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An experimental study was carried out on a large stationary compression ignition engine to evaluate the long-term compatibility and durability issues associated with the use of crude palm oil as fuel. Two different preheating temperatures (60 and 80 °C) were adopted to assess the potential improvements related to lower fuel viscosity. The results obtained, in terms of in-cylinder carbon deposits and engine wear, were compared with the results obtained using ordinary diesel fuel. For each fuel and preheating temperature, the engine was operated for 300 consecutive h, during which several engine lubricant samples were collected and analysed to determine soot and fuel contaminations, viscosity alterations, and the presence of different wear-related metals (measured by atomic absorption spectroscopy). At the end of each 300 h endurance test, the carbon deposits were scraped from engine cylinders and examined through thermogravimetric analysis (TGA). It was found that the use of crude palm oil caused a remarkable increment of in-cylinder deposits formation compared with ordinary diesel. The lubricant analysis also revealed a faster viscosity degradation and consequent stronger engine wear, above all with the lower preheating temperature. The results obtained confirmed that continuous engine operation (i.e., without a complete lubricant change) should be carefully reduced when fuelling with crude palm oil. Moreover, the findings obtained herein confirmed the favourable impacts of fuel preheating at 80 °C compared to 60 °C, i.e., reduced carbon deposits by 27% and extended engine operation time by 30%.

This study presents the results of an experimental investigation conducted on a 2:3 scale model of a two-story stone masonry building. We tested the model on the UniKORE L.E.D.A. lab shake table, simulating the Mw 6.3 earthquake ground motion that struck L’Aquila, Italy, on 6 April 2009, with progressively increasing peak acceleration levels. We installed a network of accelerometric sensors on the model to capture its structural behaviour under seismic excitation. Medium-to lower-cost MEMS accelerometers (classes A and B) were compared with traditional piezoelectric sensors commonly used in Structural Health Monitoring (SHM). The experiment assessed the structural performance and damage progression of masonry buildings subjected to realistic earthquake inputs. Additionally, the collected data provided valuable insights into the effectiveness of different sensor types and configurations in detecting key vibrational and failure patterns. All the sensors were able to accurately measure the dynamic response during seismic excitation. However, not all of them were suitable for Operational Modal Analysis (OMA) in noisy environments, where their self-noise represents a crucial factor. This suggests that the self-noise of MEMS accelerometers must be less than 1 µg/√Hz, or preferably below 0.5 µg/√Hz, to obtain good results from the OMA. Therefore, we recommend ultra-low-noise sensors for detecting differences in the structural behaviour before and after seismic events. Our findings provide valuable insights into the seismic vulnerability of masonry structures and the effectiveness of sensors in detecting damage. The management of buildings in earthquake-prone areas can benefit from these specifications.

We describe the first dense real-time urban seismic–accelerometric network in Italy, named OSU-CT, located in the historic center of Catania. The city lies in the region with the greatest danger, vulnerability, and earthquake exposure in the entire Italian territory. OSU-CT was planned and realized within the project called EWAS “an Early WArning System for cultural heritage”, aimed at the rapid assessment of earthquake-induced damage and the testing of an on-site earthquake early warning system. OSU-CT is mainly based on low-cost instrumentation realized ad hoc by using cutting-edge technologies and digital MEMS (micro-electro-mechanical systems) triaxial accelerometers with excellent resolution and low noise. Twenty of the forty scheduled stations have already been set up on the ground floor of significant historic public buildings. In order to assess the performance of an earthquake early warning (EEW) on-site system, we also installed wide-band velocimeters (ETL3D/5s) in three edifices chosen as test sites, which will be instrumented for a structural health monitoring (SHM). In addition to several laboratory and field validation tests on the developed instruments, an effective operational test of OSU-CT was the Mw 4.3 earthquake occurring on 23 December 2021, 16 km west, south-west of Catania. Peak ground accelerations (4.956 gal to 39.360 gal) recorded by the network allowed obtaining a first urban shakemap and determining a reliable distribution of ground motion in the historical center of the city, useful for the vulnerability studies of the historical edifices.

The InSEA project (“ In itiatives in S upporting the consolidation and enhancement of the E MSO research infrastructure consortium (ERIC) and related A ctivities”) has the objective, as the full name of the project indicates, to consolidate and strengthen the infrastructures concerning the EMSO (“European Multidisciplinary Seafloor and water column Observatory”) ERIC (European Research Infrastructure Consortium) and all those technical-scientific activities related to it. In particular, the project is upgrading localized and distributed marine infrastructures, laboratories, observatories and spatial measurement activities in Southern Italian seas to support those activities of surveys in fixed time series points of observation of EMSO ERIC. The project is developing according to six implementation Objectives of Research (OR) that involve four National research Institutions: INGV, ISPRA, OGS and Anton Dohrn Zoological Station of Naples. The paper illustrates with more details the relevant objectives of the InSEA project and its most significant implementation phases.

The Ionian Sea in southern Italy is at the center of active interaction and convergence between the Eurasian and African–Adriatic plates in the Mediterranean. This area is seismically active with instrumentally and/or historically recorded Mw>7.0 earthquakes, and it is affected by recently discovered long strike-slip faults across the active Calabrian accretionary wedge. Many mud volcanoes occur on top of the wedge. A recently discovered one (called the Bortoluzzi Mud Volcano or BMV) was surveyed during the Seismofaults 2017 cruise (May 2017). High-resolution bathymetric backscatter surveys, seismic reflection profiles, geochemical and earthquake data, and a gravity core are used here to geologically, geochemically, and geophysically characterize this structure. The BMV is a circular feature ≃22 m high and ≃1100 m in diameter with steep slopes (up to a dip of 22∘). It sits atop the Calabrian accretionary wedge and a system of flower-like oblique-slip faults that are probably seismically active as demonstrated by earthquake hypocentral and focal data. Geochemistry of water samples from the seawater column on top of the BMV shows a significant contamination of the bottom waters from saline (evaporite-type) CH4-dominated crustal-derived fluids similar to the fluids collected from a mud volcano located on the Calabria mainland over the same accretionary wedge. These results attest to the occurrence of open crustal pathways for fluids through the BMV down to at least the Messinian evaporites at about −3000 m. This evidence is also substantiated by helium isotope ratios and by comparison and contrast with different geochemical data from three seawater columns located over other active faults in the Ionian Sea area. One conclusion is that the BMV may be useful for tracking the seismic cycle of active faults through geochemical monitoring. Due to the widespread diffusion of mud volcanoes in seismically active settings, this study contributes to indicating a future path for the use of mud volcanoes in the monitoring and mitigation of natural hazards.

There is great interest in developing reliable biomarkers to support antemortem diagnosis of late-onset Alzheimer’s disease (AD). Early prediction and diagnosis of AD might be improved by the detection of a proteolytic dysfunction in extracts from cultured AD fibroblasts, producing altered isoelectrophoretic forms of the enzyme transketolase (TK-alkaline bands). The TK profile and apolipoprotein E (APOE) genotype were examined in fibroblasts from 36 clinically diagnosed probable late-onset sporadic AD patients and 38 of their asymptomatic relatives, 29 elderly healthy individuals, 12 neurological non-AD patients, and 5 early-onset AD patients. TK alterations occurred in (i) several probable AD patients regardless of age-of-onset and severity of disease; (ii) all early-onset AD patients and APOE ε4/4 carriers; and (iii) nearly half of asymptomatic AD relatives. Normal subjects and non-AD patients were all negative. Notably, culture conditions promoting TK alterations were also effective in increasing active BACE1 levels. Overall, the TK assay might represent a low-cost laboratory tool useful for supporting AD differential diagnosis and identifying asymptomatic subjects who are at greater risk of AD and who should enter a follow-up study. Moreover, the cultured fibroblasts were confirmed as a useful in vitro model for further studies on the pathogenetic process of AD.

Mesoamerican Manuscripts: New Scientific Approaches and Interpretations presents and connects a wide range of high-tech scientific and cultural-interpretative studies of pre-colonial and early colonial Mesoamerican manuscripts.

The Weibull distribution between volume and square root of isopach area has been recently introduced for determining volume of tephra deposits, which is crucial to the assessment of the magnitude and hazards of explosive volcanoes. We show how the decay of the size of the largest lithics with the square root of isopleth area can also be well described using a Weibull function and how plume height correlates strongly with corresponding Weibull parameters. Variations of median grain size (Md ϕ ) values with square root of area of the associated contours can be, similarly, well fitted with a Weibull function. Weibull parameters, derived for both the thinning of tephra deposits and the decrease of grain size (both maximum lithic diameter and Md ϕ ), with a proxy for the distance from vent (e.g., square root of isoline areas) can be combined to classify the style of explosive volcanic eruptions. Accounting for the uncertainty in the derivation of eruptive parameters (e.g., plume height and volume of tephra deposits) is crucial to any classification of eruptive style and hazard assessment. Considering a typical uncertainty of 20 % for the determination of plume height, a new eruption classification scheme based on selected Weibull parameters is proposed. Ultraplinian, Plinian, Subplinian, and small–moderate explosive eruptions are defined on the ground of plume height and mass eruption rate. Overall, the Weibull fitting represents a versatile and reliable strategy for the estimation of both the volume of tephra deposits and the height of volcanic plumes and for the classification of eruptive style. Nonetheless, due to the typically large uncertainties (mainly due to availability of data, compilation of isopach and isopleth maps, and discrepancies from empirical best fits), plume height, volume, and magnitude of explosive eruptions cannot be considered as absolute values, regardless of the technique used. It is important that various empirical and analytical methods are applied in order to assess such an uncertainty.

Major strides have been made in the development of FLASH radiotherapy (FLASH RT) in the last ten years, but there are still many obstacles to overcome for transfer to the clinic to become a reality. Although preclinical and first-in-human clinical evidence suggests that ultra-high dose rates (UHDRs) induce a sparing effect in normal tissue without modifying the therapeutic effect on the tumor, successful clinical translation of FLASH-RT depends on a better understanding of the biological mechanisms underpinning the sparing effect. Suitable in vitro studies are required to fully understand the radiobiological mechanisms associated with UHDRs. From a technical point of view, it is also crucial to develop optimal technologies in terms of beam irradiation parameters for producing FLASH conditions. This review provides an overview of the research progress of FLASH RT and discusses the potential challenges to be faced before its clinical application. We critically summarize the preclinical evidence and in vitro studies on DNA damage following UHDR irradiation. We also highlight the ongoing developments of technologies for delivering FLASH-compliant beams, with a focus on laser-driven plasma accelerators suitable for performing basic radiobiological research on the UHDR effects.

Flapping-Wing Aerial Vehicles (FWAVs), which take inspiration from the flight of birds and insects, have gained increasing attention over the past decades due to advantages such as low noise, biomimicry and safety, enabled by the absence of propellers. These features make them particularly suitable for applications in natural environments and operations near humans. However, their complexity introduces significant challenges, including difficulties in take-off and landing as well as limited endurance. Perching represents a promising solution to address these limitations. By equipping these drones with a perching mechanism, they could land on branches to save energy and later exploit the altitude to resume flight without requiring human intervention. Specifically, this review focuses on perching mechanisms based on grasping. It presents designs developed for flapping-wing platforms and complements them with systems originally intended for other types of aerial robots, evaluating their applicability to FWAV applications. The purpose of this work is to provide a structured overview of the existing strategies to support the development of new, effective solutions that could enhance the use of FWAVs in real-world applications.