Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
29,427
result(s) for
"Chang, Wei-Wei"
Sort by:
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease
TDP-43 inclusions are found in many Alzheimer’s disease (AD) patients presenting faster disease progression and greater brain atrophy. Previously, we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-β (Aβ) fibrillization. To elucidate the role of TDP-43 in AD, here, we examined the effect of TDP-43 in Aβ aggregation and the attributed toxicity in mouse models. We found TDP-43 inhibited Aβ fibrillization at initial and oligomeric stages. Aβ fibrillization was delayed specifically in the presence of N-terminal domain containing TDP-43 variants, while C-terminal TDP-43 was not essential for Aβ interaction. TDP-43 significantly enhanced Aβ’s ability to impair long-term potentiation and, upon intrahippocampal injection, caused spatial memory deficit. Following injection to AD transgenic mice, TDP-43 induced inflammation, interacted with Aβ, and exacerbated AD-like pathology. TDP-43 oligomers mostly colocalized with intracellular Aβ in the brain of AD patients. We conclude that TDP-43 inhibits Aβ fibrillization through its interaction with Aβ and exacerbates AD pathology.
TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models.
Journal Article
Business adaptation to climate change
\"This book addresses management and public policy students and scholars seeking a better understanding of the elements of successful business climate change adaptation strategies. It is also aimed at business and non-profit organization leaders and policy makers interested in developing and promoting such effective strategies\"-- Provided by publisher.
Book
Dynamic structure of active sites in ceria-supported Pt catalysts for the water gas shift reaction
Oxide-supported noble metal catalysts have been extensively studied for decades for the water gas shift (WGS) reaction, a catalytic transformation central to a host of large volume processes that variously utilize or produce hydrogen. There remains considerable uncertainty as to how the specific features of the active metal-support interfacial bonding—perhaps most importantly the temporal dynamic changes occurring therein—serve to enable high activity and selectivity. Here we report the dynamic characteristics of a Pt/CeO
2
system at the atomic level for the WGS reaction and specifically reveal the synergistic effects of metal-support bonding at the perimeter region. We find that the perimeter Pt
0
− O vacancy−Ce
3+
sites are formed in the active structure, transformed at working temperatures and their appearance regulates the adsorbate behaviors. We find that the dynamic nature of this site is a key mechanistic step for the WGS reaction.
Revealing the structure and dynamics of active sites is essential to understand catalytic mechanisms. Here the authors demonstrate the dynamic nature of perimeter Pt
0
−O vacancy−Ce
3+
sites in Pt/CeO
2
and the key effects of their dynamics on the mechanism of the water gas shift reaction.
Journal Article
ضمان حقوق الإنسان في الصين المعاصرة
تحقيق الحماية الكاملة لحقوق الإنسان كان ولا يزال الغاية الأساس التي عمل الشعب الصيني والحكومة الصينية من أجلها منذ فترات طويلة، فضلا عن كونه من التطلعات العامة التي يشترك فيها الشعب الصيني مع جميع شعوب العالم. وقد قام (تشانغ بينغ تشون)، بصفته أول ممثل للصين لدى الأمم المتحدة ونائب رئيس لجنة الأمم المتحدة لحقوق الإنسان، بصياغة الإعلان العالمي لحقوق الإنسان مع السيدة رزفلت وممثلين عن باقي دول العالم، وقدموا إسهاما أشاد به العالم أجمع. وتقر الحكومة الصينية بالمبادئ والقيم الخاصة بحقوق الإنسان واعتمدتها، كما حرصت أشد الحرص على استيفاء الواجبات المنصوص عليها في هذه الاتفاقيات، باذلة في الوقت نفسه، ومن واقع ظروفها الوطنية الخاصة، قصارى جهودها لاستكشاف مسار تنمية حقوق الإنسان الذي يتلاءم مع طبيعتها، وذلك لضمان تحقيق إصلاحات مستمرة لحماية حقوق الإنسان جنبا إلى جنب مع التنمية الاقتصادية والاجتماعية، وتحقيق التنسيق والتوازن في حقوق الإنسان، كما أنشأت الصين مجموعة كاملة من أنظمة الحماية الفعالة لحقوق الإنسان، فأصبح مبدأ «احترام الدولة لحقوق الإنسان وصونها» مبدأ دستوريا أساسيا للصين سطره دستور الحزب الشيوعي الصيني الحاكم ليكون المحدد الأساسي لخطط الصين نحو التنمية الاقتصادية والاجتماعية الوطنية قبل أن يصبح أحد المبادئ الرئيسة التي يلتزم بها الحزب والحكومة الصينية في حكم البلاد، ويشكل تطوير خطتي العمل الوطنيتين لحقوق الإنسان في الصين وتنفيذهما بداية مرحلة جديدة لقضية حقوق الإنسان في الصين التي تعرض التنمية المخطط لها والمستمرة والمطردة والتقدم الشامل.
Sleep Apnea and the Risk of Dementia: A Population-Based 5-Year Follow-Up Study in Taiwan
Sleep apnea (SA) has been associated with cognitive impairment. However, no data regarding the risk of dementia in patients with SA has been reported in the general population. This retrospective matched-control cohort study was designed to estimate and compare the risk of dementia in SA and non-SA patients among persons aged 40 and above over a 5-year period follow-up.
We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 1414 patients with SA aged 40 years who had at least 1 inpatient service claim or 1 ambulatory care claim. The comparison cohort comprised 7070 randomly selected patients who were matched with the study group according to sex, age, and index year. We performed Cox proportional-hazards regressions to compute the 5-year dementia-free survival rates after adjusting for potentially confounding factors.
The SA patients in this study had a 1.70-times greater risk of developing dementia within 5 years of diagnosis compared to non-SA age- and sex-matched patients, after adjusting for other risk factors (95% confidence interval (CI) = 1.26-2.31; P < .01). For the gender-dependent effect, only females with SA were more likely to develop dementia (adjust HR: 2.38, 95% CI =1.51-3.74; P < .001). For the age-dependent effect of different genders, males with SA aged 50-59 years had a 6.08 times greater risk for developing dementia (95% CI = 1.96-18.90), and females with SA aged ≥ 70 years had a 3.20 times greater risk of developing dementia (95% CI =1.71-6.00). For the time-dependent effect, dementia may be most likely to occur in the first 2.5 years of follow-up (adjusted HR:2.04, 95% CI =1.35-3.07).
SA may be a gender-dependent, age-dependent, and time-dependent risk factor for dementia.
Journal Article
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted T cell differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion and immunotherapy efficacy; however, the molecular mechanism is unclear. Here we show that PD-1 contributes to the persistence of PD-1
+
TIM-3
+
T cells by binding to the TIM-3 ligand galectin-9 (Gal-9) and attenuates Gal-9/TIM-3-induced cell death. Anti-Gal-9 therapy selectively expands intratumoral TIM-3
+
cytotoxic CD8 T cells and immunosuppressive regulatory T cells (T
reg
cells). The combination of anti-Gal-9 and an agonistic antibody to the co-stimulatory receptor GITR (glucocorticoid-induced tumor necrosis factor receptor-related protein) that depletes T
reg
cells induces synergistic antitumor activity. Gal-9 expression and secretion are promoted by interferon β and γ, and high Gal-9 expression correlates with poor prognosis in multiple human cancers. Our work uncovers a function for PD-1 in exhausted T cell survival and suggests Gal-9 as a promising target for immunotherapy.
Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3
+
T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism promotes an anti-tumor immune response.
Journal Article
Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds
Lung stem/progenitor cells are potentially useful for regenerative therapy, for example in repairing damaged or lost lung tissue in patients. Several optical imaging methods and probes have been used to track how stem cells incorporate and regenerate themselves
in vivo
over time. However, these approaches are limited by photobleaching, toxicity and interference from background tissue autofluorescence. Here we show that fluorescent nanodiamonds, in combination with fluorescence-activated cell sorting, fluorescence lifetime imaging microscopy and immunostaining, can identify transplanted CD45
–
CD54
+
CD157
+
lung stem/progenitor cells
in vivo
, and track their engraftment and regenerative capabilities with single-cell resolution. Fluorescent nanodiamond labelling did not eliminate the cells’ properties of self-renewal and differentiation into type I and type II pneumocytes. Time-gated fluorescence imaging of tissue sections of naphthalene-injured mice indicates that the fluorescent nanodiamond-labelled lung stem/progenitor cells preferentially reside at terminal bronchioles of the lungs for 7 days after intravenous transplantation.
Fluorescent nanodiamonds can be used to tag implanted lung stem cells and follow their uptake and regeneration in host tissue.
Journal Article