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The main objective of this work was to perform a comprehensive analysis and provide a race-stratified epidemiological report accounting for differences in treatment patterns and treatment related adverse events in Non-Hispanic women with breast cancer (BC). The cohort included women ≥ 18 years diagnosed with in-situ , early-stage, and late-stage BC (2005–2022). Treatment patterns included: surgery, breast radiation, chemotherapy, endocrine therapy, or biologic therapy. Treatment related adverse events were: chemotherapy complications, cardiovascular toxicities, immune-related adverse events, psychological affectations, or cognitive decline/dementia. The influence of race on the outcomes was measured via Cox proportional-hazards models. We included 17,454 patients (82% non-Hispanic Whites [NHW]). Most of the patients had a Charlson Comorbidity Score between 1 and 2 (68%), and TNM stage I (44.5%). Surgery was performed in 51.5% of the cases, while 30.6% received radiotherapy, 26.4% received chemotherapy, 3.1% received immunotherapy, and 41.2% received endocrine therapy. Non-Hispanic Blacks (NHB) had a lower probability of undergoing breast cancer surgery (aHR = 0.92, 95% CI 0.87–0.97) and of being prescribed endocrine therapy (aHR = 0.83, 95% CI 0.79–0.89), but a higher probability of receiving adjuvant radiotherapy (aHR = 1.40, 95% CI 1.29–1.52). Moreover, NHBs had lower risk of being diagnosed with psychological issues (aHR = 0.71, 95% CI 0.63–0.80) but a higher risk for cognitive decline/dementia (aHR = 1.30, 95% CI 1.08–1.56). In conclusion, NHB women diagnosed with BC were less likely than NHW to undergo curative intent surgery or receive endocrine therapy, and had a higher risk of cognitive decline/dementia after cancer treatment. Public policy measures are urgently needed which equalize access to quality healthcare for all patients and that promote a learning healthcare system which can improve cancer outcomes.

This article explores the concept of parallel process, the flow of unconscious client material from supervisee to supervisor and the reverse of this flow, which may lead to impasses within the supervisory triad. It also discusses the concept of modeling, or observational learning, which deviates from key constructs of parallel process, yet at times has been conflated with parallel process in social work scholarship, pedagogy, and practice. In highlighting the differences between the two concepts, we seek to show the scope of their respective explanatory power and to heighten awareness and help supervisors make conscious choices in supervision that align with a clear understanding of their theoretical underpinnings. We examine newer directions for parallel process that include its connections to neurobiology, trauma, and diversity, intersectionality, and cultural humility, and we provide two case vignettes to elucidate the phenomenon. Finally, we offer an integrative discussion of implications for supervision.

Background Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate survival duration after treatment for skeletal-related events (SREs) (symptomatic bone metastasis, including impending or actual pathologic fractures) in men with metastatic bone disease due to prostate cancer. Such disease-specific models could be added to the PATHFx clinical-decision support tool, which is available worldwide, free of charge. Our secondary aim was to determine disease-specific factors that should be included in an international cancer registry. Methods We analyzed records of 438 men with metastatic prostate cancer who sustained SREs that required treatment with radiotherapy or surgery from 1989–2017. We developed and validated 6 models for 1-, 2-, 3-, 4-, 5-, and 10-year survival after treatment. Model performance was evaluated using calibration analysis, Brier scores, area under the receiver operator characteristic curve (AUC), and decision curve analysis to determine the models’ clinical utility. We characterized the magnitude and direction of model features. Results The models exhibited acceptable calibration, accuracy (Brier scores < 0.20), and classification ability (AUCs > 0.73). Decision curve analysis determined that all 6 models were suitable for clinical use. The order of feature importance was distinct for each model. In all models, 3 factors were positively associated with survival duration: younger age at metastasis diagnosis, proximal prostate-specific antigen (PSA) < 10 ng/mL, and slow-rising alkaline phosphatase velocity (APV). Conclusions We developed models that estimate survival duration in patients with metastatic bone disease due to prostate cancer. These models require external validation but should meanwhile be included in the PATHFx tool. PSA and APV data should be recorded in an international cancer registry.

TP53 is one of the most frequently altered genes in prostate cancer. The precise assessment of its focal alterations in primary tumors by immunohistochemistry (IHC) has significantly enhanced its prognosis. p53 protein expression and lymphovascular invasion (LVI) were evaluated for predicting metastatic progression by IHC staining of representative whole-mounted prostate sections from a cohort of 189 radical prostatectomy patients with up to 20 years of clinical follow-up. Kaplan–Meier survival curves were used to examine time to distant metastasis (DM) as a function of p53 expression and LVI status. TP53 targeted sequencing was performed in ten tumors with the highest expression of p53 staining. Nearly half (49.8%) of prostate tumors examined showed focal p53 expression while 26.6% showed evidence of LVI. p53(+) tumors had higher pathologic T stage, Grade Group, Nuclear Grade, and more frequent LVI. p53 expression of > 5% and LVI, individually and jointly, are associated with poorer DM-free survival. TP53 mutations were detected in seven of ten tumors sequenced. Four tumors with the highest p53 expression harbored likely pathogenic or pathogenic mutations. High levels of p53 expression suggest the likelihood of pathogenic TP53 alterations and, together with LVI status, could enhance early prognostication of prostate cancer progression.

Background There is a male predominance of acute myeloid leukemia (AML) incidence, but survival data are conflicting. The objective of this study is to carry out a comprehensive analysis of sex differences in AML, and to investigate the impact of sex disparities in survival. Methods The cohort included patients ≥18 years diagnosed with AML (2010–2022). Demographics, treatment patterns, treatment adverse events, and survival were analyzed. The population was described and compared by sex, and sex‐based risks and associations were obtained via Cox proportional‐hazards regression. Results In total, 1020 AML patients were analyzed (57.4% males), with lower risk of death for females (aHR = 0.41, 95% CI 0.26–0.66). Among females, BMT (aHR = 0.51, 95% CI 0.27–0.97), hospitalization record (aHR = 0.65, 95%CI 0.45–0.93), and higher appointment completion rates (aHR = 0.98, 95% CI 0.98–0.98) were associated with lower risk of death. Overall, and similarly in males, higher age at diagnosis (aHR = 1.03, 95% CI 1.02–1.04) and a TP53 mutation (aHR = 2.24, 95% CI 1.69–2.97) were associated with higher risk of death. Conclusion Sex differences exist in both AML incidence and overall survival. Treatment and health care factors should be addressed by caregivers and public policies developed to reduce mortality rates and mitigate existing sex differences. This study, focused on sex differences in acute myeloid leukemia, reported a 1.34 male:female ratio with a later start of treatment and lower treatment adherence rates in females. Bone marrow transplant, hospitalization, and higher treatment completion rates were associated with lower risk of death in females. In patients with a hospitalization record, females were 39% less likely to receive chemotherapy, 160% more likely to have a chemotherapy adverse event, and had a 59% lower risk of death.

In prostate cancer, emerging data highlight the role of DNA damage repair genes (DDRGs) in aggressive forms of the disease. However, DDRG mutations in African American men are not yet fully defined. Here, we profile germline mutations in all known DDRGs ( N  = 276) using whole genome sequences from blood DNA of a matched cohort of patients with primary prostate cancer comprising of 300 African American and 300 European Ancestry prostate cancer patients, to determine whether the mutation status can enhance patient stratification for specific targeted therapies. Here, we show that only 13 of the 46 DDRGs identified with pathogenic/likely pathogenic mutations are present in both African American and European ancestry patients. Importantly, RAD family genes ( RAD51, RAD54L, RAD54B ), which are potentially targetable, as well as PMS2 and BRCA1 , are among the most frequently mutated DDRGs in African American, but not in European Ancestry patients. DNA damage repair genes have been linked with increased aggressiveness of prostate cancer, however, the extent of mutation of these genes has not been analyzed within a cohort of African American patients. Here, the authors identify increased mutation rates in specific DNA repair genes, compared with prostate cancer patients with European Ancestry.

Background Indigenous people tend to exhibit a higher burden of disability than their non-Indigenous counterparts, and are often underserved by disability services. Engaging appropriately with Indigenous communities, families and individuals in the initial stages of disability assessment and planning is crucial in order to build trust and understanding of disability service models and ensure that Indigenous people receive support that is tailored to their needs and cultural realities. This article aims to identify key elements of culturally competent communication in Indigenous disability assessment and planning, and provide recommendations for strengthening capacity in this area. Methods This qualitative research was designed to involve Aboriginal and Torres Strait Islander people at all stages and to reflect the views of Aboriginal and Torres Strait Islander researchers, people and families affected by disability and the community-controlled health sector. Semi-structured individual interviews were undertaken with staff implementing the National Disability Insurance Scheme (NDIS) ( n  = 4), NDIS participants ( n  = 24), disability support providers and organisational partners ( n  = 19) and Community Connectors ( n  = 8) in Queensland and the Northern Territory of Australia. Key themes derived from thematic analysis included appropriate and adequate engagement of individuals with disability and their families, the role of trusted relationships, and culturally safe and appropriate communication during planning meetings. Results Overall, the research findings highlight that a low level of cultural competence in the initial stages of the disability assessment and planning process exacerbated participant confusion and distrust towards assessment staff and the NDIS. Given difficulties in communication, participant understanding of the NDIS was generally limited. The necessity of culturally safe and appropriate use of interpreters was stressed, as was the role of trusted individuals, including existing service providers, Community Connectors and family members in providing a solid base for participant understanding of the NDIS. Conclusions Cultural competence in disability assessment and planning can be strengthened through multi-level engagement with the Aboriginal community-controlled sector and community leaders. Implementing mechanisms to enable the involvement of families, trusted service providers and Community Connectors can support a more meaningful understanding of individuals’ needs within their cultural context and in relation to their cultural roles.

Purpose: Examining the long-term outcomes of education programs delivered online can help assess the impact of the program on graduates and the value of the delivery format. The purpose of this study was to measure the overall outcomes of an online dental hygiene degree completion program and identify key alumni outcomes. Methods: A 35 item electronic survey was delivered via email to all graduates (2009-2017) of an online degree completion program based in Ann Arbor, Michigan, two years following program completion. Survey items included Likert scale, closed and open-ended questions focusing on career characteristics, leadership, scholarly activities, evidence- and community-based practices, professional confidence, and transformative learning. Descriptive and inferential statistics were used to analyze the data. Results: Of the nine alumni cohorts (n=75), 50 graduates participated in the survey for a response rate of 67%. Eighty-two percent of respondents felt they had more career options after graduation and reported post-degree career activities that included dental hygiene instruction (36%), public health (32%), and administration (14%). There was a statistically significant increase in the instructor/educator role of the participants post-graduation (p = 0.000). The majority (94%) indicated the program improved their competency in areas of leadership and evidence-based practice and all (100%) indicated a greater responsibility to use their professional skills to address oral health disparities in their communities Conclusion: Graduates of the online degree completion program reported ongoing activities in key areas of leadership, evidence- and community-based practice. Future research should focus on ensuring that program goals reflect the evolving dental hygiene profession and program delivery practices meet the needs of the working professional student. Keywords: dental hygiene education, e-learning technology, distance education, online learning, degree completion

Purpose: Health care provider perceptions of interprofessional collaboration (IPC) have been well documented, however barriers to provider participation persist. The purpose of this pilot study was to examine differences in health care providers' perceptions of IPC based on the academic degree level.Methods: Licensed health care providers with faculty appointments at a four-year university-based setting were invited to participate in an electronic survey. Attitudinal questions in the survey instrument were based on the Theory of Planned Behavior and the Social Cognitive Theory and assessed perceptions, attitudes, norms, and self-efficacy toward IPC. Descriptive statistics were used to analyze the data.Results: Respondents (n=179) included faculty in medicine (29%), dentistry (23%), nursing (13%), dental hygiene (11%), physical therapy (8%), and pharmacy (7%). Ninety percent of respondents agreed or strongly agreed that IPC is important for improving patient health outcomes. Respondents across all degree levels were significantly more comfortable taking recommendations on patient treatment from another health care provider with a doctoral degree as compared to a health care provider with an associate degree, with mean scores declining from 5.58 to 4.58 (p=0.000).Conclusion: While all respondents valued IPC in improving patient outcomes, their perceptions of other health care providers' level of academic degree may play a role in their willingness to truly collaborate with them. Despite an institution's positive culture of IPC, bias and stereotypes regarding the level of academic degree need to be addressed. Results indicate that while health care providers with lower academic degrees may be valuable contributors to the IPC team, their academic degree could be a barrier to their meaningful inclusion.Purpose: Health care provider perceptions of interprofessional collaboration (IPC) have been well documented, however barriers to provider participation persist. The purpose of this pilot study was to examine differences in health care providers' perceptions of IPC based on the academic degree level.Methods: Licensed health care providers with faculty appointments at a four-year university-based setting were invited to participate in an electronic survey. Attitudinal questions in the survey instrument were based on the Theory of Planned Behavior and the Social Cognitive Theory and assessed perceptions, attitudes, norms, and self-efficacy toward IPC. Descriptive statistics were used to analyze the data.Results: Respondents (n=179) included faculty in medicine (29%), dentistry (23%), nursing (13%), dental hygiene (11%), physical therapy (8%), and pharmacy (7%). Ninety percent of respondents agreed or strongly agreed that IPC is important for improving patient health outcomes. Respondents across all degree levels were significantly more comfortable taking recommendations on patient treatment from another health care provider with a doctoral degree as compared to a health care provider with an associate degree, with mean scores declining from 5.58 to 4.58 (p=0.000).Conclusion: While all respondents valued IPC in improving patient outcomes, their perceptions of other health care providers' level of academic degree may play a role in their willingness to truly collaborate with them. Despite an institution's positive culture of IPC, bias and stereotypes regarding the level of academic degree need to be addressed. Results indicate that while health care providers with lower academic degrees may be valuable contributors to the IPC team, their academic degree could be a barrier to their meaningful inclusion.