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The impacts of patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M‐rs738409, methylenetetrahydrofolate reductase (MTHFR) Ala222Val‐rs1801133, and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys‐rs671 on the outcomes of Taiwanese patients with steatotic liver disease (SLD) have remained elusive. An 8‐year prospective cohort study of patients with (n = 546) and without (n = 580) SLD (controls) was undertaken in a Taiwanese tertiary care center. The 546 SLD patients comprised 306 (56.0%) men and 240 (44.0%) women with mean ages of 53.3 and 56.4 years, respectively. Compared with the controls, SLD patients had an increased frequency of the PNPLA3 I148M‐rs738409 GG genotype (25.5 vs. 5.9%, p = 0.001). Among the SLD patients, 236 (43.1%) suffered cardiovascular events, 52 (9.5%) showed extrahepatic cancers, 13 (2.38%) experienced hepatic events, including hepatocellular carcinoma (n = 3, 0.5%) and liver cirrhosis (n = 8, 1.47%), and none died. The Fibrosis‐4 (FIB‐4) scores were associated with extrahepatic cancer (hazard ratio [HR] 1.325; 95% confidence interval [CI], 1.038–1.691) and cirrhosis development (HR 1.532; 95% CI, 1.055–2.224), and the PNPLA3 I148M‐rs738409 G allele (β = 0.158, 95% CI, 0.054–0.325) was associated with the FIB‐4 score. Stratified analyses showed that the impact of the FIB‐4 score on extrahepatic cancer development was evident only in SLD patients with the PNPLA3 I148M‐rs738409 GG genotype (HR 1.543; 95% CI, 1.195–1.993) and not in patients with the GC or CC genotype. Moreover, the ALDH2 Glu504Lys‐rs671 G allele had a dose‐dependent effect on alcoholism, and the MTHFR and ALDH2 genotypes were not significantly associated with SLD patient outcomes. In conclusion, special vigilance should be exercised for emerging extrahepatic cancer in SLD patients with the PNPLA3 I148M‐rs738409 GG genotype and high FIB‐4 scores.

Critically-ill surgical patients are at higher risk for sarcopenia, which is associated with worse survival. Sarcopenia may impair the respiratory musculature, which can subsequently influence the outcome of ventilator weaning. Although there are a variety of weaning parameters predictive of weaning outcomes, none have tried to incorporate \"muscle strength\" or \"sarcopenia\". The aim of the current study was to explore the association between sarcopenia and difficult-to-wean (DtW) in critically-ill surgical patients. The influence of sarcopenia on ICU mortality was also analyzed. Ninety-six patients undergoing mechanical ventilation in the surgical intensive care unit (ICU) were enrolled. Demographic data and weaning parameters were recorded from the prospectively collected database, and the total psoas muscle area (TPA) was determined at the level of the 3rd lumbar vertebra by computed tomography. Sarcopenia was defined by previously established cut-off points and its influence on clinical outcomes was examined. Receiver operating characteristic (ROC) curve analysis was conducted to investigate the predictive capability of TPA and weaning parameters for predicting weaning outcomes. The median age of the studied patients was 73 years. Thirty patients (31.3%) were sarcopenic and 30 (31.3%) were defined as DtW. Eighteen patients (18.8%) had ICU mortality. Multivariate logistic regression analyses revealed that sarcopenia was an independent risk factor for DtW and ICU mortality. The area under the ROC curve (AUC) of TPA for predicting successful weaning was 0.727 and 0.720 in female and male patients, respectively. After combining TPA and conventional weaning parameters, the AUC for DtW increased from 0.836 to 0.911 and from 0.835 to 0.922 in female and male patients, respectively. Sarcopenia is an independent risk factor for DtW and ICU mortality. TPA has predictive value when assessing weaning outcomes and can be used as an effective adjunct predictor along with conventional weaning parameters.

Little is known about food insecurity in Asian Americans (AA). We examined age/ethnic subgroup differences in food insecurity among AA in California. We examined associations between food insecurity and socio-demographic characteristics among AA (Chinese, Filipino, Korean, and Vietnamese) using the test. Rolling averages were calculated to examine food insecurity trends. California. We used data from the California Health Interview Survey (2011-2018) for AA categorised by age (18-39, 40-59 and 60+ years). Food insecurity prevalence varied by subgroup, with the highest observed in older adult (aged 60+ years) Vietnamese (26 %). Between 2011-2014 and 2015-2018, food insecurity prevalence increased 20-45 % across older adults, but showed a decreasing trend among younger adults. Being foreign born and speaking a language other than English at home were associated with increased food insecurity. Community-engaged research to develop culturally appropriate strategies for mitigating food insecurity among older AA is warranted.

Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic and targeted therapies. The development of new effective or alternative therapies is therefore urgently needed. Bromelain, an extract of pineapple, was shown to have anticancer effects, but its mechanisms in CRC have not been fully explored. Therefore, the roles of bromelain in CRC progression were investigated using different CRC cell lines, a zebrafish model, and a xenograft mouse model. The anticancer mechanisms were explored by assessing the role of bromelain in inducing reactive oxygen species (ROS), superoxide, autophagosomes, and lysosomes. The role of bromelain in the induction of apoptosis was also assessed. It was found that bromelain inhibited CRC cell growth in cell lines and tumor growth in the zebrafish and xenograft mouse models. It also induced high levels of ROS and superoxide, plus autophagosome and lysosome formation. High levels of apoptosis were also induced, which were associated with elevated amounts of apoptotic proteins like apoptotic induction factor, Endo G, and caspases-3, -8, and -9 according to a qPCR analysis. In a Western blot analysis, increases in levels of ATG5/12, beclin, p62, and LC3 conversion rates were found after bromelain treatment. Levels of cleaved caspase-3, caspase-8, caspase-9, and poly(ADP ribose) polymerase (PARP)-1 increased after bromelain exposure. This study explored the role of bromelain in CRC while giving insights into its mechanisms of action. This compound can offer a cheap alternative to current therapies.

The success of laser-foil-printing (LFP) additive manufacturing depends critically on the laser welding of sheet metals onto the substrate or the previous layer during the part fabrication process. The welding can be generally categorized into two modes: conduction mode and keyhole mode. In this study, 304L stainless steel parts fabricated by the LFP process using the two laser welding modes are compared. The porosity, microstructure, and tensile properties of the fabricated parts in these two modes are measured and compared in the laser scanning direction ( X ) and part building direction ( Z ). The parts fabricated in the conduction mode have a higher density than those fabricated in the keyhole mode. On the tensile properties, both yield strength (YS) and ultimate tensile strength (UTS) have insignificant differences statistically based on the ANOVA analysis between the tensile specimens fabricated with the two welding modes by the LFP process. However, the conduction-mode parts have higher elongation than the keyhole-mode parts in both the X and Z directions, and the difference is especially significant in the Z direction. By using the electron backscattered diffraction (EBSD), it was found that the much higher ductility for the conduction-mode parts in the Z -axis direction is mainly due to the distinct grain boundary interface density in the Z -axis direction between the two welding modes.

Accidents caused by fatigue occur frequently, and numerous scholars have devoted tremendous efforts to investigate methods to reduce accidents caused by fatigued driving. Accordingly, the assessment of the spirit status of the driver through the eyes blinking frequency and the measurement of physiological signals have emerged as effective methods. In this study, a drowsiness detection system is proposed to combine the detection of LF/HF ratio from heart rate variability (HRV) of photoplethysmographic imaging (PPGI) and percentage of eyelid closure over the pupil over time (PERCLOS), and to utilize the advantages of both methods to improve the accuracy and robustness of drowsiness detection. The proposed algorithm performs three functions, including LF/HF ratio from HRV status judgment, eye state detection, and drowsiness judgment. In addition, this study utilized a near-infrared webcam to obtain a facial image to achieve non-contact measurement, alleviate the inconvenience of using a contact wearable device, and for use in a dark environment. Furthermore, we selected the appropriate RGB channel under different light sources to obtain LF/HF ratio from HRV of PPGI. The main drowsiness judgment basis of the proposed drowsiness detection system is the use of algorithm to obtain sympathetic/parasympathetic nervous balance index and percentage of eyelid closure. In the experiment, there are 10 awake samples and 30 sleepy samples. The sensitivity is 88.9%, the specificity is 93.5%, the positive predictive value is 80%, and the system accuracy is 92.5%. In addition, an electroencephalography signal was used as a contrast to validate the reliability of the proposed method.

Satellite-based models for estimating concentrations of particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) have seldom been developed in islands with complex topography over the monsoon area, where the transport of PM2.5 is influenced by both the synoptic-scale winds and local-scale circulations compared with the continental regions. We validated Multi-Angle Implementation of Atmospheric Correction (MAIAC) aerosol optical depth (AOD) with ground observations in Japan and developed a 1-km-resolution national-scale model between 2011 and 2016 to estimate daily PM2.5 concentrations. A two-stage random forest model integrating MAIAC AOD with meteorological variables and land use data was applied to develop the model. The first-stage random forest model was used to impute the missing AOD values. The second-stage random forest model was then utilised to estimate ground PM2.5 concentrations. Ten-fold cross-validation was performed to evaluate the model performance. There was good consistency between MAIAC AOD and ground truth in Japan (correlation coefficient = 0.82 and 74.62% of data falling within the expected error). For model training, the model showed a training coefficient of determination (R2) of 0.98 and a root mean square error (RMSE) of 1.22 μg/m3. For the 10-fold cross-validation, the cross-validation R2 and RMSE of the model were 0.86 and 3.02 μg/m3, respectively. A subsite validation was used to validate the model at the grids overlapping with the AERONET sites, and the model performance was excellent at these sites with a validation R2 (RMSE) of 0.94 (1.78 μg/m3). Additionally, the model performance increased as increased AOD coverage. The top-ten important predictors for estimating ground PM2.5 concentrations were day of the year, temperature, AOD, relative humidity, 10-m-height zonal wind, 10-m-height meridional wind, boundary layer height, precipitation, surface pressure, and population density. MAIAC AOD showed high retrieval accuracy in Japan. The performance of the satellite-based model was excellent, which showed that PM2.5 estimates derived from the model were reliable and accurate. These estimates can be used to assess both the short-term and long-term effects of PM2.5 on health outcomes in epidemiological studies.

Orographically‐locked diurnal convection involves interactions between local circulation and the thermodynamic environment of convection. Here, the relationships of convective updraft structures over orographic precipitation hotspots and their upstream environment in the TaiwanVVM large‐eddy simulations are analyzed for the occurrence of the orographic locking features. Strong convective updraft columns within heavily precipitating, organized systems exhibit a mass flux profile gradually increasing with height through a deep lower‐tropospheric inflow layer. Enhanced convective development is associated with higher upstream moist static energy (MSE) transport through this deep‐inflow layer via local circulation, augmenting the rain rate by 36% in precipitation hotspots. The simulations provide practical guidance for targeted observations within the most common deep‐inflow path. Preliminary field measurements support the presence of high MSE transport within the deep‐inflow layer when organized convection occurs at the hotspot. Orographically‐locked convection facilitate both modeling and field campaign design to examine the general properties of active deep convection. Plain Language Summary Under the weather regime that favors the development of local circulation in summer, diurnal convection occurs over specific areas of Taiwan. To investigate this orographic locking feature of diurnal convection, we performed a set of simulations with realistic complex Taiwan topography by TaiwanVVM and initiated with radiosonde observations to represent the variability of the background environment. In the simulations, strong updrafts are identified for orographically‐locked diurnal convection over precipitation hotspots. The vertical air mass transport of heavily‐precipitating updrafts increases with height throughout the lower atmosphere, implying a lateral inflow. The analysis of local circulation confirms the presence of the inflow layer, enhancing the development of orographically‐locked diurnal convection via rich energy transport from upstream. A field campaign, guided by the simulations, released the Storm Tracker mini‐radiosondes to quantify the upstream environment of the most common deep‐inflow path on 26 August 2022. The initial analysis supports the existence of high energy transport within the inflow layer when diurnal convection occurs over the precipitation hotspot. The results highlight the importance of non‐local inflow, transporting energy through the local circulation to supply the growth of orographically‐locked diurnal convection. Key Points In TaiwanVVM simulations, the convective updraft structure of orographically‐locked diurnal convection exhibits a deep layer of inflow The terrain‐constrained path of coherent inflow layer by local circulation augments convection development over the precipitation hotspots Initial field observations guided by TaiwanVVM detect high moist static energy transport upstream of the precipitation hotspots

We here report on the direct observation of ferroelectric properties of water ice in its 2D phase. Upon nanoelectromechanical confinement between two graphene layers, water forms a 2D ice phase at room temperature that exhibits a strong and permanent dipole which depends on the previously applied field, representing clear evidence for ferroelectric ordering. Characterization of this permanent polarization with respect to varying water partial pressure and temperature reveals the importance of forming a monolayer of 2D ice for ferroelectric ordering which agrees with ab-initio and molecular dynamics simulations conducted. The observed robust ferroelectric properties of 2D ice enable novel nanoelectromechanical devices that exhibit memristive properties. A unique bipolar mechanical switching behavior is observed where previous charging history controls the transition voltage between low-resistance and high-resistance state. This advance enables the realization of rugged, non-volatile, mechanical memory exhibiting switching ratios of 10 6 , 4 bit storage capabilities and no degradation after 10,000 switching cycles. Ferroelectric ordering of water has been at the heart of intense debates due to its importance in enhancing our understanding of the condensed matter. Here, the authors observe ferroelectric properties of water ice in a two dimensional phase under confinement between two graphene layers.

Hyperthermia (HT) has shown feasibility and potency as an anticancer therapy. Administration of HT in the chemotherapy has previously enhanced the cytotoxicity of drugs against pancreatic cancer. However, the drugs used when conducting these studies are substantially conventional chemotherapeutic agents that may cause unwanted side effects. Additionally, the thermal dosage in the treatment of cancer cells could also probably harm the healthy cells. The purpose of this work was to investigate the potential of the two natural polyphenolic compounds, epigallocatechin gallate (EGCG) and chlorogenic acid (CGA), as heat synergizers in the thermal treatment of the PANC-1 cells. Furthermore, we have introduced a unique strategy entitled the thermal cycling-hyperthermia (TC-HT) that is capable of providing a maximum synergy and minimal side effect with the anticancer compounds. Our results demonstrate that the combination of the TC-HT and the CGA or EGCG markedly exerts the anticancer effect against the PANC-1 cells, while none of the single treatment induced such changes. The synergistic activity was attributed to the cell cycle arrest at the G2/M phase and the induction of the ROS-dependent mitochondria-mediated apoptosis. These findings not only represent the first in vitro thermal synergistic study of natural compounds in the treatment of pancreatic cancer, but also highlight the potential of the TC-HT as an alternative strategy in thermal treatment.