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"Collins, Catherine Fisher"
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Black girls and adolescents : facing the challenges
\"This one-of-a kind book challenges the current thinking about Black girls to show how America has failed them--and what can be done to make their lives better\"-- Provided by publisher.
Book
One in 18?
Why is it that so many Black women - so many Black men, for that matter - end up in prison in such disproportionate numbers without any kind of public outcry?
Newspaper Article
African American Women's Life Issues Today
Written by an all-female, all- African American team of health experts that include nurse practitioners, registered nurses, educators, and psychologists, this book focuses on the diseases and related social issues that cause the greatest harm and pose the greatest threat to African American women today.
Book Review
The Imprisonment of African-American Women: Causes, Conditions, and Future Implications
Miller reviews \"The Imprisonment of African-American Women: Causes, Conditions, and Future Implications\" by Catherine Fisher Collins.
Book Review
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary
Genomics can inform both tissue-of-origin (TOO) and precision treatments for patients with cancer of unknown primary (CUP). Here, we use whole genome and transcriptome sequencing (WGTS) for 72 patients and show diagnostic superiority of WGTS over panel testing (386–523 genes) in 71 paired cases. WGTS detects all reportable DNA features found by panel as well as additional mutations of diagnostic or therapeutic relevance in 76% of cases. Curated WGTS features and a CUP prediction algorithm (CUPPA) trained on WGTS data of known cancer types informs TOO in 71% of cases otherwise undiagnosed by clinicopathology review. WGTS informs treatments for 79% of patients, compared to 59% by panel testing. Finally, WGS of cell-free DNA (cfDNA) from patients with a high cfDNA tumour fraction (>7%), enables high-likelihood CUPPA predictions in 41% of cases. WGTS is therefore superior to panel testing, broadens treatment options, and is feasible using routine pathology samples and cfDNA.
Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.
Journal Article