Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
590
result(s) for
"Clay, Robert"
Sort by:
BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections
The global crisis of antimicrobial resistance (AMR) necessitates the development of broad-spectrum antibacterial drugs effective against multi-drug resistant (MDR) pathogens. BWC0977, a Novel Bacterial Topoisomerase Inhibitor (NBTI) selectively inhibits bacterial DNA replication via inhibition of DNA gyrase and topoisomerase IV. BWC0977 exhibited a minimum inhibitory concentration (MIC
90
) of 0.03–2 µg/mL against a global panel of MDR Gram-negative bacteria including Enterobacterales and non-fermenters, Gram-positive bacteria, anaerobes and biothreat pathogens. BWC0977 retains activity against isolates resistant to fluoroquinolones (FQs), carbapenems and colistin and demonstrates efficacy against multiple pathogens in two rodent species with significantly higher drug levels in the epithelial lining fluid of infected lungs. In healthy volunteers, single-ascending doses of BWC0977 administered intravenously (
https://clinicaltrials.gov/study/NCT05088421
) was found to be safe, well tolerated (primary endpoint) and achieved dose-proportional exposures (secondary endpoint) consistent with modelled data from preclinical studies. Here, we show that BWC0977 has the potential to treat a range of critical-care infections including MDR bacterial pneumonias.
In this work, the authors probe the efficacy of BWC0977, a bacterial topoisomerase inhibitor, in pre-clinical animal models, also demonstrating that BWC0977 is safe and well tolerated in healthy human volunteers, in a phase 1 trial.
Journal Article
Clinical development of new drug–radiotherapy combinations
The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) includes academia, industry, patient groups and regulatory bodies representatives. In this Consensus Statement, recommendations are provided with the aim of increasing the number of novel drugs being successfully registered in combination with radiotherapy in clinical trials for patients with cancer.
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments. Notably, around 40% of cancer cures include the use of radiotherapy, either as a single modality or combined with other treatments. Radiotherapy can provide enormous benefit to patients with cancer. In the past decade, significant technical advances, such as image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic radiotherapy, and proton therapy enable higher doses of radiotherapy to be delivered to the tumour with significantly lower doses to normal surrounding tissues. However, apart from the combination of traditional cytotoxic chemotherapy with radiotherapy, little progress has been made in identifying and defining optimal targeted therapy and radiotherapy combinations to improve the efficacy of cancer treatment. The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) formed a Joint Working Group with representatives from academia, industry, patient groups and regulatory bodies to address this lack of progress and to publish recommendations for future clinical research. Herein, we highlight the Working Group's consensus recommendations to increase the number of novel drugs being successfully registered in combination with radiotherapy to improve clinical outcomes for patients with cancer.
Journal Article
Dark destiny
\"It's the meeting of the trinities, as the six aforementioned heroes must save DC's Dark Trinity--Red Hood, Artemis and Bizarro! As these three antiheroes are sacrificed into the depths of the Pandora Pits by Circe and Ra's al Ghul, will Superman, Batman and Wonder Woman be able to save their demonically possessed allies?\"-- Provided by publisher.
Book
The big wedding : it's never too late to start acting like a family
To the amusement of their adult children and friends, long divorced couple Don and Ellie Griffin are once again forced to play the happy couple for the sake of their adopted son's wedding after his ultra conservative biological mother unexpectedly decides to fly halfway across the world to attend. With all of the wedding guests looking on, the Griffins are hilariously forced to confront their past, present and future, and hopefully avoid killing each other in the process.
DVD
Building an equity-minded pathway for transfer students
By disaggregating our campus data, the campus planning team developed the following action plan goals: * Implement equity-minded practices with the goal of closing student success gaps of African American transfer students * Develop and offer quality highimpact practices in the junior year of study * Create and assess signature assignments that focus on the junior seminar s social responsibility learning outcome * Increase internship opportunities and workforce preparation for rising juniors converging from general education coursework, our dual degree program, and transfer students from community colleges Given our designation as a completion college (Johnson and Bell 2014) and emphasis on social justice, the campus planning team focused our project on the dual emphasis of faculty development for teaching diverse populations and providing academic support to students in their junior year of college. [...]in our second year, we developed equity score cards for each junior seminar course and presented them to an audience of all college deans and department chairs. CONCLUSION Overall, the campus planning team has worked to incorporate the lessons we learned into our project by (l) refining and refocusing goals for the excellence in equity project, (2) scaling our work beyond the classroom, and (3) integrating the excellence in equity project with other connected initiatives. Since social justice and student success are both key institutional values, the campus planning team is connecting equity efforts more intentionally with our student success initiative (funded by a Title III federal grant) and our Male Success Initiative (funded by the Kresge Foundation).
Journal Article
SEXUAL SELECTION ON PLUMAGE AND BEHAVIOR IN AN AVIAN HYBRID ZONE: EXPERIMENTAL TESTS OF MALE-MALE INTERACTIONS
In western Panama, an unusual hybrid zone exists between white-collared manakins, Manacus candei, and golden-collared manakins, M. vitellinus. Unidirectional introgression of plumage traits from vitellinus into candei has created a region in which all definitively plumaged males have a collar that is lemon-colored. These males are nearly indistinguishable from white-collared candei genetically and morphometrically, but strongly resemble golden-collared vitellinus due to the introgression of secondary sexual plumage traits, particularly the lemon-colored collar. The introgression could be explained by sexual selection for golden-collared traits or by a series of mechanisms that do not invoke sexual selection (e.g., neutral diffusion, dominant allele). Sexual selection on male-male interactions implies behavioral differences among the plumage forms—specifically that golden- and lemon-collared males should be more aggressive than white-collared males. In contrast, the nonsexual hypotheses predict behavioral similarity between lemon- and white-collared males, based on their nearly identical genetics. We tested the sexual selection hypothesis experimentally, by presenting males with taxidermic mounts of the three forms. As response variables, we monitored vocalizations and attacks on the mounts by replicate subject males. Both golden-collared and lemon-collared males were more likely to attack than were white-collared males, as predicted under sexual selection but not by the nonsexual hypotheses. Lemon-collared males were more vocally reactive than either parental form, contrary to the prediction of the nonsexual hypotheses. Our study demonstrates that sexual selection on male-male interactions may play an important role in the dynamics of character evolution and hybrid zones. Corresponding Editor: B. Crespi
Journal Article