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77 result(s) for "Chang, Wenkai"
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Comparative analysis of Straub-Rotarex thrombectomy system and Catheter-directed thrombolysis for lower limb deep vein thrombosis
Background Deep vein thrombosis (DVT) is a serious condition that can lead to complications such as pulmonary embolism (PE) and post-thrombotic syndrome (PTS). This study aimed to compare the Straub-Rotarex thrombectomy system and catheter-directed thrombolytic therapy (CDT) for lower limb DVT. Methods This retrospective study analyzed patients with DVT treated at The Second Hospital of Shanxi Medical University between August 2017 and October 2021. The patients were grouped according to the CDT group or the Straub-Rotarex thrombectomy system (Straub-Rotarex group). Results This study included 100 patients, with 50 in the Straub-Rotarex group (27 males, mean age of 61.61 ± 3.35 years) and 50 in the CDT group (28 males, mean age 61.12 ± 3.12 years). The Straub-Rotarex thrombectomy group achieved a higher total effective rate (96.00%) than the CDT group (84.00%) and a lower re-thrombosis rate (4.00% vs. 18.00%). Post-treatment, the Straub-Rotarex group exhibited significantly lower activated partial thromboplastin time (APTT), D-dimer (D-D), prothrombin time (PT), fibrinogen (Fbg), and thromboplastin time (TT) levels (P < 0.05), a lower Porter score (P < 0.001), and smaller differences in calf and thigh circumference (P < 0.001). Conclusion The results suggest that the Straub-Rotarex thrombectomy system may help achieve a high effective rate and fewer complications than CDT. The results must be confirmed in a clinical trial.
A Super‐Capacitive Pressure Sensor with Ultrahigh Sensitivity and Wide Linear Pressure Sensing Range for Human Bio‐Signal Detection and Electronic Skin
Soft super‐capacitive sensors offer several advantages, including mechanical flexibility, high sensitivity, and rapid response, primarily due to the use of soft ionic elastomers and the electrical double layer (EDL) sensing mechanism. As for those sensors, achieving a broad linear pressure sensing range remains crucial, particularly when paired with a well‐defined microstructure in the electrolyte layer, which enhances sensor repeatability and facilitates quality control. In this study, a novel design strategy is proposed to simultaneously enhance sensitivity and extend the linear sensing range by integrating a hierarchical dome microstructure within the electrolyte layer and incorporating a curvilinear design in the top electrode. Specifically, the optimized sensor shows an ultrahigh sensitivity (34.79 nF kPa−1), a wide linear sensing range (0–800 kPa), high pressure resolution (0.1%), and stable capacitance responses for dynamic pressure even at high pressure conditions (200 kPa). Moreover, the sensor is successfully examined to perform the detection of human bio‐signals, including body movement, respiration pattern recognition, and wrist pulse detection. Additionally, the sensor demonstrates strong potential for serving as an electronic skin (e‐skin), as it enables accurate object weight estimation and object identification through machine learning techniques, achieving 100% classification accuracy. Incorporating a PVA/H3PO4 ionic elastomer and a hierarchical hemisphere structure within the electrolyte layer, along with a curvy top electrode, enables the super‐capacitive pressure sensor to achieve ultrahigh sensitivity (34.79 nF kPa−1) and a broad linear sensing range (0–800 kPa). These features highlight its strong potential for wearable electronics in human biosignal detection, health monitoring, and biomimetic e‐skin applications in soft robotics.
Understanding the Roles of Microstructure and Viscoelasticity of Soft Ionic Elastomer for Super‐Capacitive Pressure Sensors
Soft ionic conductive elastomers offer unique advantages for super‐capacitive pressure sensors, where the electrical double layer (EDL) effect enables high sensitivity and rapid response. However, the roles of microstructure and viscoelasticity on EDL‐driven sensing remain poorly understood. This study establishes detailed correlations between elastomer microstructure, intrinsic viscoelastic properties, and sensor performance by integrating mechanical and electrical analyses. Validation of the EDL mechanism reveals how microstructural optimization and viscoelastic tuning enhance sensitivity, linear range, and stability. Height‐graded architectures yield a sensor with a sensitivity of 2.70 nF/kPa, a broad linear range of 0–2000 kPa, and robust durability over 10 000 cycles. These devices demonstrate multifunctionality in robotic electronic skin, pressure mapping, and real‐time physiological monitoring such as wrist pulse detection. The findings establish key structure–property–performance relationships, providing design guidelines for next‐generation, high‐performance super‐capacitive sensors. By engineering the PVA/H3PO4 ionic elastomer with optimized viscoelasticity and a height‐graded microstructure, the pressure sensor achieves a broad linear range up to 2000 kPa and a high sensitivity of 2.70 nF/kPa. These advancements underscore its strong potential for wearable electronics, including bio‐signal detection, health monitoring, and biomimetic e‐skin for soft robotics.
Steering characteristics and path following control of a bionic underwater vehicle with multiple locomotion modes
The research on the path following control of the bionic underwater vehicle with high maneuverability and propulsive performance is a crucial issue. This paper investigates the planar path following control task of a bionic underwater vehicle with superior maneuverability. The steering characteristics of the sinusoidal offset and unilateral asymmetric steering signals are analyzed. The experimental results demonstrate that the two signals separately have smaller steering radius and power consumption in the low-frequency and relatively high-frequency range, and are consequently suitable for distinct scenarios. Furthermore, a switching nonlinear model predictive control strategy is proposed, which regulates the state error weighting values according to the real-time yaw angle error. The control strategy realizes autonomous switching of multiple locomotion modes to enhance the swimming speed of the bionic underwater vehicle and fulfills the purpose of improving the task-completing efficiency. The simulation and experimental results indicate that the bionic underwater vehicle achieved 3.49 and 2.92 times enhancement in swimming speed performance at straight and steering target path following control tasks, respectively. The proposed methods as well as obtained results can provide universal inspiration for the multiple motion-based path following control of autonomous underwater vehicles.
Toward a Cluttered Environment for Learning-Based Multi-Scale Overhead Ground Wire Recognition
In this paper, we propose a learning-based real-time method to recognize and segment an overhead ground wire (OGW) from an image, which is mainly applied to the multi-scale features in a cluttered environment. The recognition and segmentation are implemented under the framework of conditional generative adversarial nets. The generator is an end-to-end convolutional neural network (CNN) with skip connection. The discriminator is a multi-stage CNN and learns the loss function to train the generator. The OGW is recognized and shown in the downsampling visual saliency map. Thus, the location and existence of OGW are verified, which is crucial for the detection in the cluttered environment with structural lines. Detailed experiments and comparisons are performed on real-world images to demonstrate that the proposed method significantly outperforms the traditional method. Additionally, the optimized network achieves approximately 200 fps on a graphics card (GTX970) and 30 fps on an embedded platform (Jetson TX1).
Light-curable composite of siloxane/hydroxyapatite prepared by the sol-gel process for bone defect treatment
The light‐curable composite of siloxane/hydroxyapatite (HA) had been successfully achieved by photopolymerization of a kind of gel combined tetraethoxyorthosilicate (TEOS) and 3‐methacryloxypropyltrimethoxysilane (MAPS) with siloxane‐modified nano‐HA (HA‐g‐Si). HA‐g‐Si was prepared by grafting reaction of 3‐isocyanatopropyltrimethoxysilane (IPS) onto the surface of HA. Then, TEOS and MAPS were mixed as precursor, and photoinitiator 2‐hydroxy‐4′‐(2‐hydroxyethoxy)‐2‐methylpropiophenone (Irgacure 2959) and as‐prepared HA‐g‐Si were added into the precursor to form a homogenous and sticky gel. The movable gel that could be cured with UV light resulted in various sharp immovable composites of siloxane/HA in different mold. The HA, HA‐g‐Si nanoparticles, and composites were analyzed by Fourier transformed infrared spectroscopy, X‐ray photoelectron spectroscopy, X‐ray diffraction, thermogravimetric analysis, transmission electron microscopy, scanning electron microscopy, mechanical testing, and water contact angles. It could be a promising bone repairing material for orthopedic application. POLYM. COMPOS., © 2011 Society of Plastics Engineers.
A facile cost-effective method for preparing robust self-cleaning transparent superhydrophobic coating
This paper reports an easy method to prepare transparent superhydrophobic coating by two-step spray-coating method. In order to improve robustness, PDMS oligomers were used to bond the SiO 2 nanoparticle/fluoroalkylsilane composite coating to the substrate. The transmittance of coated glass was above 80 % for wavelengths larger than 500 nm. Moreover, the prepared coating exhibited excellent self-cleaning properties in either air or oil environment. Furthermore, this coating retained superhydrophobic properties after three cycles of abrasion test or strong acid/base attack. Therefore, this robust self-cleaning transparent superhydrophobic coating may have a wide range of practical applications in the optical industry.
Contribution of FOS in neutrophils to venous thromboembolism via miR‐144 based on bioinformatic prediction and validation
The Finkel‐Biskis‐Jinkins Osteosarcoma (c‐Fos; encoded by FOS) plays an important role in several cardiovascular diseases, including atherosclerosis and stroke. However, the relationship between FOS and venous thromboembolism (VTE) remains unknown. We identified differentially expressed genes in Gene Expression Omnibus dataset, GSE48000, comprising VTE patients and healthy individuals, and analysed them using CIBERSORT and weighted co‐expression network analysis (WGCNA). FOS and CD46 expressions were significantly downregulated (FOS p = 2.26E‐05, CD64 p = 8.83E‐05) and strongly linked to neutrophil activity in VTE. We used GSE19151 and performed PCR to confirm that FOS and CD46 had diagnostic potential for VTE; however, only FOS showed differential expression by PCR and ELISA in whole blood samples. Moreover, we found that hsa‐miR‐144 which regulates FOS expression was significantly upregulated in VTE. Furthermore, FOS expression was significantly downregulated in neutrophils of VTE patients (p = 0.03). RNA sequencing performed on whole blood samples of VTE patients showed that FOS exerted its effects in VTE via the leptin‐mediated adipokine signalling pathway. Our results suggest that FOS and related genes or proteins can outperform traditional clinical markers and may be used as diagnostic biomarkers for VTE.
Accurate Determination of Tributyltin in Tannery Wastewater by a New Procedure Using ID-HPLC–ICP-MS Combined with Low Temperature Extraction
Isotope dilution mass spectrometry is recognized as a primary method to obtain traceable values in the measurement of substances including trace elements and their organometallic compounds. This paper reports a novel method where isotope dilution high performance liquid chromatography inductively coupled plasma mass spectrometry (ID-HPLC–ICP-MS) was combined with low temperature extraction for the determination of tributyltin (TBT) in tannery wastewater from the leather industry. It has been found that the liquid–liquid extraction at very low temperature is in the favor of extraction of organotin, as the enrichment factor for low temperature (−80 °C) extraction was about 1.3 times higher than for extraction at room temperature (20 °C). The method detection limit of TBT, obtained from the proposed ID-HPLC–ICP-MS procedure after extraction with a sample volume of 7.5 by 2.5 mL of organic phase, was found to be 0.13 ng g−1. When TBT was determined in a range of 10–1000 ng g−1 in tannery wastewater samples, the analyte recoveries were in the range 90.1–107.2% with relative standard deviations of between 2.0 and 7.2%. Finally, the new method of ID-HPLC–ICP-MS combined with low temperature extraction was applied to the determination of TBT in actual tannery wastewater. The TBT contents from three different tanning procedures (chrome tanning, vegetable tanning and aldehyde tanning), expressed as the mean ± the expanded uncertainty (k = 2) were 378.65 ± 20.38, 110.04 ± 5.96 and 690.17 ± 35.31 ng g−1, respectively.
Formation of rod-like nanostructure by aggregation of TiO2 nanoparticles with improved performances
To improve the performance of titanium dioxide (TiO 2 )-based devices, many efforts have been made to prepare nanostructures with composite of TiO 2 nanoparticles and nanorods. In this work, a novel rod-like TiO 2 nanostructure was obtained via a controllable hydrolysis process. Morphology and structure analysis showed that the rod-like nanostructure was a well-aligned aggregate of nearly spherical TiO 2 nanoparticles. Rod-like TiO 2 nanoparticle aggregates were fabricated on a primary TiO 2 nanoparticle-based layer without the use of template, and formed a hierarchical TiO 2 composite film together. The photocatalytic activity of the TiO 2 film with rod-like nanoparticle aggregates was evaluated by the degradation of methylene blue. The antibacterial activity of fabricated hierarchical TiO 2 film was assessed against Staphylococcus aureus . The photoelectrochemical property of this film as the photoanode in assemble dye-sensitized solar cell was also tested. Compared with randomly distributed nanoparticle-based TiO 2 film, the hierarchical TiO 2 film exhibited improved performance of photocatalysis, antibacterial activity and photoelectric conversion.