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Esophageal cancer (EC) is the sixth leading cause of tumor-related deaths worldwide. Estimates of the EC burden are necessary and could offer evidence-based suggestions for local cancer control. The aim of this study was to predict the disease burden of EC in China through the estimation of disability-adjusted life years (DALYs) and direct medical expenditure by sex from 2013 to 2030. A dynamic cohort Markov model was developed to simulate EC prevalence, DALYs, and direct medical expenditure by sex. Input data were collected from the China Statistical Yearbooks, Statistical Report of China Children's Development, World Population Prospects 2019, and published papers. The JoinPoint Regression Program was used to calculate the average annual percentage change (AAPC) of DALY rates, whereas the average annual growth rate (AAGR) was applied to analyze the changing direct medical expenditure trend over time. From 2013 to 2030, the predicted EC prevalence is projected to increase from 61.0 to 64.5 per 100,000 people, with annual EC cases increasing by 11.5% (from 835,600 to 931,800). The DALYs will increase by 21.3% (from 30,034,000 to 36,444,000), and the years of life lost (YLL) will account for over 90% of the DALYs. The DALY rates per 100,000 people will increase from 219.2 to 252.3; however, there was a difference between sexes, with an increase from 302.9 to 384.3 in males and a decline from 131.2 to 115.9 in females. The AAPC was 0.8% (95% CI 0.8% to 0.9%), 1.4% (95% CI 1.3% to 1.5%), and -0.7% (95% CI -0.8% to -0.7%) for both sexes, males, and females, respectively. The direct medical expenditure will increase by 128.7% (from US $33.4 to US $76.4 billion), with an AAGR of 5.0%. The direct medical expenditure is 2-3 times higher in males than in females. EC still causes severe disease and economic burdens. YLL are responsible for the majority of DALYs, which highlights an urgent need to establish a beneficial policy to reduce the EC burden.

Phenolic glucoside gastrodin (Gas), which is a main component extracted from the Chinese herbs Gastrodia elata Bl, is a well-known natural calcium antagonist with antioxidant and anti-inflammatory functions. It has long been used clinically for treatment of cardiovascular and cerebrovascular diseases. Previous studies have shown that gastrodin possesses comprehensive pharmacological functions. However, very little is known about whether gastrodin has protective role on cardiac hypertrophy. The aim of this study was to determine whether gastrodin attenuates pressure overload-induced cardiac hypertrophy in mice and to clarify the underlying molecular mechanisms. Our data demonstrated that gastrodin prevented cardiac hypertrophy induced by aortic banding (AB), as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. Further studies showed that gastrodin attenuated fibrosis and collagen synthesis through abrogating ERK1/2 signaling pathway. Therefore, these findings indicated that gastrodin, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of ERK1/2 signaling.

As societies internationalize, the demand for, and the value of, various goods and services increase. Individuals who possess new ideas, technologies and information that abets globalization become imbued with “transnational human capital,” making them more valuable to these societies. This report looks at this issue from five perspectives. First, it shows that China's education and employment system is now highly internationalized. Secondly, since even Chinese scholars sent by the government rely heavily on foreign funds to complete their studies, China is benefiting from foreign capital invested in the cohort of returnees. Thirdly, the report shows that foreign PhDs are worth more than domestic PhDs in terms of people's perceptions, technology transfer and in their ability to bring benefits to their universities. Finally, returnees in high tech zones, compared to people in the zones who had not been overseas, were more likely to be importing technology and capital, to feel that their skills were in great demand within society, and to be using that technology to target the domestic market.

The proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the development of pulmonary vascular remodeling, ultimately leading to pulmonary hypertension. In this study, the effects and molecular mechanisms of salidroside on the platelet-derived growth factor (PDGF)-BB-induced proliferation of primary cultured rat PASMCs were investigated. The presented data demonstrated that salidroside significantly inhibited the proliferation and DNA synthesis of PASMCs induced by PDGF-BB in a dose- and time-dependent manner, without cell cytotoxicity. In accordance with these findings, salidroside blocked progression through G0/G1 to S phase of the cell cycle. The salidroside-induced inhibition of the cell cycle was associated with the inhibition of cyclin D1, cyclin E, cyclin-dependent kinase 2 (CDK2) and CDK4 mRNA expression, as well as an increase in the mRNA expression of p27 in PDGF-BB-stimulated PASMCs. Further experiments showed that the beneficial effect of salidroside on blocking the proliferation of PASMCs was associated with the suppression of the AKT/glycogen synthase kinase 3 β (GSK3β) signaling pathway, but did not involve the extracellular signal-regulated kinase 1/2, p38 and c-Jun-N-terminal kinase signaling pathways. These results indicate that salidroside suppresses PDGF-BB-induced PASMC proliferation through the AKT/GSK3β signaling pathway and suggests that it may be a feasible therapy for pulmonary vascular remodeling diseases.

As societies internationalize, the demand for, & the value of, various goods & services increase. Individuals who possess new ideas, technologies, & information that abets globalization become imbued with \"transnational human capital,\" making them more valuable to these societies. This report looks at this issue from five perspectives. First, it shows that China's education & employment system is now highly internationalized. Secondly, since even Chinese scholars sent by the government rely heavily on foreign funds to complete their studies, China is benefiting from foreign capital invested in the cohort of returnees. Thirdly, the report shows that foreign PhDs are worth more than domestic PhDs in terms of people's perceptions, technology transfer, & in their ability to bring benefits to their universities. Finally, returnees in high tech zones, compared to people in the zones who had not been overseas, were more likely to be importing technology & capital, to feel that their skills were in great demand within society, & to be using that technology to target the domestic market. 7 Tables. Adapted from the source document.

Current climate models commonly overestimate precipitation over the Tibetan Plateau (TP), which limits our understanding of past and future water balance in the region. Identifying sources of such models’ wet bias is therefore crucial. The Himalayas is considered a major pathway of water vapor transport (WVT) towards the TP. Their steep terrain, together with associated small-scale processes, cannot be resolved by coarse-resolution models, which may result in excessive WVT towards the TP. This paper, therefore, investigated the resolution dependency of simulated WVT through the central Himalayas and its further impact on precipitation bias over the TP. According to a summer monsoon season of simulations conducted using the weather research forecasting (WRF) model with resolutions of 30, 10, and 2 km, the study found that finer resolutions (especially 2 km) diminish the positive precipitation bias over the TP. The higher-resolution simulations produce more precipitation over the southern Himalayan slopes and weaker WVT towards the TP, explaining the reduced wet bias. The decreased WVT is reflected mostly in the weakened wind speed, which is due to the fact that the high resolution can improve resolving orographic drag over a complex terrain and other processes associated with heterogeneous surface forcing. A significant difference was particularly found when the model resolution is changed from 30 to 10 km, suggesting that a resolution of approximately 10 km represents a good compromise between a more spatially detailed simulation of WVT and computational cost for a domain covering the whole TP.

Li reviews 'China's Brain Drain to the United States' by David Zweig and Chen Changgui.

The Tibetan Plateau (TP) is often referred to as the “water tower of Asia” or the “Third Pole”. It remains a challenge for most global and regional models to realistically simulate precipitation, especially its diurnal cycles, over the TP. This study focuses on evaluating the summer (June–August) precipitation diurnal cycles over the TP simulated by the Weather Research and Forecasting (WRF) model. The horizontal resolution used in this study is 9 km, which is within the gray-zone grid spacing that a cumulus parameterization scheme (CU) may or may not be used. We conducted WRF simulations with different cumulus schemes (CU experiments) and a simulation without CU (No_CU experiment). The selected CUs include the Grell-3D Ensemble (Grell), New Simplified Arakawa-Schubert (NSAS), and Multiscale Kain-Fritsch (MSKF). These simulations are compared with both the in-situ observations and satellite products. Results show that the scale-aware MSKF outperforms the other CUs in simulating precipitation in terms of both the mean intensity and diurnal cycles. In addition, the peak time of precipitation intensity is better captured by all the CU experiments than by the No_CU experiment. However, all the CU experiments tend to overestimate the mean precipitation and simulate an earlier peak of precipitation frequency when compared to observations. The frequencies and initiation timings for short-duration (1–3 h) and long-duration (> 6 h) precipitation events are well captured by the No_CU experiment, while these features are poorly reproduced by the CU experiments. The results demonstrate simulation without a CU outperforms those with a CU at the gray-zone spatial resolution in regard to the precipitation diurnal cycles.