Explore the vast range of titles available.

A photoelectrochemical sensor composed of a heterojunction between titanium dioxide and gold nanoparticles was fabricated and used for the determination of ciprofloxacin, a widely used, but environmentally toxic third‐generation antibiotic. This material has been extensively characterized from the morphological, electrochemical and photoelectrochemical points of view, comparing it with the respective counterparts. It has been demonstrated that only the presence of the heterojunction allows the detection of ciprofloxacin, thanks to the properties of gold nanoparticles combined with those of titanium dioxide. These increased performances have allowed the detection of the analyte even with low power sources and wavelengths in the visible region, obtaining good detection limits and excellent resistance to possible interferents. Thanks to this, the future implementation of these sensors in integrated circuits for online and onsite analysis is foreseen. Photoelectrochemical detection of ciprofloxacin: A heterojunction formed by titanium dioxide and gold nanoparticles can determine ciprofloxacin by photoelectrochemical analysis. Thanks to the synergistic properties of the two materials, it is possible to use low‐power and visible light sources and limit interferences.

Nature-based Solutions (NbS) offer a promising, sustainable framework for addressing urban environmental challenges by harnessing the intrinsic functions of natural ecosystems. Defined as economically viable strategies inspired by nature, NbS aim to protect, manage, and restore ecosystems for mutual benefits to both people and nature. In urban and peri-urban contexts, NbS, such as green infrastructure and bioremediation, provide effective approaches to mitigating climate change, enhancing soil, air and water quality, reducing urban heat, and restoring ecological balance. Green infrastructure, comprising parks, urban forests, green roofs, and wetlands, has been shown to improve soil quality by enhancing organic carbon, nitrogen, and phosphorus accumulation, as well as fostering biodiversity. Complementarily, bioremediation strategies, including microbial remediation and phytoremediation, have proven effective in decontaminating soils laden with heavy metals, petroleum hydrocarbons, microplastics, and other pollutants, while promoting soil fertility and ecosystem services. Despite their demonstrated benefits, the efficacy of NbS is influenced by environmental factors such as soil pH, temperature, oxygen availability, and pollutant diversity. In addition, while NbS continue to evolve and their integration into urban planning represents a vital step toward creating resilient, healthy, and sustainable cities, their application in urban environments remains fragmented. Therefore, further research is required to optimize NbS interventions, scale up their implementation, and evaluate long-term impacts under urban conditions characterized by anthropogenic stressors. This review examines green infrastructure and bioremediation strategies, highlighting key case studies and evaluating their effects on soil quality and overall remediation outcomes.

Invited for this issue's Front Cover is the group of Electroanalytical Chemistry of Prof. Luigi Falciola. The Cover Feature shows the photoelectrochemical sensor prepared by covering AuNPs with a thin layer of TiO2. The obtained hybrid material, which exploits synergistically the properties of its components, was used to monitor ciprofloxacin, exhibiting a response only once irradiated. Good performances were obtained using a low‐power LED. Such discovery may pave the way for future in situ applications in environmental monitoring. Read the full text of the Research Article at 10.1002/celc.202201136. “This paper describes a photoelectrochemical sensor obtained by combining gold nanoparticles and titanium dioxide. After a wide electrochemical characterization, the analytical performances were tested using low power LED irradiation obtaining promising results that pave the way for future applications…“ Learn more about the story behind the research featured on the front cover in this issue's Cover Profile. Read the corresponding Research Article at 10.1002/celc.202201136.

The Front Cover shows the photoelectrochemical sensor prepared by covering gold nanoparticles (AuNPs) with a thin layer of TiO2. The obtained hybrid material, which exploits synergistically the properties of its components, was used to monitor ciprofloxacin, exhibiting a response only once irradiated. Good performances were obtained using a low‐power LED. Such discovery may pave the way for future in situ applications in environmental monitoring. More information can be found in the Research Article by D. Fumagalli et al.

Summary Objectives Danusertib is a serine/threonine kinase inhibitor of multiple kinases, including aurora-A, B, and C. This explorative study aims to identify possible relationships between single nucleotide polymorphisms in genes coding for drug metabolizing enzymes and transporter proteins and clearance of danusertib, to clarify the interpatient variability in exposure. In addition, this study explores the relationship between target receptor polymorphisms and toxicity of danusertib. Methods For associations with clearance, 48 cancer patients treated in a phase I study were analyzed for ABCB1 , ABCG2 and FMO3 polymorphisms. Association analyses between neutropenia and drug target receptors, including KDR, RET, FLT3, FLT4, AURKB and AURKA, were performed in 30 patients treated at recommended phase II dose-levels in three danusertib phase I or phase II trials. Results No relationships between danusertib clearance and drug metabolizing enzymes and transporter protein polymorphisms were found. Only, for the one patient with FMO3 18281AA polymorphism, a significantly higher clearance was noticed, compared to patients carrying at least 1 wild type allele. No effect of target receptor genotypes or haplotypes on neutropenia was observed. Conclusions As we did not find any major correlations between pharmacogenetic variability in the studied enzymes and transporters and pharmacokinetics nor toxicity, it is unlikely that danusertib is highly susceptible for pharmacogenetic variation. Therefore, no dosing alterations of danusertib are expected in the future, based on the polymorphisms studied. However, the relationship between FMO3 polymorphisms and clearance of danusertib warrants further research, as we could study only a small group of patients.

Background Tuberous sclerosis complex (TSC) is a rare, multisystem, genetic disorder with an estimated prevalence between 1/6800 and 1/15000. Although recent years have seen huge progress in understanding the pathophysiology and in the management of TSC, several questions remain unanswered. A disease registry could be an effective tool to gain more insights into TSC and thus help in the development of improved management strategies. Methods T uber O us SC lerosis registry to increase disease A wareness (TOSCA) is a multicentre, international disease registry to assess manifestations, interventions, and outcomes in patients with TSC. Patients of any age diagnosed with TSC, having a documented visit for TSC within the preceding 12 months, or newly diagnosed individuals are eligible. Objectives include mapping the course of TSC manifestations and their effects on prognosis, identifying patients with rare symptoms and co-morbidities, recording interventions and their outcomes, contributing to creation of an evidence-base for disease assessment and therapy, informing further research on TSC, and evaluating the quality of life of patients with TSC. The registry includes a ‘core’ section and subsections or ‘petals’. The ‘core’ section is designed to record general information on patients’ background collected at baseline and updated annually. Subsections will be developed over time to record additional data related to specific disease manifestations and will be updated annually. The registry aimed to enrol approximately 2000 patients from about 250 sites in 31 countries. The initial enrolment period was of 24 months. A follow-up observation period of up to 5 years is planned. Results A pre-planned administrative analysis of ‘core’ data from the first 100 patients was performed to evaluate the feasibility of the registry. Results showed a high degree of accuracy of the data collection procedure. Annual interim analyses are scheduled. Results of first interim analysis will be presented subsequent to data availability in 2014. Implications The results of TOSCA will assist in filling the gaps in understanding the natural history of TSC and help in planning better management and surveillance strategies. This large-scale international registry to study TSC could serve as a model to encourage planning of similar registries for other rare diseases.

Evidence regarding gender-related differences in response to transcatheter aortic valve implantation according to the valve type is lacking. This study aimed to evaluate the impact of gender on the treatment effect of Evolut PRO/PRO+ (PRO) or SAPIEN 3 Ultra (ULTRA) devices on clinical outcomes. The Comparative Analysis of Evolut PRO vs SAPIEN 3 Ultra Valves for Transfemoral Transcatheter Aortic Valve Implantation (OPERA-TAVI) is a multicenter, multinational registry including patients who underwent the latest-iteration PRO or ULTRA implantation. Overall, 1,174 of 1,897 patients were matched based on valve type and compared according to gender, whereas 470 men and 630 women were matched and compared according to valve type. The 30-day and 1-year outcomes were evaluated. In the PRO and ULTRA groups, men had a higher co-morbidity burden, whereas women had smaller aortic root. The 30-day (device success [DS], early safety outcome, permanent pacemaker implantation, patient-prosthesis mismatch, paravalvular regurgitation, bleedings, vascular complications, and all-cause death) and 1-year outcomes (all-cause death, stroke, and heart failure hospitalization) did not differ according to gender in both valve groups. However, the male gender decreased the likelihood of 30-day DS with ULTRA versus PRO (p for interaction = 0.047). A higher risk of 30-day permanent pacemaker implantation and 1-year stroke and a lower risk of patient-prosthesis mismatch was observed in PRO versus ULTRA, regardless of gender. In conclusion, gender did not modify the treatment effect of PRO versus ULTRA on clinical outcomes, except for 30-day DS, which was decreased in men (vs women) who received ULTRA (vs PRO).

The NIKA2 Sunyaev-Zel’dovich Large Program (SZLP) is focused on mapping the thermal SZ signal of a representative sample of selected Planck and ACT clusters spanning the redshift range 0.5 < z < 0.9. Hydrodynamical N-body simulations prove to be a powerful tool to endorse NIKA2 capabilities for estimating the impact of IntraCluster Medium (ICM) disturbances when re- covering the pressure radial profiles. For this goal we employ a subsample of objects, carefully extracted from the catalog Marenostrum MUltidark SImulations of galaxy Clusters (MUSIC), spanning equivalent redshift and mass ranges as the LPSZ. The joint analysis of real observations of the tSZ with NIKA2 and Planck enables to validate the NIKA2 pipeline and to estimate the ICM pressure profiles. Moreover, the possibility to identify a priori the dynamical state of the selected synthetic clusters allows us to verify the impact on the recovered ICM profile shapes and their scatters. Morphological analysis of maps of the Compton parameter seems to be a way to observationally segregate the sample based on the dynamical state in relaxed and disturbed synthetic clusters.

Background/Objectives: To date, data regarding the characteristics and management of obstructive, stable coronary artery disease (CAD) encountered in patients undergoing transcatheter aortic valve implantation (TAVI) are sparse. The aim of the study was to analyze granular details, treatment, and outcomes of patients undergoing TAVI with obstructive, stable CAD from real-world practice. Methods: REVASC-TAVI (Management of myocardial REVASCularization in patients undergoing Transcatheter Aortic Valve Implantation with coronary artery disease) is an investigator-initiated, multicenter registry, which collected data from patients undergoing TAVI with obstructive stable CAD found during the pre-TAVI work-up. Results: A total of 2025 patients from 30 centers worldwide with complete follow-up were included in the registry. Most patients had single-vessel CAD (56.1%). An involvement of proximal coronary tracts was detected in 62.5% of cases, with 12.0% of patients having CAD in left main (LM). Most patients received percutaneous coronary intervention (PCI) (n = 1617, 79.9%), especially those with proximal CAD (90.4%). At 2 years, the rates of all-cause death [Kaplan–Meier (KM) estimates 20.1% vs. 18.8%, plog-rank = 0.86] and of the composite of all-cause death, stroke, myocardial infarction, and rehospitalization for heart failure (KM estimates 29.7% vs. 27.5%, plog-rank = 0.82) did not differ between patients undergoing PCI and those who were not. Conclusions: Patients undergoing TAVI with obstructive CAD more commonly had a single-vessel disease and an involvement of proximal coronary tracts. They were commonly treated with PCI, with similar outcomes compared to those treated conservatively.