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Most present-day galaxies with stellar masses ≥1011 solar masses show no ongoing star formation and are dense spheroids. Ten billion years ago, similarly massive galaxies were typically forming stars at rates of hundreds solar masses per year. It is debated how star formation ceased, on which time scales, and how this \"quenching\" relates to the emergence of dense spheroids. We measured stellar mass and star-formation rate surface density distributions in star-forming galaxies at redshift 2.2 with ∼1-kiloparsec resolution. We find that, in the most massive galaxies, star formation is quenched from the inside out, on time scales less than 1 billion years in the inner regions, up to a few billion years in the outer disks. These galaxies sustain high star-formation activity at large radii, while hosting fully grown and already quenched bulges in their cores.

Cool gas fuels star formation Although it is thought that some galaxies in the early Universe grew rapidly through violent mergers, the properties of many early galaxies are incompatible with that scenario. Cresci et al . now report chemical abundance data from three star-forming galaxies at redshift z = 3 — equivalent to only two billion years after the Big Bang — that support an alternative model: galactic growth through the accretion of cold gas. The central star-forming regions in these galaxies are found to have lower metallicity than the outer regions. This is opposite to what is seen in local galaxies and is consistent with the accretion of cold primordial (and hence low metallicity) gas. Galaxies in the early Universe might grow through the accretion of cold, primordial, low-metallicity gas. If such gas is funnelled to the centre of a galaxy, it will result in the central region having an overall lower metallicity than outer regions. These authors report such 'inverse' metallicity gradients in three rotationally supported, star-forming galaxies at redshift ∼3, and conclude that the central gas has been diluted by the accretion of primordial gas. It has recently been suggested 1 , 2 that galaxies in the early Universe could have grown through the accretion of cold gas, and that this may have been the main driver of star formation and stellar mass growth 3 , 4 , 5 . Because the cold gas is essentially primordial, it has a very low abundance of elements heavier than helium (referred to as metallicity). If funnelled to the centre of a galaxy, it will result in the central gas having an overall lower metallicity than gas further from the centre, because the gas further out has been enriched by supernovae and stellar winds, and not diluted by the primordial gas. Here we report chemical abundances across three rotationally supported star-forming galaxies at redshift z  ≈ 3, only 2 Gyr after the Big Bang. We find ‘inverse’ gradients, with the central, star-forming regions having lower metallicities than less active ones, which is opposite to what is seen in local galaxies 6 , 7 . We conclude that the central gas has been diluted by the accretion of primordial gas, as predicted by ‘cold flow’ models.

Star formation at a rate of more than 15 solar masses a year has been observed inside a massive outflow of gas from a nearby galaxy; this could also be happening inside other galactic outflows. Star birth in gas flows Massive, galactic-scale outflows of molecular gas with the physical conditions necessary to form stars have recently been observed and several models predict that star formation could ignite within the outflow itself. Roberto Maiolino et al . report spectroscopic observations that unambiguously reveal star formation occurring in a galactic outflow at a redshift of 0.0448 and at an inferred rate exceeding 15 times the mass of the Sun per year. This new mode of star formation might be occurring in other galactic outflows and could have implications for the morphological evolution of galaxies, while contributing to the population of high-velocity stars. Recent observations have revealed massive galactic molecular outflows 1 , 2 , 3 that may have the physical conditions (high gas densities 4 , 5 , 6 ) required to form stars. Indeed, several recent models predict that such massive outflows may ignite star formation within the outflow itself 7 , 8 , 9 , 10 , 11 . This star-formation mode, in which stars form with high radial velocities, could contribute to the morphological evolution of galaxies 12 , to the evolution in size and velocity dispersion of the spheroidal component of galaxies 11 , 13 , and would contribute to the population of high-velocity stars, which could even escape the galaxy 13 . Such star formation could provide in situ chemical enrichment of the circumgalactic and intergalactic medium (through supernova explosions of young stars on large orbits), and some models also predict it to contribute substantially to the star-formation rate observed in distant galaxies 9 . Although there exists observational evidence for star formation triggered by outflows or jets into their host galaxy, as a consequence of gas compression, evidence for star formation occurring within galactic outflows is still missing. Here we report spectroscopic observations that unambiguously reveal star formation occurring in a galactic outflow at a redshift of 0.0448. The inferred star-formation rate in the outflow is larger than 15 solar masses per year. Star formation may also be occurring in other galactic outflows, but may have been missed by previous observations owing to the lack of adequate diagnostics 14 , 15 .

Excessive ethanol consumption causes adverse effects and contributes to organ dysfunction. Ethanol metabolism triggers oxidative stress, altered immune function, and gut dysbiosis. The gut microbiome is known to contribute to the maintenance of intestinal homeostasis, and disturbances are associated with pathology. A consequence of gut dysbiosis is also alterations in its metabolic and fermentation byproducts. The gut microbiota ferments undigested dietary polysaccharides to yield short-chain fatty acids, predominantly acetate, propionate, and butyrate. Butyrate has many biological mechanisms of action including anti-inflammatory and immunoprotective effects, and its depletion is associated with intestinal injury. We previously showed that butyrate protects gut-liver injury during ethanol exposure. While the intestine is the largest immune organ in the body, little is known regarding the effects of ethanol on intestinal immune function. This work is aimed at investigating the effects of butyrate supplementation, in the form of the structured triglyceride tributyrin, on intestinal innate immune responses and oxidative stress following chronic-binge ethanol exposure in mice. Our work suggests that tributyrin supplementation preserved immune responses and reduced oxidative stress in the proximal colon during chronic-binge ethanol exposure. Our results also indicate a possible involvement of tributyrin in maintaining the integrity of intestinal villi vasculature disrupted by chronic-binge ethanol exposure.

All cosmological models of structure formation predict the existence of a widespread population of dual supermassive black holes in-spiralling inside their common host galaxy, eventually merging and giving rise to intense gravitational waves. These systems can be identified as dual active galactic nuclei (AGNs) at kiloparsec separations, but only very few have been confirmed at z  > 0.5. The appearance of multiple AGNs at small angular separations can also be due to gravitational lensing of single AGNs, which are themselves very important systems for many astrophysical topics. Here we present a novel technique, dubbed the Gaia multipeak method, to obtain large and reliable samples of dual/lensed AGN candidates with sub-arcsec separations by looking for AGNs showing multiple peaks in the light profiles observed by the Gaia satellite. All of the Gaia multipeak method-selected sources with high-resolution images (26 from the Hubble Space Telescope archive and 5 from dedicated adaptive-optics-assisted imaging at the Large Binocular Telescope) show multiple components with sub-arcsec separation pointing toward a very high reliability of the method. By sampling separations down to ~2 kpc at z  > 1, this method allows us to probe the physical processes that drive the in-spiralling of a pair of supermassive black holes inside a single galaxy. A new selection method is used to obtain a sample of dual/lensed active galactic nuclei (AGN) candidates with sub-arcsec separations from Gaia data. This substantially increases the known number of dual AGNs, with implications for studies of in-spiralling supermassive black holes.

We investigated the interstellar medium (ISM) properties in the central regions of nearby Seyfert galaxies characterised by prominent conical or bi-conical outflows belonging to the MAGNUM survey by exploiting the unprecedented sensitivity, spatial and spectral coverage of the integral field spectrograph MUSE at the Very Large Telescope. We developed a novel approach based on the gas and stars kinematics to disentangle high-velocity gas in the outflow from gas in the disc to spatially track the differences in their ISM properties. This allowed us to reveal the presence of an ionisation structure within the extended outflows that can be interpreted with different photoionisation and shock conditions, and to trace tentative evidence of outflow-induced star formation (“positive” feedback) in a galaxy of the sample, Centaurus A.

Brightest cluster galaxies (BCGs) residing in cool-core clusters are known to be the stage of intricate baryon cycle phenomena (e.g. gas inflows, AGN outflows, star formation feedback). The scenarios describing the observed properties of these galaxies are still controversial, suffering from limitations due to the spatial resolving power of the instruments, specifically for galaxies beyond the Local Universe. However, the dramatic improvements introduced by the integral-field unit instruments (e.g. MUSE) could shed light on the physical processes driving the evolution of these galaxies. We present an extensive analysis of the stellar and gas properties (i.e. kinematics, stellar mass, star formation rate) of the radio-loud BCG sitting at the centre of the X-ray luminous cool-core cluster Abell 2667 (z = 0.23), based on MUSE data. Our results indicate that the BCG is a massive elliptical, hosting an AGN that is possibly undergoing accretion of cold star-forming clouds of ICM or galactic cannibalism.

In this work transient mixed convection in a porous medium in a horizontal channel with a open cavity below is studied numerically. The cavity presents a heated wall at uniform heat flux and the other walls of the cavity and the channel are assumed adiabatic. Air flows through the horizontal channel. The heated wall of the cavity experiences a uniform heat flux in such a way that the forced flow is perpendicular to the motion due to natural convection. The study is carried out employing Brinkman-Forchheimer-extended Darcy model and two energy equations due to the local thermal non-equilibrium assumption. The flow in the channel is assumed to be two-dimensional, laminar, incompressible. Boussinesq approximation is considered. The thermophysical properties of the fluid are evaluated at the ambient temperature. The results for stream function and temperature distribution given at different times are obtained. Wall temperature value are given and also, the velocity and temperature profiles in several sections of the cavity are presented. In addition, the Nusselt number, both local and average, is presented along with the temporal variations of the average Nusselt number.

Dysregulation of gut microbiota and intestinal barrier function has emerged as potential mechanisms underlying digestive diseases, yet targeted therapies are lacking The purpose of this investigation was to assess the efficacy of UCC118, a characterized probiotic strain, on exercise‐induced GI permeability in healthy humans. In a randomized, double‐blind, placebo‐controlled crossover study, seven healthy adults received 4 weeks of daily UCC118 or placebo supplementation. GI hyperpermeability was induced by strenuous treadmill running performed before and after each supplementation period. While running, participants ingested 5 g of lactulose, rhamnose, and sucrose. Urine was collected before, immediately after, and every hour for 5 h after exercise to assess GI permeability. Metagenomic sequencing was performed on fecal homogenates collected prior to exercise to identify changes in microbial diversity and taxon abundances. Inflammatory biomarkers were assessed from blood and fecal homogenates collected prior to and immediately following the cessation of exercise. Exercise significantly induced intestinal permeability of lactulose, rhamnose, and sucrose (P < 0.001). UCC118 significantly reduced sucrose (Δ = −0.38 ± 0.13 vs. 1.69 ± 0.79; P < 0.05) recovery, with no substantial change in lactulose (Δ = −0.07 ± 0.23 vs. 0.35 ± 0.15; P = 0.16) or rhamnose (Δ = −0.06 ± 0.22 vs. 0.48 ± 0.28; P = 0.22). Taxonomic sequencing revealed 99 differentially regulated bacteria spanning 6 taxonomic ranks (P < 0.05) after UCC118 supplementation. No differences in plasma IL‐6 or fecal zonulin were observed after UCC118 supplementation. The results described herein provide proof of principle that 4 weeks of UCC118 supplementation attenuated exercise‐induced intestinal hyperpermeability. Further research is warranted to investigate the as‐yet‐to‐be defined molecular processes of intestinal hyperpermeability and the effects of probiotic supplementation. Dysregulation of gut microbiota and intestinal barrier function have emerged as potential mechanisms underlying digestive diseases, yet targeted therapies are lacking. In a randomized, double‐blind, placebo‐controlled crossover study, 7 healthy adults 30 received 4 weeks of daily UCC118 or placebo supplementation. UCC118 significantly reduced sucrose recovery. Taxonomic sequencing revealed 99 differentially regulated gut microbes by UCC118. The results herein provide proof of principle that UCC118 supplementation can reduce intestinal hyperpermeability.