Explore the vast range of titles available.

Sarah Colquhoun's teaching experience was predominantly in small rural schools where libraries did not exist, however she always loved finding innovative ways to expose her students to literature by integrating quality children's literature across all curriculum areas. Since completing a Master of Education in Teacher Librarianship 12 years ago, Sarah has had experience working in public, university, secondary and primary school libraries. By visiting a range of different school libraries and speaking with staff and students we were able to collect data and analyse our observations to contribute to our understanding of a dynamic library environment. [...]the literature that tells us that school libraries can be safe and reliable spaces for students; that libraries are valued fortheircapacitytofosterbelonging and sanctuary (Merga, 2021) hadn't been published when we started our discussion. Wording can make a big difference because a precise way a question is stated plays an important role in determining the nature of the data that will be required to provide an adequate answer.

The COVID-19 pandemic presented enormous data challenges in the United States. Policy makers, epidemiological modelers, and health researchers all require up-to-date data on the pandemic and relevant public behavior, ideally at fine spatial and temporal resolution. The COVIDcast API is our attempt to fill this need: Operational since April 2020, it provides open access to both traditional public health surveillance signals (cases, deaths, and hospitalizations) and many auxiliary indicators of COVID-19 activity, such as signals extracted from deidentified medical claims data, massive online surveys, cell phone mobility data, and internet search trends. These are available at a fine geographic resolution (mostly at the county level) and are updated daily. The COVIDcast API also tracks all revisions to historical data, allowing modelers to account for the frequent revisions and backfill that are common for many public health data sources. All of the data are available in a common format through the API and accompanying R and Python software packages. This paper describes the data sources and signals, and provides examples demonstrating that the auxiliary signals in the COVIDcast API present information relevant to tracking COVID activity, augmenting traditional public health reporting and empowering research and decision-making.

Spinal cord injury (SCI) occurs when the spinal cord is physically crushed, impinged, severed, or otherwise damaged; resulting in irreversible disruption to the neuronal pathways responsible for motor and sensory function. The main obstacles to spinal cord repair include neuronal damage, loss of oligodendrocytes (leading to axonal demyelination), and scar formation with glial and fibrotic components. Despite the prevalence of SCI and its costly impact on society, treatment remains limited. Ependymal cells (ECs) lining the central canal show promise as a pool of endogenous stem cells within the spinal cord. These cells are found to proliferate, differentiate, and migrate in response to injury, however at present, little is known about this neurogenic niche and how the local microenvironment influences cellular behaviour. This project aims to investigate whether endogenous EC behaviour can be altered by manipulating the properties of the surrounding matrix. Nestin is a type VI intermediate filament protein and a marker of neural stem and progenitor cells in the central nervous system. Characterisation of transgenic mice expressing green fluorescent protein (GFP) under the control of nestin was carried out within this thesis; identifying these cells as ECs and pericytes in the spinal cord. (Nestin) GFP-positive ECs colocalised with a number of stem cell markers including: CD24, Sox2, and foxJ1. ECs were also shown to express chemokine receptor type 4 (CXCR4), the main receptor to stromal cell-derived factor-1 (SDF-1); both of which are involved in the directed migration of neural cells through chemotaxis. The results of spinal cord slice cultures and intraspinal injections presented in this thesis suggest that EC behaviour can be manipulated using hydrogels and SDF-1α; towards repair of SCI.

Using Amstein's (1969) ladder of participation and Treseder's (1997) degrees of participation, this study looks at ways of increasing the involvement of children with learning disabilities in their individualised educational programmes (IEPs). It adopts an action research model, consisting of four cycles of research. Each cycle feeds directly into classroom practice and is designed to increase the children's participation in the IEP process. The study uses a variety of data collection methods. Throughout the research process, these methods are re-negotiated with the participants in order to take into account pragmatic and ethical issues. The study suggests a number of interventions and strategies to increase the children's knowledge and understanding of their targets, to involve them in the setting of their targets and to help them to participate in the IEP review meetings. However, it also concludes that the structure and procedures of such meetings need to change to enable children with learning difficulties to play an active and meaningful role. In addition, it maintains that if this group of children are going to be meaningfully and actively involved in decision-making processes, researchers need to adopt an expanded social model of disability and develop and explore more effective ways of communicating with them. If this does not happen there is a danger that their voices will be silenced or ignored.

If there were jobs out there, people would prefer to be working, and not receiving the pittance that the provincial government now provides for general welfare. The minister's suggestion that welfare recipients do not have to look for work reinforces myths that are not true, and as such is offensive and uninformed. [Sarah E. Colquhoun] Kinna-Aweya Legal Clinic Thunder Bay

Mr. [Paul Martin] suggests that the unemployment rate has doubled since the sixties because of our social programs. Surprise. Those programs were around in the sixties. It is not the social programs that are not working, it is the economy. Cuts in social programs will simply mean that more Canadians will live in misery, and we cannot let that happen. [Sarah E.

The article discusses the changes that have been implemented in the social assistance system, reducing the benefits paid to recipients, and the huge backlog and delays associated with the appeal system. It then states that \"none of this would pose a problem were it not for payment of interim assistance.\" Oh yeah? What about the thousands of appellants who are not receiving interim assistance, many of whom are also not receiving benefits to which they are entitled?

Thunder Bay, Ont. -- Most of the reports about the proposed changes to the Unemployment Insurance Act speak of people no longer being eligible for unemployment insurance if they leave their job without \"good reason.\" In fact, what the legislation requires is that claimants prove that they had \"just cause\" to leave their employment, a legal test that is much stricter than good reason.

Most of the reports about the proposed changes to the Unemployment Insurance Act speak of people no longer being eligible for unemployment insurance if they leave their job without \"good reason.\" In fact, what the legislation requires is that claimants prove that they had \"just cause\" to leave their employment, a legal test that...

Our understanding of the rapid adaptation of bacteria to resist novel drugs is growing beyond known mechanisms such as mobile genetic elements and mutation selection. Heteroresistance (HR) is a form of antibiotic resistance where a phenotypically unstable minority resistant subpopulation co-exists with a susceptible population. We sought to uncover the mechanism of heteroresistance to cefiderocol, a novel β-lactam developed to resist β-lactamases including extended-spectrum-β-lactamases (ESBLs), which has been recently reported but poorly understood. We observe HR to cefiderocol among clinical isolates collected before its use. The resistant subpopulation in Enterobacter is a continuum; increasing copy number of a gene encoding an ESBL ineffective against cefiderocol mediates increased resistance in decreasing numbers of cells. We then pursued the factors that control the magnitude of amplification. We observe that ESBL activity correlates with the level of amplification, and thus that increased copy number can compensate for poor enzymatic activity. A Klebsiella isolate from a clinical treatment failure also demonstrates amplification, highlighting the potential relevance of this β-lactamase gene amplification-mediated HR. These data provide insights into factors controlling dynamics of HR and how bacteria can use gene amplification to flexibly confront new antibiotic threats. Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular subpopulations, flexibly overcoming enhanced β-lactams without new evolution and threatening the β-lactam pipeline.