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X-Men: Legion : Shadow King rising
David Haller is no ordinary mutant. Son of Charles Xavier, founder of the X-Men, David's incredible mental powers fractured his mind and now, each of his personalities controls a different ability! And they're not all friendly, as Xavier and the New Mutants find out the hard way! But as Legion struggles to control the chaos in his head, he attracts the attention of one of Xavier's oldest and most malevolent foes: Amahl Farouk, the Shadow King, who's secretly been stalking and manipulating the X-Men and their allies. When the Shadow King sinks his hooks deep into David's mind, will two teams of X-Men be enough to defeat him -- or will David be the key to the villain's ultimate victory? Includes the Muir Island Saga storyline.
BOOK
Differential splicing across immune system lineages
Alternative splicing (AS) allows increased diversity and orthogonal regulation of the transcriptional products of mammalian genomes. To assess the distribution and variation of alternative splicing across cell lineages of the immune system, we comprehensively analyzed RNA sequencing and microarray data generated by the Immunological Genome Project Consortium. AS is pervasive: 60% of genes showed frequent AS isoforms in T or B lymphocytes, with 7,599 previously unreported isoforms. Distinct cell specificity was observed, with differential exon skipping in 5% of genes otherwise coexpressed in both B and T cells. The distribution of isoforms was mostly all or none, suggesting on/off switching as a frequent mode of AS regulation in lymphocytes. From the identification of differential exon use in the microarray data, clustering of exon inclusion/exclusion patterns across all Immunological Genome Project cell types showed that ∼70% of AS exons are distributed along a common pattern linked to lineage differentiation and cell cycling. Other AS events distinguished myeloid from lymphoid cells or affected only a small set of exons without clear lineage specificity (e.g., Ptprc). Computational analysis predicted specific associations between AS exons and splicing regulators, which were verified by detection of the hnRPLL/ Ptprc connection.
Journal Article
Estuche Good to Great + Girando la Rueda
Good to great: Referenciado como uno de los diez mejores libros sobre gestión empresarial, \"Good to Great\" nos ofrece todo un conjunto de directrices y paradigmas que debe adoptar cualquier empresa que pretenda diferenciarse de las demás. Después de revisar montañas de datos, de hacer miles de entrevistas y de utilizar rigurosas.
eBook
Knowledge, Attitudes, and Practices of Nonpharmaceutical Interventions following School Dismissals during the 2009 Influenza A H1N1 Pandemic in Michigan, United States
Many schools throughout the United States reported an increase in dismissals due to the 2009 influenza A H1N1 pandemic (pH1N1). During the fall months of 2009, more than 567 school dismissals were reported from the state of Michigan. In December 2009, the Michigan Department of Community Health, in collaboration with the United States Centers for Disease Control and Prevention, conducted a survey to describe the knowledge, attitudes, and practices (KAPs) of households with school-aged children and classroom teachers regarding the recommended use of nonpharmaceutical interventions (NPIs) to slow the spread of influenza.
A random sample of eight elementary schools (kindergarten through 5th grade) was selected from each of the eight public health preparedness regions in the state. Within each selected school, a single classroom was randomly identified from each grade (K-5), and household caregivers of the classroom students and their respective teachers were asked to participate in the survey.
In total, 26% (2,188/8,280) of household caregivers and 45% (163/360) of teachers from 48 schools (of the 64 sampled) responded to the survey. Of the 48 participating schools, 27% (13) experienced a school dismissal during the 2009 fall term. Eighty-seven percent (1,806/2,082) of caregivers and 80% (122/152) of teachers thought that the 2009 influenza A H1N1 pandemic was severe, and >90% of both groups indicated that they told their children/students to use NPIs, such as washing hands more often and covering coughs with tissues, to prevent infection with influenza.
Knowledge and instruction on the use of NPIs appeared to be high among household caregivers and teachers responding to the survey. Nevertheless, public health officials should continue to explain the public health rationale for NPIs to reduce pandemic influenza. Ensuring this information is communicated to household caregivers and teachers through trusted sources is essential.
Journal Article
New capability for ozone dial profiling measurements in the troposphere and lower stratosphere from aircraft
Recently, we successfully demonstrated a new compact and robust ozone DIAL lidar for smaller aircraft such as the NASA B200 and the ER-2 high-altitude aircraft. This is the first NASA airborne lidar to incorporate advanced solid-state lasers to produce the required power at the required ultraviolet wavelengths, and is compact and robust enough to operate nearly autonomously on the high-altitude ER-2 aircraft. This technology development resulted in the first new NASA airborne ozone DIAL instrument in more than 15 years. The combined ozone, aerosol, and clouds measurements provide valuable information on the chemistry, radiation, and dynamics of the atmosphere. In particular, from the ER-2 it offers a unique capability to study the upper troposphere and lower stratosphere.
Journal Article
The Use Values of Narrativity in Digital Cultures
This article investigates the changing use values of narrativity in the early twenty-first century by focusing on the frenetic expansion of narrative universes. Popular narratives continue to have the power to mesmerize, but now they also serve another function—they exist to be made use of, to be taken up and extended by professionals and amateurs alike. This article looks at two parallel dimensions of this expansion--narrative “world building” and quality serial television. How do we develop a better understanding of how narrativity moves across media when books, films, and television programs are all MP3 files which “play” on the same screens on our personal digital devices? How does it change the way we tell stories? How does it change how we encounter culture and make it our own? Those questions must be pursued in tandem, because if “narrative theory” is to become relevant again in the twenty-first century, it has to account for how narrative texts—whether they be novels, films, television programs, or web series—are shaped by how we acquire, curate, and “play” them across ever more diversified formats within the devices which are the repositories of all our cultural stuff.
Journal Article
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
By comparing gene-expression profiles, Randolph and colleagues distinguish different types of macrophages and pinpoint the differences between macrophages and dendritic cells.
We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages rather than dendritic cells, and many of these were not present in all macrophages. Nonetheless, well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages. TCEF3, C/EBP-α, Bach1 and CREG-1 were among the transcriptional regulators predicted to regulate these core macrophage-associated genes. The mRNA encoding other transcription factors, such as
Gata6
, was associated with single macrophage populations. We further identified how these transcripts and the proteins they encode facilitated distinguishing macrophages from dendritic cells.
Journal Article
Reading, in a Digital Archive of One's Own
WHAT ARE WE REALLY TALKING ABOUT WHEN WE TALK ABOUT THE STATE OF READING? AND WHAT DO WE HOPE TO LEARN FROM THE Answers to that question? Confirmation of deeply held prejudices, or a better understanding of what reading means in digital cultures? We need to pose those questions right up front because the debate about the state of reading has been precipitated by the increasing ubiquity of the e-book, even though reading culture has been undergoing massive infrastructural changes for over a decade in the United States. The public discourse on the state of reading and on whether it has a viable future has focused on the future of the book and of literary reading now that e-books have apparently changed everything. The state of reading, as such, is not at stake because it doesn't seem likely that firemen from Ray Bradbury's Fahrenheit 451 will be swinging by your place anytime soon to torch your books and replace them with a well-appointed wall screen, eliminating reading forever in favor of mindless viewing. People will keep reading, if only to take in the endless text that comes at them on their various screens, from the ones on the wall to the ones they carry around with them everywhere on their portable devices. Try looking at those screens without reading. No, it's clear from the assumptions that underpin the end-is-near pronouncements about the e-book that there's reading and then there's reading and that when people talk about the future of reading, they're worried about whether readers worthy of the name will continue reading literary fiction in the twenty-first century. But that isn't a very interesting question because it imagines the act of reading in such an ahistorical manner, curled up in a well-upholstered time warp, far from the unruliness of contemporary reading cultures.
Journal Article
Deciphering the transcriptional network of the dendritic cell lineage
The transcriptional regulation of commitment to the dendritic cell (DC) lineage and functional specialization of DCs
in vivo
is poorly understood. In this Resource, Merad and colleagues identify the lineage relationships among various tissue DC subsets.
Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs
in vivo
remains poorly understood. We made a comprehensive comparative analysis of CD8
+
, CD103
+
, CD11b
+
and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.
Journal Article