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This research paper presents a review of the state of the art of desalination in Mexico, with the aim of clarifying the main challenges and opportunity areas for desalination as the main solution to overcome water stress. First, the current situation and forecasts on the availability of water resources in Mexico are described, followed by the main economic, social, and legislative issues of desalination. Mexico’s installed capacity for the different desalination technologies and their evolution in recent years was investigated, followed by a comparison with global trends. The current state of research and development in desalination technologies carried out by Mexican institutions was also studied. The results show that membrane technology plants account for 88.85%, while thermal technology plants account for the remaining 11.15%. Although Mexico presented a 240% increase in its desalination capacity in the last 10 years, it has not been enough to overcome water stress, so it is concluded that in the future, it is necessary to increase its capacity in greater proportion, specifically in the areas with greater scarcity, which can be achieved with the joint participation of academy–industry–government through the creation of autonomous organizations, social programs, and/or public policies that promote it.

This study shows the results of a simulation tool using the TRNSyS 2017 simulator, validated with experimental data from a greenhouse in an arid zone in northwestern Mexico. Additionally, experimental data on the performance of geothermal heat pumps are shown during the year 2020 in heating and cooling mode. With this information, an average deviation of the simulator for the outlet fluid temperature of the geothermal heat exchanger (GHE) of 2.77% and an average deviation of the coefficient of performance in cooling mode (EER) of the geothermal heat pump (GHP) of 3.7% was obtained. In the experimental study, it was observed that in the last 2 weeks of July and the first 2 weeks of August, the subsoil is saturated, which causes a decrease in the thermal inertia of the GHE. During the experimental study, it was possible to determine that the flow indicated in the GHE to obtain the highest performance of the GHP system in greenhouses in arid zones corresponds to 1 GPM, obtaining an EER of 3.24.

Solar energy is one of the main alternatives for the decarbonization of the electricity sector and the reduction of the existing energy deficit in some regions of the world. However, one of its main limitations lies in its storage, since this energy source is intermittent. This paper evaluates the potential of an underground thermal energy storage tank supplied by solar thermal collectors to provide hot water for the activation of a single-effect absorption cooling system. A simulator was developed in TRNSYS 17 software. Experimentally on-site measured data of soil temperature were used in order to increase the accuracy of the simulation. The results show that the underground tank reduces thermal energy losses by 27.6% during the entire hot period compared with the air-exposed tank. The electrical energy savings due to the reduction in pumping time during the entire hot period was 639 kWh, which represents 23.6% of the electrical energy consumption of the solar collector pump. It can be concluded that using an underground thermal energy storage tank is a feasible option in areas with high levels of solar radiation, especially in areas where ambient temperature drops significantly during night hours and/or when access to electrical energy is limited.

Thurincin H is a bacteriocin produced by Bacillus thuringiensis, it is encoded in a group of ten genes, most of which have been characterized experimentally or by homology. However, the activity of the thnI gene encoding a 95 amino acid ORF remains unknown. In this work, the thnI gene was cloned under the regulation of two promoters and transformed into a sensitive strain to determine if it acts as an immunity protein. In addition, a deletion mutant without the thnI gene was used to test whether thnI is required or not for the biosynthesis of thurincin H. It was concluded that thnI does not provide immunity and is not required to produce thurincin H.

Child and maternal health outcomes have notably improved in Mexico since 1990, whereas rising adult mortality rates defy traditional epidemiological transition models in which decreased death rates occur across all ages. These trends suggest Mexico is experiencing a more complex, dissonant health transition than historically observed. Enduring inequalities between states further emphasise the need for more detailed health assessments over time. The Global Burden of Diseases, Injuries, and Risk Factors Study 2013 (GBD 2013) provides the comprehensive, comparable framework through which such national and subnational analyses can occur. This study offers a state-level quantification of disease burden and risk factor attribution in Mexico for the first time. We extracted data from GBD 2013 to assess mortality, causes of death, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) in Mexico and its 32 states, along with eight comparator countries in the Americas. States were grouped by Marginalisation Index scores to compare subnational burden along a socioeconomic dimension. We split extracted data by state and applied GBD methods to generate estimates of burden, and attributable burden due to behavioural, metabolic, and environmental or occupational risks. We present results for 306 causes, 2337 sequelae, and 79 risk factors. From 1990 to 2013, life expectancy from birth in Mexico increased by 3·4 years (95% uncertainty interval 3·1–3·8), from 72·1 years (71·8–72·3) to 75·5 years (75·3–75·7), and these gains were more pronounced in states with high marginalisation. Nationally, age-standardised death rates fell 13·3% (11·9–14·6%) since 1990, but state-level reductions for all-cause mortality varied and gaps between life expectancy and years lived in full health, as measured by HALE, widened in several states. Progress in women's life expectancy exceeded that of men, in whom negligible improvements were observed since 2000. For many states, this trend corresponded with rising YLL rates from interpersonal violence and chronic kidney disease. Nationally, age-standardised YLL rates for diarrhoeal diseases and protein-energy malnutrition markedly decreased, ranking Mexico well above comparator countries. However, amid Mexico's progress against communicable diseases, chronic kidney disease burden rapidly climbed, with age-standardised YLL and DALY rates increasing more than 130% by 2013. For women, DALY rates from breast cancer also increased since 1990, rising 12·1% (4·6–23·1%). In 2013, the leading five causes of DALYs were diabetes, ischaemic heart disease, chronic kidney disease, low back and neck pain, and depressive disorders; the latter three were not among the leading five causes in 1990, further underscoring Mexico's rapid epidemiological transition. Leading risk factors for disease burden in 1990, such as undernutrition, were replaced by high fasting plasma glucose and high body-mass index by 2013. Attributable burden due to dietary risks also increased, accounting for more than 10% of DALYs in 2013. Mexico achieved sizeable reductions in burden due to several causes, such as diarrhoeal diseases, and risks factors, such as undernutrition and poor sanitation, which were mainly associated with maternal and child health interventions. Yet rising adult mortality rates from chronic kidney disease, diabetes, cirrhosis, and, since 2000, interpersonal violence drove deteriorating health outcomes, particularly in men. Although state inequalities from communicable diseases narrowed over time, non-communicable diseases and injury burdens varied markedly at local levels. The dissonance with which Mexico and its 32 states are experiencing epidemiological transitions might strain health-system responsiveness and performance, which stresses the importance of timely, evidence-informed health policies and programmes linked to the health needs of each state. Bill & Melinda Gates Foundation, Instituto Nacional de Salud Pública.

In this study, we analyzed the sequences of SARS-CoV-2 isolates of the Delta variant in Mexico, which has completely replaced other previously circulating variants in the country due to its transmission advantage. Among all the Delta sublineages that were detected, 81.5 % were classified as AY.20, AY.26, and AY.100. According to publicly available data, these only reached a world prevalence of less than 1%, suggesting a possible Mexican origin. The signature mutations of these sublineages are described herein, and phylogenetic analyses and haplotype networks are used to track their spread across the country. Other frequently detected sublineages include AY.3, AY.62, AY.103, and AY.113. Over time, the main sublineages showed different geographical distributions, with AY.20 predominant in Central Mexico, AY.26 in the North, and AY.100 in the Northwest and South/Southeast. This work describes the circulation, from May to November 2021, of the primary sublineages of the Delta variant associated with the third wave of the COVID-19 pandemic in Mexico and highlights the importance of SARS-CoV-2 genomic surveillance for the timely identification of emerging variants that may impact public health.

(1) Background: Lipases and esterases are important enzymes that share the α/β hydrolase fold. The activity and cellular localization are important characteristics to understand the role of such enzymes in an organism. (2) Methods: Bioinformatic and biochemical tools were used to describe a new α/β hydrolase from a Litopenaeus vannamei transcriptome (LvFHS for Family Serine Hydrolase). (3) Results: The enzyme was obtained by heterologous overexpression in Escherichia coli and showed hydrolytic activity towards short-chain lipid substrates and high affinity to long-chain lipid substrates. Anti-LvFHS antibodies were produced in rabbit that immunodetected the LvFSH enzyme in several shrimp tissues. (4) Conclusions: The protein obtained and analyzed was an α/β hydrolase with esterase and lipase-type activity towards long-chain substrates up to 12 carbons; its immunodetection in shrimp tissues suggests that it has an intracellular localization, and predicted roles in energy mobilization and signal transduction.

The quality of life in patients with inflammatory bowel diseases (IBD) is strongly impaired. Alterations of intestinal epithelial homeostasis contribute to the development and establishment of IBD. Intestinal Paneth and Paneth-like cells produce and secrete luminal proteins sustaining epithelial homeostasis. Here we show that IFN-γ stimulates Paneth and Paneth-like cells degranulation that triggers the proliferation of intestinal epithelial cells (IEC) in a Wnt/β-catenin independent manner. Degranulation in Paneth and Paneth-like cells was mTORC1 and necroptosis dependent. Remarkably, lack of IFN-γ, inhibition of mTORC1, or impeding necroptosis reduces IEC proliferation cytokine-mediated. Our findings identify a new role for IFN-γ in stimulating IEC proliferation through inducing degranulation of Paneth and Paneth-like cells which is mTORC1 and necroptosis- dependent. In a mouse model of colitis, mTORC1 activation and necroptosis regulate Paneth and Paneth-like cell secretion. Furthermore, the colitogenic environment triggers PC metaplasia in the distal region of the large intestine to simulate cell proliferation. IFN-γ stimulates proliferation, β-catenin independent. IFN-γ enhances mitochondrial activity and proliferation IFN-γ regulates PC biogenesis. mTORC1-dependent necroptosis mediates secretion in Paneth and Paneth-like cells.