Explore the vast range of titles available.

\"J.M.W. Turner is one of the greatest artists Britain has ever produced. His watercolours, with their extraordinary effects of shifting light and dramatic cloudscapes, are especially highly regarded. For the first time, the secrets of his technique are revealed, allowing present-day watercolourists to learn from his achievements. Uniquely, this book combines unrivalled knowledge of Turner's working methods from Tate curators and conservators with practical advice from some of the world's most respected watercolour experts. Each of the twenty-two thematic exercises is illustrated with one of Turner's works. Expert contemporary watercolourists then explain, step by step, how to paint a similar composition, learning from Turner's techniques. This book is packed with invaluable information, from the materials Turner used to achieve the masterpieces we know and love today, to the modern materials the twenty-first-century watercolourist will need if they aspire to take on similar subject matter. Backed by the authority of Tate, the world centre for Turner scholarship, with a glossary of technical terms and the highest quality colour reproductions, this is an invaluable resource both for lovers of Turner's art and of watercolour painting\"--Back cover.

So, you finally sat down with an attorney and drew up a will. That's great, but what happens when your spouse gets the money you leave--can he or she manage It to get the greatest income? What if you both die at the same time in an accident--who manages the money for the kids?

As turfgrass manager, one is continually monitoring fertilization and irrigation programs to ensure optimal visual quality while minimizing losses to the environment and maximizing profit. This requires much time and attention due to the wide variability in soil type and soil quality that exists on many turfgrass sites. Here, Kruse et al shows how to make the job of a turfgrass manager a little easier with remote sensing technology.

Objective To investigate whether an early rehabilitation intervention initiated during acute admission for exacerbations of chronic respiratory disease reduces the risk of readmission over 12 months and ameliorates the negative effects of the episode on physical performance and health status.Design Prospective, randomised controlled trial.Setting An acute cardiorespiratory unit in a teaching hospital and an acute medical unit in an affiliated teaching district general hospital, United Kingdom.Participants 389 patients aged between 45 and 93 who within 48 hours of admission to hospital with an exacerbation of chronic respiratory disease were randomised to an early rehabilitation intervention (n=196) or to usual care (n=193).Main outcome measures The primary outcome was readmission rate at 12 months. Secondary outcomes included number of hospital days, mortality, physical performance, and health status. The primary analysis was by intention to treat, with prespecified per protocol analysis as a secondary outcome.Interventions Participants in the early rehabilitation group received a six week intervention, started within 48 hours of admission. The intervention comprised prescribed, progressive aerobic, resistance, and neuromuscular electrical stimulation training. Patients also received a self management and education package.Results Of the 389 participants, 320 (82%) had a primary diagnosis of chronic obstructive pulmonary disease. 233 (60%) were readmitted at least once in the following year (62% in the intervention group and 58% in the control group). No significant difference between groups was found (hazard ratio 1.1, 95% confidence interval 0.86 to 1.43, P=0.4). An increase in mortality was seen in the intervention group at one year (odds ratio 1.74, 95% confidence interval 1.05 to 2.88, P=0.03). Significant recovery in physical performance and health status was seen after discharge in both groups, with no significant difference between groups at one year.Conclusion Early rehabilitation during hospital admission for chronic respiratory disease did not reduce the risk of subsequent readmission or enhance recovery of physical function following the event over 12 months. Mortality at 12 months was higher in the intervention group. The results suggest that beyond current standard physiotherapy practice, progressive exercise rehabilitation should not be started during the early stages of the acute illness.Trial registration Current Controlled Trials ISRCTN05557928.

Quantum computing leverages the quantum resources of superposition and entanglement to efficiently solve computational problems considered intractable for classical computers. Examples include calculating molecular and nuclear structure, simulating strongly interacting electron systems, and modeling aspects of material function. While substantial theoretical advances have been made in mapping these problems to quantum algorithms, there remains a large gap between the resource requirements for solving such problems and the capabilities of currently available quantum hardware. Bridging this gap will require a co-design approach, where the expression of algorithms is developed in conjunction with the hardware itself to optimize execution. Here we describe an extensible co-design framework for solving chemistry problems on a trapped-ion quantum computer and apply it to estimating the ground-state energy of the water molecule using the variational quantum eigensolver (VQE) method. The controllability of the trapped-ion quantum computer enables robust energy estimates using the prepared VQE ansatz states. The systematic and statistical errors are comparable to the chemical accuracy, which is the target threshold necessary for predicting the rates of chemical reaction dynamics, without resorting to any error mitigation techniques based on Richardson extrapolation.

With increasing sea water temperatures, higher latitude temperate and sub-tropical coral reefs are becoming increasingly tropicalised. Although these cooler areas might offer refuge to tropical species escaping the heat, the reshaping of ecosystems can have devastating effects on the biodiversity in these areas, especially when habitat structure is affected. Recently, feeding aggregations of corallivorous gastropod Drupella cornus , a tropical species capable of large-scale reef degradation, were found at Rottnest Island in Western Australia (32°S). We provide evidence that D. cornus spawned at Rottnest Island for 2 consecutive years in 2021 and 2022, and Drupella veligers from an egg case collected at the island hatched and grew at temperatures in the laboratory that were predominantly lower than those at Rottnest Island at the same time. The spawning was possibly triggered by higher than usual La Niña-associated SSTs during the survey period, or the long period of high sea water temperature anomalies recorded around Rottnest Island. A spawning population of D. cornus can greatly affect these higher latitude reef areas, especially when accompanied by increased heat stress. Monitoring and management should be implemented to further understand what effects a breeding population of D. cornus has on Rottnest Island.

Hospitalization represents a major event for the patient with chronic respiratory disease. There is a high risk of readmission, which over the longer term may be related more closely to the underlying condition of the patient, such as skeletal muscle dysfunction. We assessed the risk of hospital readmission at 1 year, including measures of lower limb muscle as part of a larger clinical trial. Patients hospitalized with an exacerbation of chronic respiratory disease underwent measures of muscle function including quadriceps ultrasound. Independent factors influencing time to hospital readmission or death were identified. Patients were classified into four quartiles based on quadriceps size and compared. One hundred and ninety-one patients (mean age, 71.6 [SD, 9.1] yr) were recruited. One hundred and thirty (68%) were either readmitted or died. Factors associated with readmission or death were age (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.01-1.08; P = 0.015), Medical Research Council (MRC) dyspnea grade (OR, 4.57; 95% CI, 2.62-7.95; P < 0.001), home oxygen use (OR, 12.4; 95% CI, 4.53-33.77; P < 0.001), quadriceps (rectus femoris) cross-sectional area (Qcsa) (OR, 0.34; 95% CI, 0.17-0.65; P = 0.001), and hospitalization in the previous year (OR, 4.82; 95% CI, 2.42-9.58; P < 0.001). In the multivariate analyses, home oxygen use (OR, 4.80; 95% CI, 1.68-13.69; P = 0.003), MRC dyspnea grade (OR, 2.57; 95% CI, 1.44-4.59; P = 0.001), Qcsa (OR, 0.46; 95% CI, 0.22-0.95; P = 0.035), and previous hospitalization (OR, 3.04; 95% CI, 1.47-6.29; P = 0.003) were independently associated with readmission or death. Patients with the smallest muscle spent more days in hospital than those with largest muscle (28.1 [SD, 33.9] vs. 12.2 [SD, 23.5] d; P = 0.007). Smaller quadriceps muscle size, as measured by ultrasound in the acute care setting, is an independent risk factor for unscheduled readmission or death, which may have value both in clinical practice and for risk stratification.

Research studies have described the morbidity associated with inherited bleeding disorders such as hemophilia and von Willebrand disease in women, but their effect on daily living has long been underrecognized. This systematic review sought to document the lived experience of women with a bleeding disorder by assessing research findings on quality of health care, socioeconomic factors, and mental health. A systematic search was carried out in Web of Science, the Cumulative Index to Nursing and Allied Health Literature, and PubMed on July 31, 2020. References were hand searched. Abstracts of the 2019 and 2020 congresses on bleeding disorders were hand searched. Key journals were screened for relevant studies published after the search date until the analysis was completed on December 7, 2020. Of 635 potentially eligible publications, 27 published since 1998 were selected for review. Most studies were of moderate to high quality but meta‐analysis of quantitative studies was not possible due to difference in outcomes and assessment. Women with a bleeding disorder experience obstacles to accessing care, difficulties living with their disorder, interference with schooling and work, and poor mental health. Diagnostic delay and lack of recognition of symptoms mean treatment and support may not be available. Where comparisons with controls were made, women’s negative experiences were greater than those of men. Women with bleeding disorders experience major negative impacts of their disorders on daily life and mental well‐being. Many of the challenges identified in earlier research are evident in more recent studies.

ObjectivesThe aim of this study was to determine if an interactive web-based pulmonary rehabilitation (PR) programme is a feasible alternative to conventional PR.DesignRandomised controlled feasibility trial.SettingParticipants with a diagnosis of chronic obstructive pulmonary disease were recruited from PR assessments, primary care and community rehabilitation programmes. Patients randomised to conventional rehabilitation started the programme according to the standard care at their referred site on the next available date.Participants103 patients were recruited to the study and randomised: 52 to conventional rehabilitation (mean (±SD) age 66 (±8) years, Medical Research Council (MRC) 3 (IQR2–4)); 51 to the web arm (mean (±SD) age 66 (±10) years, MRC 3 (IQR2–4)). Participants had to be willing to participate in either arm of the trial, have internet access and be web literate.InterventionsPatients randomised to the web-based programme worked through the website, exercising and recording their progress as well as reading educational material. Conventional PR consisted of twice weekly, 2 hourly sessions (an hour for exercise training and an hour for education).Outcome measuresRecruitment rates, eligibility, patient preference and dropout and completion rates for both programmes were collected. Standard outcomes for a PR assessment including measures of exercise capacity and quality of life questionnaires were also evaluated.ResultsA statistically significant improvement (p≤0.01) was observed within each group in the endurance shuttle walk test (WEB: mean change 189±211.1; PR classes: mean change 184.5±247.4 s) and Chronic Respiratory disease Questionnaire-Dyspnoea (CRQ-D; WEB: mean change 0.7±1.2; PR classes: mean change 0.8±1.0). However, there were no significant differences between the groups in any outcome. Dropout rates were higher in the web-based programme (57% vs 23%).ConclusionsAn interactive web-based PR programme is feasible and acceptable when compared with conventional PR. Future trials maybe around choice-based PR programmes for select patients enabling stratification of patient care.Trial registration numberISRCTN03142263; Results.