Overall, the BCI training was associated with a standardized mean difference of 0.79 (95% CI: 0.37 to 1.20) in FMA‐UE compared to control conditions, which is in the range of medium to large summary effect size. In addition, several studies indicated BCI‐induced functional and structural neuroplasticity at a subclinical level. This suggests that BCI technology could be an effective intervention for post‐stroke upper limb rehabilitation. However, more studies with larger sample size are required to increase the reliability of these results.

The shoots of Asparagus L. are consumed worldwide, although most species belonging to this genus have a restricted range, and several taxa remain unstudied. In this work, a total of four taxa from different locations were scrutinized and compared with cultivated A. officinalis. All shoots were screened for saponins via LC-MS, and in vitro antiproliferative activities against the HT-29 colorectal cancer cell line were assessed via the MTT assay. The total saponins (TS) contained in the crude extracts ranged from 710.0 (A. officinalis) to 1258.6 mg/100 g dw (A. acutifolius). The richness of the compounds detected in this work stands out; a total of 47 saponins have been detected and quantified in the edible parts (shoots) of five taxa of Asparagus. The structure of all the saponins found present skeletons of the furostane and spirostane type. In turn, the structures with a furostane skeleton are divided into unsaturated and dioxygenated types, both in the 20–22 position. The sum of dioscin and derivatives varied largely among the studied taxa, reaching the following percentages of TS: 27.11 (A. officinalis), 18.96 (A. aphyllus), 5.37 (A. acutifolius), and 0.59 (A. albus); while in A. horridus, this compound remains undetected. Aspachiosde A, D, and M varied largely among samples, while a total of seven aspaspirostanosides were characterized in the analyzed species. The hierarchical cluster analysis of the saponin profiles clearly separated the various taxa and demonstrated that the taxonomic position is more important than the place from which the samples were acquired. Thus, saponin profiles have chemotaxonomic significance in Asparagus taxa. The MTT assay showed dose- and time-dependent inhibitory effects of all saponins extracts on HT-29 cancer cells, and the strongest cell growth inhibition was exercised by A. albus and A. acutifolius (GI50 of 125 and 175 µg/mL). This work constitutes a whole approach to evaluating the saponins from the shoots of different Asparagus taxa and provides arguments for using them as functional foods.

Wild Asparagus shoots are consumed worldwide, although most species remain understudied. In this work, a total of four wild Asparagus species were collected from different locations and analyzed compared with farmed A. officinalis. Shoots were screened for (i) phenolic compounds by HPLC-DAD and LC-MS; (ii) total phenolic acids and total flavonoid content by the Folin–Ciocalteu and aluminum chloride methods; (iii) vitamin C by HPLC-DAD; (iv) antioxidant activity by the DPPH and ABTS•+ methods; and (v) the in vitro antiproliferative activities against HT-29 colorectal cancer cells by the MTT assay. Phenolics ranged from 107.5 (A. aphyllus) to 605.4 mg/100 g dry weight (dw) (A. horridus). Vitamin C ranged from 15.8 (A. acutifolius) to 22.7 mg/100 g fresh weight (fw) (A. officinalis). The antioxidant activity was similar in all species, standing out in A. officinalis with 5.94 (DPPH) and 4.64 (ABTS) mmol TE/100 g dw. Among phenolics, rutin reached the highest values (574 mg/100 g dw in A. officinalis), followed by quercetin, nicotiflorin, asterin, and narcissin. The MTT assay revealed the inhibitory effects of ethanol extracts against HT-29 cancer cells, highlighting the cell growth inhibition exercised by A. albus (300 µg/mL after 72 h exposure to cells). This work improves knowledge on the phytochemicals and bioactivities of the shoots of wild Asparagus species and confirms their suitability for use as functional foods.

Polyamines (PAs) are ubiquitous low molecular weight, molecules found in all living cells with participation in a variety of processes. The establishment of symbiotic interactions between soil nitrogen fixing bacteria (rhizobia) and leguminous plants, as well as the formation of the root nodules where the rhizobia are hosted, depends on the production of PAs by both partners. In the bacteria, PAs provide certain traits that facilitate the recognition between the symbionts, while in the plant, PAs participate in the production of signaling molecules like hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO), detected during the initial stages of the symbiosis. Once the symbiosis is established, the high amount and variety of PAs in the root nodules together to their participation in the metabolic reactions supporting nitrogen fixation, suggest their involvement in the nodule functioning. In addition, PAs are key players in the response to abiotic stresses contributing to the adaptation of the symbiosis to salinity, specially, by an increment in the production of PAs in the bacteroids and their interactions with other anti-stress plant hormones. Considering the importance of biological nitrogen fixation in soil fertility and agriculture productivity in a context of climate change, in this review we describe the participation of PAs to the rhizobia-legume interaction and the nitrogen fixation process, as well as its involvement in the response to salinity in the symbiosis.

Dysfunction of the LIS1 gene causes lissencephaly, a drastic neurological disorder characterized by a deep disruption of the cortical structure. We aim to uncover alterations of the cortical neuronal networks related with the propagation of epileptiform activity in the Lis1/sLis1 mouse, a model lacking the LisH domain in heterozygosis. We did extracellular field-potential and intracellular recordings in brain slices of the anterior cingulate cortex (ACC) or the retrosplenial cortex (RSC) to study epileptiform activity evoked in the presence of bicuculline (10 µM), a blocker of GABAA receptors. The sensitivity to bicuculline of the generation of epileptiform discharges was similar in wild type (WT) and Lis1/sLis1 cortex (EC50 1.99 and 2.24 µM, respectively). In the Lis1/sLis1 cortex, we observed a decreased frequency of the oscillatory post-discharges of the epileptiform events; also, the propagation of epileptiform events along layer 2/3 was slower in the Lis1/sLis1 cortex (WT 47.69 ± 2.16 mm/s, n = 25; Lis1/sLis1 37.34 ± 2.43 mm/s, n = 15; p = 0.004). The intrinsic electrophysiological properties of layer 2/3 pyramidal neurons were similar in WT and Lis1/sLis1 cortex, but the frequency of the spontaneous EPSCs was lower and their peak amplitude higher in Lis1/sLis1 pyramidal neurons. Finally, the propagation of epileptiform activity was differently affected by AMPA receptor blockers: CNQX had a larger effect in both ACC and RSC while GYKI53655 had a larger effect only in the ACC in the WT and Lis1/sLis1 cortex. All these changes indicate that the dysfunction of the LIS1 gene causes abnormalities in the properties of epileptiform discharges and in their propagation along the layer 2/3 in the anterior cingulate cortex and in the restrosplenial cortex.

Rugulopteryx okamurae is an invasive brown macroalga that has recently proliferated in the western Mediterranean Sea, causing significant environmental challenges. This alga, however, contains valuable bioactive compounds—alginate, mannitol, and phlorotannins—that can serve as biofertilizers to promote plant growth and aid in bioremediation of degraded or contaminated soils. This study focused on optimizing the extraction of these compounds from R. okamurae, transforming an ecological issue into a beneficial resource. Algae samples collected from the Spanish Mediterranean coast were processed through a randomized factorial response surface design. Extraction conditions varied by time, temperature, algae-to-solvent ratio, and ethanol-to-water ratio to determine optimal yields. The highest yields achieved were 29.4, 11.9, and 0.35 g/100 g for alginate, mannitol, and phlorotannin’s under extraction conditions of 6, 6, and 3 h; 58.8, 60.0, and 60.0 °C; and an algae:solvent ratio of 1:50, 2:45, and 1.40 g/mL, respectively. Characterization of the extracted sodium alginate using 1H-NMR, FTIR, and high-resolution electron microscopy confirmed its high purity and typical morphological features. This study highlights a sustainable approach to mitigating the invasive spread of R. okamurae while supporting soil health and sustainable agriculture. Harnessing this invasive species’ biofertilizer potential provides a dual solution, aiding marine ecosystem conservation and developing eco-friendly agricultural practices.

Background and purpose: : The pathophysiology of stroke-associated infection (SAI) is uncertain. The cytokine profile and peripheral white cell response were assessed in patients with or without SAI. Methods: The incidence of SAI was assessed in 110 patients with ischaemic stroke allocated antibiotic prophylaxis or placebo within 24 h of clinical onset. Peripheral white cell counts, interleukin (IL)6, tumour necrosis factor (TNF)α and IL10 were measured in plasma. Results: 17 (15%) patients developed infection and showed time-dependent increases of total white cell count, neutrophils, monocytes, lymphocytes, IL6 and IL10, whereas TNFα and the TNFα/IL10 ratio decreased. In logistic regression, IL10 (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.01 to 1.16), monocyte count (OR 1.42, 95% CI 1.08 to 1.87) and National Institute for Health Stroke Survey score on admission (OR 1.17, 95% CI 1.05 to 1.31) were independent predictors of systemic infection. Conclusions: SAI is associated with stroke severity, excessive IL10-mediated response and an increased number of circulating monocytes. These results support the finding that acute ischaemic brain injury triggers a blood-borne anti-inflammatory response that decreases the antimicrobial drive of the immune system.

Ionospheric disturbances observed by bottom‐side soundings of the ionosphere appear at many temporal and spatial scales. Australia has many simultaneous observations from vertically orientated ionospheric sounders with spatial separations on the scale of 1000 km. However, with this spatial sampling only large scale ionospheric disturbances can be mapped and subsequently modeled. DSTO has an experimental program in progress to investigate the smaller spatial scale disturbances. These are often seen on vertical incidence soundings and are uncorrelated with soundings from greater than 500 km away. They can also be uncorrelated with soundings from the same site only 15 min later. The DSTO program to investigate these ionospheric disturbances is called SpICE, for Spatial Ionospheric Correlation Experiment. SpICE uses a small set of transmitters and receivers with varying separations to achieve a geographically spread set of near‐vertical incidence ionospheric “reflection” points separated by 50–150 km, allowing us to probe disturbances at this spatial scale. Using the latest digital receiver technology we can collect amplitude and phase information from the ionospheric returns of the continuous wave transmissions of a nearby transmitter that is rapidly sweeping through the HF band. The returned signal is processed at a very high resolution to achieve good signal‐to‐noise complex ionograms at better than one‐minute time updates. To date there have been three SpICE campaigns. This paper will discuss the SpICE program goals and highlight some of the unusual features observed in the first campaign. Following papers will look more closely at this data set and the subsequent campaigns. Key Points Introduces set of experiments by DSTO to investigate ionospheric disturbances Band‐passed h'F2 found to be tracer for disturbances Spatial sampling needs to be smaller than 100 km to adequately capture structure

Polyamines (PAs) are small nitrogen polycationic compounds involved in the response to salinity as well as in biotic interactions. Legumes are salt sensitive species characterised by their ability to establish symbiotic interactions with nitrogen fixing bacteria known as rhizobia that colonize the roots inducing the formation of nodules where the nitrogen fixation occurs. The content of PAs can be regulated among others by the catabolic enzymes diamine oxidase (DAO) and polyamine oxidase that additionally, are a source of H2O2, required in the regulation of biotic interactions including the rhizobia-legume symbiosis. Therefore, the role of PAs catabolism in the symbiosis between Medicago truncatula and Sinorhizobium meliloti under salt stress conditions was assessed in this work by the inhibition of DAO with the specific inhibitor aminoguanidine (AG). Treatment with AG limited the symbiosis, reducing root nodule formation and nitrogenase activity. Under salt stress conditions, the reduction of the PAs levels in nodules, together with glutamic acid (Glu), support that synthesis of PAs would be involved in the regulation of PAs levels rather than degradation. In addition, the content of H2O2 in mature nodules and leaves is regulated by catalase activity (CAT), instead of PAs oxidation, while H2O2 produced by PAs catabolism seems to be involved in the inhibition of the symbiosis establishment.