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Background The COVID-19 pandemic has exacerbated the global burden of respiratory diseases (RD), intensifying syndemic threats and the “immunity debt” effect. However, evidence gaps persist regarding RD impacts on Quality of Life (QoL) and socioeconomic disparities in the post-pandemic context. Methods Cross-sectional data from the 2022 China Family Panel Studies (CFPS) covered Chinese residents aged 15–89. Surveys were conducted from May to December 2022. QoL was assessed via Consumption Upgrading Index (CUI) and Subjective Well-Being (SWB). Regression models, Propensity Score Matching (PSM), and mediation/moderation analyses examined RD-QoL relationships. Results (1) RD prevalence reached 39.94% in 2022 (a 1.29-percentage-point increase from 2020). (2) RD showed significant negative correlations with QoL, reducing both CUI and SWB. (3) Subgroup analyses revealed greater CUI reductions among males, rural residents, the unemployed, and Eastern China residents; more pronounced SWB declines occurred among females and Eastern residents. (4) Pandemic incidence exacerbated RD’s negative impact on CUI (particularly for females). (5) Hospitalization (health mediator) and reduced non-medical spending (economic mediator) were core pathways. Conclusions Post-pandemic RD burden creates “dual deprivation” of QoL, undermining economic resilience and mental health. Policies addressing sex/urban-rural disparities and strengthening integrated health-economic safeguards are needed.

Menstrual blood-derived stem cells (MenSCs) are a novel source of mesenchymal stem cells (MSCs). MenSCs are attracting more and more attention since their discovery in 2007. MenSCs also have no moral dilemma and show some unique features of known adult-derived stem cells, which provide an alternative source for the research and application in regenerative medicine. Currently, people are increasingly interested in their clinical potential due to their high proliferation, remarkable versatility, and periodic acquisition in a non-invasive manner with no other sources of MSCs that are comparable in adult tissue. In this review, the plasticity of pluripotent biological characteristics, immunophenotype and function, differentiative potential, and immunomodulatory properties are assessed. Furthermore, we also summarize their therapeutic effects and functional characteristics in various diseases, including liver disease, diabetes, stroke, Duchenne muscular dystrophy, ovarian-related disease, myocardial infarction, Asherman syndrome, Alzheimer’s disease, acute lung injury, cutaneous wound, endometriosis, and neurodegenerative diseases. Subsequently, the clinical potential of MenSCs is investigated. There is a need for a deeper understanding of its immunomodulatory and diagnostic properties with safety concern on a variety of environmental conditions (such as epidemiological backgrounds, age, hormonal status, and pre-contraceptive). In summary, MenSC has a great potential for reducing mortality and improving the quality of life of severe patients. As a kind of adult stem cells, MenSCs have multiple properties in treating a variety of diseases in regenerative medicine for future clinical applications.

Menstrual blood-derived stem cells (MenSCs) have great potential in the treatment of various diseases. As a novel type of mesenchymal stem cells (MSCs), MenSCs have attracted more interest due to their therapeutic effects in both animal models and clinical trials. Here, we described the differentiation, immunomodulation, paracrine, homing, and engraftment mechanisms of MenSCs. These include differentiation into targeting cells, immunomodulation with various immune cells, the paracrine effect on secreting cytokines, and homing and engraftment into injured sites. To better conduct MenSC-based therapy, some novel hotspots were proposed such as CRISPR (clustered regularly interspaced short palindromic repeats)/cas9-mediated gene modification, exosomes for cell-free therapy, single-cell RNA sequence for precision medicine, engineered MenSC-based therapy for the delivery platform, and stem cell niches for improving microenvironment. Subsequently, current challenges were elaborated on, with regard to age of donor, dose of MenSCs, transplantation route, and monitoring time. The management of clinical research with respect to MenSC-based therapy in diseases will become more normative and strict. Thus, a more comprehensive horizon should be considered that includes a combination of traditional solutions and novel strategies. In summary, MenSC-based treatment has a great potential in treating diseases through diverse strategies, and more therapeutic mechanisms and novel strategies need to be elucidated for future regenerative medicine and clinical applications.

Background Biochar amendments have been widely proposed as a conventional and efficient strategy to promote soil organic carbon (SOC) sequestration via negative priming. Unfortunately, the extent and biological mechanisms responsible for biochar-induced negative priming are still not fully understood. Despite traditional explanations focused on the environmental filtering mechanisms of biochar amendments on microbial biomass and community composition underlying the priming effect on SOC dynamics, whether and how a biochar-induced competitive interaction with keystone taxa determines SOC mineralization in natural ecosystems has been minimally explored. Results Here, we paid particular attention to the relationships between the diversity and network structure of soil bacterial and fungal communities and SOC mineralization. A 3-year field experiment was conducted comprising five treatments: no fertilization, conventional fertilization, and conventional fertilization with three rates of biochar amendments. Biochar amendments considerably increased soil moisture capacity and pH and subsequently shaped the composition and co-occurrence networks of soil bacterial and fungal communities. Importantly, network analysis revealed that the biochar amendments triggered the competitive interaction with putative keystone taxa in the bacterial and fungal networks. Structural equation modeling suggested that the competitive interaction with keystone taxa promoted bacterial and fungal diversity and consequently reduced carbohydrate catabolism and soil metabolic quotient. Stable isotope probing incubations further provided consistent evidence of competition by keystone taxa with the increases in bacterial and fungal diversity under the biochar amendments. Conclusions We found that biochar-induced competition with keystone taxa stimulated the bacterial and fungal diversity and consequently decreased SOC mineralization. The comprehensive understanding of the unexplored biological mechanisms underlying the biochar-induced negative priming may provide crucial implications for enabling SOC sequestration.

Selenium (Se) is an essential trace element that is crucial for human health. As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. Currently, over 30 types of selenoproteins have been identified, with more than 20 of them containing selenocysteine residues. Among these, glutathione peroxidases (GPXs), thioredoxin reductases (TrxRs), and iodothyronine deiodinases (DIOs) have been widely studied. Selenium boasts numerous biological functions, including antioxidant properties, immune system enhancement, thyroid function regulation, anti-cancer effects, cardiovascular protection, reproductive capability improvement, and anti-inflammatory activity. Despite its critical importance to human health, the range between selenium’s nutritional and toxic doses is very narrow. Insufficient daily selenium intake can lead to selenium deficiency, while excessive intake carries the risk of selenium toxicity. Therefore, selenium intake must be controlled within a relatively precise range. This article reviews the distribution and intake of selenium, as well as its absorption and metabolism mechanisms in the human body. It also explores the multiple biological functions and mechanisms of selenium in maintaining human health. The aim is to provide new insights and evidence for further elucidating the role of selenium and selenoproteins in health maintenance, as well as for future nutritional guidelines and public health policies.

To evaluate the effectiveness of tracer mitoxantrone hydrochloride injection (MHI) in mapping central lymph nodes and its role in preserving parathyroid function during endoscopic radical resection of thyroid carcinoma. A retrospective analysis was conducted on 82 patients with primary papillary thyroid carcinoma (PTC) who were treated at the Department of General Surgery, Gansu Provincial People’s Hospital, from May, 2022 to May, 2024. All patients underwent endoscopic total thyroidectomy with central lymph node dissection (CLND), with 42 receiving intraoperative tracer mitoxantrone hydrochloride injection (observation group) and 40 not receiving the injection (control group). Postoperative metrics compared between the two groups included the number of central lymph nodes dissected, the number of metastatic lymph nodes, the incidence of parathyroid gland misdissection, serum parathyroid hormone (PTH) levels, and blood calcium levels. Both groups successfully completed the surgeries. The observation group exhibited a higher number of central lymph nodes dissected and metastatic lymph nodes detected compared to the control group ( P  < 0.05). Additionally, the rate of parathyroid misdissection was significantly lower in the observation group ( P  < 0.05). From 1 week to 6 months post-operation, the observation group showed significantly higher PTH levels than the control group ( P  < 0.05). Similarly, blood calcium levels were significantly elevated in the observation group over the same period ( P  < 0.05). The incidence of temporary and permanent hypoparathyroidism was also significantly lower in the observation group (χ 2  = 6.071, P  = 0.033). The application of MHI during endoscopic radical resection of PTC enhances the identification and dissection of both central and metastatic lymph nodes, thereby reducing the risk of postoperative recurrence. It helps to identify the parathyroid glands, reduces the rate of parathyroid miscarriage, reduces the occurrence of postoperative complications, and has clinical promotion value.

The Global Positioning System (GPS) is unable to provide precise localization services indoors, which has led to wireless sensor network (WSN) localization technology becoming a hot research issue in the field of indoor location. At present, the ranging technology of wireless sensor networks based on received signal strength has been extensively used in indoor positioning. However, wireless signals have serious multipath effects in indoor environments. In order to reduce the adverse influence of multipath effects on distance estimation between nodes, a multi-channel ranging localization algorithm based on signal diversity is herein proposed. In real indoor environments, the parameters used for multi-channel localization algorithms are generally unknown or time-varying. In order to increase the positioning accuracy of the multi-channel location algorithm in a multipath environment, we propose an optimal multi-channel trilateration positioning algorithm (OMCT) by establishing a novel multi-objective evolutionary model. The presented algorithm utilizes a three-edge constraint to prevent the traditional multi-channel localization algorithm falling into local optima. The results of a large number of practical experiments and numerical simulations show that no matter how the channel number and multipath number change, the positioning error of our presented algorithm is always smaller compared with that of the state-of-the-art algorithm.

All-oral regimens are associated with higher effectiveness and shorter treatment duration for chronic hepatitis C. Given its superior effect and enormous patients in China, clinicians or patients may be compelled to consider delaying treatment for all-oral regimen. To estimate cost-effectiveness of delaying treatment for all-oral regimen in the subsequent years under different assumptions about their price and efficacy compared with standard of care in China. A state-transition Markov model was developed to estimate lifetime costs and quality-adjusted life years (QALYs). Incremental cost-effectiveness ratio (ICER) and net monetary benefit (NB) were calculated. And sensitivity analyses were also performed to assess the impact of uncertainty. For treatment naive patients with Genotype 1, immediate treatment with all-oral regimen under assumed cost and efficacy at present was cost-effective compared with peginterferon α-2a (PegIFN) regimen at present with an ICER of $12536 per QALY gained and a positive NB of $6832 at a willingness-to-pay threshold of $21209. And it was more than 95% likely to be cost-effective if weekly drug cost was less than $1000. Moreover, patients delaying treatment for all-oral regimen in the 1st year were associated with increase in QALYs of 0.62 and increase in cost of $10114 compared with initiating PegIFN regimen at present, which resulted in a positive NB of $3115. From a payer perspective, all-oral regimen is associated with good long-term health and economic benefit for treatment-naive patients infected with HCV genotype 1. Particularly, if all-oral regimen would become available at lower price in the future, delaying treatment for all-oral regimen may be a good choice for patients in China.

Land water, one of the important components of land cover, is the indispensable and important basic information for climate change studies, ecological environment assessment, macro-control analysis, etc. This article describes the overall study on land water in the program of global land cover remote sensing mapping. Through collection and processing of Landsat TM/ETM＋, China＇s HJ-1 satellite image, etc., the program achieves an effective overlay of global multi-spectral image of 30 m resolution for two base years, namely, 2000 and 2010, with the image rectification accuracy meeting the requirements of 1 ： 200000 map- ping and the error in registration of images for the two periods being controlled within 1 pixel. The indexes were designed and selected reasonably based on spectral features and geometric shapes of water on the scale of 30 m resolution, the water infor- mation was extracted in an elaborate way by combining a simple and easy operation through pixel-based classification method with a comprehensive utilization of various rules and knowledge through the object-oriented classification method, and finally the classification results were further optimized and improved by the human-computer interaction, thus realizing high-resolution remote sensing mapping of global water. The completed global land water data results, including Global Land 30-water 2000 and Global Land 30-water 2010, are the classification results featuring the highest resolution on a global scale, and the overall accuracy of self-assessment is 96%. These data are the important basic data for developing relevant studies, such as analyzing spatial distribution pattern of global land water, revealing regional difference, studying space-time fluctuation law, and diag- nosing health of ecological environment.

Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell type, spatial organization, and microenvironment but also have adverse effects in stem cell cultures, whereas PDX are expensive with a low transplantation success rate and require a long culture time. In recent years, advances in three‐dimensional (3D) organoid culture technology have led to the development of novel physiological systems that model the tissues of origin more precisely than traditional culture methods. Patient‐derived cancer organoids bridge the conventional gaps in PDC and PDX models and closely reflect the pathophysiological features of natural tumorigenesis and metastasis, and have led to new patient‐specific drug screening techniques, development of individualized treatment regimens, and discovery of prognostic biomarkers and mechanisms of resistance. Synergistic combinations of cancer organoids with other technologies, for example, organ‐on‐a‐chip, 3D bio‐printing, and CRISPR‐Cas9‐mediated homology‐independent organoid transgenesis, and with treatments, such as immunotherapy, have been useful in overcoming their limitations and led to the development of more suitable model systems that recapitulate the complex stroma of cancer, inter‐organ and intra‐organ communications, and potentially multiorgan metastasis. In this review, we discuss various methods for the creation of organ‐specific cancer organoids and summarize organ‐specific advances and applications, synergistic technologies, and treatments as well as current limitations and future prospects for cancer organoids. Further advances will bring this novel 3D organoid culture technique closer to clinical practice in the future. We discuss various methods for creation of organ‐specific cancer organoids and summarize organ‐specific advances and applications, synergistic technologies, and treatments as well as current limitations and future prospects for cancer organoids. Further advances will bring this novel 3D culture organoid technique closer to clinical practice in the future.