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"Chan, S."
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Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory
Collinsella
have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications.
Microbiota-gut-brain axis may play an important role in Parkinson’s disease (PD). Here, the authors assess gut microbiota in early PD, REM sleep behaviour disorder (RBD) and first-degree relatives of RBD and show PD-like gut dysbiosis occurs in RBD and their first-degree relatives.
Journal Article
Community development arenas in Singapore
\"In the last two decades or so, community development efforts in Singapore have strongly focused on task-centred community activities namely short-term projects revolving around socio-educational and recreational activities. Such an emphasis is further reinforced by the outsourcing of community services to the private sector which is contracted to deliver services or activities. Although the consequences are not seen immediately, they will in the longer term reinforce learned helplessness of the participants or beneficiaries who are usually relegated to passive or dependent roles. Through the insights of contributors who are practitioners in the community development field, this book argues that more resources and initiatives must be accorded to community organisations so as to redirect to a community- or resident-centric approach towards community work intervention. In short, more reaching out to people or community groups should be undertaken. Covering a broad range of arenas including health, housing, ageing, community integration and bonding, among others, this book will open up a wider horizon for community development efforts and provide a reservoir of ideas and strategies to build a stronger and resilient community for more effective community problem-solving\"-- Provided by publisher.
Book
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles
ObjectiveSporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.DesignWe established paired cancer (n=32) and normal organoids (n=18) from 20 patients enriched in microsatellite-stable EOCRC. Exome and transcriptome analysis was performed.ResultsWe observed a striking diversity of molecular phenotypes, including PTPRK-RSPO3 fusions. Transcriptionally, RSPO fusion organoids resembled normal colon organoids and were distinct from APC mutant organoids, with high BMP2 and low PTK7 expression. Single cell transcriptome analysis confirmed the similarity between RSPO fusion organoids and normal organoids, with a propensity for maturation on Wnt withdrawal, whereas the APC mutant organoids were locked in progenitor stages. CRISPR/Cas9 engineered mutation of APC in normal human colon organoids led to upregulation of PTK7 protein and suppression of BMP2, but less so with an engineered RNF43 mutation. The frequent co-occurrence of RSPO fusions with SMAD4 or BMPR1A mutation was confirmed in TCGA database searches. RNF43 mutation was found in organoid from a leukaemia survivor with a novel mutational signature; and organoids with POLE proofreading mutation displayed ultramutation. The cancer organoid genomes were stable over long culture periods, while normal human colon organoids tended to be subject to clonal dominance over time.ConclusionsThese organoid models enriched in EOCRCs with linked genomic data fill a gap in existing CRC models and reveal distinct genetic profiles and novel pathway cooperativity.
Journal Article
The Forgotten Role of Alcohol: A Systematic Review and Meta-Analysis of the Clinical Efficacy and Perceived Role of Chlorhexidine in Skin Antisepsis
Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis. However, study outcomes due to chlorhexidine-alcohol combinations are often attributed to chlorhexidine alone. Thus, we sought to review the efficacy of chlorhexidine for skin antisepsis and the extent of a possible misinterpretation of evidence.
We performed a systematic literature review of clinical trials and systematic reviews investigating chlorhexidine compounds for blood culture collection, vascular catheter insertion and surgical skin preparation. We searched PubMed, CINAHL, the Cochrane Library, the Agency for Healthcare Research and Quality website, several clinical trials registries and a manufacturer website. We extracted data on study design, antiseptic composition, and the following outcomes: blood culture contamination, catheter colonisation, catheter-related bloodstream infection and surgical site infection. We conducted meta-analyses of the clinical efficacy of chlorhexidine compounds and reviewed the appropriateness of the authors' attribution.
In all three application areas and for all outcomes, we found good evidence favouring chlorhexidine-alcohol over aqueous competitors, but not over competitors combined with alcohols. For blood cultures and surgery, we found no evidence supporting chlorhexidine alone. For catheters, we found evidence in support of chlorhexidine alone for preventing catheter colonisation, but not for preventing bloodstream infection. A range of 29 to 43% of articles attributed outcomes solely to chlorhexidine when the combination with alcohol was in fact used. Articles with ambiguous attribution were common (8-35%). Unsubstantiated recommendations for chlorhexidine alone instead of chlorhexidine-alcohol were identified in several practice recommendations and evidence-based guidelines.
Perceived efficacy of chlorhexidine is often in fact based on evidence for the efficacy of the chlorhexidine-alcohol combination. The role of alcohol has frequently been overlooked in evidence assessments. This has broader implications for knowledge translation as well as potential implications for patient safety.
Journal Article
Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
Nanomaterials (NMs) have gained prominence in technological advancements due to their tunable physical, chemical and biological properties with enhanced performance over their bulk counterparts. NMs are categorized depending on their size, composition, shape, and origin. The ability to predict the unique properties of NMs increases the value of each classification. Due to increased growth of production of NMs and their industrial applications, issues relating to toxicity are inevitable. The aim of this review is to compare synthetic (engineered) and naturally occurring nanoparticles (NPs) and nanostructured materials (NSMs) to identify their nanoscale properties and to define the specific knowledge gaps related to the risk assessment of NPs and NSMs in the environment. The review presents an overview of the history and classifications of NMs and gives an overview of the various sources of NPs and NSMs, from natural to synthetic, and their toxic effects towards mammalian cells and tissue. Additionally, the types of toxic reactions associated with NPs and NSMs and the regulations implemented by different countries to reduce the associated risks are also discussed.
Journal Article
Maritime cooperation and security in the Indo-Pacific region : essays in honour of Sam Bateman
\"More than twenty Indo-Pacific scholars and emerging experts come together in this definitive volume to deliver fresh perspectives and original research on maritime cooperation and security. With subjects ranging from the Philippines to Antarctica, Coast Guards to climate change, these essays pay tribute to the late Commodore Sam Bateman (PhD) while laying the academic groundwork for the improved policies and behaviours that provide for improved good order at sea\"-- Provided by publisher.
BOOK
The Macanese Diaspora in British Hong Kong
Diaspora transformed the urban terrain of colonial societies, creating polyglot worlds out of neighborhoods, workplaces, recreational clubs, and public spheres. It was within these spaces that communities reimagined and reshaped their public identities vis-à-vis emerging government policies and perceptions from other communities. Through a century of Macanese activities in British Hong Kong, The Macanese Diaspora in British Hong Kong: A Century of Transimperial Drifting explores how mixed-race diasporic communities survived within unequal, racialized, and biased systems beyond the colonizer-colonized dichotomy. Originating from Portuguese Macau yet living outside the control of the empire, the Macanese freely associated with more than one identity and pledged allegiance to multiple communal, political, and civic affiliations. They drew on colorful imaginations of the Portuguese and British empires in responding to a spectrum of changes encompassing Macau's woes, Hong Kong's injustice, Portugal's political transitions, global developments in print culture, and the rise of new nationalisms during the inter-war period.
eBook