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Microvolt T-wave alternans testing provides a reliable means of guiding anti-arrhythmic therapy
The ICD implantation itself is associated with an inhospital mortality of approximately 1% and a high complication rate subsequent to implantation.7 Conversely, patients with a non-negative MTWA test have SCD event rates that are greater than the event rates in the studies for which ICD therapy was demonstrated to provide a mortality benefit. [...]ICD therapy has been directly demonstrated to provide a mortality benefit only in patients with a non-negative MTWA result but not in patients with a negative result.8 Consistent with other analyses,3,6,8 the results of Gupta et al1--when surrogate end points are excluded--indicate that, in fact, MTWA testing is an accurate and reliable means of guiding antiarrhythmic therapy.
Journal Article
