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How is syntactic analysis implemented by the human brain during language comprehension? The current study combined methods from computational linguistics, eyetracking, and fMRI to address this question. Subjects read passages of text presented as paragraphs while their eye movements were recorded in an MRI scanner. We parsed the text using a probabilistic context-free grammar to isolate syntactic difficulty. Syntactic difficulty was quantified as syntactic surprisal, which is related to the expectedness of a given word's syntactic category given its preceding context. We compared words with high and low syntactic surprisal values that were equated for length, frequency, and lexical surprisal, and used fixation-related (FIRE) fMRI to measure neural activity associated with syntactic surprisal for each fixated word. We observed greater neural activity for high than low syntactic surprisal in two predicted cortical regions previously identified with syntax: left inferior frontal gyrus (IFG) and less robustly, left anterior superior temporal lobe (ATL). These results support the hypothesis that left IFG and ATL play a central role in syntactic analysis during language comprehension. More generally, the results suggest a broader cortical network associated with syntactic prediction that includes increased activity in bilateral IFG and insula, as well as fusiform and right lingual gyri. •Participants read connected text paragraphs naturally with eyetracking and fMRI•Fixation-related (FIRE) fMRI was used to relate syntactic surprisal to activation.•Predicted activation for higher surprisal was observed in left IFG and left ATL.•Activation also seen in bilateral insula; and right IFG, fusiform, and lingual gyri.

The pinewood nematode (PWN), Bursaphelenchus xylophilus, is a causative agent of pine wilt disease (PWD). To date, although several molecular diagnostic methods have been developed, rapid on-site diagnostic tools for detecting PWN in pinewood are limited. In this study, a point of care diagnostic (POCD) method for detecting PWN in pinewood using recombinase polymerase amplification (RPA) assay was developed. This method comprises quick gDNA extraction buffer (DAP buffer) for the direct extraction of gDNA of PWN from pinewood and a battery-mounted portable optical isothermal device (POID) for the detection of PWD in the field. The RPA assay can distinguish between the PWN and its conspecies which exist in pinewood and can complete diagnostic procedures within 25 min in the field. Moreover, the RPA assay can detect PWN in old wood samples in both natural and stored conditions. The POCD-RPA assay to detect PWN will be useful for epidemiological investigations in the field as well as for quarantine processes in the wood trade.

Most previous studies investigating the neural correlates of reading have presented text using serial visual presentation (SVP), which may not fully reflect the underlying processes of natural reading. In the present study, eye movements and BOLD data were collected while subjects either read normal paragraphs naturally or moved their eyes through \"paragraphs\" of pseudo-text (pronounceable pseudowords or consonant letter strings) in two pseudo-reading conditions. Eye movement data established that subjects were reading and scanning the stimuli normally. A conjunction fMRI analysis across natural- and pseudo-reading showed that a common eye-movement network including frontal eye fields (FEF), supplementary eye fields (SEF), and intraparietal sulci was activated, consistent with previous studies using simpler eye movement tasks. In addition, natural reading versus pseudo-reading showed different patterns of brain activation: normal reading produced activation in a well-established language network that included superior temporal gyrus/sulcus, middle temporal gyrus (MTG), angular gyrus (AG), inferior frontal gyrus, and middle frontal gyrus, whereas pseudo-reading produced activation in an attentional network that included anterior/posterior cingulate and parietal cortex. These results are consistent with results found in previous single-saccade eye movement tasks and SVP reading studies, suggesting that component processes of eye-movement control and language processing observed in past fMRI research generalize to natural reading. The results also suggest that combining eyetracking and fMRI is a suitable method for investigating the component processes of natural reading in fMRI research.

We report the results of an eye tracking experiment that used the gaze-contingent moving window technique to examine individual differences in the size of readers’ perceptual span. Participants read paragraphs while the size of the rightward window of visible text was systematically manipulated across trials. In addition, participants completed a large battery of individual-difference measures representing two cognitive constructs: language ability and oculomotor processing speed. Results showed that higher scores on language ability measures and faster oculomotor processing speed were associated with faster reading times and shorter fixation durations. More interestingly, the size of readers’ perceptual span was modulated by individual differences in language ability but not by individual differences in oculomotor processing speed, suggesting that readers with greater language proficiency are more likely to have efficient mechanisms to extract linguistic information beyond the fixated word.

The question of whether phonological information is integrated through the parafovea has remained unanswered particularly in Korean sentence reading. The current study used homophones with identical underlying phonological forms but with different orthography to examine phonological preview benefit effects in Korean. In an eye-tracking experiment using the boundary paradigm, target fixations were shorter (a) when the preview-target pairs were identical than when they were unrelated, (b) when the pairs were orthographically similar than when they were unrelated, and most importantly, (c) when the pairs were phonologically identical than when they were phonologically similar but different. These results indicate that underlying phonological information of a word, aside from orthographic information, is integrated through parafoveal preview during Korean sentence reading.

Background: Despite the increasing attention to electronic health management information systems (HMISs) in global health, most African countries still depend on inefficient paper-based systems. Good Neighbors International and Evaluate 4 Health have recently supported the Ghana Health Service on the rollout of a mobile health–based HMIS called the e-Tracker system in 2 regions in Ghana. The e-Tracker is an Android-based tracker capture app that electronically manages maternal and child health (MCH) data. The Ghana Health Service has implemented this new system in Community Health Planning and Services in the 2 regions (Volta and Eastern). Objective: This study aims to evaluate changes in health workers’ capacity and behavior after using the e-Tracker to deliver MCH services. Specifically, the study assesses the changes in knowledge, attitude, and practice (KAP) of the health workers toward the e-Tracker system by comparing the pre- and postsurvey results. Methods: The KAP of frontline health workers was measured through self-administered surveys before and after using the e-Tracker system to assess their capacity and behavioral change toward the system. A total of 1124 health workers from the Volta and Eastern regions responded to the pre-post surveys. This study conducted the McNemar chi-square test and Wilcoxon signed-rank test for a pre-post comparison analysis. In addition, random-effects ordered logistic regression analysis and random-effects panel analysis were conducted to identify factors associated with KAP level. Results: The pre-post comparison analysis showed significant improvement in health workers’ capacity, with higher knowledge and practice levels after using the e-Tracker system. As for knowledge, there was a 9.9%-point increase (from 559/1109, 50.41% to 669/1109, 60.32%) in the proportion of the respondents who were able to generate basic statistics on the number of children born in a random month within 30 minutes. In the practice section, the percentage of respondents who had scheduled clientencounters increased from 91.41% (968/1059) to 97.83% (1036/1059). By contrast, responses to the attitude (acceptability) became less favorable after experiencing the actual system. For instance, 48.53% (544/1121) initially expressed their preferences for an electronic system; however, the proportion decreased to 33.45% (375/1121) after the intervention. Random-effects ordered logistic regression showed that days of overwork were significantly associated with health workers’ attitudes toward the e-Tracker system. Conclusions: This study provides empirical evidence that the e-Tracker system is conducive to enhancing capacity in MCH data management for providing necessary MCH services. However, the change in attitude implies that the users appear to feel less comfortable using the new system. As Ghana plans to scale up the electronic HMIS system using the e-Tracker to the national level, strategies to enhance health workers’ attitudes are necessary to sustain this new system.

This study investigated Korean-English second language (L2) speakers’ recognition of high- and low-frequency English words and compared two individual difference measures in their role of representing lexical quality in L2: cloze test scores and inverse efficiency scores (IES; response latency corrected for the amount of errors committed), obtained from lexical decision on a separate set of words. Cloze test scores aimed to assess general L2 proficiency, whereas IES was purported to measure lexical processing efficiency. 109 adult Korean-English L2 speakers participated in the study. Results showed significant main effects of word frequency, cloze test scores, and IES on lexical decision times, replicating previous findings and confirming the predictions of the lexical quality hypothesis. Crucially, IES was revealed to be a better measure of individual differences in L2 lexical quality than were cloze test scores. These findings suggest that lexical quality (which can be operationalized in terms of online lexical processing efficiency) comprises a distinct subdomain of language skills on its own, which cannot be measured in full using conventional language proficiency tests.

This study investigated Korean-English second language (L2) speakers' recognition of high- and low-frequency English words and compared two individual difference measures in their role of representing lexical quality in L2: cloze test scores and inverse efficiency scores (IES; response latency corrected for the amount of errors committed), obtained from lexical decision on a separate set of words. Cloze test scores aimed to assess general L2 proficiency, whereas IES was purported to measure lexical processing efficiency. 109 adult Korean-English L2 speakers participated in the study. Results showed significant main effects of word frequency, cloze test scores, and IES on lexical decision times, replicating previous findings and confirming the predictions of the lexical quality hypothesis. Crucially, IES was revealed to be a better measure of individual differences in L2 lexical quality than were cloze test scores. These findings suggest that lexical quality (which can be operationalized in terms of online lexical processing efficiency) comprises a distinct subdomain of language skills on its own, which cannot be measured in full using conventional language proficiency tests.

Background Using analysis of air samples from the workplace, we report on one case of pneumoconiosis in an individual who has been working in a polytetrafluoroethylene (PTFE) spraying process for 28 years. Case presentation The patient was diagnosed with granulomatous lung disease caused by PTFE using computed tomography (CT), lung biopsy and electron microscopy. To assess the qualitative and quantitative exposure to PTFE in workplace, Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX) and thermogravimetric analysis (TGA) were performed on air samples from the workplace. The presence of PTFE particles was confirmed, and the airborne concentration of PTFE was estimated to be 0.75 mg/m 3 . Conclusions This case demonstrates that long-term exposure to PTFE spraying can cause granulomatous lung lesions such as pneumoconiosis; such lesions appear to be caused not by the degradation products of PTFE from high temperatures but by spraying the particles of PTFE. Along with air-sampling analysis, we suggest monitoring the concentration of airborne PTFE particles related to chronic lung disease.

The goal of this study was to examine how the lexical characteristics of L1 translated words affect L2 word recognition by Korean speakers of English as a foreign language (EFL) with different English proficiency levels. To this end, we conducted a lexical decision task, in which participants decided whether English strings were words or nonwords. The experiment had three critical conditions: (1) English words that only had a loanword translation in Korean (e.g., card), (2) English words whose native word translation had a lower frequency than their loanword translation (e.g., coat), and (3) English words whose native word translation had a higher frequency than their loanword translation (e.g., cash). Results showed that English words whose native word translations in Korean were of high frequency were recognized faster than those with low frequency native word translations. More interestingly, the L1 native word frequency effect was stronger for speakers with lower English proficiency than for more proficient EFL speakers. These findings are discussed with respect to L2 lexical processing models.