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"Chen, Jack"
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Anecdote, Network, Gossip, Performance
Anecdote, Network, Gossip, Performance is a study of the Shishuo xinyu, the most important anecdotal collection of medieval China—and arguably of the entire traditional era. In a set of interconnected essays, Jack W. Chen offers new readings of the Shishuo xinyu that draw upon social network analysis, performance studies, theories of ritual and mourning, and concepts of gossip and reputation to illuminate how the anecdotes of the collection imagine and represent a political and cultural elite. Whereas most accounts of the Shishuo have taken a historical approach, Chen argues that the work should be understood in literary terms.At its center, Anecdote, Network, Gossip, Performance is an extended meditation on the very nature of the anecdote form, both what the anecdote affords in terms of representing a social community and how it provides a space for the rehearsal of certain longstanding philosophical and cultural arguments. Although each of the chapters may be read separately as an essay in its own right, when taken together, they present a comprehensive account of the Shishuo in all of its literary complexity.
eBook
Nanoprecipitation to produce hydrophobic cellulose nanospheres for water-in-oil Pickering emulsions
In recent years, there has been growing interest in replacing petroleum-based water-in-oil (W/O) emulsifiers with sustainable and less toxic natural materials. Pickering emulsifiers are considered well-suited candidates due to their high interfacial activity and the ability to form emulsions with long-term stability. However, only sporadic examples of natural materials have been considered as inverse Pickering emulsifiers. This study describes the synthesis of a series of hydrophobic cellulose nanospheres by bulk modification with acyl groups of different chain lengths followed by nanoprecipitation, and their application as inverse emulsifiers. Modification with acyl groups of longer chain length (C16, C18) afforded lower degrees of substitution, but resulted in greater thermal stability than groups with shorter acyl chains (C12, C14). Formation of nanospheres with low aspect ratios and narrow size distributions required low initial cellulose concentrations (< 1% w/v), high volumetric ratios of antisolvent to solvent (> 10:1), and slow addition rates (< 20 mL/h). The modified cellulose nanospheres were able to reduce the interfacial tension between water and hexane from 45.8 mN/m to 31.1 mN/m, with an effect that increased with the number of carbons in the added acyl chains. The stearate-modified nanospheres exhibited superhydrophobic behavior, showing a contact angle of 156° ± 4° with water, and demonstrated emulsification performance comparable to the commonly used molecular surfactant sorbitan stearate. Our findings suggest that hydrophobically modified cellulose nanospheres have the potential to be a bio-derived alternative to traditional molecular W/O emulsifiers.
Journal Article
Light-Switchable Membrane Permeability in Giant Unilamellar Vesicles
In this work, giant unilamellar vesicles (GUVs) were synthesized by blending the natural phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with a photoswitchable amphiphile (1) that undergoes photoisomerization upon irradiation with UV-A (E to Z) and blue (Z to E) light. The mixed vesicles showed marked changes in behavior in response to UV light, including changes in morphology and the opening of pores. The fine control of membrane permeability with consequent cargo release could be attained by modulating either the UV irradiation intensity or the membrane composition. As a proof of concept, the photocontrolled release of sucrose from mixed GUVs is demonstrated using microscopy (phase contrast) and confocal studies. The permeability of the GUVs to sucrose could be increased to ~4 × 10–2 μm/s when the system was illuminated by UV light. With respect to previously reported systems (entirely composed of synthetic amphiphiles), our findings demonstrate the potential of photosensitive GUVs that are mainly composed of natural lipids to be used in medical and biomedical applications, such as targeted drug delivery and localized topical treatments.
Journal Article
Autocatalytic base editing for RNA-responsive translational control
Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. To this end, here we engineer programmable single-transcript RNA sensors in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert target hybridization into a translational output. Dubbed DART VADAR (Detection and Amplification of RNA Triggers via ADAR), our system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. Amplification is mediated by the expression of a hyperactive, minimal ADAR variant and its recruitment to the edit site via an orthogonal RNA targeting mechanism. This topology confers high dynamic range, low background, minimal off-target effects, and a small genetic footprint. We leverage DART VADAR to detect single nucleotide polymorphisms and modulate translation in response to endogenous transcript levels in mammalian cells.
Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. Here the authors engineer programmable RNA sensors, DART VADARs, in which ADARs autocatalytically convert target hybridization into a translational output, thus amplifying editing by endogenous ADAR via positive feedback and conferring high dynamic range and a small genetic footprint.
Journal Article
Combining catalysis and replication
It’s not known how life’s essential properties of replication, metabolism and compartmentalization were first integrated. Two recent articles now shed light on how metabolic characteristics may be incorporated into replicating systems, harnessing an external energy source to increase their rate of replication and acquiring catalytic activity.
Journal Article
Drivers and Impacts of the Record-Breaking 2023 Wildfire Season in Canada
The 2023 wildfire season in Canada was unprecedented in its scale and intensity, spanning from mid-April to late October and across much of the forested regions of Canada. Here, we summarize the main causes and impacts of this exceptional season. The record-breaking total area burned (~15 Mha) can be attributed to several environmental factors that converged early in the season: early snowmelt, multiannual drought conditions in western Canada, and the rapid transition to drought in eastern Canada. Anthropogenic climate change enabled sustained extreme fire weather conditions, as the mean May–October temperature over Canada in 2023 was 2.2 °C warmer than the 1991–2020 average. The impacts were profound with more than 200 communities evacuated, millions exposed to hazardous air quality from smoke, and unmatched demands on fire-fighting resources. The 2023 wildfire season in Canada not only set new records, but highlights the increasing challenges posed by wildfires in Canada.
The record-breaking 2023 wildfire season in Canada ( ~ 15 Mha burned) was enabled by early snowmelt, drought, and extreme weather. It had profound impacts that included evacuation of >200 communities, millions exposed to hazardous smoke, and a strain on fire-fighting resources.
Journal Article
Contributions of the Liquid and Ice Phases to Global Surface Precipitation: Observations and Global Climate Modeling
This study is the first to reach a global view of the precipitation process partitioning, using a combination of satellite and global climate modeling data. The pathways investigated are 1) precipitating ice (ice/snow/graupel) that forms above the freezing level and melts to produce rain (S) followed by additional condensation and collection as the melted precipitating ice falls to the surface (R); 2) growth completely through condensation and collection (coalescence), warm rain (W); and 3) precipitating ice (primarily snow) that falls to the surface (SS). To quantify the amounts, data from satellite-based radar measurements—CloudSat, GPM, and TRMM—are used, as well as climate model simulations from the Community Atmosphere Model (CAM) and the Met Office Unified Model (UM). Total precipitation amounts and the fraction of the total precipitation amount for each of the pathways is examined latitudinally, regionally, and globally. Carefully examining the contributions from the satellite-based products leads to the conclusion that about 57% of Earth’s precipitation follows pathway S, 15% R, 23% W, and 5% SS, each with an uncertainty of ±5%. The percentages differ significantly from the global climate model results, with the UM indicating smaller fractional S, more R, and more SS; and CAM showing appreciably greater S, negative R (indicating net evaporation below the melting layer), a much larger percentage of W and much less SS. Possible reasons for the wide differences between the satellite- and model-based results are discussed.
Journal Article
Penaeid shrimp genome provides insights into benthic adaptation and frequent molting
Crustacea, the subphylum of Arthropoda which dominates the aquatic environment, is of major importance in ecology and fisheries. Here we report the genome sequence of the Pacific white shrimp
Litopenaeus vannamei
, covering ~1.66 Gb (scaffold N50 605.56 Kb) with 25,596 protein-coding genes and a high proportion of simple sequence repeats (>23.93%). The expansion of genes related to vision and locomotion is probably central to its benthic adaptation. Frequent molting of the shrimp may be explained by an intensified ecdysone signal pathway through gene expansion and positive selection. As an important aquaculture organism,
L. vannamei
has been subjected to high selection pressure during the past 30 years of breeding, and this has had a considerable impact on its genome. Decoding the
L. vannamei
genome not only provides an insight into the genetic underpinnings of specific biological processes, but also provides valuable information for enhancing crustacean aquaculture.
The Pacific white shrimp
Litopenaeus vannamei
is an important aquaculture species and a promising model for crustacean biology. Here, the authors provide a reference genome assembly, and show that gene expansion is involved in the regulation of frequent molting as well as benthic adaptation of the shrimp.
Journal Article