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Most business schools require students to take at least one technical Management Information System (MIS) course. Due to the technical nature of the material, the course and the assessments tend to be anxiety inducing. With over three out of every five students in US colleges suffering from \"overwhelming anxiety\" in some form, we study whether or not the perception of test format congruence (i.e., ability to reward knowledge) leads to satisfaction with the test format and lower test anxiety. In this study, we also considered the impact risk-taking profiles have on satisfaction with the test format. Using data collected from our survey, we conducted an exploratory factor analysis on the measurement model and a confirmatory factor analysis on the structural model. We found that test congruence positively impacts satisfaction with the format, satisfaction impacts anxiety negatively, and risk profile does not seem to play a role. These findings contribute theoretically as we create an integrated framework grounded in different theoretical views. The findings also have practical implications as they allow instructors to see that aligning assessments to reward knowledge can help manage students' anxiety.

Student cheating is a growing concern in all aspects of higher education, particularly in technical programs such as information systems. Technology is also enabling student cheating. This paper utilizes existing literature and various behavioral theories, including incentive theory, the theory of planned behavior, social reciprocity theory, expected utility theory, and deterrence theory to develop a model of cheating incentive in students. The model was tested using a survey of 245 undergraduate students in a decision sciences class at a large US land-grant university, with the results showing that the incentive to cheat is predicted by the student's satisfaction with the assessment process and observed cheating by peers. Perceived evaluation congruence (the perception of the student that the exam measures knowledge of the course material) was, in turn, found to be a precursor of satisfaction. Many institutions focus on increasing the risk of being caught and punished, but focusing on the student's satisfaction with the assessment process as a way of reducing the incentive to cheat is also key. This may begin a virtuous cycle, where greater congruence between the class material and the assessment mechanism leads to greater satisfaction with the assessment, which leads to a reduction in the incentive to cheat. This, in turn, leads to more valid testing data for the instructor, which leads to even greater congruence and satisfaction. The reduction in individual cheating will lead to a reduction in observed cheating, lowering the incentive to cheat even further.

The Internet and social computing technology have revolutionized our ability to gather information as well as enabled new modes of communication and forms of self-expression. As the popularity of social computing technologies has increased, our society has begun to witness modifications in socialization behaviors. Social psychology theory suggests that technological changes can influence an individual’s expectation of privacy, through adaptive behaviors resulting from use (Laufer and Wolfe in J Soc Issues 33(3): 22–42 ( 1977 )). We adapt traditional privacy theory to explore the influence of developmental and environmental factors on the individual’s inner privacy identity, which is comprised of the individual’s belief in his or her right to control (1) personal information and (2) interactions with others, and is continuously shaped by privacy experiences. We then use the inner privacy identity to examine interpersonal behaviors in the online context. We find that individuals’ belief in their right to control their information impacts their information disclosure practices when consequences are implied and that their belief in their right to control the interaction impacts their online information sharing practices. We do not find support for a relationship between the interaction management component of the IPI and online interaction behavior, which considered in the presence of the relationship between interaction management and online information sharing, suggests that interaction behavior is more complicated in the online context. Insights from the model developed in this study can inform future studies of situational privacy behaviors.

PurposeThis research aims at understanding the routes public e-marketplaces take, in the motor carrier spot market, to generate trust among participants.Design/methodology/approachThis work borrows cue signaling theory and an e-marketplace content analysis instrument from information systems literature. Our primary data captures differences in usage of a broad spectrum of cues between motor carrier spot e-marketplaces and a control sample.FindingsTransportation e-marketplaces use graphical cues more frequently than the control sample, display these cues on their “operational path” (where users click to conduct transactions) and try to generate beliefs in participants' integrity and competence.Research limitations/implicationsThe motor carrier online spot market constitutes a relevant test bed for trust-related theories. Several levels of trust-building conceptualizations are tested; the cue level shows the most potential. This paper extends cue signaling theory in the transportation e-marketplace context and calls for further work on operational path cues to enrich swift trust theories.Practical implicationsThis study helps e-marketplace designers by identifying essential and facultative cues for the motor carrier spot market.Originality/valueResearch on public spot e-marketplaces in the motor carrier context is scant. The context is described in detail to show its specificities in structures and behaviors. This helps to contribute to both practice and research. By evolving an existing research instrument from information systems literature, this study ensures replicability (problematic in academic research) .

As a student from France in Pittsburgh, I was surprised by Pittsburgh's environmental design.

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with rising incidence and a remarkable resistance to current therapies. The reasons for this therapeutic failure include the tumor's extensive infiltration by immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). By using light sheet fluorescent microscopy, we identified here direct interactions between these major immunoregulatory cells in PDAC. The depletion of MDSCs led to a significant reduction in Tregs in the pancreatic tumors. Through videomicroscopy and functional assays we have shown that (i) MDSCs are able to induce Treg cells in a cell-cell dependent manner; (ii) Treg cells affect the survival and/or the proliferation of MDSCs. Furthermore, we have observed contacts between MDSCs and Treg cells at different stages of human cancer. Overall our findings suggest that interactions between MDSCs and Treg cells contribute to PDAC immunosuppressive environment.

Vascular Ehlers-Danlos syndrome is a rare severe disease that causes arterial dissections and ruptures that can lead to early death. No preventive treatment has yet been validated. Our aim was to assess the ability of celiprolol, a β1-adrenoceptor antagonist with a β2-adrenoceptor agonist action, to prevent arterial dissections and ruptures in vascular Ehlers-Danlos syndrome. Our study was a multicentre, randomised, open trial with blinded assessment of clinical events in eight centres in France and one in Belgium. Patients with clinical vascular Ehlers-Danlos syndrome were randomly assigned to 5 years of treatment with celiprolol or to no treatment. Randomisation was done from a centralised, previously established list of sealed envelopes with stratification by patients' age (≤32 years or >32 years). 33 patients were positive for mutation of collagen 3A1 (COL3A1). Celiprolol was administered twice daily and uptitrated every 6 months by steps of 100 mg to a maximum of 400 mg per day. The primary endpoints were arterial events (rupture or dissection, fatal or not). This study is registered with ClinicalTrials.gov, number NCT00190411. 53 patients were randomly assigned to celiprolol (25 patients) or control groups (28). Mean duration of follow-up was 47 (SD 5) months, with the trial stopped early for treatment benefit. The primary endpoints were reached by five (20%) in the celiprolol group and by 14 (50%) controls (hazard ratio [HR] 0·36; 95% CI 0·15–0·88; p=0·040). Adverse events were severe fatigue in one patient after starting 100 mg celiprolol and mild fatigue in two patients related to dose uptitration. We suggest that celiprolol might be the treatment of choice for physicians aiming to prevent major complications in patients with vascular Ehlers-Danlos syndrome. Whether patients with similar clinical presentations and no mutation are also protected remains to be established. French Ministry of Health, Programme Hospitalier de Recherche Clinique 2001.

Replication-deficient chimpanzee adenovirus (ChAd) vectors represent an attractive vaccine platform and are thus employed as vaccine candidates against several infectious diseases. Since inducing effective immunity depends on the interplay between innate and adaptive immunity, a deeper understanding of innate immune responses elicited by intramuscularly injected ChAd vectors in tissues can advance the platform’s development. Using different candidate vaccines based on the Group C ChAd type 155 (ChAd155) vector, we characterized early immune responses in injected muscles and draining lymph nodes (dLNs) from mice, and complemented these analyses by evaluating cytokine responses and gene expression patterns in peripheral blood from ChAd155-injected macaques. In mice, vector DNA levels gradually decreased post-immunization, but local transgene mRNA expression exhibited two transient peaks [at 6 h and Day (D)5], which were most obvious in dLNs. This dynamic pattern was mirrored by the innate responses in tissues, which developed as early as 1–3 h (cytokines/chemokines) or D1 (immune cells) post-vaccination. They were characterized by a CCL2- and CXCL9/10-dominated chemokine profile, peaking at 6 h (with CXCL10/CCL2 signals also detectable in serum) and D7, and clear immune-cell infiltration peaks at D1/D2 and D6/D7. Experiments with a green fluorescent protein-expressing ChAd155 vector revealed infiltrating hematopoietic cell subsets at the injection site. Cell infiltrates comprised mostly monocytes in muscles, and NK cells, T cells, dendritic cells, monocytes, and B cells in dLNs. Similar bimodal dynamics were observed in whole-blood gene signatures in macaques: most of the 17 enriched immune/innate signaling pathways were significantly upregulated at D1 and D7 and downregulated at D3, and clustering analysis revealed stronger similarities between D1 and D7 signatures versus the D3 signature. Serum cytokine responses (CXCL10, IL1Ra, and low-level IFN-α) in macaques were predominantly observed at D1. Altogether, the early immune responses exhibited bimodal kinetics with transient peaks at D1/D2 and D6/D7, mostly with an IFN-associated signature, and these features were remarkably consistent across most analyzed parameters in murine tissues and macaque blood. These compelling observations reveal a novel aspect of the dynamics of innate immunity induced by ChAd155-vectored vaccines, and contribute to ongoing research to better understand how adenovectors can promote vaccine-induced immunity.

Herein, transient releases either from NADH-loaded liposomes or enzymatic reactions confined in giant liposomes were imaged by electrochemiluminescence (ECL). NADH was first encapsulated with the [Ru(bpy)3]2+ luminophore inside giant liposomes (around 100 µm in diameter) made of DOPC/DOPG phospholipids (i.e., 1,2-dioleolyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol-3-phospho-(1′-rac-glycerol) sodium salt) on their inner- and outer-leaflet, respectively. Then, membrane permeabilization triggered upon contact between the liposome and a polarized ITO electrode surface and ECL was locally generated. Combination of amperometry, photoluminescence, and ECL provided a comprehensive monitoring of a single liposome opening and content release. In a second part, the work is focused on the ECL characterization of NADH produced by glucose dehydrogenase (GDH)-catalyzed oxidation of glucose in the confined environment delimited by the liposome membrane. This was achieved by encapsulating both the ECL and catalytic reagents (i.e., the GDH, glucose, NAD+, and [Ru(bpy)3]2+) in the liposome. In accordance with the results obtained, NADH can be used as a biologically compatible ECL co-reactant to image membrane permeabilization events of giant liposomes. Under these conditions, the ECL signal duration was rather long (around 10 s). Since many enzymatic reactions involve the NADH/NAD+ redox couple, this work opens up interesting prospects for the characterization of enzymatic reactions taking place notably in artificial cells and in confined environments.

Non-coding RNAs (ncRNA) represent 1/5 of the mammalian transcript number, and 90% of the genome length is transcribed. Many ncRNAs play a role in cancer. Among them, non-coding natural antisense transcripts (ncNAT) are RNA sequences that are complementary and overlapping to those of either protein-coding (PCT) or non-coding transcripts. Several ncNATs were described as regulating protein coding gene expression on the same loci, and they are expected to act more frequently in cis compared to other ncRNAs that commonly function in trans . In this work, 22 breast cancers expressing estrogen receptors and their paired adjacent non-malignant tissues were analyzed by strand-specific RNA sequencing. To highlight ncNATs potentially playing a role in protein coding gene regulations that occur in breast cancer, three different data analysis methods were used: differential expression analysis of ncNATs between tumor and non-malignant tissues, differential correlation analysis of paired ncNAT/PCT between tumor and non-malignant tissues, and ncNAT/PCT read count ratio variation between tumor and non-malignant tissues. Each of these methods yielded lists of ncNAT/PCT pairs that were enriched in survival-associated genes. This work highlights ncNAT lists that display potential to affect the expression of protein-coding genes involved in breast cancer pathology.