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"Chavez, Barbara"
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Prevalence of Latent and Active Tuberculosis among Dairy Farm Workers Exposed to Cattle Infected by Mycobacterium bovis
by
Torres-Rojas, Martha
,
Bobadilla-del-Valle, Miriam
,
Martinez-Gamboa, Areli
in
Adult
,
Animals
,
Cattle
2013
Human tuberculosis caused by M. bovis is a zoonosis presently considered sporadic in developed countries, but remains a poorly studied problem in low and middle resource countries. The disease in humans is mainly attributed to unpasteurized dairy products consumption. However, transmission due to exposure of humans to infected animals has been also recognized. The prevalence of tuberculosis infection and associated risk factors have been insufficiently characterized among dairy farm workers (DFW) exposed in settings with poor control of bovine tuberculosis.
Tuberculin skin test (TST) and Interferon-gamma release assay (IGRA) were administered to 311 dairy farm and abattoir workers and their household contacts linked to a dairy production and livestock facility in Mexico. Sputa of individuals with respiratory symptoms and samples from routine cattle necropsies were cultured for M. bovis and resulting spoligotypes were compared. The overall prevalence of latent tuberculosis infection (LTBI) was 76.2% (95% CI, 71.4-80.9%) by TST and 58.5% (95% CI, 53.0-64.0%) by IGRA. Occupational exposure was associated to TST (OR 2.72; 95% CI, 1.31-5.64) and IGRA (OR 2.38; 95% CI, 1.31-4.30) adjusting for relevant variables. Two subjects were diagnosed with pulmonary tuberculosis, both caused by M. bovis. In one case, the spoligotype was identical to a strain isolated from bovines.
We documented a high prevalence of latent and pulmonary TB among workers exposed to cattle infected with M. bovis, and increased risk among those occupationally exposed in non-ventilated spaces. Interspecies transmission is frequent and represents an occupational hazard in this setting.
Journal Article
Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility Profile: A Fifteen-Year Laboratory-Based Surveillance
by
Cervera-Hernández, Miguel Enrique
,
Cinta-Severo, Carmen
,
Chávez-Mazari, Bárbara
in
Antitubercular agents
,
Antitubercular Agents - therapeutic use
,
Cattle
2015
Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, and it is less frequently attributed to animal-to-human or human-to-human contact. We describe the trends of M. bovis isolation from human samples and first-line drug susceptibility during a 15-year period in a referral laboratory located in a tertiary care hospital in Mexico City.
Data on mycobacterial isolates from human clinical samples were retrieved from the laboratory's database for the 2000-2014 period. Susceptibility to first-line drugs: rifampin, isoniazid, streptomycin (STR) and ethambutol was determined. We identified 1,165 isolates, 73.7% were M. tuberculosis and 26.2%, M. bovis. Among pulmonary samples, 16.6% were M. bovis. The proportion of M. bovis isolates significantly increased from 7.8% in 2000 to 28.4% in 2014 (X(2)trend, p<0.001). Primary STR resistance was higher among M. bovis compared with M. tuberculosis isolates (10.9% vs.3.4%, p<0.001). Secondary multidrug resistance (MDR) rates were 38.5% and 34.4% for M. bovis and M. tuberculosis, respectively (p = 0.637). A rising trend of primary STR monoresistance was observed for both species (3.4% in 2000-2004 vs. 7.6% in 2010-2014; p = 0.02).
There is a high prevalence and a rising trend of M. bovis isolates in our region. The proportion of pulmonary M. bovis isolates is higher than in previous reports. Additionally, we report high rates of primary anti-tuberculosis resistance and secondary MDR in both M. tuberculosis and M. bovis. This is one of the largest reports on drug susceptibility of M. bovis from human samples and shows a significant proportion of first-line anti-tuberculosis drug resistance.
Journal Article
Comparative Resuscitative Methods for Venlafaxine Toxicity in a Swine Model
by
O'Sullivan, Joseph
,
Johnson, Don
,
Kahl, Brooke
in
Animals
,
Cardiopulmonary Resuscitation - methods
,
Drug Overdose - mortality
2016
Venlafaxine overdose can lead to cardiovascular collapse that is difficult to resuscitate with traditional Advanced Cardiovascular Life Support protocols. Evidence has suggested that lipid emulsion infusion therapy has been successful in the treatment of antidepressant overdose. No studies have determined the optimal combination of lipid/advanced cardiovascular life support therapy for treatment.
This study was a prospective, experimental, between subjects design with a swine model investigating the effectiveness of drug combinations administered with cardiopulmonary resuscitation (CPR) postvenlafexine overdose. Subjects were randomly assigned to 1 of eight groups containing seven subjects. The groups tested were CPR only and CPR with epinephrine alone; vasopressin alone; lipid alone; epinephrine and vasopressin; epinephrine and lipid; vasopressin and lipid; and epinephrine, vasopressin, and lipid. The outcomes of interest were survival odds and time to return of spontaneous circulation.
Results on these swine models indicate that the use of vasopressin coupled with lipids for venlafaxine overdose resulted in a higher survival rate when compared to the control group (p = 0.023). Groups receiving vasopressin experienced statistically faster times to return of spontaneous circulation than other groups (p = 0.019).
The results suggest that in swine models, the optimal treatment for venlafaxine overdose would include vasopressin with lipids.
Journal Article
Prevalence of Latent and Active Tuberculosis among Dairy Farm Workers Exposed to Cattle Infected by Mycobacterium bovis
by
Torres-Rojas, Martha
,
Bobadilla-del-Valle, Miriam
,
Martinez-Gamboa, Areli
in
Abattoirs
,
Cattle
,
Dairy farms
2013
Background Human tuberculosis caused by M. bovis is a zoonosis presently considered sporadic in developed countries, but remains a poorly studied problem in low and middle resource countries. The disease in humans is mainly attributed to unpasteurized dairy products consumption. However, transmission due to exposure of humans to infected animals has been also recognized. The prevalence of tuberculosis infection and associated risk factors have been insufficiently characterized among dairy farm workers (DFW) exposed in settings with poor control of bovine tuberculosis. Methodology/Principal Findings Tuberculin skin test (TST) and Interferon-gamma release assay (IGRA) were administered to 311 dairy farm and abattoir workers and their household contacts linked to a dairy production and livestock facility in Mexico. Sputa of individuals with respiratory symptoms and samples from routine cattle necropsies were cultured for M. bovis and resulting spoligotypes were compared. The overall prevalence of latent tuberculosis infection (LTBI) was 76.2% (95% CI, 71.4-80.9%) by TST and 58.5% (95% CI, 53.0-64.0%) by IGRA. Occupational exposure was associated to TST (OR 2.72; 95% CI, 1.31-5.64) and IGRA (OR 2.38; 95% CI, 1.31-4.30) adjusting for relevant variables. Two subjects were diagnosed with pulmonary tuberculosis, both caused by M. bovis. In one case, the spoligotype was identical to a strain isolated from bovines. Conclusions We documented a high prevalence of latent and pulmonary TB among workers exposed to cattle infected with M. bovis, and increased risk among those occupationally exposed in non-ventilated spaces. Interspecies transmission is frequent and represents an occupational hazard in this setting.
Journal Article
Successful Albuquerque, N.M., Woman Teaches Etiquette to Young Girls
2003
Domenici also teaches Social Survival 101 for college and graduate students, to prepare them for the work world; ShyForce for girls in their early teens as they deal with dating and peer pressure; and SForce for high school junior and senior girls preparing for independence. As former president of Hospital Home Healthcare and former vice president of St. Joseph Healthcare Corp. (and a sister of Sen. Pete Domenici), Domenici has learned and lived what works in the world. After 30 years in business, she still teaches careerists what she thinks works out there. These days, however, you might catch Domenici having the most fun teaching etiquette and community service to young girls.
Newsletter
U.S.-WOMEN: WOMEN BREAKING COURTS' GLASS CEILINGS -- SLOWLY
2003
In New Mexico, the faces on the bench are changing intentionally. Newly-elected Gov. Bill Richardson recently rejected a list of possible candidates to fill vacant appellate court seats because he said the lists did not include any women. \"I don't believe our courts can adequately claim to represent the people of our community if the judges are not representative of that community,\" Richardson said. He also instructed the search committees of these seats to \"do their homework\" before coming up with a new list of possible judges. On Jan 30, Richardson also appointed Edward L. Chavez to the state supreme court to fill the vacancy left by retiring Justice Gene Franchini. As a woman and a Latina, [Petra Jimenez Maes] still is an anomaly among the nation's top judges. Of the 52 chief justices in America's highest state courts, Maes is one of 20 women. She is only one of two ethnic minority women in the states' highest courts: Chief Judge Annice M. Wagner of the court of appeals in Washington, the District of Columbia's highest court, is African American. Maes, a state district judge in Santa Fe for 17 years, was appointed to the Supreme Court in 1998 to fill a vacancy and won election last November to a full eight-year term. In New Mexico, justices can be appointed to fill a vacancy, but then must win a retention election in the next partisan election. She was elected to the chief justice post on Jan. 8 by fellow justices.
Newsletter
Albuquerque, N.M., Hair Salon Lets Nonprofit Groups Do Advertising
2002
Nov. 29--John Hindi has a business concept some might just think is a little \"hair-brained.\" Hindi owns HairHut, a hair salon on Albuquerque's West Side that opened about seven months ago. He said he knew the city probably didn't need another hair salon, but he also was thinking about doing something very different. So Hindi set up his business at 9421 Coors NW to offer fund- raising opportunities for nonprofit groups. Hindi has computer software that tracks customer purchases and credits the appropriate nonprofit account. \"In a perfect world it would be great to say we won't have to fund-raise anymore,\" said Amy Solberg, Valley's choir director. \"We do other fund raisers that take up a lot more time than HairHut. \"We basically have made fliers that we hand out telling people to go to HairHut and tell them the Valley choir sent them,\" she said. \"It basically is easy to do since we're not doing the actual selling. We just promote the company.\"
Newsletter
Albuquerque, N.M., Hair Salon Offers Fund-Raising Opportunities for Nonprofits
2002
Nov. 25--ALBUQUERQUE, N.M.--John Hindi has a business concept you might just think is a little hair-brained. Hindi owns HairHut, a hair salon on Albuquerque's West Side that opened about seven months ago. He said he knew the city probably didn't need another hair salon, but he also was thinking about doing something very different. So Hindi set up his business at 9421 Coors NW to offer fund- raising opportunities for nonprofit groups. Hindi has computer software that tracks customer purchases and credits the appropriate nonprofit account. \"In a perfect world it would be great to say we won't have to fund-raise anymore,\" said Amy Solberg, Valley's choir director. \"We do other fund raisers that take up a lot more time than HairHut. \"We basically have made fliers that we hand out telling people to go to HairHut and tell them the Valley choir sent them,\" she said. \"It basically is easy to do since we're not doing the actual selling. We just promote the company.\"
Newsletter
Hispanic Broadcasting Corp. Buys Five Albuquerque, N.M., Radio Stations
2002
Simmons sold KIOT-FM (102.5), KRQS-FM (105.1), KOSZ-FM (101.7), KKRG-FM (101.3) and KKSS-FM (97.3). Both KOSZ, formerly an easy- listening format, and KKRG, formerly classic country music, have both changed to Spanish stations.
Newsletter
RELIGION: A.M.E. CHURCH'S WOMAN BISHOP IS A SYMBOL OF CHANGE
2002
[Murphy McKenzie] made history in 2000, when she was elected the 117th bishop, making her the first woman to achieve the highest rank in the African Methodist Episcopal Church. Since McKenzie was elected, two more female pastors have announced they are candidates to become bishops in the African Methodist Episcopal Church. \"That,\" said McKenzie, \"is just the tip of the iceberg.\" The African Methodist Episcopal Church has a long history of social activism. It was one of the first major religious denominations in the Western world with origins based on sociological rather than theological beliefs and differences. The African Methodist Episcopal Church was formed in 1816 by Richard Allen and others who had fought to end segregation within their churches. Allen, a member of the Episcopal Church, united with Methodist leaders to form the new church. Today there are African Methodist Episcopal churches worldwide in the United States, Canada, Africa, South America, England, the Bahamas and the Caribbean. (The African Methodist Episcopal Zion Church, established in 1796 in New York City by James Varick, Abraham Thompson, William Miller and others, was similar in that it grew from the Methodist Episcopal Church and was necessitated by discrimination and denial of religious liberty.)
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