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Specialized, bimodal neural systems integrate visual and tactile information in the space near the hand. Here, we show that visuo-tactile representations allow attention to influence early perceptual processing, namely, figure-ground assignment. Regions that were reached toward were more likely than other regions to be assigned as foreground figures, and hand position competed with image-based information to bias figure-ground assignment. Our findings suggest that hand position allows attention to influence visual perceptual processing and that visual processes typically viewed as unimodal can be influenced by bimodal visuo-tactile representations.

Digital measures may provide objective, sensitive, real-world measures of disease progression in Parkinson’s disease (PD). However, multicenter longitudinal assessments of such measures are few. We recently demonstrated that baseline assessments of gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, and research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD and 50 age-matched controls. Here, we evaluated the longitudinal change in these assessments over 12 months in a multicenter observational study using a generalized additive model, which permitted flexible modeling of at-home data. All measurements were included until participants started medications for PD. Over one year, individuals with early PD experienced significant declines in several measures of gait, an increase in the proportion of day with tremor, modest changes in speech, and few changes in psychomotor function. As measured by the smartwatch, the average (SD) arm swing in-clinic decreased from 25.9 (15.3) degrees at baseline to 19.9 degrees (13.7) at month 12 ( P  = 0.004). The proportion of awake time an individual with early PD had tremor increased from 19.3% (18.0%) to 25.6% (21.4%; P  < 0.001). Activity, as measured by the number of steps taken per day, decreased from 3052 (1306) steps per day to 2331 (2010; P  = 0.16), but this analysis was restricted to 10 participants due to the exclusion of those that had started PD medications and lost the data. The change of these digital measures over 12 months was generally larger than the corresponding change in individual items on the Movement Disorder Society—Unified Parkinson’s Disease Rating Scale but not greater than the change in the overall scale. Successful implementation of digital measures in future clinical trials will require improvements in study conduct, especially data capture. Nonetheless, gait and tremor measures derived from a commercially available smartwatch and smartphone hold promise for assessing the efficacy of therapeutics in early PD.

Recent studies have demonstrated that brief periods of training facilitate the ability to overcome distraction during future performance of a given task, and researchers have proposed that these effects rely on relational memory systems that enable individuals to link specific attentional states to their learned context. In the current work, we examined whether medial temporal lobe (MTL) structures critical for relational and contextual learning contribute to these effects. A group of amnesic patients with bilateral MTL damage and a group of matched comparison subjects both completed an attentional-capture task in which a brief training session typically leads to decreased distraction in a subsequent testing session. Whereas the comparison subjects showed normal training-related decreases in distractibility, the amnesic patients did not. Thus, our results indicate that MTL-mediated learning plays a critical role in the ability to use past experience to overcome distraction. This suggests a tight linkage between MTL-dependent relational-learning mechanisms and cognitive control.

Parkinson’s Disease is a progressive neurodegenerative disorder afflicting almost 12 million people. Increased understanding of its complex and heterogenous disease pathology, etiology and symptom manifestations has resulted in the need to design, capture and interrogate substantial clinical datasets. Herein we advocate how advances in the deployment of artificial intelligence models for Federated Data Analysis and Federated Learning can help spearhead coordinated and sustainable approaches to address this grand challenge.

Much is known about the cues that determine figure–ground assignment, but less is known about the consequences of figure–ground assignment on later visual processing. Previous work has demonstrated that regions assigned figural status are subjectively more shape-like and salient than background regions. The increase in subjective salience of figural regions could be caused by a number of processes, one of which may be enhanced perceptual processing (e.g., an enhanced neural representation) of figures relative to grounds. We explored this hypothesis by having observers perform a perceptually demanding spatial resolution task in which targets appeared on either figure or ground regions. To rule out a purely attentional account of figural salience, observers discriminated targets on the basis of a region’s color (red or green), which was equally likely to define the figure or the ground. The results of our experiments showed that targets appearing on figures were discriminated more accurately than those appearing in ground regions. In addition, targets appearing on figures were discriminated better than those presented in regions considered figurally neutral, but targets appearing within ground regions were discriminated more poorly than those appearing in figurally neutral regions. Taken together, our findings suggest that when two regions share a contour, regions assigned as figure are perceptually enhanced, whereas regions assigned as ground are perceptually suppressed.

The abrupt appearance of a new object captures attention, even when the object is task irrelevant. These findings suggest that abrupt onsets capture attention in a stimulus-driven manner and are not susceptible to top-down influences on attentional control. However, previous studies examining the ability of abrupt onsets to capture attention have used search displays that lacked significant complexity. Because attention is a limited capacity mechanism, it is possible that increasing the complexity, or perceptual load, of the search arrays may modulate capture by abrupt onsets. We used a flanker task to examine the effect of perceptual load on attentional capture by abruptly appearing objects. Subjects searched for a target letter through low-load (set size=1) and high-load (set size=6) displays. On each trial, irrelevant flankers also appeared, one as an onset and the other as an offset. Onset flankers affected search in low-load but not high-load displays. This modulation of attentional capture was not caused by generalized slowing when subjects searched through high-load displays; search for a single perceptually degraded target slowed response times but did not affect attentional capture. These findings demonstrate that attentional capture by an abrupt onset is attenuated when people search through high-load scenes.

Recent work on statistical learning has demonstrated that environmental regularities can influence aspects of perception, such as familiarity judgments. Here, we ask if statistical co-occurrences accumulated from visual statistical learning could form objects that serve as the units of attention (i.e., object-based attention). Experiment 1 demonstrated that, after observers first viewed pairs of shapes that co-occurred in particular spatial relationships, they were able to recognize the co-occurring pairs, and were faster to discriminate two targets when they appeared within a learned pair (“object”) than when the targets appeared between learned pairs, demonstrating an equivalent of an object-based attention effect. Experiment 2 replicated the results of Experiment 1 using a different set of shape pairs, and revealed a negative association between the attention effect and familiarity judgments of the co-occurred pairs. Experiment 3 reports three control experiments that validated the task procedure and ruled out alternative accounts.

Attentional capture by abrupt onsets can be modulated by several factors, including the complexity, or perceptual load, of a scene. We have recently demonstrated that observers are less likely to be captured by abruptly appearing, task-irrelevant stimuli when they perform a search that is high, as opposed to low, in perceptual load (Cosman & Vecera, 2009), consistent with perceptual load theory. However, recent results indicate that onset frequency can influence stimulus-driven capture, with infrequent onsets capturing attention more often than did frequent onsets. Importantly, in our previous task, an abrupt onset was present on every trial, and consequently, attentional capture might have been affected by both onset frequency and perceptual load. In the present experiment, we examined whether onset frequency influences attentional capture under conditions of high perceptual load. When onsets were presented frequently, we replicated our earlier results; attentional capture by onsets was modulated under conditions of high perceptual load. Importantly, however, when onsets were presented infrequently, we observed robust capture effects. These results conflict with a strong form of load theory and, instead, suggest that exposure to the elements of a task (e.g., abrupt onsets) combines with high perceptual load to modulate attentional capture by task-irrelevant information.

The onset of motion captures attention during visual search even if the motion is not task relevant, which suggests that motion onsets capture attention in a stimulus-driven manner. However, we have recently shown that stimulus-driven attentional capture by abruptly appearing objects is attenuated under conditions of high perceptual load. In the present study, we examined the influence of perceptual load on attentional capture by another type of dynamic stimulus: the onset of motion. Participants searched for a target letter through briefly presented low- and high-load displays. On each trial, two irrelevant flankers also appeared, one with a motion onset and one that was static. Flankers defined by a motion onset captured attention in the low-load but not in the high-load displays. This modulation of capture in high-load displays was not the result of overall lengthening of reaction times (RTs) in this condition, since search for a single low-contrast target lengthened RTs but did not influence capture. These results, together with those of previous studies, suggest that perceptual load can modulate attentional capture by dynamic stimuli.

The onset of motion captures attention during visual search even if the motion is not task relevant, which suggests that motion onsets capture attention in a stimulus-driven manner. However, we have recently shown that stimulus-driven attentional capture by abruptly appearing objects is attenuated under conditions of high perceptual load. In the present study, we examined the influence of perceptual load on attentional capture by another type of dynamic stimulus: the onset of motion. Participants searched for a target letter through briefly presented low- and high-load displays. On each trial, two irrelevant flankers also appeared, one with a motion onset and one that was static. Flankers defined by a motion onset captured attention in the low-load but not in the high-load displays. This modulation of capture in high-load displays was not the result of overall lengthening of reaction times (RTs) in this condition, since search for a single low-contrast target lengthened RTs but did not influence capture. These results, together with those of previous studies, suggest that perceptual load can modulate attentional capture by dynamic stimuli.