Explore the vast range of titles available.

To investigate how implementing the PHsHIT framework within a mind map concept and instructional approach could enhance learning experience, leading to enhanced self-perceived clinical reasoning abilities, self-confidence, and clinical decision-making skills among nursing students, while also reducing their levels of anxiety. Nursing graduates face challenges in applying clinical reasoning proficiently within their initial year of practice. This study employed a quasi-experimental pretest-posttest design. Purposive sampling involving a total of 125 nursing students. The intervention group (n = 67) attended a 2-hour tutorial class using the PHsHIT framework, whereas the control group (n = 58) attended a standard tutorial class using conventional methods. Descriptive statistics, chi-square test, parametric between-participants and within-participants analyses of variance were conducted to compare the self-perceived clinical-reasoning ability, self-confidence and anxiety levels, and clinical decision-making ability of the two groups. At the post-training time point, a significant difference was observed between the two groups in terms of their clinical decision-making ability (MD = 1.18, SE = 0.35, p = 0.001), which suggested that the PHsHIT framework had a short-term training effect. The PHsHIT framework exhibited short-term benefits for improving students’ clinical decision-making ability, and participants welcomed the method. •Nursing students lack clinical reasoning.•Nursing students lack effective learning strategies.•Nursing students are not able to apply knowledge into clinical practice.•Using learning in teaching exhibited short-term benefits for improving clinical decision-making.•Mnemonic PHsHIT can be used in classroom and clinical learning to develop clinical reasoning.

Background Self-stigma among people with mental illness is negatively associated with personal and clinical recovery. Due to the concealable nature of mental illness, people with mental illness experience constant struggles between concealment and disclosure. Disclosure of mental health challenges can potentially minimize negative impacts of self-stigma and enhance self-esteem and sense of empowerment. Honest, Open, Proud (HOP) is a peer-led intervention that promotes autonomous and dignified decisions about disclosure. Purpose This study examined the effectiveness of HOP on concealment motivation, empowerment, self-stigma, stigma stress, and recovery among people with lived experience of mental illness in Hong Kong. Methodology A total of 162 participants with a mean age of 45.38 were recruited and randomized into intervention group and waitlist control group. Participants in the intervention group were invited to attend a 6-session HOP group intervention. Results Significant improvement in optimism score from the empowerment scale was found in the intervention group compared to the waitlist control group and the effect was sustained at 1-month follow-up. However, significant changes were not found in other outcome variables. Conclusion Only improvement in optimism was observed in the current study. Future study needs to examine the effects of HOP with further modification to maximize the benefit for people with lived experience of mental illness in the local context.

The strong association between music and speech has been supported by recent research focusing on musicians' superior abilities in second language learning and neural encoding of foreign speech sounds. However, evidence for a double association--the influence of linguistic background on music pitch processing and disorders--remains elusive. Because languages differ in their usage of elements (e.g., pitch) that are also essential for music, a unique opportunity for examining such language-to-music associations comes from a cross-cultural (linguistic) comparison of congenital amusia, a neurogenetic disorder affecting the music (pitch and rhythm) processing of about 5% of the Western population. In the present study, two populations (Hong Kong and Canada) were compared. One spoke a tone language in which differences in voice pitch correspond to differences in word meaning (in Hong Kong Cantonese, /si/ means 'teacher' and 'to try' when spoken in a high and mid pitch pattern, respectively). Using the On-line Identification Test of Congenital Amusia, we found Cantonese speakers as a group tend to show enhanced pitch perception ability compared to speakers of Canadian French and English (non-tone languages). This enhanced ability occurs in the absence of differences in rhythmic perception and persists even after relevant factors such as musical background and age were controlled. Following a common definition of amusia (5% of the population), we found Hong Kong pitch amusics also show enhanced pitch abilities relative to their Canadian counterparts. These findings not only provide critical evidence for a double association of music and speech, but also argue for the reconceptualization of communicative disorders within a cultural framework. Along with recent studies documenting cultural differences in visual perception, our auditory evidence challenges the common assumption of universality of basic mental processes and speaks to the domain generality of culture-to-perception influences.

Is our memory for pairs of items dependent on item characteristics? The present study explores this question using a word learning paradigm; specifically, we examined whether referent characteristics, such as referent type (face/object) and familiarity (known/unknown), may influence word-referent mapping. Moreover, we examined this effect across two test sessions to determine if the influence of referent characteristics might be more pronounced over time, and across two age groups (young vs. older adults) to determine if there might be age-related differences. Participants were presented with pseudoword-referent mappings in four referent conditions (face/object × known/unknown) and then were tested with a recognition task immediately after learning, and again after a short delay. Our findings indicated that names for faces were not learned better than names for objects, despite previous literature suggesting that faces are processed differently. We also found that known referents (defined as having a pre-existing label for a referent) were learned better than unknown items but this familiarity advantage was only observed for faces and not for objects. While there were several age-related findings, these might be due to the longer delay between the immediate and delayed tests among the older adults relative to young adults. Taken together, our results suggest that certain referent characteristics do interact and influence our learning of and memory for such pairings.

HFE (Hemochromatosis) is a conventional iron level regulator and its loss of function due to gene mutations increases the risk of cancers including hepatocellular carcinoma (HCC). Likewise, studies focusing on HFE overexpression in cancers are all limited to linking up these events as a consequence of iron level deregulation. No study has explored any iron unrelated role of HFE in cancers. Here, we first reported HFE as an oncogene in HCC and its undescribed function on promoting abscission in cytokinesis during mitotic cell division, independent of its iron-regulating ability. Clinical analyses revealed HFE upregulation in tumors linking to large tumor size and poor prognosis. Functionally and mechanistically, HFE promoted cytokinetic abscission via facilitating ESCRT abscission machinery recruitment to the abscission site through signaling a novel HFE/ALK3/Smads/LIF/Hippo/YAP/YY1/KIF13A axis. Pharmacological blockage of HFE signaling axis impeded tumor phenotypes in vitro and in vivo. Our data on HFE-driven HCC unveiled a new mechanism utilized by cancer cells to propel rapid cell division. This study also laid the groundwork for tumor intolerable therapeutics development given the high cytokinetic dependency of cancer cells and their vulnerability to cytokinetic blockage.

Despite the growing number of bicultural bilinguals in the world, the way in which multisensory emotions are evaluated by bilinguals who identify with two or more cultures remains unknown. In the present study, Chinese-English bicultural bilinguals from Singapore viewed Asian or Caucasian faces and heard Mandarin or English speech, and evaluated the emotion from one of the two simultaneously-presented modalities. Reliance on the visual modality was greater when bicultural bilinguals processed Western audio-visual emotion information. Although no differences between modalities emerged when processing East-Asian audio-visual emotion information, correlations revealed that bicultural bilinguals increased their reliance on the auditory modality with more daily exposure to East-Asian cultures. Greater interference from the irrelevant modality was observed for Asian faces paired with English speech than for Caucasian faces paired with Mandarin speech. We conclude that processing of emotion in bicultural bilinguals is guided by culture-specific norms, and that familiarity influences how the emotions of those who speak a foreign language are perceived and evaluated.

C1q deficiency is a rare inborn error of immunity characterized by increased susceptibility to infections and autoimmune manifestations mimicking SLE, with an associated morbidity and mortality. Because C1q is synthesized by monocytes, to date, four patients treated with allogeneic HSCT have been reported, with a positive outcome in three. We conducted an international retrospective study to assess the outcome of HSCT in C1q deficiency. Eighteen patients, fourteen previously unreported, from eleven referral centres, were included. Two patients had two HSCTs, thus 20 HSCTs were performed in total, at a median age of 10 years (range 0.9—19). Indications for HSCT were autoimmune manifestations not controlled by ongoing treatment in seventeen, and early development of MALT lymphoma in one patient. Overall survival (OS) was 71% and event-free survival was 59% at two years (considering an event as acute GvHD ≥ grade III, disease recurrence and death). In eleven patients HSCT led to resolution of autoimmune features and discontinuation of immunosuppressive treatments (follow-up time range 3–84 months). Five patients died due to transplant-related complications. Patients with a severe autoimmune phenotype, defined as neurological and/or renal involvement, had the worst OS (40% vs 84%; p  = 0.034). Reviewing data of 69 genetically confirmed C1q deficient patients, we found that anti-Ro antibodies are associated with neurologic involvement, and anti-RNP and anti-DNA antibodies with renal involvement. In conclusion, HSCT may be a valid curative option for C1q deficiency, but careful selection of patients, with an accurate assessment of risk and benefit, is mandatory.

Integration of smoking cessation program into routine oral health care has been advocated by World Health Organization since it brings extensive benefits to oral health. By tobacco cessation, patients are less prone to progression of periodontal disease, have less future tooth loss, have reduced risks of oral mucosal lesions and head and neck cancers. Evidence indicates that dentists are in a favorable position to deliver effective smoking cessation advice to improve patients’ oral health. This article aims to present the current situation of smoking cessation in dental setting, including dental management of smoking patients, perceptions of dentists and dental students towards smoking cessation, challenges dental professionals face when carrying out cessation interventions. Patients’ perspectives are also evaluated to provide a clearer picture of smoking cessation practice in the dental field. Review of past surveys show most patients welcome smoking cessation advice from dental practitioners. Meanwhile dentists may have wrong assumption that patients would disapprove them if they advise patient to quit smoking. On top of that, main obstacles identified are lack of training, inadequate treatment time and insufficient knowledge towards smoking cessation guidelines and referral routes. With regard to the potential barriers, evidence demonstrates that more trainings on smoking cessation strategies are needed. Future research in this aspect is also indicated to further foster the practice of smoking cessation counselling in dental setting.

The effect of language on the categorical perception of color is stronger for stimuli in the right visual field (RVF) than in the left visual field, but the neural correlates of the behavioral RVF advantage are unknown. Here we present brain activation maps revealing how language is differentially engaged in the discrimination of colored stimuli presented in either visual hemifield. In a rapid, event-related functional MRI study, we measured subjects' brain activity while they performed a visual search task. Compared with colors from the same lexical category, discrimination of colors from different linguistic categories provoked stronger and faster responses in the left hemisphere language regions, particularly when the colors were presented in the RVF. In addition, activation of visual areas 2/3, responsible for color perception, was much stronger for RVF stimuli from different linguistic categories than for stimuli from the same linguistic category. Notably, the enhanced activity of visual areas 2/3 coincided with the enhanced activity of the left posterior temporoparietal language region, suggesting that this language region may serve as a top-down control source that modulates the activation of the visual cortex. These findings shed light on the brain mechanisms that underlie the hemifield- dependent effect of language on visual perception.

Background Point-of-care ultrasound (POCUS) is a core skill in emergency medicine (EM), however, there is a lack of objective competency measures. Eye-tracking technology is a potentially useful assessment tool, as gaze patterns can reliably discriminate between experts and novices across medical specialties. We aim to determine if gaze metrics change in an independent and predictable manner during ultrasound training. Methods A convenience sample of first-year residents from a single academic emergency department was recruited. Participants interpreted 16 ultrasound videos of the focused assessment with sonography for trauma (FAST) scan while their gaze patterns were recorded using a commercially available eye-tracking device. The intervention group then completed an introductory ultrasound course whereas the control group received no additional education. The gaze assessment was subsequently repeated. The primary outcome was total gaze duration on the area of interest (AOI). Secondary outcomes included time to fixation, mean duration of first fixation and mean number of fixations on the AOI. Results 10 EM residents in the intervention group and 10 non-EM residents in the control group completed the study. After training, there was an 8.8 s increase in the total gaze time on the AOI in the intervention group compared to a 4.0 s decrease in the control group ( p  = .03). EM residents were also 3.8 s quicker to fixate on the AOI whereas the control group became 2.5 s slower ( p  = .04). There were no significant interactions on the number of fixations (0.43 vs. 0.18, p  = .65) or duration of first fixation on the AOI (0.02 s vs. 0.06 s, p  = .63). Conclusions There are significant and quantifiable changes in gaze metrics, which occur with incremental learning after an ultrasound course. Further research is needed to validate the serial use of eye-tracking technology in following a learner’s progress toward competency in point-of-care ultrasound image interpretation.