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Excessive inflammatory reaction aggravates brain injury and hinders the recovery of neural function in nervous system diseases. Microglia, as the major players of neuroinflammation, control the progress of the disease. There is an urgent need for effective non-invasive therapy to treat neuroinflammation mediated by microglia. However, the lack of specificity of anti-inflammatory agents and insufficient drug dose penetrating into the brain lesion area are the main problems. Here, we evaluated a series of calixarenes and found that among them the self-assembling architecture of amphiphilic sulfonatocalix[8]arene (SC8A12C) had the most potent ability to suppress neuroinflammation in vitro and in vivo. Moreover, SC8A12C assemblies were internalized into microglia through macropinocytosis. In addition, after applying the SC8A12C assemblies to the exposed brain tissue, we observed that SC8A12C assemblies penetrated into the brain parenchyma and eliminated the inflammatory factor storm, thereby restoring neurobiological functions in a mouse model of traumatic brain injury.

Radiotherapy (RT) has been viewed as one of the most effective and extensively applied curatives in clinical cancer therapy. However, the radioresistance of tumor severely discounts the radiotherapy outcomes. Here, an innovative supramolecular radiotherapy strategy, based on the complexation of a hypoxia‐responsive macrocycle with small‐molecule radiosensitizer, is reported. To exemplify this tactic, a carboxylated azocalix[4]arene (CAC4A) is devised as molecular container to quantitatively package tumor sensitizer banoxantrone dihydrochloride (AQ4N) through reversible host–guest interaction. Benefited from the selective reduction of azo functional groups under hypoxic microenvironment, the supramolecular prodrug CAC4A•AQ4N exhibits high tumor accumulation and efficient cellular internalization, thereby significantly amplifying radiation‐mediated tumor destruction without appreciable systemic toxicity. More importantly, this supramolecular radiotherapy strategy achieves an ultrahigh sensitizer enhancement ratio (SER) value of 2.349, which is the supreme among currently reported noncovalent‐based radiosensitization approach. Further development by applying different radiosensitizing drugs can make this supramolecular strategy become a general platform for boosting therapeutic effect in cancer radiotherapies, tremendously promising for clinical translation. The authors propose a novel concept of supramolecular radiotherapy to enhance the antitumor activity of radiation by host–guest strategy. Through complexing radiosensitive drugs within hypoxia‐responsive macrocyclic hosts to form supramolecular formulation, the supramolecular radiotherapy strategy significantly amplifies radiation‐mediated tumor destruction and reduces undesirable damage to normal tissues.

The development of a versatile platform for the synthesis of 1,2-difunctionalized bicyclo[1.1.1]pentanes to potentially mimic ortho/meta-substituted arenes is described. The syntheses of useful building blocks bearing alcohol, amine, and carboxylic acid functional handles have been achieved from a simple common intermediate. Several ortho- and meta-substituted benzene analogs, as well as simple molecular matched pairs, have also been prepared using this platform. The results of in-depth ADME (absorption, distribution, metabolism, and excretion) investigations of these systems are presented, as well as computational studies which validate the ortho- or meta-character of these bioisosteres.

The development of a versatile platform for the synthesis of 1,2-difunctionalized bicyclo[1.1.1]pentanes to potentially mimic ortho/meta-substituted arenes is described. The syntheses of useful building blocks bearing alcohol, amine, and carboxylic acid functional handles have been achieved from a simple common intermediate. Several ortho- and meta-substituted benzene analogs, as well as simple molecular matched pairs, have also been prepared using this platform. The results of in-depth ADME (absorption, distribution, metabolism, and excretion) investigations of these systems are presented, as well as computational studies which validate the ortho- or meta-character of these bioisosteres.The development of a versatile platform for the synthesis of 1,2-difunctionalized bicyclo[1.1.1]pentanes to potentially mimic ortho/meta-substituted arenes is described. The syntheses of useful building blocks bearing alcohol, amine, and carboxylic acid functional handles have been achieved from a simple common intermediate. Several ortho- and meta-substituted benzene analogs, as well as simple molecular matched pairs, have also been prepared using this platform. The results of in-depth ADME (absorption, distribution, metabolism, and excretion) investigations of these systems are presented, as well as computational studies which validate the ortho- or meta-character of these bioisosteres.

To improve the charging of high-temperature billets, it is crucial to produce them with zero defects and achieve effective insulation during their hot delivery. A mathematical model was developed based on the heat transfer characteristics of the billet during its hot delivery. The accuracy of the model was established by studying the thermal performance of the cover of the roller conveyer for small billets in Tangshan Iron and Steel Company. The results show that the cover of the roller conveyer of the continuous casting billet can effectively reduce the heat loss during the hot delivery of the billets, and the hot loading temperature was increased by 51.6 °C. The uniformity of the temperature of the casting billet section increased substantially. The temperature difference in the casting billet section was reduced by 120 °C. The heat preservation effects of temperature holding hoods of different materials were compared. It was found that the material of the temperature holding hood has slight effect on the heat preservation.

The influence of explosive charge thickness on the quality of explosive welding of dissimilar metals was investigated. The lower limit law should be followed in the course of explosive welding. Three welding experiments of stainless steel (410S) and steel (Q345R) were carried out in three different kinds of explosive charge thicknesses, namely 15, 25 and 35 mm. Interfaces of morphology and mechanical properties of three samples were observed and tested. It was found that micro and small wavy bonding is mainly formed for charge thickness of 15 mm whose strength is the highest with minor deformation and few defects in the interface; small and middle wavy bonding are mainly formed for charge thickness of 25 mm whose strength is comparatively mediocre; big wavy bonding is mainly formed for charge thickness of 35 mm whose strength is the lowest. The cause of high bonding strength of the micro and small wavy interface was analyzed and verified on the basis of the results of Electron Probe Micro-Analyzer (EPMA) tests of three selected samples.

The influence of explosive charge thickness on the quality of explosive welding of dissimilar metals was investigated.The lower limit law should be followed in the course of explosive welding.Three welding experiments of stainless steel(410S)and steel(Q345R)were carried out in three different kinds of explosive charge thicknesses,namely 15,25and 35mm.Interfaces of morphology and mechanical properties of three samples were observed and tested.It was found that micro and small wavy bonding is mainly formed for charge thickness of 15mm whose strength is the highest with minor deformation and few defects in the interface;small and middle wavy bonding are mainly formed for charge thickness of 25 mm whose strength is comparatively mediocre;big wavy bonding is mainly formed for charge thickness of 35 mm whose strength is the lowest.The cause of high bonding strength of the micro and small wavy interface was analyzed and verified on the basis of the results of Electron Probe Micro-Analyzer(EPMA)tests of three selected samples.

Objectives Work‐related musculoskeletal disorders (WMSDs) are common occupational injuries for nurses. Furthermore, rotating and irregular shift work may exacerbate muscle tension and pain in nurses. The objective of this study was to examine the differences between fixed day shift (FDS) nurses and rotating and irregular shift (RS + IS) nurses in WMSDs using a systematic literature review and meta‐analysis. Methods Databases including PubMed, CINAHL, Cochrane Library, EBSCOhost, and Google Scholar were searched for relevant studies published between 2010 and 2020 using the target keywords. Results This study obtained data on a total of 18 199 nurses, among which 12 786 comprised the RS + IS group and 5413 constituted the FDS group. The result of the heterogeneity test was Q = 79.27 (P < .001) and I squared = 57.11%, indicating that heterogeneity existed among the studies. Subgroup analyses were also conducted with four groups: neck pain (n = 1818), shoulder and upper limb pain (n = 2525), back pain (n = 11 962), and hip and lower limb pain (n = 1894). Significant differences were found between the RS + IS group and the FDS group with regard to back pain, with the forest plot presenting an odds ratio equaling 1.40 (95% CI: 1.19–1.64, P < .001). Conclusions This meta‐analysis indicated that RS + IS nurses are more likely to experience back pain associated with WMSD than are FDS nurses. The results can serve as a reference to the clinical management for work improvement and thereby reduce or prevent the adverse effects of rotating and irregular shift work on back pain experienced by nurses.

Objectives This study was to conduct a meta‐analysis of studies that used actigraphs to compare the influence of day and night shifts on the sleep quality of workers as well as examine the moderating effect of age. Methods Databases including PubMed, CINAHL, the Cochrane Library, MEDLINE, and EBSCOhost were searched for relevant studies published in English between January 1st, 2000 and April 30st, 2021. Our main targets were studies that used actigraphs to assess the sleep quality of night shift workers. This meta‐analysis included 12 papers and was performed using Comprehensive Meta‐Analysis (CMA) Version 3.0. Effect sizes were displayed in a forest plot using standardized mean difference (SMD) and 95% confidence intervals (CI). Results Among the sleep quality indices of the day and night shift workers, no significant difference existed in terms of sleep efficiency (SE) (SMD = 0.27, 95% CI: −0.03‐0.57), whereas night shift workers presented longer sleep‐onset latency (SOL) (SMD = 0.62, 95% CI: 0.15‐1.08), greater wake after sleep onset (WASO) (SMD = 0.41, 95% CI: 0.12‐0.70), and longer total sleep time (TST) (SMD = 0.85, 95% CI: 0.32‐1.39) than did day shift workers. The differences between the day and night shift workers in SOL, WASO, and TST did not vary with age. Conclusions Among the sleep quality indices, night shift workers presented longer SOL and greater WASO than did day shift workers. However, night shift workers could regulate their rest time and had adequate TST; thus, their SE was not different from that of day shift workers.

Objectives: This study aimed to investigate factors that influence the sleep quality and menstrual cycles of female rotating-shift nurses.Methods: A cross-sectional study was conducted in which 213 female rotating-shift nurses between the ages of 20 and 45 were recruited from a medical center in Taiwan from November 1, 2023, to December 31, 2023. Binary logistic regression analysis was performed with regard to sleep quality or menstrual cycle.Results: Female rotating-shift nurses who perceived a higher level of stress (P < .001), were late chronotypes (P = .020), or were working the night shift (P = .006) were more likely to have poor sleep quality. Late-type nurses working the day shift were more likely to have poor sleep quality than were early- and intermediate-type nurses (P < .001). With regard to menstrual cycles, female rotating-shift nurses who perceived a higher level of stress (P = .008), were working the night shift (P < .001), or had poor sleep quality (P = .001) were more likely to have irregular menstrual cycles. Late-type nurses working the day shift were more likely to have irregular menstrual cycles than were early- and intermediate-type nurses (P = .013).Conclusions: A higher likelihood of poor sleep quality was found in female rotating-shift nurses when they perceived high levels of stress, and the interactions between chronotype and shift type could influence sleep quality. Shift type and the interactions between chronotype and shift type could also influence menstrual regularity.