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Mitochondria are vital cellular organelles associated with energy production as well as cell signaling pathways. These organelles, responsible for metabolism, are highly abundant in hepatocytes that make them key players in hepatotoxicity. The literature suggests that mitochondria are targeted by various environmental pollutants. Arsenic, a toxic metalloid known as an environmental pollutant, readily contaminates drinking water and exerts toxic effects. It is toxic to various cellular organs; among them, the liver seems to be most affected. A growing body of evidence suggests that within cells, arsenic is highly toxic to mitochondria and reported to cause oxidative stress and alter an array of signaling pathways and functions. Hence, it is imperative to highlight the mechanisms associated with altered mitochondrial functions and integrity in arsenic-induced liver toxicity. This review provides the details of mechanistic aspects of mitochondrial dysfunction in arsenic-induced hepatotoxicity as well as various ameliorative measures undertaken concerning mitochondrial functions.

Human gait provides a way of locomotion by combined efforts of the brain, nerves, and muscles. Conventionally, the human gait has been considered subjectively through visual observations but now with advanced technology, human gait analysis can be done objectively and empirically for the better quality of life. In this paper, the literature of the past survey on gait analysis has been discussed. This is followed by discussion on gait analysis methods. Vision-based human motion analysis has the potential to provide an inexpensive, non-obtrusive solution for the estimation of body poses. Data parameters for gait analysis have been discussed followed by preprocessing steps. Then the implemented machine learning techniques have been discussed in detail. The objective of this survey paper is to present a comprehensive analysis of contemporary gait analysis. This paper presents a framework (parameters, techniques, available database, machine learning techniques, etc.) for researchers in identifying the infertile areas of gait analysis. The authors expect that the overview presented in this paper will help advance the research in the field of gait analysis. Introduction to basic taxonomies of human gait is presented. Applications in clinical diagnosis, geriatric care, sports, biometrics, rehabilitation, and industrial area are summarized separately. Available machine learning techniques are also presented with available datasets for gait analysis. Future prospective in gait analysis are discussed in the end.

Purpose To help alleviate the immense suffering caused by humanitarian crises worldwide, organisations are forming relationships for effective coordination and resource sharing. However, organisations can struggle to build trust because of the uncertain context, varying institutional mandates and socio-cultural differences. Thus, this paper aims to better understand how humanitarian groups can leverage formal mechanisms to produce greater trust. Design/methodology/approach This paper adopts a logical–positivist research paradigm to formulate and test its hypotheses. This paper answered this study’s research question using structural equation modelling from survey data of 180 humanitarian managers. Findings In inter-organisational humanitarian relationships, formal mechanisms indirectly foster trust through two mediators: distributive justice and information sharing. Research limitations/implications This research presents the perspective of only one partner in inter-organisational relationships. Moreover, the operationalisations of formal mechanisms and trust were not comprehensive (i.e. only contracts and integrity-based trust, respectively). Originality/value To the best of the author’s knowledge, this research is a first attempt to empirically link the widely discussed idea of formal mechanisms, distributive justice, information sharing and trust in inter-organisational humanitarian relationships. Further, this research is the first attempt to present and empirically validate a theoretical model that addresses how formal mechanisms foster trust in inter-organisational relationships.

Ruddlesden–Popper (RP) phase metal halide organo perovskites are being extensively studied due to their quasi-two dimensional (2D) nature which makes them an excellent material for several optoelectronic device applications such as solar cells, photo-detectors, light emitting diodes (LEDs), lasers etc. While most of reports show use of linear carbon chain based organic moiety, such as n-Butylamine, as organic spacer in RP perovskite crystal structure, here we report a new series of quasi 2D perovskites with a ring type cyclic carbon group as organic spacer forming RP perovskite of type (CH) 2 (MA) n−1 Pb n I 3n+1 ; CH = 2-(1-Cyclohexenyl)ethylamine; MA = Methylamine). This work highlights the synthesis, structural, thermal, optical and optoelectronic characterizations for the new RP perovskite series n = 1–4. The demonstrated RP perovskite of type for n = 1–4 have shown formation of highly crystalline thin films with alternate stacking of organic and inorganic layers, where the order of PbI 6 octahedron layering are controlled by n-value, and shown uniform direct bandgap tunable from 2.51 eV (n = 1) to 1.92 eV (n = 4). The PL lifetime measurements supported the fact that lifetime of charge carriers increase with n-value of RP perovskites [154 ps (n = 1) to 336 ps (n = 4)]. Thermogravimetric analysis (TGA) showed highly stable nature of reported RP perovskites with linear increase in phase transition temperatures from 257 °C (n = 1) to 270 °C (n = 4). Scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDAX) are used to investigate the surface morphology and elemental compositions of thin films. In addition, the photodetectors fabricated for the series using (CH) 2 (MA) n−1 Pb n I 3n+1 RP perovskite as active absorbing layer and without any charge transport layers, shown sharp photocurrent response from 17 nA/cm 2 for n = 1 to 70 nA/cm 2 for n = 4, under zero bias and low power illumination conditions (470 nm LED, 1.5 mW/cm 2 ). Furthermore, for lowest bandgap RP perovskite n = 4, (CH) 2 MA 3 Pb 4 I 13 the photodetector showed maximum photocurrent density of ~ 508 nA/cm 2 at 3 V under similar illumination condition, thus giving fairly large responsivity (46.65 mA/W). Our investigations show that 2-(1-Cyclohexenyl)ethylamine based RP perovskites can be potential solution processed semiconducting materials for optoelectronic applications such as photo-detectors, solar cells, LEDs, photobatteries etc.

Nutrient deficiencies in soil–crop contexts and inappropriate managements are the important reasons for low crop productivity, reduced nutritional quality of agricultural produce and animal/human malnutrition, across the world. The present investigation was carried out to evaluate nutrient deficiencies of sulphur (S) and micronutrients [zinc (Zn), boron (B), iron (Fe), copper (Cu) and manganese (Mn)] in agricultural soils of India for devising effective management strategies to achieve sustainable crop production, improved nutritional quality in crops and better animal/human health. A total of 2,42,827 surface (0–15 cm depth) soil samples were collected from agriculture fields of 615 districts lying in 28 states of India and were analysed for available S and micronutrients concentration. The study was carried out under the aegis of All India Coordinated Research Project on Micro- and Secondary-Nutrients and Pollutant Elements in Soils and Plants. The mean concentrations were 27.0 ± 29.9 mg kg −1 for available S, 1.40 ± 1.60 mg kg −1 for available Zn and 1.40 ± 4.70 mg kg −1 for available B, 31.0 ± 52.2 mg kg −1 for available Fe, 2.30 ± 3.50 mg kg −1 for available Cu and 17.5 ± 21.4 mg kg −1 for available Mn. There were variable and widespread deficiencies of S and micronutrients in different states. The deficiencies (acute deficient + deficient + latent deficiency) of S (58.6% of soils), Zn (51.2% of soils) and B (44.7% of soils) were higher compared to the deficiencies of Fe (19.2% of soils), Cu (11.4% of soils) and Mn (17.4% of soils). Out of 615 districts, > 50% of soils in 101, 131 and 86 districts were deficient in available S, available Zn and available B, respectively. Whereas, > 25% of soils in 83, 5 and 41 districts had deficiencies of available Fe, available Cu and available Mn, respectively. There were occurrences of 2-nutrients deficiencies such S + Zn (9.30% of soils), Zn + B (8.70% of soils), S + B (7.00% of soils) and Zn + Fe (5.80% of soils) to a greater extent compared to the deficiencies of Zn + Mn (3.40% of soils), S + Fe (3.30% of soils), Zn + Cu (2.80% of soils) and Fe + B (2.70% of soils). Relatively lower % of soils were deficient in 3-nutrients (namely S + Zn + B, S + Zn + B and Zn + Fe + B), 4-nutrients (namely Zn + Fe + Cu + Mn) and 5-nutrients (namely Zn + Fe + Cu + Mn + B) simultaneously. The information regarding the distribution of deficiencies of S and micronutrients (both single and multi-nutrients) could be used by various stakeholders for production, supply and application of right kind of fertilizers in different districts, states and agro-ecological regions of India for better crop production, crop nutritional quality, nutrient use efficiency, soil health and for tackling human and animal malnutrition.

The present study reports beneficial effect of hydroxytyrosol (HT) against arsenic (As)-induced oxidative stress in the rat brain. Rats were orally administered with sodium arsenite dissolved in distilled water (25 ppm, by oral gavage) for 8 weeks or HT (10 mg/kg b. wt.) in combination with As. Results showed increase in protein oxidation and lipid peroxidation, while catalase and superoxide dismutase (SOD) activities as well as GSH content were decreased after As exposure in rat brain. Fourier transform infrared analysis showed significant alteration in peak area values that also validated the oxidative damage to lipids and proteins. In addition, As exposure caused increase in protein expression of caspase-3 and Bax, while Bcl-2 expression was downregulated resulting in translocation of cytochrome c from mitochondria to cytosol. Treatment of HT with As reversed protein oxidation, lipid peroxidation, and increased GSH content as well as catalase and SOD activities. Administration of HT also prevented translocation of cytochrome c from mitochondria and increased mitochondria/cytosol ratio of cytochrome c. Hence, treatment of HT with As improved antioxidant system and efficiently lowered the generation of oxidative stress in rat brain.

Toxicity of three textile dyes—Optilan yellow, Drimarene blue and Lanasyn brown, was evaluated in a green alga Chlorella vulgaris. The unialgal populations of the alga showed a concentration-dependent decrease in specific growth rate and pigments after exposure to graded concentrations of above dyes. The elemental profile (C, H, N, S) of the treated and untreated cells showed a change which was evident from a significant decrease in the quantity of elements after exposure to the dyes. The observations provide convincing evidence that the textile dyes inhibited the growth, pigment and elemental composition of the algal cells. The findings of the present investigation will contribute to gaining a better understanding of the impacts of textile dyes on ecologically important aquatic organisms.

PurposeMy way or the highway: A stronger partner in humanitarian relief collaboration often seeks control over its weaker partners by leveraging diverse power tactics that may be non-coercive or coercive in nature. In this backdrop, this research accentuates the perspective of weaker partners to understand how a weaker partner drives collaborative synergy under power tactics. Weaker partner in the collaborative dyad resembles the humanitarian organization (HO) who is less capable in terms of access to resources. This partner is further dependent on the stronger HO's directives to participate in the relief work.Design/methodology/approachBased on social exchange theory (SET), a collaborative dyad in humanitarian relief work is visualized from the perspectives of power and power disparity. In terms of power, mediated power tactics such as legal, coercive and reward powers are considered. Disparity recognizes the presence of a stronger and a weaker partner. Set also magnifies the insight on conflict and trust that can respectively hamper and improve the synergy between partners. In total, 295 executives representing self-reported weaker HOs are surveyed.FindingsLegal power, as experienced by the weaker partner, bears a positive impact over collaborative performance to improve collaborative synergy. Coercive power shows a negative impact. Reward power again bears a positive impact. Coercion can complicate collaborative synergy by establishing conflicts. Yet, the trust of weaker partner on stronger HO positively moderates the negative impact of conflict over collaborative performance.Originality/valueThis research invokes the view of power disparity to explain synergy in inter-organizational collaboration from the perspective of weaker partners.

Traditional ecological knowledge (TEK) continues to erode as a result of globalization and the homogenization of diverse cultures, yet it has helped to conserve natural resources and preserve nature for centuries. Biosphere reserves have been established in regions where both cultural and natural resource assortments are deemed rich. The present study was carried out in the Pachmarhi Biosphere Reserve (PBR) of India with the major objective of investigating the TEK of local communities with respect to the sustainability of nature and natural resources. Through both a questionnaire and interviews with tribal groups in PBR, a total of 128 plant species were documented, of which the highest number of species (52%) was used for food, followed by medicine (40%), cultural practices (13%), and construction of houses (11%). Apart from the collection of plants from the adjacent forests for their sustenance, the tribal groups engaged in various other activities including farming practices, maintenance of home gardens, soil and water conservation, and continuance of sacred groves. The nature and natural resource-based livelihood and conservation activities of tribal groups involve specific cultural practices and customary norms. This study reveals that the traditional knowledge of tribal communities offers unique ideas for developing and contributing to more effective sustainable management practices and nature conservation. It has a great potential to strengthen the agriculture and health sectors, as the tribal communities have accumulated a fair amount of knowledge in such sectors.