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"Chiang, Janice"
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The shadow hero
In the comics boom of the 1940s, a legend was born: the Green Turtle. He solved crimes and fought injustice just like the other comics characters. But this mysterious masked crusader was hiding something more than your run-of-the-mill secret identity: the Green Turtle was the first Asian American super hero. The comic had a short run before lapsing into obscurity, but Gene Luen Yang has revived this character in Shadow Hero, a new graphic novel that creates an origin story for the Green Turtle.
Book
Healthcare worker access to molnupiravir: A case series
Molnupiravir, an oral antiviral shown to reduce COVID-19 severity, is available in Australia via the Pharmaceutical Benefits Scheme (PBS) for treatment of mild-moderate COVID-19. For people less than 70 years of age it is only available with risk factors for severe disease, hence the majority of healthcare workers do not qualify. Currently, Australian health services are under considerable strain due to COVID-related staff shortages. Thirty staff members of a tertiary hospital, not eligible under the PBS, were offered molnupiravir within the first five days of COVID-19 illness. Their median age was 43 years, and 73% were female. All completed treatment with rates of adverse events that were low and comparable with clinical trial data. The reported duration of illness ranged from 1–16 days with a median of four days. A negative rapid antigen test on the final day of treatment was reported in 81% of people, and 73% reported being well enough to return to work at the completion of mandatory isolation. Only 22% of people reported transmission in their household after they commenced treatment. The implementation of a policy allowing access to molnupiravir outside of PBS recommendations for healthcare workers with mild-moderate COVID-19 may have important individual benefits to workers health and wellbeing and help alleviate the acute staff shortages experienced currently by the Australian healthcare workforce.
Journal Article
DC super hero girls. Powerless
When the electric grid and Gotham's cloud computing technology get knocked out on the same night, the Metropolis High Hamsters must figure out how to deal with the city's loss of power.
Book
DC super hero girls. Spaced out : a graphic novel
\"Earth's new Green Lantern, Jessica Cruz, learns that she must report to Oa and introduce herself to the Green Lantern Corps--as if learning new powers and being the new girl at Super Hero High weren't enough. Luckily, some of her new friends are willing to accompany Jessica. But when they arrive, instead of the Green Lantern Corps they find General Zod, Faora and Non\"--Publisher marketing.
Book
Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication after organ transplantation frequently associated with the Epstein-Barr virus (EBV). Immunosuppressive treatment is thought to allow the expansion of EBV-infected B cells, which often express all eight oncogenic EBV latent proteins. Here, we assessed whether HLA-A2 transgenic humanized NSG mice treated with the immunosuppressant FK506 could be used to model EBV-PTLD. We found that FK506 treatment of EBV-infected mice led to an elevated viral burden, more frequent tumor formation and diminished EBV-induced T cell responses, indicative of reduced EBV-specific immune control. EBV latency III and lymphoproliferation-associated cellular transcripts were up-regulated in B cells from immunosuppressed animals, akin to the viral and host gene expression pattern found in EBV-PTLD. Utilizing an unbiased gene expression profiling approach, we identified genes differentially expressed in B cells of EBV-infected animals with and without FK506 treatment. Upon investigating the most promising candidates, we validated sCD30 as a marker of uncontrolled EBV proliferation in both humanized mice and in pediatric patients with EBV-PTLD. High levels of sCD30 have been previously associated with EBV-PTLD in patients. As such, we believe that humanized mice can indeed model aspects of EBV-PTLD development and may prove useful for the safety assessment of immunomodulatory therapies.
Journal Article
DC super hero girls. Date with disaster : an original graphic novel
Catwoman is out alone on the prowl one night when KABOOM--an explosion at S.T.A.R. Labs rouses the other girls from their slumber. Star students Batgirl and Lois Lane both know the lab incident is fishy, and they meet later to share clues. But nothing could've prepared Batgirl for what they see next: Batgirl's dad on a date.
Book
Contextual interference enhances motor learning through increased resting brain connectivity during memory consolidation
Increasing contextual interference (CI) during practice benefits learning, making it a desirable difficulty. For example, interleaved practice (IP) of motor sequences is generally more difficult than repetitive practice (RP) during practice but leads to better learning. Here we investigated whether CI in practice modulated resting-state functional connectivity during consolidation. 26 healthy adults (11 men/15 women, age = 23.3 ± 1.3 years) practiced two sets of three sequences in an IP or RP condition over 2 days, followed by a retention test on Day 5 to evaluate learning. On each practice day, functional magnetic resonance imaging (fMRI) data were acquired during practice and also in a resting state immediately after practice. The resting-state fMRI data were processed using independent component analysis (ICA) followed by functional connectivity analysis, showing that IP on Day 1 led to greater resting connectivity than RP between the left premotor cortex and left dorsolateral prefrontal cortex (DLPFC), bilateral posterior cingulate cortices, and bilateral inferior parietal lobules. Moreover, greater resting connectivity after IP than RP on Day 1, between the left premotor cortex and the hippocampus, amygdala, putamen, and thalamus on the right, and the cerebellum, was associated with better learning following IP. Mediation analysis further showed that the association between enhanced resting premotor-hippocampal connectivity on Day 1 and better retention performance following IP was mediated by greater task-related functional activation during IP on Day 2. Our findings suggest that the benefit of CI to motor learning is likely through enhanced resting premotor connectivity during the early phase of consolidation.
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•Introducing contextual interference (CI) in practice benefits motor learning.•High-CI practice enhanced resting brain connectivity immediately after practice.•Enhanced brain connectivity after high-CI practice was linked to better learning.
Journal Article
DC super hero girls. Finals crisis : an original graphic novel
It was the night before finals and the student body is hard at work--and nothing is going right. Wonder Woman, Supergirl, Harley Quinn, Batgirl, and their friends are learning to become heroes, but no one knew the trials that awaited them. In the first original graphic novel from the DC Super Hero Girls line, meet the students of Superhero High School as they find out that fun, friendship, and hard work are all parts of growing up.
Book
Correction: Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice
[This corrects the article DOI: 10.1371/journal.ppat.1008477.].
Journal Article