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The Grain Impact Analyser and Dust Accumulator (GIADA) onboard the ROSETTA mission to comet 67P/Churyumov–Gerasimenko is devoted to study the cometary dust environment. Thanks to the rendezvous configuration of the mission, GIADA will be plunged in the dust environment of the coma and will be able to explore dust flux evolution and grain dynamic properties with position and time. This will represent a unique opportunity to perform measurements on key parameters that no ground-based observation or fly-by mission is able to obtain and that no tail or coma model elaborated so far has been able to properly simulate. The coma and nucleus properties shall be, then, clarified with consequent improvement of models describing inner and outer coma evolution, but also of models about nucleus emission during different phases of its evolution. GIADA shall be capable to measure mass/size of single particles larger than about 15 μm together with momentum in the range 6.5 × 10−10 ÷ 4.0 × 10−4 kg m s−1 for velocities up to about 300 m s−1. For micron/submicron particles the cumulative mass shall be detected with sensitivity 10−10 g. These performances are suitable to provide a statistically relevant set of data about dust physical and dynamic properties in the dust environment expected for the target comet 67P/Churyumov–Gerasimenko. Pre-flight measurements and post-launch checkouts demonstrate that GIADA is behaving as expected according to the design specifications.

IntroductionThe purpose of the research project is to analyze the long-term evolution of obsessive-compulsive disorder (OCD) from of a study of a cohort of patients prospectively followed over a period ranging from 5 to 20 years, treated for according to therapeutic guidelines mediating serotonin reuptake inhibitors (IRS) and drug enhancers (antipsychotics) and cognitive behavioral therapy and evaluated in a standardized manner.ObjectivesTo assess the long-term course of Obsessive-Compulsive Disorder (OCD) in a cohort of patients treated according to current clinical guidelines; to analyse possible prognostic factors associated with the long-term course of the disorder including clinical and sociodemographic variables, as well as genetic and neuroimaging biomarkers, and their interaction, and finally to study neuroanatomical and functional cerebral connectivity changes after 15 years of treatment in a subsample of patients.MethodsProspective, descriptive, and observational study of a cohort of OCD patients, receiving treatment at the Department of Psychiatry of Hospital de Bellvitge since 1998, according to a standardized protocol. Follow-up period ranges from 5 (n=423), to 10 (n= 247) and 15 years (123). Baseline clinical and sociodemographic assessment, long-term evolution and information on treatments provided are available for the whole sample. Data on whole exome sequencing is available for 300 of the patients included in the cohort and baseline structural neuroimaging and cerebral functional connectivity has been analysed in 168 subjects. To expand the analysis of genetic biomarkers, we propose the study of de novo variants through exome analysis of 50 trios (patient and both parents) selected among those subjects that have reached 15 years of follow-up (25 trios with patients within the “long-term remission” group and 25 trios with patients with chronic OCD). De novo variants detected in the trio analysis will be replicated in the rest of the sample. A structural and resting state MRI will be obtained in a subsample of 100 patients recruited among those who have completed a minimum follow-up period of 15 years, to assess cerebral changes associated with the long-term course of the disorder.Resultsin the current moment the recruitment period of the study has ended and all the data is being statistically analysed in order to provide solid results in a short period of time.ConclusionsThe identification of those factors associated with an increased risk of chronic disease is an element essential to offer personalized treatment to our patients and improve their prognosis, emphasizing the intensive use of those therapeutic strategies for which we can predict a better response and modifying to the extent of, if possible, environmental factors or factors of access to treatment that contribute to perpetuate obsessive symptoms.Disclosure of InterestNone Declared