Explore the vast range of titles available.

Tricholepis glaberrima commonly known as Potato weed widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Tricholepis glaberrima (METG) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in STZ induced diabetic rats. METG (100, 200mg/kg) and Glibenclamide (5mg/kg) were administered orally in STZ (60mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of METG no mortality upto 1000mg/kg was observed. OGTT, fasting blood glucose level, body weight, plasma insulin, were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract of Tricholepis glaberrima. These results suggest that METG (200mg/kg) showed antihyperglycemic activity in STZ induced diabetic rats.

Galinosa parviflora commonly known as Potato weed widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Galinosa parviflora (MEGP) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in STZ induced diabetic rats. MEGP (100, 200 mg/kg) and Glibenclamide (5mg/kg) were administered orally in STZ (60mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of MEGP no mortality upto 1000 mg/kg was observed. OGTT, Fasting blood glucose level, body weight, plasma insulin, were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract of Galinosa parviflora. These results suggest that MEGP (200mg/kg) showed antihyperglycemic activity in STZ induced diabetic rats.

[...]the aim of the present investigation was to develop simultaneous method for estimation of Candesartan and HCTZ for its Pharmaceutical Preparation. [...]it is desirable to develop simple and reproducible analytical methods For chromatographic method used in analytical application, there should be more consistency in validation practice with key analytical parameter, including. [...]the proposed method was successfully applied to analyze preparation containing Candesartan and HCTZ. Ashok K. Peepliwal, Chandrakant G. Bonde, Krishna priya Mohan Raj; Bio analytical method development and its validation for determination of candesartan cilexetil by high performance liquid chromatography with UV detection; Acta Pharmaceutica Sciencia; 2010;52;247-253. D. Suchitra, A.B.N. Nageshwar Rao, A. Ravindranath, S. Sakunthala Madhavendra, V. Jayathirtha Rao; A validated method for the simultaneous estimation od Ramipril, Telmisartan and Hydrochlorothiazide by RP-HPLC in bulk and the pharmaceutical dosage form; International Journal of Pharmacy and Pharmaceutical Sciences ; 2011;3(4),185-189.

The pumpkin belongs to the family of Cucurbitaceae, is a well-known edible plant that has been frequently used as functional food or herbal medicine. Pumpkins contain rich unsaturated fatty acids, phytoestrogens and vitamins E in their seeds that have potential pharmaceutical, nutraceutical, and cosmeceutical properties. Information regarding their nutritional components and therapeutic properties of pumpkin seeds has expanded dynamically in the recent years and this review focus on the three main components of pumpkin seeds that described before. Several types of unsaturated fatty acids are the dominant component in pumpkin seeds which can play a role in the disease prevention and promote health. Pumpkin seeds also contain the important phytoestrogen compounds, i.e., secoisolariciresinol and lariciresinol that have estrogenic-like effect such as preventing hyperlipidemia and osteoporosis for menopausal women. Phytoestrogens in pumpkin seeds also could be related to a reduced hormone-dependent tumor. Pumpkin seeds are rich in vitamin E contents as an emerging free radical scavenger, anti-aging and antioxidant such as a-tocopherol and g-tocopherol. Findings of these studies prove that patents field for the innovation product of pumpkin seeds holds promise for the future along with their immense nutraceutical properties.

The present study described the gelation temperature, gelation time, viscosity study, pH, properties of thermosensitive gel prepared of poloxamer 407 and carbopol 934P which are not affected by the concentration of each component. i.e. addition of Drugs or reference catanionic mixture. The use of Catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining sustained drug release from Insitu gels. The effects of changes in the pH and ionic strength on the catanionic aggregates was also investigated, and this method of sustaining the release was found to be quite resilient to variations in both. Although the phase behavior was somewhat affected, large micelles and vesicles were still readily found. The drug release was significantly sustained even under NaCl. Comparing the diffusion coefficients for drugs being released from gels with those for drugs from catanionic mixtures in gels revealed differences in the order of magnitude of 10 to 100. This means that the release of a drug can be extended over time, for example, from 30 minutes to 12 hours, potentially improving both the efficiency of the formulation and the patient compliance.

[...]it is finding new popularity as an alternative conventional medicine even in the industrialized countries and the adoption of crude extracts of plants for selfmedication by the general public is in the increase.4 Over the past decade several news-catching episodes in developed communities indicated adverse effects, sometimes life threatening, allegedly arisen consequential to taking of OTC herbal products or traditional medicines from various ethnic groups. The public's belief that herbal and natural products are safer than synthetic medicines can only be ascertained by imposing regulatory standards on these products that should be manufactured using this Good Practices.5 The manufacture of the finished products should be in accordance with the good manufacturing practices (GMPs), with post-marketing quality assurance surveillance Evaluation of the toxicity and adverse drug reaction of the herbal preparation has been a neglected area, as herbs are considered natural products and, therefore safe. Preparation of Standards Arsenic standard solution Arsenic standard solution was prepared from Stock solution (1000 ppm Reagecon stock solution) standard solution of concentrations 0.02, 0.04, 0.06,.0.08 ppm were prepared The absorption of standard solution was measured at 193 nm using hallow cathode lamp as a light source and air acetylene flame with N2 gas source on Hydride generator mode on Atomic absorption Spectrophometer. Prolong consumption of such herbal medicine might reduce chronic or subtle health hazards. [...]our findings indicate that the medicinal plant or plant parts used for different diseases must be checked for heavy metals contamination in order to make it safe for human consumption.

The present work describes a validated reverse phase high performance liquid chromatographic method involved with diode array detection for simultaneous estimation of Rabeprazole sodium (RAB) and Aceclofenac (ACL) in combined dosage form. Chromatographic separation was performed on Prontosil C18(4.6 id x 250 mm 5μm particle size) Column with mobile phase consisting methanol: water pH 2.5 (75:25 v/v). The flow rate was 1.0 ml/min and eluents were monitored at 273nm by using Photo Diode Array(PDA) detector at ambient temperature. The separation of both drug were found effectively on 3.23min of RAB and 7.78min of ACL with total run time upto10 mins. The proposed method was found to be simple as was involved with water as mobile phase component it was fast, accurate, precise, reproducible, linear, robust and rugged which have been further used for simultaneous analysis of RAB and ACL in combined pharmaceutical formulations.