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In this paper we present a novel approach to emulating a universal quantum computer with a classical system, one that uses a signal of bounded duration and amplitude to represent an arbitrary quantum state. The signal may be of any modality (e.g., acoustic, electromagnetic, etc), but we focus our discussion here on electronic signals. Unitary gate operations are performed using analog electronic circuit devices, such as four-quadrant multipliers, operational amplifiers, and analog filters, although non-unitary operations may be performed as well. In this manner, the Hilbert space structure of the quantum state, as well as a universal set of gate operations, may be fully emulated classically. The required bandwidth scales exponentially with the number of qubits, however, thereby limiting the scalability of the approach, but the intrinsic parallelism, ease of construction, and classical robustness to decoherence may nevertheless lead to capabilities and efficiencies rivaling that of current high performance computers.

يتناول هذا الكتاب قصة حياة طبيب عد بلا منازع رائد الطب في مصر الحديثة؛ هو الطبيب الفرنسي أنطوان بارتيليمي كلوت، الذي أنعم عليه الوالي محمد علي باشا بلقب «بك» ؛ تقديرا لتفانيه في مواجهة وباء الكوليرا الذي ضرب البلاد حينذاك. ألف هذا الكتاب الدكتور الطبيب برونو أرجيمي عضو أكاديمية مارسيليا ورئيس جمعية علم المصريات، وقد اعتمد في تأليفه على «مذكرات كلوت بك» التي جمعها جاك تاجر بناء على طلب من الملك فاروق الأول. يتكون الكتاب من جزأين مقسمين إلى عدة فصول. يتحدث الجزء الأول عن حياة الطبيب منذ ولادته إلى معاناته في بداية رحلته العلمية والعملية في فرنسا، ثم عن كفاحه واجتهاده في الأعوام التي قضاها في مصر، ومثلت طفرة عظيمة بالنسبة إلى الأوضاع الصحية السائدة آنذاك. ويأتي الجزء الثاني «رجل متعدد الجوانب»؛ جامعا بين كلوت بك الإنسان، ورجل العلوم، ومارا بحياته العاطفية وخصاله وهواياته، حتى نصل إلى الفصل الأخير وهو التكريم. فالكتاب إذن يعد توثيقا شاملا لحياة تلك الشخصية المتفردة علما وعملا، ولجوانبها المتعددة التي أسهمت في توثيق صفحات من تاريخ تطور مصر الحديثة.

AbstractObjectiveTo compare the ongoing pregnancy rate between a freeze-all strategy and a fresh transfer strategy in assisted reproductive technology treatment.DesignMulticentre, randomised controlled superiority trial.SettingOutpatient fertility clinics at eight public hospitals in Denmark, Sweden, and Spain.Participants460 women aged 18-39 years with regular menstrual cycles starting their first, second, or third treatment cycle of in vitro fertilisation or intracytoplasmic sperm injection.InterventionsWomen were randomised at baseline on cycle day 2 or 3 to one of two treatment groups: the freeze-all group (elective freezing of all embryos) who received gonadotropin releasing hormone agonist triggering and single frozen-thawed blastocyst transfer in a subsequent modified natural cycle; or the fresh transfer group who received human chorionic gonadotropin triggering and single blastocyst transfer in the fresh cycle. Women in the fresh transfer group with more than 18 follicles larger than 11 mm on the day of triggering had elective freezing of all embryos and postponement of transfer as a safety measure.Main outcome measuresThe primary outcome was the ongoing pregnancy rate defined as a detectable fetal heart beat after eight weeks of gestation. Secondary outcomes were live birth rate, positive human chorionic gonadotropin rate, time to pregnancy, and pregnancy related, obstetric, and neonatal complications. The primary analysis was performed according to the intention-to-treat principle.ResultsOngoing pregnancy rate did not differ significantly between the freeze-all and fresh transfer groups (27.8% (62/223) v 29.6% (68/230); risk ratio 0.98, 95% confidence interval 0.87 to 1.10, P=0.76). Additionally, no significant difference was found in the live birth rate (27.4% (61/223) for the freeze-all group and 28.7% (66/230) for the fresh transfer group; risk ratio 0.98, 95% confidence interval 0.87 to 1.10, P=0.83). No significant differences between groups were observed for positive human chorionic gonadotropin rate or pregnancy loss, and none of the women had severe ovarian hyperstimulation syndrome; only one hospital admission related to this condition occurred in the fresh transfer group. The risks of pregnancy related, obstetric, and neonatal complications did not differ between the two groups except for a higher mean birth weight after frozen blastocyst transfer and an increased risk of prematurity after fresh blastocyst transfer. Time to pregnancy was longer in the freeze-all group.ConclusionsIn women with regular menstrual cycles, a freeze-all strategy with gonadotropin releasing hormone agonist triggering for final oocyte maturation did not result in higher ongoing pregnancy and live birth rates than a fresh transfer strategy. The findings warrant caution in the indiscriminate application of a freeze-all strategy when no apparent risk of ovarian hyperstimulation syndrome is present.Trial registrationClinicaltrials.gov NCT02746562.

One of the major challenges of conducting operations of unmanned aircraft, especially operations beyond visual line-of-sight (BVLOS), is to make a realistic and sufficiently detailed risk assessment. An important part of such an assessment is to identify the risk of fatalities, preferably in a quantitative way since this allows for comparison with manned aviation to determine whether an equivalent level of safety is achievable. This work presents a method for quantifying the probability of fatalities resulting from an uncontrolled descent of an unmanned aircraft conducting a BVLOS flight. The method is based on a standard stochastic model, and employs a parameterized high fidelity ground impact distribution model that accounts for both aircraft specifications, parameter uncertainties, and wind. The method also samples the flight path to create an almost continuous quantification of the risk as a function of mission flight time. The methodology is exemplified with a 180 km flight in Danish airspace with a Penguin C aircraft.

The U.S. National Oceanic and Atmospheric Administration (NOAA) Coral Reef Watch (CRW) program has developed a daily global 5-km product suite based on satellite observations to monitor thermal stress on coral reefs. These products fulfill requests from coral reef managers and researchers for higher resolution products by taking advantage of new satellites, sensors and algorithms. Improvements of the 5-km products over CRW’s heritage global 50-km products are derived from: (1) the higher resolution and greater data density of NOAA’s next-generation operational daily global 5-km geo-polar blended sea surface temperature (SST) analysis; and (2) implementation of a new SST climatology derived from the Pathfinder SST climate data record. The new products increase near-shore coverage and now allow direct monitoring of 95% of coral reefs and significantly reduce data gaps caused by cloud cover. The 5-km product suite includes SST Anomaly, Coral Bleaching HotSpots, Degree Heating Weeks and Bleaching Alert Area, matching existing CRW products. When compared with the 50-km products and in situ bleaching observations for 2013–2014, the 5-km products identified known thermal stress events and matched bleaching observations. These near reef-scale products significantly advance the ability of coral reef researchers and managers to monitor coral thermal stress in near-real-time.

The large diversity of unmanned aircraft requires a suitable and proper risk assessment. In this paper, we propose the use of risk maps to define the risk associated to accidents with unmanned aircraft. It is a two-dimensional location-based map that quantifies the risk to the population on ground of flight operations over a specified area. The risk map is generated through a probabilistic approach and combines several layers, including population density, sheltering factor, no-fly zones, and obstacles. Each element of the risk map has associated a risk value that quantifies the risk of flying over a specific location. Risk values are defined by a risk assessment process using different uncontrolled descent events, drone parameters, environmental characteristics, as well as uncertainties on parameters. The risk map is able to quantify the risk of large areas, such as urban environments, and allows for easy identification of high and low-risk locations. The map is a tool for informed decision making, and our results report some examples of risk map with different aircraft in a realistic urban environment.

The National Oceanic and Atmospheric Administration’s Coral Reef Watch program developed and operates several global satellite products to monitor bleaching-level heat stress. While these products have a proven ability to predict the onset of most mass coral bleaching events, they occasionally miss events; inaccurately predict the severity of some mass coral bleaching events; or report false alarms. These products are based solely on temperature and yet coral bleaching is known to result from both temperature and light stress. This study presents a novel methodology (still under development), which combines temperature and light into a single measure of stress to predict the onset and severity of mass coral bleaching. We describe here the biological basis of the Light Stress Damage (LSD) algorithm under development. Then by using empirical relationships derived in separate experiments conducted in mesocosm facilities in the Mexican Caribbean we parameterize the LSD algorithm and demonstrate that it is able to describe three past bleaching events from the Great Barrier Reef (GBR). For this limited example, the LSD algorithm was able to better predict differences in the severity of the three past GBR bleaching events, quantifying the contribution of light to reduce or exacerbate the impact of heat stress. The new Light Stress Damage algorithm we present here is potentially a significant step forward in the evolution of satellite-based bleaching products.

Most of over a thousand mitochondrial proteins are encoded by nuclear genes and must be imported from the cytosol. Little is known about the cytosolic events regulating mitochondrial protein import, partly due to the lack of appropriate tools for its assessment in living cells. We engineered an inducible biosensor for monitoring the main presequence-mediated import pathway with a quantitative, luminescence-based readout. This tool was used to explore the regulation of mitochondrial import by the PINK1 kinase-driven Parkin ubiquitin ligase, which is dysfunctional in autosomal recessive Parkinson’s disease. We show that mitochondrial import was stimulated by Parkin, but not by disease-causing Parkin variants. This effect was dependent on Parkin activation by PINK1 and accompanied by an increase in the abundance of K11 ubiquitin chains on mitochondria and by ubiquitylation of subunits of the translocase of outer mitochondrial membrane. Mitochondrial import efficiency was abnormally low in cells from patients with PINK1- and PARK2 -linked Parkinson’s disease and was restored by phosphomimetic ubiquitin in cells with residual Parkin activity. Altogether, these findings uncover a role of ubiquitylation in mitochondrial import regulation and suggest that loss of this regulatory loop may underlie the pathophysiology of Parkinson’s disease, providing novel opportunities for therapeutic intervention.