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"Clark, Willow"
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Motorcycles on the move
From cruisers to superbikes, this book features some of the fastest and most exhilarating motorcycles in the world. Discover how they work, and be introduced to various kinds and their uses.
Book
Five lessons for avoiding failure when scaling in conservation
Many attempts to scale conservation actions have failed to deliver their intended benefits, caused unintended harm or later been abandoned, hampering efforts to bend the curve on biodiversity loss. Here we encourage those calling for scaling to pause and reflect on past scaling efforts, which offer valuable lessons: the total impact of an action depends on both its effectiveness and scalability; effectiveness can change depending on scale for multiple reasons; feedback processes can change socio-ecological conditions influencing future adoption; and the drive to scale can incentivize bad practices that undermine long-term outcomes. Cutting across these themes is the recognition that monitoring scaling can enhance evidence-informed adaptive management, reporting and research. We draw on evidence and concepts from disparate fields, explore new linkages between often isolated concepts and suggest strategies for practitioners, policymakers and researchers. Reflecting on these five lessons may help in the scaling of effective conservation actions in responsible ways to meet the triple goals of reversing biodiversity loss, combating climate change and supporting human wellbeing.
This Perspective encourages conservation practitioners to learn from past efforts to scale conservation actions in the hope that enhanced understanding of linkages between scaling, effectiveness and social justice will benefit future attempts to scale up, out and deep.
Journal Article
Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis
G protein-coupled receptors (GPCRs) mediate a variety of signaling pathways and are the most common pharmacological targets. While advances in structural biochemistry have provided deep functional insights into key receptors, many of the 800+ human GPCRs remain understudied. We introduce a versatile \"deep receptor scanning\" platform that can be used to experimentally characterize 766 human GPCRs and 174 known GPCR splice variants in parallel. We use this platform to quantitatively characterize the relative abundance of canonical and alternative receptor transcripts, their translational efficiency, and the plasma membrane expression of each receptor in the context of a recombinant pool of HEK293T cells expressing individual GPCRs. We then employ machine learning to identify specific structural features that modulate GPCR expression. This experimental platform and informatic approach are compatible with a variety of assays and can be used to efficiently explore the biochemical and pharmacological properties of the GPCRome.
Journal Article
Bikes on the move
A broad introduction to bicycles, including bicycle history, bike safety, and an examination of the many different types of bicycling, from mountain biking to motocross.
Book
Cars on the move
Cars are not just boring vehicles that get us safely to school and work. Some cars are tricked out in funky designs and colors. Others race down tracks at super fast speeds. Learn about these amazing cars in \"Cars on the Move.\"
Book
