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60-minute CEO : the fast track to top leadership
\"Looking toward the C-suite? Take heed. Author and serial CEO Dick Cross pulls back the curtain on this top leadership role, explaining in his new book that being a successful leader, running a business, and doing it extraordinarily well isn't a full-time job. In 60-Minute CEO: The Fast Track to Top Leadership, Cross makes the case that the single greatest determinant of business success revolves around the job at the top. Cross suggests that the most important, and often overlooked, duty for a CEO is thinking about how to improve his or her business and how to be a leader. Cross also reveals that a mediocre leader can be transformed into an exemplary one simply by refining two key things: thinking and character. In Cross's trademark conversational style, he conveys why strategy and execution, while important, should take a back seat to authenticity and responsibility, and that the essential elements of the CEO role can be accomplished in several 60-minute sessions every week. Executives may fill their time with other tasks, but leading and running a company requires explicit skills different from those needed for any other corporate position. The good news is that those skills are easy to learn, fun to do, and not time-consuming. In an entertaining style, Cross offers executives the fast track to the top leadership position. And while 60 minutes may seem like a quick fix, as Cross sees it, three 60-minute sessions a week devoted solely to considering your business and your role as leader are crucial to business and leadership success. In 60-Minute CEO, Dick Cross brings over 25 years of experience of transforming companies in various stages of underperformance into industry powerhouses. Cross combines his knowledge and experience with the stories and lessons of preeminent leaders and thinkers including General George Patton and Seattle Seahawks quarterback Russell Wilson\"-- Provided by publisher.
Book
Standardized definitions of molecular response in chronic myeloid leukemia
The International Randomized Study of Interferon and STI571 (IRIS) demonstrated long-term cytogenetic responses in patients with chronic-phase chronic myeloid leukemia (CML-CP) treated with the tyrosine kinase inhibitor (TKI) imatinib. However, deep molecular responses (MRs), as measured by reductions in
BCR-ABL
transcript levels below the threshold of major MR, were achieved only by a small proportion of patients. With the advent of the second-generation TKIs nilotinib and dasatinib for the treatment of patients with newly diagnosed CML-CP, the proportion of patients who achieve the deepest levels of MR is likely to increase significantly. With these changes, the potential for patient eligibility in TKI cessations studies is becoming a more widely discussed topic and area for research. These developments highlight the need for robust, standardized and workable definitions of deep MRs. Specifically, it is critical that the measurement of MR is standardized in a manner to withstand both intra- and inter-laboratory variability, as well as new methodological developments. This review summarizes the relevant clinical background and proposes a framework within which standardization of MR can be taken forward.
Journal Article
Just run it! : running an exceptional business is easier than you think
\"Americans launch more than half a million businesses each year, but most fail within the first five years. Their failure rate isn't high because of a lack of drive, solid ideas, or even capital on the part of the founders. The problem is a pervasive lack of know-how about marrying the nuts and bolts of an idea into a larger framework for business success. \"--P. [4] of cover.
Book
Mastering the Semi-Structured Interview and Beyond
Mastering the Semi-Structured Interview and Beyondoffers an in-depth and captivating step-by-step guide to the use of semi-structured interviews in qualitative research. By tracing the life of an actual research project-an exploration of a school district's effort over 40 years to address racial equality-as a consistent example threaded across the volume, Anne Galletta shows in concrete terms how readers can approach the planning and execution of their own new research endeavor, and illuminates unexpected real-life challenges they may confront and how to address them.The volume offers a close look at the inductive nature of qualitative research, the use of researcher reflexivity, and the systematic and iterative steps involved in data collection, analysis, and interpretation. It offers guidance on how to develop an interview protocol, including the arrangement of questions and ways to evoke analytically rich data.Particularly useful for those who may be familiar with qualitative research but have not yet conducted a qualitative study,Mastering the Semi-Structured Interview and Beyondwill serve both undergraduate and graduate students as well as more advanced scholars seeking to incorporate this key methodological approach into their repertoire.Anne Gallettais Associate Professor at the College of Education and Human Services at Cleveland State University.William E. Cross, Jr.is the author of Shades of Black: Diversity in African-American Identity.In theQualitative Studies in Psychologyseries
eBook
The ideologies of Japanese tea : subjectivity, transience and national identity
This study of the Japanese tea ceremony examines the ideological foundation of its place in history and the broader context of Japanese cultural values where it has emerged as a so-called 'quintessential' component of the culture.
Book
Self-assembly of graphene ribbons by spontaneous self-tearing and peeling from a substrate
The controllable self-assembly of graphene ribbons on a substrate is shown, demonstrating an effect which could be applied to patterning and actuating devices made from two-dimensional materials.
Adding a new dimension to monolayer graphene
More than twenty years ago it was envisioned that graphene could be folded and cut into useful forms as a kind of nanoscale origami. In this issue James Annett and Graham Cross describe a system in which single-layer graphene can reorganize itself into three dimensions by a process of folding, sliding and tearing. When a small flap of graphene sheet is folded over to touch itself, it spontaneously starts to slide, tearing into a ribbon-like strip in the process. On removal of a kinetic barrier, the two-dimensional material can coalesce into its more familiar three-dimensional, layered form. The driver for this peeling phenomenon is a thermodynamic mechanism that is robust enough to work over large areas even in air at room temperature. The findings hold promise as a novel mechanism to mechanically actuate two-dimensional materials as well as a new way of assembling them into complex three-dimensional architectures.
Graphene and related two-dimensional materials have shown unusual and exceptional mechanical properties
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,
2
,
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, with similarities to origami-like paper folding
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,
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and kirigami-like cutting
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,
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demonstrated. For paper analogues, a critical difference between macroscopic sheets and a two-dimensional solid is the molecular scale of the thin dimension of the latter, allowing the thermal activation of considerable out-of-plane motion. So far thermal activity has been shown to produce local wrinkles in a free graphene sheet that help in theoretically understanding its stability
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, for example, and give rise to unexpected long-range bending stiffness
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. Here we show that thermal activation can have a more marked effect on the behaviour of two-dimensional solids, leading to spontaneous and self-driven sliding, tearing and peeling from a substrate on scales approaching the macroscopic. We demonstrate that scalable nanoimprint-style contact techniques can nucleate and direct the parallel self-assembly of graphene ribbons of controlled shape in ambient conditions. We interpret our observations through a simple fracture-mechanics model that shows how thermodynamic forces drive the formation of the graphene–graphene interface in lieu of substrate contact with sufficient strength to peel and tear multilayer graphene sheets. Our results show how weak physical surface forces can be harnessed and focused by simple folded configurations of graphene to tear the strongest covalent bond. This effect may hold promise for the patterning and mechanical actuating of devices based on two-dimensional materials.
Journal Article
Off the ice
\"Claire O'Connor is back in Juniper Falls, but that doesn't mean she wants to be. One semester off, that's what she promised herself. Just long enough to take care of her father and keep the family business-a hockey bar beside the ice rink-afloat. After that, she's getting the hell out. Again. Enter Tate Tanley. What happened between them the night before she left town resurfaces the second they lay eyes on each other. But the guy she remembers has been replaced by a total hottie. When Tate is unexpectedly called in to take over for the hockey team's star goalie, suddenly he's in the spotlight and on his way to becoming just another egotistical varsity hockey player. And Claire's sworn off Juniper Falls hockey players for good. It's the absolute worst time to fall in love. For Tate and Claire, hockey isn't just a game. And they both might not survive a body check to the heart. \"-- Page [4] of cover.
Book
Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia
Treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors has advanced to a stage where many patients achieve very low or undetectable levels of disease. Remarkably, some of these patients remain in sustained remission when treatment is withdrawn, suggesting that they may be at least operationally cured of their disease. Accurate definition of deep molecular responses (MRs) is therefore increasingly important for optimal patient management and comparison of independent data sets. We previously published proposals for broad standardized definitions of MR at different levels of sensitivity. Here we present detailed laboratory recommendations, developed as part of the European Treatment and Outcome Study for CML (EUTOS), to enable testing laboratories to score MR in a reproducible manner for CML patients expressing the most common
BCR-ABL1
variants.
Journal Article
Mediating madness : mental distress and cultural representation
\"Mediating Madness examines how mediations of madness emerge, disappear and interleave, only to re-emerge at unexpected moments. Drawing on social and cultural histories of madness, history of art, and popular journalism, the book offers a unique interdisciplinary understanding of historical and contemporary media representations of madness\"--Provided by publisher.
Book
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Among children and young adults with the Dravet syndrome, a developmental disorder that is associated with treatment-resistant seizures, cannabidiol reduced the frequency of convulsive seizures but caused sleepiness and elevated liver enzymes in some patients.
Seizures are difficult to control in the Dravet syndrome, a rare genetic form of epileptic encephalopathy primarily due to loss-of-function mutations in the
SCN1A
gene. Interest in cannabidiol for the treatment of epilepsy was generated by media reports of efficacy in children with the Dravet syndrome.
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Four small trials of cannabidiol had yielded mixed results.
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–
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A series of in vitro and in vivo preclinical models of seizure showed that cannabidiol had activity against convulsive seizures.
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Subsequently, the safety and effectiveness of a standardized oral solution of cannabidiol was tested in an open-label trial involving 214 children and young adults . . .
Journal Article