Explore the vast range of titles available.

The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps, which may harm intestinal health. Traditional Chinese medicine (TCM) has been applied clinically for thousands of years, and how TCMs regulate intestinal health to achieve their effects of disease treatment has become a hot research topic that needs to be resolved. This paper reviews the recent research on the effects of TCMs on intestinal microorganisms and the intestinal mucosal barrier after entering the intestine, discusses the interaction mechanisms between TCMs and intestinal flora, and details the repair effect of TCMs on the intestinal mucosal barrier to provide a reference for the development, utilization, and modernization of TCM.

The gut microbiota offers numerous benefits to the human body, including the promotion of nutrient absorption, participation in metabolic processes, and enhancement of immune function. Recent studies have introduced the concept of the gut-organ axis, which encompasses interactions such as the gut-brain axis, gut-liver axis, and gut-lung axis. This concept underscores the complex interplay between gut microbiota and various organs and tissues, including the brain, heart, lungs, liver, kidneys, muscles, and bones. Growing evidence indicates that gut microbiota can influence the onset and progression of multi-organ system diseases through their effects on the gut-organ axis. Traditional Chinese medicine has demonstrated significant efficacy in regulating the gastrointestinal system, leveraging its unique advantages. Considerable advancements have been made in understanding the role of gut microbiota and the gut-organ axis within the mechanisms of action of traditional Chinese medicine. This review aims to elucidate the roles of gut microbiota and the gut-organ axis in human health, explore the potential connections between traditional Chinese medicine and gut microbiota, and examine the therapeutic effects of traditional Chinese medicine on the microbiota-gut-organ axis. Furthermore, the review addresses the limitations and challenges present in current research while proposing potential directions for future investigations in this area.

Liver disease is a common and serious threat to human health. The progression of liver diseases is influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, and autophagy. Various factors lead to the dysfunction of these processes and basing on the different pathogeny, pathology, clinical manifestation, and pathogenesis, liver diseases are grouped into different categories. Specifically, Sirtuin1 (SIRT1), a member of the sirtuin protein family, has been extensively studied in the context of liver injury in recent years and are confirmed the significant role in liver disease. SIRT1 has been found to play a critical role in regulating key processes in liver injury. Further, SIRT1 seems to cause divers outcomes in different types of liver diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring a novel therapeutic target. To elucidate the mechanisms underlying the role of sirtuin1 in liver injury and its potentiality as a therapeutic target, this review outlines the key signaling pathways associated with sirtuin1 and liver injury, and discusses recent advances in therapeutic strategies targeting sirtuin1 in liver diseases.

Non-equilibrium plasma has significant chemical kinetic effect and aerodynamic effect, both of which play an important role in the plasma-assisted combustion. In this paper, the numerical study on plasma-assisted combustion in gaseous methane rocket engine is carried out to investigate the impact of kinetic effect on its combustion performance. There are three schemes of plasma excitation via oxygen, methane and both of them in the numerical simulation model. The variations of combustion chamber temperature, pressure, species concentration and special impulse with different dissociation degrees are analysed in three discharge schemes. The results show that non-equilibrium plasma can effectively increase methane burning rate, shorten unburnt area upstream of combustion chamber, and increase the width of combustion zone in shear layer upstream of combustion chamber. And this phenomenon becomes more obvious with the increase of excitation intensity. In addition, more methane and oxygen are added to the combustion process under plasma actuation, and the mole fraction of water is increased in combustion products. The specific impulse of engine is also increased under plasma actuation. At the same degree of dissociation, the combustion-supporting effect of simultaneous discharge of oxygen and methane is significantly greater than that of any component discharge. And in the condition of single component discharge, the combustion-supporting effect of methane is better than that of oxygen.

Aiming at the structure of small thrust rocket engine injector, a coaxial shear-type dielectric barrier discharge plasma nozzle was designed, and the effects of methane discharge and air discharge on combustion effect under different excitation and different mixing ratio conditions are studied. The results show that: the flashback occurs when the methane discharge voltage is high, the air discharge can broaden the blow off limit of the air/methane diffusion flame, and has the effect of stabilizing the flame and reducing the lift height.