Explore the vast range of titles available.

Patients with acute upper gastrointestinal bleeding were assigned to receive endoscopy within 6 hours or between 6 and 24 hours after gastroenterologic consultation. Mortality at 30 days was 8.9% in the former group and 6.6% in the latter group; earlier endoscopy did not lower mortality.

The past three decades have borne witness to many advances in the understanding of the molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus (EBV)-associated cancer endemic to southern China, southeast Asia and north Africa. In this Review, we provide a comprehensive, interdisciplinary overview of key research findings regarding NPC pathogenesis, treatment, screening and biomarker development. We describe how technological advances have led to the advent of proton therapy and other contemporary radiotherapy approaches, and emphasize the relentless efforts to identify the optimal sequencing of chemotherapy with radiotherapy through decades of clinical trials. Basic research into the pathogenic role of EBV and the genomic, epigenomic and immune landscape of NPC has laid the foundations of translational research. The latter, in turn, has led to the development of new biomarkers and therapeutic targets and of improved approaches for individualizing immunotherapy and targeted therapies for patients with NPC. We provide historical context to illustrate the effect of these advances on treatment outcomes at present. We describe current preclinical and clinical challenges and controversies in the hope of providing insights for future investigation.Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated malignancy endemic to southern China, southeast Asia and north Africa. The authors of this Review present a comprehensive overview of advances from the past three decades on the pathogenic role of EBV, and the genomic, epigenomic and immune landscape of NPC, which have led to the development of new biomarkers, therapeutic targets and improved treatment approaches for patients with NPC.

14-3-3 proteins are a family of structurally similar phospho-binding proteins that regulate essentially every major cellular function. Decades of research on 14-3-3s have revealed a remarkable network of interacting proteins that demonstrate how 14-3-3s integrate and control multiple signaling pathways. In particular, these interactions place 14-3-3 at the center of the signaling hub that governs critical processes in cancer, including apoptosis, cell cycle progression, autophagy, glucose metabolism, and cell motility. Historically, the majority of 14-3-3 interactions have been identified and studied under nutrient-replete cell culture conditions, which has revealed important nutrient driven interactions. However, this underestimates the reach of 14-3-3s. Indeed, the loss of nutrients, growth factors, or changes in other environmental conditions (e.g., genotoxic stress) will not only lead to the loss of homeostatic 14-3-3 interactions, but also trigger new interactions, many of which are likely stress adaptive. This dynamic nature of the 14-3-3 interactome is beginning to come into focus as advancements in mass spectrometry are helping to probe deeper and identify context-dependent 14-3-3 interactions—providing a window into adaptive phosphorylation-driven cellular mechanisms that orchestrate the tumor cell’s response to a variety of environmental conditions including hypoxia and chemotherapy. In this review, we discuss emerging 14-3-3 regulatory mechanisms with a focus on post-translational regulation of 14-3-3 and dynamic protein–protein interactions that illustrate 14-3-3’s role as a stress-adaptive signaling hub in cancer.

Bound states in the continuum (BICs) have attracted attention in photonics owing to their interesting properties. For example, BICs can effectively confine light in a counterintuitive way, and the far-field radiation of photonic structures that exhibit BICs has fascinating topological characteristics. Early research into photonic BICs was primarily focused on designing artificial structures to produce BICs. However, since the mid-2010s, exploring the potential applications of BICs has been a growing trend in research. In this Review, we detail the unique properties of BICs, including the ability to achieve enhanced light confinement, sharp Fano resonances and topological characteristics. We explore phenomena derived from BICs, including the generation of circularly polarized states and unidirectional guided resonances, and the impact of BICs on various applications such as lasing, nonlinear frequency conversion, waveguiding, sensing and wavefront control. We also discuss the insights provided by BICs in several emerging research frontiers, such as parity–time symmetric systems, higher-order topology, exciton–photon coupling and moiré superlattices.Photonic systems provide a versatile platform to explore and use bound states in the continuum. This Review discusses the potential of these states for enhancing light–matter interactions in various applications and investigating the physics of emerging photonic systems.

Non-Hermitian systems distinguish themselves from Hermitian systems by exhibiting a phase transition point called an exceptional point (EP), at which two eigenstates coalesce under a system parameter variation. Many interesting EP phenomena, such as level crossings in nuclear and condensed matter physics, and unusual phenomena in optics, such as loss-induced lasing and unidirectional transmission, can be understood by considering a simple 2×2 non-Hermitian matrix. At a higher dimension, more complex EP physics not found in two-state systems arises. We consider the emergence and interaction of multiple EPs in a four-state system theoretically and realize the system experimentally using four coupled acoustic cavities with asymmetric losses. We find that multiple EPs can emerge, and as the system parameters vary, these EPs can collide and merge, leading to higher-order singularities and topological characteristics much richer than those seen in two-state systems. The new physics obtained is not limited to the acoustic systems demonstrated here. It also applies to other systems as well, such as coupled photonic cavities and waveguides.

Light can exert radiation pressure on any object it encounters and that resulting optical force can be used to manipulate particles. It is commonly assumed that light should move a particle forward and indeed an incident plane wave with a photon momentum ħ k can only push any particle, independent of its properties, in the direction of k . Here we demonstrate, using full-wave simulations, that an anomalous lateral force can be induced in a direction perpendicular to that of the incident photon momentum if a chiral particle is placed above a substrate that does not break any left–right symmetry. Analytical theory shows that the lateral force emerges from the coupling between structural chirality (the handedness of the chiral particle) and the light reflected from the substrate surface. Such coupling induces a sideway force that pushes chiral particles with opposite handedness in opposite directions. Light carries momentum and therefore can be used to push small particles forward. Here, Wang and Chan demonstrate that under the right conditions a light beam can also exert sideway forces on chiral particles.

The most intriguing properties of non-Hermitian systems are found near the exceptional points (EPs) at which the Hamiltonian matrix becomes defective. Because of the complex topological structure of the energy Riemann surfaces close to an EP and the breakdown of the adiabatic theorem due to non-Hermiticity, the state evolution in non-Hermitian systems is much more complex than that in Hermitian systems. For example, recent experimental work [Doppler et al., Nature (London) 537, 76 (2016)] demonstrated that dynamically encircling an EP can lead to chiral behaviors; i.e., encircling an EP in different directions results in different output states. Here, we propose a coupled ferromagnetic waveguide system that carries two EPs and design an experimental setup in which the trajectory of state evolution can be controlled in situ using a tunable external field, allowing us to dynamically encircle zero, one, or even two EPs experimentally. The tunability allows us to control the trajectory of encircling in the parameter space, including the size of the encircling loop and the starting/end point. We discovered that whether or not the dynamics is chiral actually depends on the starting point of the loop. In particular, dynamically encircling an EP with a starting point in the parity-time-broken phase results in nonchiral behaviors such that the output state is the same no matter which direction the encircling takes. The proposed system is a useful platform to explore the topology of energy surfaces and the dynamics of state evolution in non-Hermitian systems and will likely find applications in mode switching controlled with external parameters.

Crohn’s disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the development and progression of IBD. Indeed, epidemiological and genetic association studies have identified a number of promising dietary and genetic risk factors for IBD. These preliminary studies have led to major interest in investigating the complex interaction between diet, host genetics, the gut microbiota and immune function in the pathogenesis of IBD. In this Review, we discuss the recent epidemiological, gene–environment interaction, microbiome and animal studies that have explored the relationship between diet and the risk of IBD. In addition, we highlight the limitations of these prior studies, in part by explaining their contradictory findings, and review future directions.

This Opinion article summarizes the evidence supporting the use of aspirin to prevent colorectal cancer. By considering the pathways that mediate the anticancer effects of aspirin, the authors evaluate potential biomarkers that may enable a precision medicine approach to aspirin chemoprevention. Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades of research have provided considerable evidence demonstrating its potential for the prevention of cancer, particularly colorectal cancer. Broader clinical recommendations for aspirin-based chemoprevention strategies have recently been established; however, given the known hazards of long-term aspirin use, larger-scale adoption of an aspirin chemoprevention strategy is likely to require improved identification of individuals for whom the protective benefits outweigh the harms. Such a precision medicine approach may emerge through further clarification of aspirin's mechanism of action.

Weyl points, as monopoles of Berry curvature in momentum space, have captured much attention recently in various branches of physics. Realizing topological materials that exhibit such nodal points is challenging and indeed, Weyl points have been found experimentally in transition metal arsenide and phosphide and gyroid photonic crystal whose structure is complex. If realizing even the simplest type of single Weyl nodes with a topological charge of 1 is difficult, then making a real crystal carrying higher topological charges may seem more challenging. Here we design, and fabricate using planar fabrication technology, a photonic crystal possessing single Weyl points (including type-II nodes) and multiple Weyl points with topological charges of 2 and 3. We characterize this photonic crystal and find nontrivial 2D bulk band gaps for a fixed k z and the associated surface modes. The robustness of these surface states against k z -preserving scattering is experimentally observed for the first time. To realize Weyl points carrying topological charges higher than one is challenging. Here, Chen et al . report a photonic crystal possessing single and multiple Weyl points with topological charges of two and three using planar fabrication technology.