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"Christian, David"
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Agriculture 4.0: Broadening Responsible Innovation in an Era of Smart Farming
Agriculture is undergoing a new technology revolution supported by policy-makers around the world. While smart technologies, such as Artificial Intelligence, robotics, and the Internet of Things, could play an important role in achieving enhanced productivity and greater eco-efficiency, critics have suggested that the consideration of social implications is being side-lined. Research illustrates that some agricultural practitioners are concerned about using certain smart technologies. Indeed, some studies argue that agricultural societies may be changed, or “re-scripted,” in undesirable ways, and there is precedent to suggest that wider society may be concerned about radical new agricultural technologies. We therefore encourage policy-makers, funders, technology companies, and researchers to consider the views of both farming communities and wider society. In agriculture, the concept of responsible innovation has not been widely considered, although two recent papers have made useful suggestions. We build on these interventions by arguing that key dimensions of responsible innovation—anticipation, inclusion, reflexivity, and responsiveness—should be applied to this fourth agricultural revolution. We argue, however, that ideas of responsible innovation should be further developed in order to make them relevant and robust for emergent agri-tech, and that frameworks should be tested in practice to see if they can actively shape innovation trajectories. In making suggestions on how to construct a more comprehensive framework for responsible innovation in sustainable agriculture, we call for: (i) a more systemic approach that maps and attends to the wider ecology of innovations associated with this fourth agricultural revolution; (ii) a broadening of notions of “inclusion” in responsible innovation to account better for diverse and already existing spaces of participation in agri-tech, and (iii) greater testing of frameworks in practice to see if they are capable of making innovation processes more socially responsible.
Journal Article
Origin story : a big history of everything
\"Most historians study the smallest slivers of time, emphasizing specific dates, individuals, and documents. But what would it look like to study the whole of history, from the big bang through the present day--and even into the remote future? How would looking at the full span of time change the way we perceive the universe, the earth, and our very existence? These were the questions David Christian set out to answer when he created the field of \"Big History,\" the most exciting new approach to understanding where we have been, where we are, and where we are going. In Origin Story, Christian takes readers on a wild ride through the entire 13.8 billion years we've come to know as \"history.\" By focusing on defining events (thresholds), major trends, and profound questions about our origins, Christian exposes the hidden threads that tie everything together--from the creation of the planet to the advent of agriculture, nuclear war, and beyond. With stunning insights into the origin of the universe, the beginning of life, the emergence of humans, and what the future might bring, Origin Story boldly reframes our place in the cosmos.\"-- Jacket.
Book
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). However, CD19-negative relapses have emerged as a major problem that is observed in approximately 30% of treated patients. Developing approaches to preventing and treating antigen-loss escapes would therefore represent a vertical advance in the field. Here, we found that in primary patient samples, the IL-3 receptor α chain CD123 was highly expressed on leukemia-initiating cells and CD19-negative blasts in bulk B-ALL at baseline and at relapse after CART19 administration. Using intravital imaging in an antigen-loss CD19-negative relapse xenograft model, we determined that CART123, but not CART19, recognized leukemic blasts, established protracted synapses, and eradicated CD19-negative leukemia, leading to prolonged survival. Furthermore, combining CART19 and CART123 prevented antigen-loss relapses in xenograft models. Finally, we devised a dual CAR-expressing construct that combined CD19- and CD123-mediated T cell activation and demonstrated that it provides superior in vivo activity against B-ALL compared with single-expressing CART or pooled combination CART. In conclusion, these findings indicate that targeting CD19 and CD123 on leukemic blasts represents an effective strategy for treating and preventing antigen-loss relapses occurring after CD19-directed therapies.
Journal Article
An achromatic X-ray lens
Diffractive and refractive optical elements have become an integral part of most high-resolution X-ray microscopes. However, they suffer from inherent chromatic aberration. This has to date restricted their use to narrow-bandwidth radiation, essentially limiting such high-resolution X-ray microscopes to high-brightness synchrotron sources. Similar to visible light optics, one way to tackle chromatic aberration is by combining a focusing and a defocusing optic with different dispersive powers. Here, we present the first successful experimental realisation of an X-ray achromat, consisting of a focusing diffractive Fresnel zone plate (FZP) and a defocusing refractive lens (RL). Using scanning transmission X-ray microscopy (STXM) and ptychography, we demonstrate sub-micrometre achromatic focusing over a wide energy range without any focal adjustment. This type of X-ray achromat will overcome previous limitations set by the chromatic aberration of diffractive and refractive optics and paves the way for new applications in spectroscopy and microscopy at broadband X-ray tube sources.
X-ray diffractive and refractive optical elements suffer from chromatic aberrations, limiting high-resolution X-ray microscopes mainly to bright synchrotron sources. Here, the authors experimentally realise an achromatic X-ray lens by combing a focusing diffractive Fresnel zone plate and a defocusing refractive lens.
Journal Article
Exploring the Potential of Precision Livestock Farming Technologies to Help Address Farm Animal Welfare
The rise in the demand for animal products due to demographic and dietary changes has exacerbated difficulties in addressing societal concerns related to the environment, human health, and animal welfare. As a response to this challenge, Precision Livestock Farming (PLF) technologies are being developed to monitor animal health and welfare parameters in a continuous and automated way, offering the opportunity to improve productivity and detect health issues at an early stage. However, ethical concerns have been raised regarding their potential to facilitate the management of production systems that are potentially harmful to animal welfare, or to impact the human-animal relationship and farmers' duty of care. Using the Five Domains Model (FDM) as a framework, the aim is to explore the potential of PLF to help address animal welfare and to discuss potential welfare benefits and risks of using such technology. A variety of technologies are identified and classified according to their type [sensors, bolus, image or sound based, Radio Frequency Identification (RFID)], their development stage, the species they apply to, and their potential impact on welfare. While PLF technologies have promising potential to reduce the occurrence of diseases and injuries in livestock farming systems, their current ability to help promote positive welfare states remains limited, as technologies with such potential generally remain at earlier development stages. This is likely due to the lack of evidence related to the validity of positive welfare indicators as well as challenges in technology adoption and development. Finally, the extent to which welfare can be improved will also strongly depend on whether management practices will be adapted to minimize negative consequences and maximize benefits to welfare.
Journal Article
قصة الأصل : تاريخ جامع لكل شئ
هذا الكتاب رحلة جامحة عبر ال 13.8 مليار سنة التي صرنا نعرفها باسم \"التاريخ\" يكشف الخيوط الخفية التي تربط كل شيء معا من تشكل الكواكب إلى اختراع الزراعة والحرب النووية وما بعدها فيقدم رؤى مدهشة حول أصل الكون وبدايات الحياة وظهور البشر وما قد يأتي به المستقبل إنه قصة آسرة للكون من الانفجار العظيم إلى الديناصورات إلى العولمة الشاملة وما بعدها.
Book
Linking task structure and neural network dynamics
The solutions found by neural networks to solve a task are often inscrutable. We have little insight into why a particular structure emerges in a network. By reverse engineering neural networks from dynamical principles, Dubreuil, Valente et al. show how neural population structure enables computational flexibility.
Journal Article