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A 13-year-old girl presented with a 6-month history of a recurrent single erythematous nodule on her right cheek associated with periodic drainage of inflammatory exudate. The patient did not have any discomfort or history of trauma or infection. Physical examination revealed a well-defined soft erythematous nodule about 1 cm in diameter in her right mandibular angle (figure 1A). Skin biopsy from the lesion showed non-specific chronic inflammation (figure 1B). The sagittal T2 STIR MRI images showed that the sinus tract extended from the right mandibular first molar tooth (#46, figure 2A), passed through the muscles into the subcutaneous fat and reached the skin, forming a bulging nodule (figure 2B). The CT scan showed the destruction of the apex of the tooth and the alveolar bone. A diagnosis of odontogenic cutaneous sinus tract (OCST) was confirmed. The patient was referred to the maxillofacial team for root canal therapy and there was no recurrence.

Buildings with electrified heat pump systems, onsite photovoltaic (PV) generation, and energy storage offer strong potential for demand flexibility. This study compares two storage configurations, thermal energy storage (TES) and battery energy storage (BESS), to evaluate their impact on cooling performance and cost savings. A Model Predictive Control (MPC) framework was developed to optimize system operations, aiming to minimize costs while maintaining occupant comfort. Results show that both configurations achieve substantial savings relative to a baseline. The TES system reduces daily operating costs by about 50%, while the BESS nearly eliminates them (over 90% reduction) and cuts grid electricity use by more than 65%. The BESS achieves superior performance because it can serve both the controllable heating, ventilation, and air conditioning (HVAC) system and the home’s broader electrical loads, thereby maximizing PV self-consumption. In contrast, the TES primarily influences the thermal load. These findings highlight that the choice between thermal and electrical storage greatly affects system outcomes. While the BESS provides a more comprehensive solution for whole-home energy management by addressing all electrical demands, further techno-economic evaluation is needed to assess the long-term feasibility and trade-offs of each configuration.

Carnosine, a common dipeptide in mammals, has previously been shown to dissemble alpha-crystallin amyloid fibrils. To date, the dipeptide's anti-fibrillogensis effect has not been thoroughly characterized in other proteins. For a more complete understanding of carnosine's mechanism of action in amyloid fibril inhibition, we have investigated the effect of the dipeptide on lysozyme fibril formation and induced cytotoxicity in human neuroblastoma SH-SY5Y cells. Our study demonstrates a positive correlation between the concentration and inhibitory effect of carnosine against lysozyme fibril formation. Molecular docking results show carnosine's mechanism of fibrillogenesis inhibition may be initiated by binding with the aggregation-prone region of the protein. The dipeptide attenuates the amyloid fibril-induced cytotoxicity of human neuronal cells by reducing both apoptotic and necrotic cell deaths. Our study provides solid support for carnosine's amyloid fibril inhibitory property and its effect against fibril-induced cytotoxicity in SH-SY5Y cells. The additional insights gained herein may pave way to the discovery of other small molecules that may exert similar effects against amyloid fibril formation and its associated neurodegenerative diseases.

Background Obesity is a significant manifestation of Circadian Syndrome (CircS), and the Body Roundness Index (BRI) is one of the anthropometric indicators associated with obesity. However, it remains unclear whether BRI is linked to the risk of CircS. Methods In this population-based cross-sectional study, data from adults aged ≥ 20 years from the 2009–2018 National Health and Nutrition Examination Survey (NHANES) database were analyzed. Logistic regression analysis was employed to investigate the relationship between BRI and CircS after adjusting for various covariates. To further explore the trend of association between different BRI levels and CircS, BRI was categorized into four classes to enhance the robustness of the results. Restricted cubic spline (RCS) analysis was utilized to illustrate the dose-response relationship between BRI and CircS. Additionally, subgroup analyses were performed to assess the consistency and stability of the study results. Results This study included 8,024 participants aged 20 years and older, of whom 2,634 had CircS. In fully adjusted models, BRI was positively associated with the prevalence of CircS (OR = 2.821, 95% CI: 2.038–3.768). When BRI was transformed from a continuous to a categorical variable, higher levels of BRI were correlated with a higher prevalence of CircS compared to the lowest quartile of BRI. RCS analyses demonstrated a positive association between BRI and CircS prevalence, with threshold effect analyses identifying a threshold value of BRI at 5.91. To the left of this threshold, each one-unit increase in BRI elevated the prevalence of CircS by a factor of 2.681 (OR = 2.681, 95% CI: 2.524–2.851). Stratified factorial subgroup analyses indicated that the positive association between BRI and CircS persisted. Conclusion The findings of our cross-sectional study indicate a significant positive correlation between elevated BRI and increased prevalence of CircS.

Cataract, a major cause of visual impairment worldwide, is the opacification of the eye's crystalline lens due to aggregation of the crystallin proteins. The research reported here is aimed at investigating the aggregating behavior of γ-crystallin proteins in various incubation conditions. Thioflavin T binding assay, circular dichroism spectroscopy, 1-anilinonaphthalene-8-sulfonic acid fluorescence spectroscopy, intrinsic (tryptophan) fluorescence spectroscopy, light scattering, and electron microscopy were used for structural characterization. Molecular dynamics simulations and bioinformatics prediction were performed to gain insights into the γD-crystallin mechanisms of fibrillogenesis. We first demonstrated that, except at pH 7.0 and 37°C, the aggregation of γD-crystallin was observed to be augmented upon incubation, as revealed by turbidity measurements. Next, the types of aggregates (fibrillar or non-fibrillar aggregates) formed under different incubation conditions were identified. We found that, while a variety of non-fibrillar, granular species were detected in the sample incubated under pH 7.0, the fibrillogenesis of human γD-crystallin could be induced by acidic pH (pH 2.0). In addition, circular dichroism spectroscopy, 1-anilinonaphthalene-8-sulfonic acid fluorescence spectroscopy, and intrinsic fluorescence spectroscopy were used to characterize the structural and conformational features in different incubation conditions. Our results suggested that incubation under acidic condition led to a considerable change in the secondary structure and an enhancement in solvent-exposure of the hydrophobic regions of human γD-crystallin. Finally, molecular dynamics simulations and bioinformatics prediction were performed to better explain the differences between the structures and/or conformations of the human γD-crystallin samples and to reveal potential key protein region involved in the varied aggregation behavior. Bioinformatics analyses revealed that the initiation of amyloid formation of human γD-crystallin may be associated with a region within the C-terminal domain. We believe the results from this research may contribute to a better understanding of the possible mechanisms underlying the pathogenesis of senile nuclear cataract.

This study estimates the relationship between poor indoor environmental quality (IEQ) and the increasing labor costs in green buildings in Taiwan. Specifically, poor performance of IEQ including HVAC, lighting, and indoor air quality, influences the health and well-being of occupants and leads to worse productivity, ultimately causing increased personnel cost. In Taiwan’s green building certification (GBC) system, the energy-savings category is mandatory while the IEQ category is only optional. It means that certified building cases may not reach the expected level in IEQ. Thus, this study reviews the thermal environment, indoor air quality (IAQ), and illumination performances of IEQ-certified and non-IEQ-certified buildings in 20 green buildings. Building energy and IEQ simulations were conducted to analyze the relationships between indoor comfort, energy cost, and personnel cost in green buildings. The results show that IEQ-certified green buildings averagely perform better than non-IEQ-certified ones in the aspects of IEQ and building costs. Besides, 3 of 13 non-IEQ-certified green buildings undertake extremely high additional expenditure for the poor IEQ. The results correspond to some previous findings that green-certified buildings do not necessarily guarantee good building performance. This study further inspects the pros and cons of Taiwan’s GBC system and proposes recommendations against its insufficient IEQ evaluation category. As the trade-off of energy-saving benefits with health and well-being in green buildings has always been a concern, this study aims to stimulate more quantitative research and promote a more comprehensive green building certification system in Taiwan.

Strategies to reduce energy consumption are presently experiencing vigorous development. Phase change materials (PCMs) are novel materials that can reduce indoor temperatures via the change in material phase. Regarding the situation in Taiwan, there is no practical utilization of PCMs in school buildings at present, especially in combination with rooftops. In this paper, we discuss the feasibility and utilization potential of installing PCMs in the rooftops of school buildings. School buildings located in northern and southern Taiwan (Taipei and Kaohsiung) were selected to analyze the energy-saving potential and optimization of indoor thermal comfort by installing PCMs with different properties in rooftops over two time periods, including the air conditioning (AC) and natural ventilation (NV) seasons. Based on the simulation results, the feasible patterns of PCM simultaneity are found to be appropriate for improved indoor comfort and energy saving during the different seasons. Specifically, the efficient phase change temperature (PCT) for different PCM thicknesses is clarified to be 29 °C. The economic thickness of PCM was clarified to be 20 mm for Taipei and Kaohsiung. Through the recommendations proposed in this study, it is expected that the PCMs may be efficiently implemented in school buildings to realize the goal of energy conservation and improve thermal comfort.

Lung cancer is the leading cause of cancer deaths worldwide, and squamous cell carcinoma (SQC) is Taiwan’s second most common lung carcinoma histotype. This study aimed to investigate changes in the long-term trend of the SQC incidence rate in Taiwan. SQC cases between 1985 and 2019 were adopted from Taiwan‘s Cancer Registry System; the age-adjusted incidence rate was calculated using the World Standard Population in 2000. The long-term trends of the age, period, and birth cohort effect of SQC incidence rates were estimated using the SEER Age-Period-Cohort Web Tool. The results revealed that the incidence of lung carcinoma in Taiwan increased, while the incidence of SQC exhibited a slight decrease during this study period. The age rate ratio (ARR) of the incidence rate in men declined gradually, and the period effect changed more slowly for women than men. The cohort effect formed a bimodal curve. The annual percentage change results for women indicated that the ARR decreased from 1.652 (95% confidence interval (CI): 1.422, 1.9192) at 30 to 34 years to 0.559 (95% CI: 0.4988, 0.6265) at 75 to 79 years; the period effect decreased from 1.2204 (95% CI: 1.1148, 1.336) in 1995 to 1999 to 0.608 (95% CI: 0.5515, 0.6704) in 2015 to 2019, with a greater decline in the later period. The cohort effect was unimodal, with the SQC risk value peaking in the 1915 birth cohort and exhibiting a steady decline thereafter. The results of this study suggest that a decrease in the smoking rate may be the reason for the decline in the incidence of SQC, and we observed a similar trend between SQC and the smoking rate in men.

Large language models (LLMs) are gaining attention due to their potential to enhance efficiency and sustainability in the building domain, a critical area for reducing global carbon emissions. Built on transformer architectures, LLMs excel at text generation and data analysis, enabling applications such as automated energy model generation, energy management optimization, and fault detection and diagnosis. These models can potentially streamline complex workflows, enhance decision-making, and improve energy efficiency. However, integrating LLMs into building energy systems poses challenges, including high computational demands, data preparation costs, and the need for domain-specific customization. This perspective paper explores the role of LLMs in the building energy system sector, highlighting their potential applications and limitations. We propose a development roadmap built on in-context learning, domain-specific fine-tuning, retrieval augmented generation, and multimodal integration to enhance LLMs’ customization and practical use in this field. This paper aims to spark ideas for bridging the gap between LLMs capabilities and practical building applications, offering insights into the future of LLM-driven methods in building energy applications.

Ultrastructural observation of biological specimens or nanogranules usually requires the use of electron microscopy. Electron microscopy takes a lot of time, requires many steps, and uses many chemicals, which may affect the native state of biological specimens. A novel microchip (K-kit) was used as a specimen kit for in situ imaging of human platelet granules in an aqueous solution using a transmission electron microscope. This microchip enabled us to observe the native human platelet granules very quickly and easily. The protocols included blood collection, platelet purification, platelet granule isolation, sample loading into this microchip, and then observation by a transmission electron microscope. In addition, these granules could still remain in aqueous solution, and only a very small amount of the sample was required for observation and analysis. We used this microchip to identify the native platelet granules by negative staining. Furthermore, we used this microchip to perform immunoelectron microscopy and successfully label α-granules of platelets with the anti-P-selectin antibody. These results demonstrate that the novel microchip can provide researchers with faster and better choices when using a transmission electron microscope to examine nanogranules of biological specimens in aqueous conditions.