Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,304
result(s) for
"Chen, Victor"
Sort by:
Cut loose : jobless and hopeless in an unfair economy
\"Years after the Great Recession, the economy is still weak, and an unprecedented number of workers have sunk into long spells of unemployment, increasingly unlikely to get another good job in their lifetimes. Based on a careful crossnational comparison, \"Cut Loose\" describes the experiences of American and Canadian unemployed workers and the impact of the different social policies meant to help them. It focuses on a historically important group: autoworkers. Their well-paid factory jobs built a strong middle class in the decades after World War II. But today, they find themselves lost and beleaguered in a changed economy of greater inequality and risk, one that favors the well-educated--or well-connected. Their declining fortunes tell us something about what the white-collar workforce should expect in the years ahead, as job-killing technologies and the shipping of work overseas take away even more good jobs. Their frustrating experiences with retraining question whether education is really the cure-all it is made out to be. And their grim prospects in the job market reveal today's frenzied competition and harsh culture of judgment that has trickled down to a group long known for its strong belief in equality. \"Cut Loose\" provides a poignant look at how the long-term unemployed struggle in today's unfair economy to support their families, rebuild their lives, and cope with shame and self-blame. Yet it is also a call to action--a blueprint for a new kind of politics, one that offers a measure of grace in a society of ruthless advancement.\"--Provided by publisher.
Book
Chinese lives : the people who made a civilization
Tells the story of China through 96 short biographies.
Book
Real world effectiveness of tixagevimab/cilgavimab (Evusheld) in the Omicron era
Pre-exposure prophylaxis for COVID-19 with tixagevimab/cilgavimab (T/C) received Emergency Use Authorization (EUA) based on results of a clinical trial conducted prior to the emergence of the Omicron variant. The clinical effectiveness of T/C has not been well described in the Omicron era. We examined the incidence of symptomatic illness and hospitalizations among T/C recipients when Omicron accounted for virtually all local cases.
Through retrospective electronic medical record chart review, we identified patients who received T/C between January 1 -July 31, 2022 within our quaternary referral health system. We determined the incidence of symptomatic COVID-19 infections and hospitalizations due to or presumed to be caused by early Omicron variants before and after receiving T/C (pre-T/C and post-T/C). Chi square and Mann-Whitney Wilcoxon two-sample tests were used to examine differences between the characteristics of those who got COVID-19 before or after T/C prophylaxis, and rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess differences in hospitalization rates for the two groups.
Of 1295 T/C recipients, 105 (8.1%) developed symptomatic COVID-19 infection before receiving T/C, and 102 (7.9%) developed symptomatic disease after receiving it. Of the 105 patients who developed symptomatic infection pre-T/C, 26 (24.8%) were hospitalized, compared with six of the 102 patients (5.9%) who were diagnosed with COVID-19 post-T/C (RR = 0.24; 95% CI = 0.10-0.55; p = 0.0002). Seven of the 105 (6.7%) patients infected pre-T/C, but none of the 102 infected post-T/C required ICU care. No COVID-related deaths occurred in either group. The majority of COVID-19 cases among those infected pre-T/C treatment occurred during the Omicron BA.1 surge, while the majority of post-T/C cases occurred when Omicron BA.5 was predominant. In both groups, having at least one dose of vaccine strongly protected against hospitalization (pre-T/C group RR = 0.31, 95% CI = 0.17-0.57, p = 0.02; post-T/C group RR = 0.15; 95% CI = 0.03-0.94; p = 0.04).
We identified COVID-19 infections after T/C prophylaxis. Among patients who received T/C at our institution, COVID-19 Omicron cases occurring after T/C were one-fourth as likely to require hospitalization compared to those with Omicron prior to T/C. However, due to the presence of changing vaccine coverage, multiple therapies, and changing variants, the effectiveness of T/C in the Omicron era remains difficult to assess.
Journal Article
The development of Chinese martial arts fiction
\"Chen Pingyuan is one of the leading scholars of modern Chinese literature, known particularly for his work on wuxia, a popular and influential genre of historical martial arts fiction still celebrated around the world today. This work, presented here in English translation for the first time, is considered to be the seminal work on the evolution, aesthetics and politics of the modern Chinese wuxia novel in the nineteenth and early twentieth centuries, tracing the resurgence of interest in classical chivalric tales in late Qing China\"-- Provided by publisher.
Book
Structural and functional regulation of lactate dehydrogenase-A in cancer
Dysregulated metabolism is one of the hallmarks of cancer. Under normal physiological conditions, ATP is primarily generated by oxidative phosphorylation. Cancers commonly undergo a dramatic shift toward glycolysis, despite the presence of oxygen. This phenomenon is known as the Warburg effect, and requires the activity of LDHA. LDHA converts pyruvate to lactate in the final step of glycolysis and is often upregulated in cancer. LDHA inhibitors present a promising therapeutic option, as LDHA blockade leads to apoptosis in cancer cells. Despite this, existing LDHA inhibitors have shown limited clinical efficacy. Here, we review recent progress in LDHA structure, function and regulation as well as strategies to target this critical enzyme.
Journal Article
شعر من الصين
يتناول كتاب (شعر من الصين) والذي قام بتأليفه (نظم ماوتسي تونغ) في حوالي (110) صفحة من القطع المتوسط موضوع (الشعر الصيني) مستعرضا أبرز القصائد وشرحها التالية : القصيدة الأولى : تشانغ تشا، القصيدة الثانية : عش الكراكي الأصفر، القصيدة الثامنة : ثلاث مقطوعات، القصيدة السابعة عشرة : الخالدان، القصيدة الثامنة عشرة : طرد إله الطاعون.
Book
Performance of Treponemal Tests for the Diagnosis of Syphilis
Abstract
Background
Treponemal immunoassays are increasingly used for syphilis screening with the reverse sequence algorithm. There are few data describing performance of treponemal immunoassays compared to traditional treponemal tests in patients with and without syphilis.
Methods
We calculated sensitivity and specificity of 7 treponemal assays: (1) ADVIA Centaur (chemiluminescence immunoassay [CIA]); (2) Bioplex 2200 (microbead immunoassay); (3) fluorescent treponemal antibody absorption test (FTA-ABS); (4) INNO-LIA (line immunoassay); (5) LIAISON CIA; (6) Treponema pallidum particle agglutination assay (TPPA); and (7) Trep-Sure (enzyme immunoassay [EIA]), using a reference standard combining clinical diagnosis and serology results. Sera were collected between May 2012-January 2013. Cases were characterized as: (1) current clinical diagnosis of syphilis: primary, secondary, early latent, late latent; (2) prior treated syphilis only; (3) no evidence of current syphilis, no prior history of syphilis, and at least 4 of 7 treponemal tests negative.
Results
Among 959 participants, 262 had current syphilis, 294 had prior syphilis, and 403 did not have syphilis. FTA-ABS was less sensitive for primary syphilis (78.2%) than the immunoassays or TPPA (94.5%-96.4%) (all P ≤ .01). All immunoassays were 100% sensitive for secondary syphilis, 95.2%-100% sensitive for early latent disease, and 86.8%-98.5% sensitive in late latent disease. TPPA had 100% specificity.
Conclusions
Treponemal immunoassays demonstrated excellent sensitivity for secondary, early latent, and seropositive primary syphilis. Sensitivity of FTA-ABS in primary syphilis was poor. Given its high specificity and superior sensitivity, TPPA is preferred to adjudicate discordant results with the reverse sequence algorithm over the FTA-ABS.
We compared performance of 5 treponemal immunoassays, the Treponema pallidum particle agglutination assay (TPPA), and the fluorescent treponemal antibody absorption test (FTA-ABS). FTA-ABS was less sensitive for primary syphilis (78%) than the immunoassays or TPPA (94%-96% sensitivity). TPPA was 100% specific.
Journal Article
Avengers Academy : the complete collection. Vol. 2
The Avengers Academy faces Fear Itself! No, not prom night - though they have to survive that too, when the Sinister Six crash the party! We mean actual Fear Itself, as the Serpent's army assaults the Marvel Universe and the squad must battle the possessed, hammer-wielding versions of Titania and the Absorbing Man! Meanwhile, as Speedball returns to the scene of his greatest failure, can he rally the town of Stamford against the Serpent and finally earn forgiveness from its people - or himself? Plus, the students get schooled by a substitute teacher - the Amazing Spider-Man - but their lesson is interrupted by Psycho-Man! And as Hank Pym relocates the Academy to California, they come under attack by...the West Coast Avengers?!
Book
Milking the Orchil: How the Presence of Goat Milk in the Orchil Dyebath May Affect the Color of Dyed Wool
Among the craft recipes for artisans collected in the 4th-century Egyptian documents the Leyden and Stockholm papyri, there is one calling for adding animal milk to orchil for wool dyeing. To understand the rationale for this practice, wool yarns were dyed with and without goat milk added to orchil dyebaths, each made using lichens from three different sources. The results showed orchil containing milk dyed yarns a noticeably deeper red hue. The colorants extracted from the dyed yarns were analyzed by liquid chromatography-diode-array-detector-mass spectrometry to assess the relative amounts of nine identifiable orceins. The data showed that the yarns dyed with milk gave extracts exhibiting several fold more α-aminoorcein and α-hydroxyorcein, with only small differences in the other seven. Scanning electron microscopic analysis of a representative pair of dyed yarns showed that milk promoted surface changes in the fiber that may indicate increased cutaneous damage. Hypotheses for the milk’s effects on orchil dyeing were proposed that included the formation of milk–protein complexes with the two enriched orceins that possibly enhanced wool binding and/or better wool uptake of free and/or complexed orceins due to biodegradation of the wool’s surface cuticle caused by microbial growth promoted by the addition of milk.
Journal Article