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Although both theoretical predictions and experimental observations have demonstrated that the Gilbert damping is anisotropic at ferromagnet/semiconductor interface possessing robust interfacial spin-orbit coupling, it is not well understood whether non-local Gilbert damping driven by spin pumping in heavy metal/ferromagnetic metallic bilayers is anisotropic or not. Here, we investigated the angular and frequency dependence of magnetic relaxation in epitaxial Pd/Fe films on MgO(001) substrates. After disentangling parasitic contributions, we unambiguously observe that the non-local Gilbert damping is isotropic in the Fe(001) plane, suggesting that the spin transport across the Pd/Fe interface is independent of the Fe magnetization orientation. First principles calculations reveal that the effective spin mixing conductance of the Pd/Fe interface is nearly invariant for different magnetization directions, in good agreement with the experimental observations. These results offer valuable insight into spin transport in metallic bilayers, and facilitate the development of next-generation spintronic devices.

The need of a reliable calculation of the nuclear matrix elements for the 0 νββ decay has ignited a new interest about the quenching of the axial coupling constant g A , a procedure introduced to reproduce experimental results connected with GT decays. The goal of this work is to present a preliminary study to tackle this problem within the framework of the realistic shell model.

Mineral salt bricks are often used in cow raising as compensation for mineral losses to improve milk yield, growth, and metabolic activity. Generally, effects of minerals are partially thought to result from improvement of microbial metabolism, but their influence on the rumen microbiota has rarely been documented to date. In this study, we investigated the response of microbiota to mineral salt in heifer and adult cows and evaluated ruminal fermentation and enteric methane emissions of cows fed mineral salts. Twelve lactating Holstein cows and twelve heifers fed a total mixed ration (TMR) diet were randomly allocated into two groups, respectively: a treatment group comprising half of the adults and heifers that were fed mineral salt and a control group containing the other half fed a diet with no mineral salt supplement. Enteric methane emissions were reduced by 9.6% (P < 0.05) in adults ingesting a mineral salt diet, while concentrations of ruminal ammonia, butyrate, and propionate were increased to a significant extent (P < 0.05). Enteric methane emissions were also reduced in heifers ingesting a mineral salt diet, but not to a significant extent (P > 0.05). Moreover, the concentrations of ammonia and volatile fatty acids (VFAs) were not significantly altered in heifers (P > 0.05). Based on these results, we performed high-throughput sequencing to explore the bacterial and archaeal communities of the rumen samples. Succiniclasticum and Prevotella, two propionate-producing bacteria, were predominant in samples of both adults and heifers. At the phylotype level, mineral salt intake led to a significant shift from Succiniclasticum to Prevotella and Prevotellaceae populations in adults. In contrast, reduced abundance of Succiniclasticum and Prevotella phylotypes was observed, with no marked shift in propionate-producing bacteria in heifers. Methanogenic archaea were not significantly abundant between groups, either in adult cows or heifers. The shift of Succiniclasticum to Prevotella and Prevotellaceae in adults suggests a response of microbiota to mineral salt that contributes to higher propionate production, which competes for hydrogen utilized by methanogens. Our data collectively indicate that a mineral salt diet can alter interactions of bacterial taxa that result in enteric methane reduction, and this effect is also influenced in an age-dependent manner.

Several methods for dealing uncertainties in electrical network planning are compared and analysed. Fuzzy evaluation model with the blind number representing uncertainties in electrical network planning is proposed. The model well describes the planner's satisfaction degree with respect to the economic objective and reliability objective of the planning scheme, and is more universal to deal with the uncertainties inherent in the planning. Moreover, the model is suitable to be processed by the meta-heuristic algorithms and the computation burden brought by massive information processing can be reduced by the proposed techniques. Finally, the model is illustrated and justified by an 18-bus sample system. [PUBLICATION ABSTRACT]

An analysis of a series of experiments using the least squares method (LSM) showed that the registration error of an induction watthour meter in the presence of harmonics contained contributions from three aspects: the amplitudes obtained from the LSM analysis of frequency response test data which meant the max registration when the frequency and RMS of voltages and currents were not varied, only their phase angle varied, they decreased with the harmonic order increasing; the phase shifts of voltage and current circuits which obtained from the LSM analysis of frequency response test data too; and variances in the reported fundamental energy affected by the harmonics. These harmonic experiments involved a frequency response test, a harmonic power test, a harmonic current test and a harmonic voltage test. The analysis also showed that the amplitudes and phase shifts remained constant, and their DC offsets were negligible, when the current amplitudes and phases varied. [PUBLICATION ABSTRACT]

Introduction Mental illness stigma is prevalent among Asian Americans, and it is a key barrier that prevents them from seeking psychological services. Limited studies have experimentally examined how Asian Americans respond to biological and social explanations of mental illness. Understanding how to educate and communicate about mental illness effectively is crucial in increasing service utilization among Asian Americans. Purpose To assess how genetic, neurobiological, and social explanations for the onset of depression affects Asian American and European American’s mental illness stigma. Methods 231 Asian Americans and 206 European Americans read about an individual with major depression and were randomly assigned to be informed that the cause was either genetic, neurobiological, social, or unknown. Various stigma outcomes, including social distance, fear, and depression duration were assessed. Results Consistent with prior research, Asian Americans had higher baseline levels of stigma compared to European Americans. Greater social essentialist beliefs predicted positive stigma outcomes for Asian Americans, such as a greater willingness to be near, help, and hire someone with depression, but genetic essentialist beliefs predicted negative stigma outcomes, such as fear. In addition, a social explanation for the etiology of depression led to lower stigma outcomes for Asian Americans; it decreased their fear of someone with depression and increased the perception that depression is treatable. For European Americans, both genetic and social essentialist beliefs predicted a greater perception of depression treatability. Conclusion Although genetics do play a role in the development of depression, emphasizing a social explanation for the origin of depression may help reduce stigma for Asian Americans.

Nuclei in the vicinity of driplines have been receiving a lot of attention in nuclear structure studies. In the nuclei, the continuum coupling is crucial in reproducing weakly-bound and unbound phenomena. To calculate observables of the nuclei as open quantum systems, we have developed valence-space effective operators in the complex-energy Berggren basis using many-body perturbation theory. We focus on the Gamow-Teller \\(\\beta\\) decay in the {\\it sd} shell. The two- plus three-nucleon force from the chiral effective field theory (EFT), named EM1.8/2.0, has been used. The Gamow shell model which takes the continuum coupling into account can properly reproduce experimental observations of weakly-bound and unbound states. The \\(\\beta\\)-decay isospin asymmetry between the dripline nucleus \\(^{22}\\rm Si\\) and its mirror partner \\(^{22}\\rm O\\) is reproduced, in which the \\(s_{1/2}\\) continuum plays a key role. Significant Thomas-Ehrman shift is seen through mirror energy differences between the mirror daughters \\(^{22}\\rm Al\\) and \\(^{22}\\rm F\\), in which the continuum effect plays an important role.

Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In this work, we report on a comprehensive characterization of gene expression profiles of hepatitis B virus-positive HCC through the generation of a large set of 5′-read expressed sequence tag (EST) clusters (11,065 in total) from HCC and noncancerous liver samples, which then were applied to a cDNA microarray system containing 12,393 genes/ESTs and to comparison with a public database. The commercial cDNA microarray, which contains 1,176 known genes related to oncogenesis, was used also for profiling gene expression. Integrated data from the above approaches identified 2,253 genes/ESTs as candidates with differential expression. A number of genes related to oncogenesis and hepatic function/differentiation were selected for further semiquantitative reverse transcriptase-PCR analysis in 29 paired HCC/noncancerous liver samples. Many genes involved in cell cycle regulation such as cyclins, cyclin-dependent kinases, and cell cycle negative regulators were deregulated in most patients with HCC. Aberrant expression of the Wnt-β-catenin pathway and enzymes for DNA replication also could contribute to the pathogenesis of HCC. The alteration of transcription levels was noted in a large number of genes implicated in metabolism, whereas a profile change of others might represent a status of dedifferentiation of the malignant hepatocytes, both considered as potential markers of diagnostic value. Notably, the altered transcriptome profiles in HCC could be correlated to a number of chromosome regions with amplification or loss of heterozygosity, providing one of the underlying causes of the transcription anomaly of HCC.

With both three-nucleon force and continuum coupling included, we have developed a self-consistent ıt ab initio Gamow shell model within the Gamow Hartree-Fock (GHF) basis obtained by the realistic interaction itself. With the chiral two-nucleon N\\(^3\\)LO and three-nucleon N\\(^2\\)LO interactions, the Gamow shell model has been applied to the mirror systems of \\(Z=8\\) neutron-rich isotopes and \\(N=8\\) proton-rich isotones, giving good agreements with data in binding energies, dripline positions and excitation spectra. The GHF calculated that the \\(0d_3/2\\), \\(1s_1/2\\) and \\(1p_3/2\\) orbitals are resonances. The resonance states and their interplay with nonresonant continua play a crucial role in the descriptions of nuclei around driplines. Excitation spectra and Thomas-Ehrman shifts observed can be better described when both three-nucleon force and continuum coupling are considered in calculations. The three-nucleon force and continuum coupling produce a combined effect on the Thomas-Ehrman shift, e.g., for the \\(1/2^+\\) resonance level of \\(^19\\)Na. The calculations help the understandings of related nuclear astrophysical processes.

Background The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range. Additionally, enhanced gamma oscillations may serve as a compensatory mechanism for motor inhibition mediated by beta activity and also reinstate plasticity in the primary motor cortex affected by Parkinson’s disease. Transcranial alternating current stimulation (tACS) can synchronize endogenous oscillations with exogenous rhythms, thereby modulating cortical activity. The objective of this study is to investigate whether the addition of tACS to multidisciplinary intensive rehabilitation treatment (MIRT) can improve symptoms of PWP so as to enhance the quality of life in individuals with Parkinson’s disease based on the central-peripheral-central theory. Methods The present study was a randomized, double-blind trial that enrolled 60 individuals with Parkinson’s disease aged between 45 and 70 years, who had Hoehn-Yahr scale scores ranging from 1 to 3. Participants were randomly assigned in a 1:1 ratio to either the tACS + MIRT group or the sham-tACS + MIRT group. The trial consisted of a two-week double-blind treatment period followed by a 24-week follow-up period, resulting in a total duration of twenty-six weeks. The primary outcome measured the change in PDQ-39 scores from baseline (T0) to 4 weeks (T2), 12 weeks (T3), and 24 weeks (T4) after completion of the intervention. The secondary outcome assessed changes in MDS-UPDRS III scores at T0, the end of intervention (T1), T2, T3, and T4. Additional clinical assessments and mechanistic studies were conducted as tertiary outcomes. Discussion The objective of this study is to demonstrate that tACS can enhance overall functionality and improve quality of life in PWP, based on the framework of MIRT. Additionally, it seeks to establish a potential correlation between these therapeutic effects and neuroplasticity alterations in relevant brain regions. The efficacy of tACS will be assessed during the follow-up period in order to optimize neuroplasticity and enhance its potential impact on rehabilitation efficiency for PWP. Trial registration Chinese Clinical Trial Registry ChiCTR2300071969. Registered on 30 May 2023.