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Mrs. Jeffries takes tea at three
\"Everyone's awed by Inspector Witherspoon's Scotland Yard success, but they don't know about his secret weapon. Her name is Mrs. Jeffries, and she keeps house for the Inspector--and keeps him on his toes. No matter how messy the murder or how dirty the deed, her polished detection skills are up to the task.\"--P. [4] of cover.
Book
Understanding the Associations between Helicopter Parenting and Emerging Adults’ Adjustment
Emerging adulthood is an important developmental period where youth continue to grow and develop. Parents may affect a smooth transition into adult roles by utilizing parenting practices that are developmentally inappropriate, such as helicopter parenting. Despite the recent attention on helicopter parenting, we know little about why helicopter parenting may be disadvantageous to adjustment and for whom helicopter parenting may be most disadvantageous. In the current study, the associations among helicopter parenting and college students’ relationship competence (friendship and romantic), substance use problems, and depressive symptoms was examined, as were potential mediators of these associations. To examine these associations a sample of 637 college students in the Northeastern United States (Mage = 20.03; 70% female; 63% White) completed surveys. Structural equation models indicated that helicopter parenting was associated with increased depressive symptoms, substance use problems, and decreased relationship competence and that these relationships were similar across males and females and youth of different racial/ethnic backgrounds. Perceived stress and youth’s perception that their basic psychological needs were undermined mediated the relationship between helicopter parenting and depressive symptoms. Undermining of psychological needs was the only significant mediator for the association between helicopter parenting and relationship competence. These findings are critical for informing the understanding of the mechanisms that link parenting during emerging adulthood to maladjustment.HighlightsHelicopter parenting was associated with important emerging adult outcomes.Psychological needs explained associations between parenting and outcomes.Findings have implications for understanding why helicopter parenting is harmful.
Journal Article
Racial/Ethnic Differences in Patterns of Sexual Risk Behavior and Rates of Sexually Transmitted Infections Among Female Young Adults
Objectives. We examined patterns of sexual behavior and risk for sexually transmitted infections (STIs) in young adulthood for Black, Hispanic, and White females. Methods. We used a nationally representative sample of 7015 female young adults from wave III of the National Longitudinal Study of Adolescent Health. Sexual risk items assessed behaviors occurring in the previous 6 years and past year to determine classes of sexual risk and links to STIs in young adulthood. Results. Latent class analysis revealed 3 sexual risk classes for Black and Hispanic youths and 4 sexual risk classes for White youths. The moderate and high risk classes had the highest probabilities of risky sexual partners, inconsistent condom use, and early age of sexual initiation, which significantly increased odds for STIs compared with recent abstainers. Conclusions. We found different classes of sexual behavior by race/ethnicity, with Black and Hispanic young women most at risk for STIs in young adulthood. Preventive efforts should target younger adolescents and focus on sexual partner behavior.
Journal Article
APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids.
APOLLO-1 (NCT02815709) was a phase III, double-blind, randomized trial in patients with moderate-to-severe pain following bunionectomy. Patients received a loading dose of either placebo, oliceridine (1.5 mg), or morphine (4 mg), followed by demand doses via patient-controlled analgesia (0.1, 0.35, or 0.5 mg oliceridine, 1 mg morphine, or placebo). The primary endpoint compared the proportion of treatment responders through 48 hours for oliceridine regimens and placebo. Secondary outcomes included a composite measure of respiratory safety burden (RSB, representing the cumulative duration of respiratory safety events) and the proportion of treatment responders vs morphine.
Effective analgesia was observed for all oliceridine regimens, with responder rates of 50%, 62%, and 65.8% in the 0.1 mg, 0.35 mg, and 0.5 mg regimens, respectively (all
<0.0001 vs placebo [15.2%]; 0.35 mg and 0.5 mg non-inferior to morphine). RSB showed a dose-dependent increase across oliceridine regimens (mean hours [SD]: 0.1 mg: 0.04 [0.33]; 0.35 mg: 0.28 [1.11]; 0.5 mg: 0.8 [3.33]; placebo: 0 [0]), but none were statistically different from morphine (1.1 [3.03]). Gastrointestinal adverse events also increased in a dose-dependent manner in oliceridine regimens (0.1 mg: 40.8%; 0.35 mg: 59.5%; 0.5 mg: 70.9%; placebo: 24.1%; morphine: 72.4%). The odds ratio for rescue antiemetic use was significantly lower for oliceridine regimens compared to morphine (
<0.05).
Oliceridine is a novel and effective IV analgesic providing rapid analgesia for the relief of moderate-to-severe acute postoperative pain compared to placebo. Additionally, it has a favorable safety and tolerability profile with regard to respiratory and gastrointestinal adverse effects compared to morphine, and may provide a new treatment option for patients with moderate-to-severe postoperative pain where an IV opioid is required.
Journal Article
Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice
In humans, loss-of-function mutations in the
UBE3A
gene lead to the neurodevelopmental disorder Angelman syndrome (AS). AS patients have severe impairments in speech, learning and memory, and motor coordination, for which there is currently no treatment. In addition,
UBE3A
is duplicated in > 1–2% of patients with autism spectrum disorders—a further indication of the significant role it plays in brain development. Altered expression of UBE3A, an E3 ubiquitin ligase, is hypothesized to lead to impaired levels of its target proteins, but identifying the contribution of individual UBE3A targets to UBE3A-dependent deficits remains of critical importance. Ephexin5 is a putative UBE3A substrate that has restricted expression early in development, regulates synapse formation during hippocampal development, and is abnormally elevated in AS mice, modeled by maternally-derived
Ube3a
gene deletion. Here, we report that Ephexin5 can be directly ubiquitylated by UBE3A. Furthermore, removing Ephexin5 from AS mice specifically rescued hippocampus-dependent behaviors, CA1 physiology, and deficits in dendritic spine number. Our findings identify Ephexin5 as a key driver of hippocampal dysfunction and related behavioral deficits in AS mouse models. These results demonstrate the exciting potential of targeting Ephexin5, and possibly other UBE3A substrates, to improve symptoms of AS and other UBE3A-related developmental disorders.
Journal Article
Assessing the Feasibility of Geothermal-to-X for Sustainable Maritime Refueling in Alaska
The Arctic is warming three to four times faster than the global average. This is transforming global maritime routes, thereby increasing shipping and resource extraction in Alaska. This surge requires sustainable energy solutions as policy trends towards stricter emissions standards. This article assesses the potential of Geothermal-to-X (GtX) technologies in establishing clean refueling infrastructure across Alaska, using its untapped geothermal resources. GtX uses electrolysis to split water into hydrogen and oxygen, a process powered by geothermal energy. Hydrogen and its X products, such as green methane or green ammonia, can be stored as fuels and are largely recognized as the key to a carbon-free future to address the growing energy demand. This study assesses the technical, economic, strategic, and geological feasibility of GtX refueling hubs in Alaska. Five locations were denoted as potential candidates and beckon future research. This study concludes that Unalaska is the most viable initial GtX hub given the highest Multi Criteria Decision Analysis (MCDA) score from its combination of a high-quality geothermal resource, an existing and accessible deepwater port, and a sizable local energy demand. The goal of this study is to provide an accessible and comprehensive resource for stakeholders and policymakers, outlining an energy future with sustainable maritime development, powered by affordable and secure energy.
Journal Article
Network Structure and Consolidation in the U.S. Airline Industry, 1990–2015
We study the effect of consolidation on airline network connectivity using three measures of centrality from graph theory: Degree; Closeness; and Betweenness. Changes in these measures from 1990 to 2015 imply: (i) the average airport services a greater proportion of possible routes; (ii) the average origin airport is fewer stops away from any given destination; and (iii) the average hub is less often along the shortest route between two other airports. Yet, we find the trend toward greater connectivity in the national network structure is largely unaffected by consolidation—in the form of mergers and codeshare agreements—during this period.
Journal Article
The Interactive Effects of Stressful Family Life Events and Cortisol Reactivity on Adolescent Externalizing and Internalizing Behaviors
This study investigated the associations between stressful family life events and adolescent externalizing and internalizing behaviors, and the interactive effects of family life events and cortisol reactivity on problem behaviors. In a sample of 100 mothers and their adolescents (M age = 15.09;
SD
age = .98; 68 % girls), adolescent cortisol reactivity was measured in response to a mother–adolescent conflict interaction task designed to elicit a stress response. Mothers reported on measures of family life events and adolescent problem behaviors. Results indicated that a heightened adolescent cortisol response moderated the relations between stressful family life events and both externalizing and internalizing behaviors. Results support context-dependent theoretical models, suggesting that for adolescents with higher cortisol reactivity (compared to those with lower cortisol reactivity), higher levels of stressful family life events were associated with greater problem behaviors, whereas lower levels of stressful family life events were related to fewer problem behaviors.
Journal Article
Individual Differences in Adolescents’ Emotional Reactivity across Relationship Contexts
Understanding individual differences in adolescents’ ability to regulate emotions within interpersonal relationships is paramount for healthy development. Thus, the effect of individual vulnerabilities (depressive affect, social anxiety, self-blame, and coping efficacy problems) on the transmission of emotional reactivity in response to conflict from family to peers (friends and romantic partners) was prospectively examined across six waves of data in a community-based sample of 416 adolescents (Mage Wave 1 = 11.90, 51% girls). Multiple-group models estimated in structural equation modeling suggested that youth who were higher in social anxiety or coping efficacy problems were more likely to transmit emotional reactivity developed in the family-of-origin to emotional reactivity in response to conflict in close friendships. Additionally, those youth higher in self-blame and depressive affect were more likely to transmit emotional reactivity from friendships to romantic relationships.
Journal Article
Missed Exams and Lost Opportunities: Who Could Gain From Expanded College Admission Testing?
When students with the capacity to succeed in a 4-year college do not take a college admission test, this represents a potential loss of opportunity for students and colleges alike. However, the costs of testing—both pecuniary and nonpecuniary—may exceed the benefits for students who lack the interest in or qualifications for college attendance. In states like Virginia, access to admission tests varies markedly with district and family circumstances. We estimate that universal testing in Virginia could increase the number of high school graduates with test scores competitive for admission at broad-access universities in the state by as much as 40%—and at the most selective institutions by nearly 20%—with larger increases for low-income students. Alternative policies that encourage testing among students with strong demonstrated academic performance could realize nearly these increases without generating testing costs for students who are unlikely to attend a 4-year college.
Journal Article