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"Cotler, Stephen L"
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Cheesie Mack is running like crazy!
Sixth-grader Ronald \"Cheesie\" Mack, finds the best way to earn points against his older sister is to become popular, and decides to join the cross-country team, help his best friend run for class president, and ignore her attempts to embarrass him.
Book
Cheesie Mack is not a genius or anything
Eleven-year-old Ronald \"Cheesie\" Mack relates events he and his best friend, Georgie, experience as fifth grade comes to an end and their summer plans are drastically changed, due in part to an old, possibly valuable coin that may belong to the mysterious inhabitant of a place they call The Haunted Toad.
Book
Cheesie Mack is sort of freaked out
\"Cheesie and his best friend, Georgie, pull off a fantastic UFO prank, but when things go wrong, the victims of the prank plan a sinister plot as payback\"-- Provided by publisher.
Book
The Protein Kinase—Interacting Domain in the Hepatitis C Virus Envelope Glycoprotein—2 Gene Is Highly Conserved in Genotype 1—Infected Patients Treated with Interferon
The hepatitis C virus (HCV) envelope glycoprotein-2 inhibits the interferon (IFN)–induced, double-stranded RNA-activated protein kinase (PKR) via the PKR eukaryotic initiation factor-2α phosphorylation homology domain (PePHD). The present study examined the genetic variability of the PePHD in patients receiving IFN therapy. The PePHD from 12 HCV genotype 1 (HCV-1)—infected patients receiving daily IFN therapy was amplified by reverse-transcriptase polymerase chain reaction and analyzed by direct and clonal sequencing. The PePHD was highly conserved in 38 HCV GenBank isolates. There was no difference in pretreatment PePHD sequences isolated from IFN responders versus nonresponders. The major PePHD quasi-species variant did not change after 6 weeks of daily IFN therapy, and in 1 patient the major quasi-species variant did not change during 9 months of observation. Sequencing of 25 pretreatment PePHD clones from 3 patients confirmed that there was extremely low sequence variability surrounding the PePHD. The PePHD is highly conserved in HCV-1—infected IFN responders and nonresponders and does not appear to evolve in response to IFN therapy.
Journal Article