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Ambrosia artemisiifolia is an invasive weed in Europe with highly allergenic pollen. Populations are currently well established and cause significant health problems in the French Rhône valley, Austria, Hungary and Croatia but transient or casual introduced populations are also found in more Northern and Eastern European countries. A process-based model of weed growth, competition and population dynamics was used to predict the future potential for range expansion of A.artemisiifolia under climate change scenarios. The model predicted a northward shift in the available climatic niche for populations to establish and persist, creating a risk of increased health problems in countries including the UK and Denmark. This was accompanied by an increase in relative pollen production at the northern edge of its range. The southern European limit for A.artemisiifolia was not expected to change; populations continued to be limited by drought stress in Spain and Southern Italy. The process-based approach to modelling the impact of climate change on plant populations has the advantage over correlative species distribution models of being able to capture interactions of climate, land use and plant competition at the local scale. However, for this potential to be fully realised, additional empirical data are required on competitive dynamics of A.artemisiifolia in different crops and ruderal plant communities and its capacity to adapt to local conditions.

Debate over effective climate change communication must be grounded in rigorous affective science. Rather than treating emotions as simple levers to be pulled to promote desired outcomes, emotions should be viewed as one integral component of a cognitive feedback system guiding responses to challenging decision-making problems.

Repeated head impact in sports leads to chronic cognitive and neurobehavior deficits even in the absence of brain pathology. High-frequency head impact (HFHI) in mice causes a chronic change to the synaptic properties in core hippocampal circuits, and causes no cell death, no axonal damage, no tau or amyloid accumulation, and no inflammation, yet results in impaired cognitive function. It is unknown how HFHI affects intrinsic plasticity events and if neural biomarkers of HFHI can be detected. Sharp-wave ripples (SWR) are hippocampal population events consisting of a sharp wave (1–30 Hz) and associated ripple oscillation (120–220 Hz). SWR are strongly associated with memory and are an established biomarker for cognition and memory. To characterize the effect of HFHI on SWR, we prepared acute slices 24 hours after HFHI and used field recordings to characterize hippocampal SWR. Physiological SWR were present in both sham and HFHI mice, and their architecture was grossly intact. We did not detect pathological ripples. Quantification of SWR features showed a decreased amplitude and power of SWR in HFHI brains compared to sham. Further analysis of the ripple oscillations found decreased number of ripple cycles within each event, and reduced ripple power in HFHI brains. These data show that HFHI alters hippocampal SWR architecture, reducing metrics including SWR amplitude and power, which may play a role in impaired cognition in this mouse model.

The shift away from mission studies to intercultural theology within a number of universities coincides with the emergence of postmodernism. This article explores the extent to which a postmodern outlook pervades intercultural theology and explores whether or not an alternative epistemological orientation, particularism, might be better suited to the task of bringing diverse cultures and languages into dialogue and, moreover, uniting Christian congregations.

Niche shifts of nonnative plants can occur when they colonize novel climatic conditions. However, the mechanistic basis for niche shifts during invasion is poorly understood and has rarely been captured within species distribution models. We quantified the consequence of between-population variation in phenology for invasion of common ragweed (Ambrosia artemisiifolia L.) across Europe. Ragweed is of serious concern because of its harmful effects as a crop weed and because of its impact on public health as a major aeroallergen. We developed a forward mechanistic species distribution model based on responses of ragweed development rates to temperature and photoperiod. The model was parameterized and validated from the literature and by reanalyzing data from a reciprocal common garden experiment in which native and invasive populations were grown within and beyond the current invaded range. It could therefore accommodate between-population variation in the physiological requirements for flowering, and predict the potentially invaded ranges of individual populations. Northern-origin populations that were established outside the generally accepted climate envelope of the species had lower thermal requirements for bud development, suggesting local adaptation of phenology had occurred during the invasion. The model predicts that this will extend the potentially invaded range northward and increase the average suitability across Europe by 90% in the current climate and 20% in the future climate. Therefore, trait variation observed at the population scale can trigger a climatic niche shift at the biogeographic scale. For ragweed, earlier flowering phenology in established northern populations could allow the species to spread beyond its current invasive range, substantially increasing its risk to agriculture and public health. Mechanistic species distribution models offer the possibility to represent niche shifts by varying the traits and niche responses of individual populations. Ignoring such effects could substantially underestimate the extent and impact of invasions.

Aim: Although global trade is implicated in biological invasions, the assumption that trade networks explain the large-scale distributions of non-native species remains largely untested. We addressed this by analysing relationships between global trade networks and plant pest invasion. Location: Forty-eight countries in Europe and the Mediterranean. Time period: Current. Major taxa studied: Four hundred and twenty-two non-native plant pests (173 invertebrates, 166 pathogens, 83 plants). Methods: Ten types of connectivity index were developed, representing potential roles of trade networks, air transport links, geographical proximity, climatic similarity and source country wealth in facilitating invasion. Generalized linear mixed models (GLMMs) identified the connectivity index that best explained both historical and recent invasion. Then, more complex GLMMs were developed including connectivity through trade networks for multiple commodities relevant for pests (live plants, forest products, fruit and vegetables and seeds) and species' transport associations with those commodities. Results: Total import volumes, species' global prevalence and connectivity measures based on air transport, geographical distance or climate did not explain invasion as well as connectivity through global trade networks. Invasion was strongly promoted by agricultural imports from countries in which the focal species was present and that were climatically similar to the importing country. However, live plant imports from nearby countries provided a better explanation of the most recent invasions. Connectivity through multiple trade networks predicted invasion better than total agricultural trade, and there was support for our hypothesis that species known to be transported with a particular network had greater sensitivity to its connectivity. Main conclusions: Our findings show that patterns of invasion are governed to a large extent by global trade networks connecting source areas for non-native species and the dispersal of those species through multiple trade networks. This enhances potential for developing a predictive framework to improve risk assessment, biosecurity and surveillance for invasions.

Summary Pollinator network structure arising from the extent and strength of interspecific mutualistic interactions can promote species persistence and community robustness. However, environmental change may re‐organise network structure limiting capacity to absorb or resist shocks and increasing species extinctions. We investigated if habitat disturbance and the level of mutualism dependence between species affected the robustness of insect–flower visitation networks Following a recently developed Stochastic Co‐extinction Model (SCM), we ran simulations to produce the number of extinction episodes (cascade degree), which we correlated with network structure in undisturbed and disturbed habitat. We also explicitly modelled whether a species’ intrinsic dependence on mutualism affected the propensity for extinction cascades in the network. Habitat disturbance generated a gradient in network structure with those from disturbed sites being less connected, but more speciose and so larger. Controlling for network size (z‐score standardisation against the null model) revealed that disturbed networks had disproportionately low linkage density, high specialisation, fewer insect visitors per plant species (vulnerability) and lower nestedness (NODF). This network structure gradient driven by disturbance increased and decreased different aspects of robustness to simulated plant extinction. Disturbance decreased the risk that an initial insect extinction would follow a plant species loss. Although, this effect disappeared when network size and connectance were standardised, suggesting the lower connectance of disturbed networks increased robustness to an initial secondary extinction. However, if a secondary extinction occurred then networks from disturbed habitat were more prone to large co‐extinction cascades, likely resulting from a greater chance of extinction in these larger, speciose networks. Conversely, when species mutualism dependency was explicit in the SCM simulations the disturbed networks were disproportionately more robust to very large co‐extinction cascades, potentially caused by non‐random patterns of interaction between species differing in dependence on mutualism. Our results showed disturbance altered the size and the distribution of interspecific interactions in the networks to affect their robustness to co‐extinction cascades. Controlling for effects due to network size and the interspecific variation in demographic dependence on mutualism can improve insight into properties conferring the structural robustness of networks to environmental changes. A lay summary is available for this article. Lay Summary

It is a privilege to be invited to contribute to the Festschrift dedicated to Professor Johan Buitendag, Emeritus Dean, Faculty of Theology and Religion at the University of Pretoria, South Africa. While his own work often examined the relationship between theology and natural science, he was also passionate about ecumenism and, in that spirit, the present essay utilised what might be described as an inductive approach to an important ecumenical question, the unity between Methodists and Catholics. Ecumenical dialogue is often undertaken from a theological and dogmatic perspective. This essay took a different approach in that it sought to inductively examine what might be described as the inner logic of two ecclesial systems (Methodist and Catholic). In doing so, it was premised upon an Aristotelian philosophical principle, epistemic fit, in that it presupposed that both these ecclesial bodies possess an intrinsic logic that can be brought to the surface in order to exhibit parallel contours in the wider ecclesial terrain.ContributionThis article fits well within the scope of HTS Teologiese Studies/Theological Studies in that it contributed to a new subdiscipline in epistemology, which explores the conceptual and epistemological dimensions of ecclesiology. Using the concept of epistemic fit, the article offered an inductive approach to some of the practical issues that emerge in ecumenical dialogue.

Dying tumour cells can elicit a potent anticancer immune response by exposing the calreticulin (CRT)/ERp57 complex on the cell surface before the cells manifest any signs of apoptosis. Here, we enumerate elements of the pathway that mediates pre‐apoptotic CRT/ERp57 exposure in response to several immunogenic anticancer agents. Early activation of the endoplasmic reticulum (ER)‐sessile kinase PERK leads to phosphorylation of the translation initiation factor eIF2α, followed by partial activation of caspase‐8 (but not caspase‐3), caspase‐8‐mediated cleavage of the ER protein BAP31 and conformational activation of Bax and Bak. Finally, a pool of CRT that has transited the Golgi apparatus is secreted by SNARE‐dependent exocytosis. Knock‐in mutation of eIF2α (to make it non‐phosphorylatable) or BAP31 (to render it uncleavable), depletion of PERK, caspase‐8, BAP31, Bax, Bak or SNAREs abolished CRT/ERp57 exposure induced by anthracyclines, oxaliplatin and ultraviolet C light. Depletion of PERK, caspase‐8 or SNAREs had no effect on cell death induced by anthracyclines, yet abolished the immunogenicity of cell death, which could be restored by absorbing recombinant CRT to the cell surface.