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Never grow up
Everyone knows Jackie Chan. Whether it's from Rush Hour, Shanghai Noon, The Karate Kid, or Kung Fu Panda, Jackie is admired by generations of moviegoers for his acrobatic fighting style, comic timing, and mind-bending stunts. In 2016-after fifty-six years in the industry, over 200 films, and many broken bones-he received an honorary Academy Award for his lifetime achievement in film. But at 64 years-old, Jackie is just getting started. Now, in Never Grow Up, the global superstar reflects on his early life, including his childhood years at the China Drama Academy (in which he was enrolled at the age of six), his big breaks (and setbacks) in Hong Kong and Hollywood, his numerous brushes with death (both on and off film sets), and his life as a husband and father (which has been, admittedly and regrettably, imperfect). Jackie has never shied away from his mistakes. Since The Young Master in 1980, Jackie's films have ended with a bloopers reel in which he stumbles over his lines, misses his mark, or crashes to the ground in a stunt gone south. In Never Grow Up, Jackie applies the same spirit of openness to his life, proving time and time again why he's beloved the world over: he's honest, funny, kind, brave beyond reckoning and-after all this time-still young at heart.
BOOK
Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis
To provide a complete toxicity profile, toxicity spectrum, and a safety ranking of immune checkpoint inhibitor (ICI) drugs for treatment of cancer.
Systematic review and network meta-analysis.
Electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) were systematically searched to include relevant studies published in English between January 2007 and February 2018.
Only head-to-head phase II and III randomised controlled trials comparing any two or three of the following treatments or different doses of the same ICI drug were included: nivolumab, pembrolizumab, ipilimumab, tremelimumab, atezolizumab, conventional therapy (chemotherapy, targeted therapy, and their combinations), two ICI drugs, or one ICI drug with conventional therapy. Eligible studies must have reported site, organ, or system level data on treatment related adverse events. High quality, single arm trials and placebo controlled trials on ICI drugs were selected to establish a validation group.
36 head-to-head phase II and III randomised trials (n=15 370) were included. The general safety of ICI drugs ranked from high to low for all adverse events was as follows: atezolizumab (probability 76%, pooled incidence 66.4%), nivolumab (56%, 71.8%), pembrolizumab (55%, 75.1%), ipilimumab (55%, 86.8%), and tremelimumab (54%, not applicable). The general safety of ICI drugs ranked from high to low for severe or life threatening adverse events was as follows: atezolizumab (49%, 15.1%), nivolumab (46%, 14.1%), pembrolizumab (72%, 19.8%), ipilimumab (51%, 28.6%), and tremelimumab (28%, not applicable). Compared with conventional therapy, treatment-related adverse events for ICI drugs occurred mainly in the skin, endocrine, hepatic, and pulmonary systems. Taking one ICI drug was generally safer than taking two ICI drugs or one ICI drug with conventional therapy. Among the five ICI drugs, atezolizumab had the highest risk of hypothyroidism, nausea, and vomiting. The predominant treatment-related adverse events for pembrolizumab were arthralgia, pneumonitis, and hepatic toxicities. The main treatment-related adverse events for ipilimumab were skin, gastrointestinal, and renal toxicities. Nivolumab had a narrow and mild toxicity spectrum, mainly causing endocrine toxicities. Integrated evidence from the pooled incidences, subgroup, and sensitivity analyses implied that nivolumab is the best option in terms of safety, especially for the treatment of lung cancer.
Compared with other ICI drugs used to treat cancer, atezolizumab had the best safety profile in general, and nivolumab had the best safety profile in lung cancer when taking an integrated approach. The safety ranking of treatments based on ICI drugs is modulated by specific treatment-related adverse events.
PROSPERO CRD42017082553.
Journal Article
Large‐Scale, Mechanically Robust, Solvent‐Resistant, and Antioxidant MXene‐Based Composites for Reliable Long‐Term Infrared Stealth
MXene‐based thermal camouflage materials have gained increasing attention due to their low emissivity, however, the poor anti‐oxidation restricts their potential applications under complex environments. Various modification methods and strategies, e.g., the addition of antioxidant molecules and fillers have been developed to overcome this, but the realization of long‐term, reliable thermal camouflage using MXene network (coating) with excellent comprehensive performance remains a great challenge. Here, a MXene‐based hybrid network comodified with hyaluronic acid (HA) and hyperbranched polysiloxane (HSi) molecules is designed and fabricated. Notably, the presence of appreciated HA molecules restricts the oxidation of MXene sheets without altering infrared stealth performance, superior to other water‐soluble polymers; while the HSi molecules can act as efficient cross‐linking agents to generate strong interactions between MXene sheets and HA molecules. The optimized MXene/HA/HSi composites exhibit excellent mechanical flexibility (folded into crane structure), good water/solvent resistance, and long‐term stable thermal camouflage capability (with low infrared emissivity of ≈0.29). The long‐term thermal camouflage reliability (≈8 months) under various outdoor weathers and the scalable coating capability of the MXene‐coated textile enable them to disguise the IR signal of various targets in complex environments, indicating the great promise of achieved material for thermal camouflage, IR stealth, and counter surveillance. A high‐performance thermal camouflage material is designed and successfully fabricated by decorating MXene network with hyaluronic acid (HA) and hyperbranched polysiloxane (HSi). Besides excellent mid‐infrared (IR) thermal camouflage, such material also integrates multiple advantages into itself, including being large‐scale, mechanically flexible, weather‐resistant, and thus showing great potential for stealth applications.
Journal Article
Fire Intumescent, High-Temperature Resistant, Mechanically Flexible Graphene Oxide Network for Exceptional Fire Shielding and Ultra-Fast Fire Warning
HighlightsGraphene oxide-based hybrid networks were fabricated via introducing multi-amino molecule with triple roles (i.e., cross-linker, fire retardant and reducing agent).The optimized hybrid network with mechanically robust, exceptional intumescent effect and ultra-sensitive fire alarm response (~ 0.6 s) can be used as desirable smart fire alarm sensor materials.Exceptional fire shielding performances, e.g., ~ 60% reduction in peak heat release rate and limiting oxygen index of ~ 36.5%, are achieved, when coated such hybrid network onto combustible polymer foam.Smart fire alarm sensor (FAS) materials with mechanically robust, excellent flame retardancy as well as ultra-sensitive temperature-responsive capability are highly attractive platforms for fire safety application. However, most reported FAS materials can hardly provide sensitive, continuous and reliable alarm signal output due to their undesirable temperature-responsive, flame-resistant and mechanical performances. To overcome these hurdles, herein, we utilize the multi-amino molecule, named HCPA, that can serve as triple-roles including cross-linker, fire retardant and reducing agent for decorating graphene oxide (GO) sheets and obtaining the GO/HCPA hybrid networks. Benefiting from the formation of multi-interactions in hybrid network, the optimized GO/HCPA network exhibits significant increment in mechanical strength, e.g., tensile strength and toughness increase of ~ 2.3 and ~ 5.7 times, respectively, compared to the control one. More importantly, based on P and N doping and promoting thermal reduction effect on GO network, the excellent flame retardancy (withstanding ~ 1200 °C flame attack), ultra-fast fire alarm response time (~ 0.6 s) and ultra-long alarming period (> 600 s) are obtained, representing the best comprehensive performance of GO-based FAS counterparts. Furthermore, based on GO/HCPA network, the fireproof coating is constructed and applied in polymer foam and exhibited exceptional fire shielding performance. This work provides a new idea for designing and fabricating desirable FAS materials and fireproof coatings.
Journal Article
Shinjuku incident
\"A simple Chinese immigrant wages a perilous war against one of the most powerful criminal organizations on the planet in this sprawling action drama directed by Derek Yee (One Night in Mongkok) and starring Jackie Chan, Daniel Wu, and Masaya Kato. In Japan, foreign migrants are shunned by mainstream society. Taunted by the yakuza, they live in constant fear of being discovered and repatriated. Into this world ventures Steelhead (Chan), a humble tractor repairman who has traveled to Tokyo in search of his missing girlfriend, Xiu Xiu (Xu Jinglei), who vanished into thin air shortly after arriving in the city. After locating his brother Joe (Daniel Wu), Steelhead discovers that Xiu Xiu has adapted a Japanese identity and married up-and-coming yakuza chief Eguchi (Masaya Kato), with whom he forms an uneasy alliance. Over time, Steelhead earns the respect of his fellow Chinese immigrants by establishing a place for them to gather. But the dark side still beckons to Steelhead, because after helping Eguchi dispense with a powerful rival, he is granted full control of Shinjuku's most popular nightspots. Resistant to the allure of the criminal lifestyle, Steelhead discovers a new love and opens a tractor-repair business just outside the city. When Eguchi begins using Steelhead's former compatriots as pawns to front the yakuza's drug trade, the vengeful immigrant returns to the city determined to exact justice, even if it means destroying the future of the woman he once loved\"--Allmovie.com, viewed October 18, 2018.
DVD
Study on Disaster Mechanism of Roadway Deformation and Roof Energy Accumulation in Advance Working Face
It is one of the important disasters faced by coal mine that roof energy accumulation leads to its advance failure and roadway failure. Identifying the position of roof energy accumulation can predict the position of roof advance failure and roadway deformation, so as to take preventive measures. Based on two generalized displacement beams, the accumulation law of the bending moment and energy density of the top coal wall under different loads, different thicknesses, and different cantilever lengths is investigated. The following conclusions are drawn: (1) Under different load conditions, the peak of the bending moment and energy density both appear at 10 m in front of the coal wall and rapidly decrease to 0 after reaching the peak and no longer change. The peak value of the bending moment increases linearly with the increase of the load, and the relation is M = −143.32 q − 286.63. The peak value of bending moment changes exponentially with the increase of load, and the relation is U e = 200.46e 0.42 q . (2) Under different thicknesses, the bending moment of the thickness to the rock layer has an irregular distribution at the peak value. When the thickness is 12.5 and 15 m, the change tends to be consistent, and when the thickness is 7.5 and 10 m, the bending moment of the roof is small when the thickness is 17.5 m. When the thickness is less than 17.5 m, the smaller the thickness is, the larger the peak value is, and the more advanced the peak value is. The smaller the thickness of the roof, the smaller the range of energy density accumulation. (3) Under different cantilever lengths, with the increase of cantilever length, the peak bending moment presents a linear increase, and the relationship is M e = −158.22 L + 137.4, and the range of bending moment accumulation increases with the increase of the roof cantilever length. With the increase of the cantilever length, the peak energy density of the roof increases exponentially, and the relationship is U e = 3.5536 e 1.1067 L , and the lead energy accumulation distance of the roof increases. (4) When the thickness of the roof is 10 m, the stress peak occurs more frequently within 5–15 m in front of the working face, which well confirms the correctness of the theoretical analysis.
Journal Article
Signatures of the Adler–Bell–Jackiw chiral anomaly in a Weyl fermion semimetal
Weyl semimetals provide the realization of Weyl fermions in solid-state physics. Among all the physical phenomena that are enabled by Weyl semimetals, the chiral anomaly is the most unusual one. Here, we report signatures of the chiral anomaly in the magneto-transport measurements on the first Weyl semimetal TaAs. We show negative magnetoresistance under parallel electric and magnetic fields, that is, unlike most metals whose resistivity increases under an external magnetic field, we observe that our high mobility TaAs samples become more conductive as a magnetic field is applied along the direction of the current for certain ranges of the field strength. We present systematically detailed data and careful analyses, which allow us to exclude other possible origins of the observed negative magnetoresistance. Our transport data, corroborated by photoemission measurements, first-principles calculations and theoretical analyses, collectively demonstrate signatures of the Weyl fermion chiral anomaly in the magneto-transport of TaAs.
Anomalous conducting behavior of solids may reflect the presence of novel quantum states. Here, Zhang
et al
. report an increased conductivity in TaAs with a magnetic field applied along the direction of the current, which reveals an inherent property of the Weyl Fermion.
Journal Article
