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"Chen, Shu"
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Instability Challenges and Stabilization Strategies of Pharmaceutical Proteins
Maintaining the structure of protein and peptide drugs has become one of the most important goals of scientists in recent decades. Cold and thermal denaturation conditions, lyophilization and freeze drying, different pH conditions, concentrations, ionic strength, environmental agitation, the interaction between the surface of liquid and air as well as liquid and solid, and even the architectural structure of storage containers are among the factors that affect the stability of these therapeutic biomacromolecules. The use of genetic engineering, side-directed mutagenesis, fusion strategies, solvent engineering, the addition of various preservatives, surfactants, and additives are some of the solutions to overcome these problems. This article will discuss the types of stress that lead to instabilities of different proteins used in pharmaceutics including regulatory proteins, antibodies, and antibody-drug conjugates, and then all the methods for fighting these stresses will be reviewed. New and existing analytical methods that are used to detect the instabilities, mainly changes in their primary and higher order structures, are briefly summarized.
Journal Article
Collateral Benefit of COVID-19 Control Measures on Influenza Activity, Taiwan
Taiwan has strictly followed infection control measures to prevent spread of coronavirus disease. Meanwhile, nationwide surveillance data revealed drastic decreases in influenza diagnoses in outpatient departments, positivity rates of clinical specimens, and confirmed severe cases during the first 12 weeks of 2020 compared with the same period of 2019.
Journal Article
Social Robots for Depression in Older Adults: A Systematic Review
Purpose In recent years, there has been an increase in the number of studies using social robots to improve psychological well‐being. This systematic review investigates the effect of social robot interventions for depression in older adults. Methods The Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) method was used to identify and select existing studies. Nine electronic databases were searched for relevant studies. Methodological quality was assessed using the Joanna Briggs Institute Meta‐Analysis of Statistics Assessment and Review Instrument. Screening, data extraction, and synthesis were performed by three reviewers. Inclusion criteria covered original quantitative studies investigating social robots for depression in older adults. Findings Seven studies were identified—six randomized controlled trials and one comparison study—with all classified as good quality. Social robot interventions consisted of companion, communication, and health‐monitoring robots. Three studies presented promising outcomes for reducing depressive symptoms in older adults following social robot interventions, and three studies showed decreased, but nonsignificant, trends in depression scores. Conclusions The results highlight the potential of social robot interventions for reducing depression in older adults. However, the evidence is not strong enough to formulate recommendations on clinical effectiveness. Clinical Relevance Social robots are being used with increasing frequency to potentially provide personal support to older adults living in long‐term care facilities. Social robots can be used to help alleviate depressive symptoms when used in group activities.
Journal Article
Survival outcomes of management in metastatic gastric adenocarcinoma patients
Chemotherapy is generally considered as the main treatment for metastatic gastric adenocarcinoma. The role of gastrectomy for metastatic gastric cancer without obvious symptoms is controversial. The objective of this study is to investigate survival outcomes of treatment modalities using a real-world data setting. A retrospective cohort study was designed using the Taiwan Cancer Registry database. We identified the treatment modalities and used Kaplan–Meier estimates and Cox regressions to compare patient survival outcomes. From 2008 to 2015, 5599 gastric adenocarcinoma patients were diagnosed with metastatic disease (M1). The median overall survival (OS) of patients with surgery plus chemotherapy had the longest survival of 14.2 months. The median OS of the patients who received chemotherapy alone or surgery alone was 7.0 and 3.9, respectively. Age at diagnosis, year of diagnosis, tumor grade, and treatment modalities are prognostic factors for survival. The hazard ratios for patients who received surgery plus chemotherapy, surgery alone, and supportive care were 0.47 (95% CI 0.44–0.51), 1.22 (95% CI 1.1–1.36), and 3.23 (95% CI 3.01–3.46), respectively, by multivariable Cox regression analysis when using chemotherapy alone as a referent. Chemotherapy plus surgery may have a survival benefit for some selected gastric adenocarcinoma patients with metastatic disease.
Journal Article
Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis
[...]our report indicates COVID-19 patients with PE may have up to 45% higher mortality rate compared to general cases (in-hospital mortality rate 4%) [22]. [...]first-line healthcare providers should be vigilant about the occurrence of severe and potentially fatal PE complications in COVID-19 patients [23]. [...]clinical heterogeneity between studies is noteworthy; for example, the included studies apply different diagnostic tools of varying sensitivity and specificity to investigate PE incidence. [...]prevention and control of COVID-19 remains paramount in the current pandemic, but repeated assessment and optimal management of PE complications may significantly modify the prognosis and reduce mortality in patients with COVID-19 [24].
Journal Article
Guillain-Barré Syndrome Associated with COVID-19 Vaccination
We conducted a multi-institutional study in Taiwan and a systematic review of the literature for reports of Guillain-Barré syndrome after coronavirus disease vaccination. This condition, mostly the classic form and the acute inflammatory demyelinating polyneuropathy subtype, has been reported in 39 cases and has occurred within 2 weeks of vaccine administration.
Journal Article
Highly active nanostructured CoS2/CoS heterojunction electrocatalysts for aqueous polysulfide/iodide redox flow batteries
Aqueous polysulfide/iodide redox flow batteries are attractive for scalable energy storage due to their high energy density and low cost. However, their energy efficiency and power density are usually limited by poor electrochemical kinetics of the redox reactions of polysulfide/iodide ions on graphite electrodes, which has become the main obstacle for their practical applications. Here, CoS
2
/CoS heterojunction nanoparticles with uneven charge distribution, which are synthesized in situ on graphite felt by a one-step solvothermal process, can significantly boost electrocatalytic activities of I
−
/I
3
−
and S
2−
/S
x
2−
redox reactions by improving absorptivity of charged ions and promoting charge transfer. The polysulfide/iodide flow battery with the graphene felt-CoS
2
/CoS heterojunction can deliver a high energy efficiency of 84.5% at a current density of 10 mA cm
−2
, a power density of 86.2 mW cm
−2
and a stable energy efficiency retention of 96% after approximately 1000 h of continuous operation.
Polysulfide/iodide redox flow batteries are promising due to low cost and high-solubility components, but are limited by energy efficiency and power density. Here the authors fabricate heterojunction electrocatalysts to achieve improved performance in a polysulfide/iodide redox flow battery.
Journal Article
MicroRNA‐351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is known as different degree glucose intolerance that is initially identified during pregnancy. MicroRNAs (miRs) may be a potential candidate for treatment of GDM. Herein, we suggested that miR‐351 could be an inhibitor in the progression of GDM via the phosphoinositide 3‐kinase/protein kinase B (PI3K/AKT) pathway. Microarray analysis was used to identify differentially expressed genes and predict miRs regulating flotillin 2 (FLOT2). Target relationship between miR‐351 and FLOT2 was verified. Gestational diabetes mellitus mice were treated with a series of mimic, inhibitor and small interfering RNA to explore the effect of miR‐351 on insulin resistance (IR), cell apoptosis in pancreatic tissues and liver gluconeogenesis through evaluating GDM‐related biochemical indexes, as well as expression of miR‐351, FLOT2, PI3K/AKT pathway‐, IR‐ and liver gluconeogenesis‐related genes. MiR‐351 and FLOT2 were reported to be involved in GDM. FLOT2 was the target gene of miR‐351. Gestational diabetes mellitus mice exhibited IR and liver gluconeogenesis, up‐regulated FLOT2, activated PI3K/AKT pathway and down‐regulated miR‐351 in liver tissues. Additionally, miR‐351 overexpression and FLOT2 silencing decreased the levels of FLOT2, phosphoenolpyruvate carboxykinase, glucose‐6‐phosphatase, fasting blood glucose, fasting insulin, total cholesterol, triglyceride, glyeosylated haemoglobin and homeostasis model of assessment for IR index (HOMA‐IR), extent of PI3K and AKT phosphorylation, yet increased the levels of HOMA for islet β‐cell function, HOMA for insulin sensitivity index and glucose transporter 2 expression, indicating reduced cell apoptosis in pancreatic tissues and alleviated IR and liver gluconeogenesis. Our results reveal that up‐regulation of miR‐351 protects against IR and liver gluconeogenesis by repressing the PI3K/AKT pathway through regulating FLOT2 in GDM mice, which identifies miR‐351 as a potential therapeutic target for the clinical management of GDM.
Journal Article