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High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR) and type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is not clear whether mitochondrial dysfunction is a direct effect of a HFD, or if mitochondrial function is reduced with increased HFD duration. We hypothesized that the function of mitochondrial oxidative and lipid metabolism functions in skeletal muscle mitochondria for HFD mice are similar, or elevated, relative to standard diet (SD) mice; thereby, IR is neither cause nor consequence of mitochondrial dysfunction. We applied a chemical probe approach to identify functionally reactive ATPases and nucleotide-binding proteins in mitochondria isolated from skeletal muscle of C57Bl/6J mice fed HFD or SD chow for 2-, 8-, or 16-weeks; feeding time points known to induce IR. A total of 293 probe-labeled proteins were identified by mass spectrometry-based proteomics, of which 54 differed in abundance between HFD and SD mice. We found proteins associated with the TCA cycle, oxidative phosphorylation (OXPHOS), and lipid metabolism were altered in function when comparing SD to HFD fed mice at 2-weeks, however by 16-weeks HFD mice had TCA cycle, β-oxidation, and respiratory chain function at levels similar to or higher than SD mice.

A bstract A measurement of the Ξ cc + + mass is performed using data collected by the LHCb experiment between 2016 and 2018 in pp collisions at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5 . 6 fb − 1 . The Ξ cc + + candidates are reconstructed via the decay modes Ξ cc + + → Λ c + K − π + π + and Ξ cc + + → Ξ c + π + . The result, 3621 . 55 ± 0 . 23 (stat) ± 0 . 30 (syst) MeV/ c 2 , is the most precise measurement of the Ξ cc + + mass to date.

A bstract A precision measurement of the B c + meson mass is performed using proton- proton collision data collected with the LHCb experiment at centre-of-mass energies of 7 , 8 and 13 TeV, corresponding to a total integrated luminosity of 9 . 0 fb − 1 . The B c + mesons are reconstructed via the decays B c + → J/ψπ + , B c + → J/ψπ + π − π + , B c + → J / ψp p ¯ π + , B c + → J / ψ D s + , B c + → J/ψ D 0 K + and B c + → B s 0 π + . Combining the results of the individual decay channels, the B c + mass is measured to be 6274 . 47 ± 0 . 27 (stat) ± 0 . 17 (syst) MeV /c 2 . This is the most precise measurement of the B c + mass to date. The difference between the B c + and B s 0 meson masses is measured to be 907 . 75 ± 0 . 37 (stat) ± 0 . 27 (syst) MeV /c .

A bstract A search is presented for the lepton flavour violating decay B + → K + μ − τ + using a sample of proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated luminosity of 9 fb − 1 . The τ leptons are selected inclusively, primarily via decays with a single charged particle. The four-momentum of the τ lepton is determined by using B + mesons from B s 2 ∗ 0 → B + K − decays. No significant excess is observed, and an upper limit is set on the branching fraction ℬ( B +  →  K + μ − τ + ) < 3.9 × 10 −5  at 90 %  confidence level. The obtained limit is comparable to the world-best limit.

The decay-time-dependent CP asymmetry in Bs0→J/ψK+K- decays is measured using proton–proton collision data, corresponding to an integrated luminosity of 1.9fb-1, collected with the LHCb detector at a centre-of-mass energy of 13TeV in 2015 and 2016. Using a sample of approximately 117 000 signal decays with an invariant K+K- mass in the vicinity of the ϕ(1020) resonance, the CP-violating phase ϕs is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the Bs0-B¯s0 system, ΔΓs. The difference of the average Bs0 and B0 meson decay widths, Γs-Γd, is determined using in addition a sample of B0→J/ψK+π- decays. The values obtained are ϕs=-0.083±0.041±0.006rad, ΔΓs=0.077±0.008±0.003ps-1 and Γs-Γd=-0.0041±0.0024±0.0015ps-1, where the first uncertainty is statistical and the second systematic. These are the most precise single measurements of these quantities to date and are consistent with expectations based on the Standard Model and with a previous LHCb analysis of this decay using data recorded at centre-of-mass energies 7 and 8 TeV. Finally, the results are combined with recent results from Bs0→J/ψπ+π- decays obtained using the same dataset as this analysis, and with previous independent LHCb results.

A bstract This paper presents an analysis of the Λ b 0 → J/ψ Λ angular distribution and the transverse production polarisation of Λ b 0 baryons in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV. The measurements are performed using data corresponding to an integrated luminosity of 4.9 fb − 1 , collected with the LHCb experiment. The polarisation is determined in a fiducial region of Λ b 0 transverse momentum and pseudorapidity of 1 < p T < 20 GeV/ c and 2 < η < 5, respectively. The data are consistent with Λ b 0 baryons being produced unpolarised in this region. The parity-violating asymmetry parameter of the Λ → pπ − decay is also determined from the data and its value is found to be consistent with a recent measurement by the BES III collaboration.

A search for the doubly charmed baryon Ξ c c + is performed through its decay to the Λ c + K − π + final state, using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7, 8 and 13 TeV. The data correspond to a total integrated luminosity of 9 fb −1 . No significant signal is observed in the mass range from 3.4 to 3.8 GeV/ c 2 . Upper limits are set at 95% credibility level on the ratio of the Ξ c c + production cross-section times the branching fraction to that of Λ c + and Ξ c c + + baryons. The limits are determined as functions of the Ξ c c + mass for different lifetime hypotheses, in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/ c .

A bstract A new baryon state is observed in the Λ b 0 π + π − mass spectrum with high significance using a data sample of pp collisions, collected with the LHCb detector at centre-of-mass energies s = 7 , 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb − 1 . The mass and natural width of the new state are measured to be m = 6072.3 ± 2.9 ± 0.6 ± 0.2 MeV , Γ = 72 ± 11 ± 2 MeV , where the first uncertainty is statistical and the second systematic. The third uncertainty for the mass is due to imprecise knowledge of the Λ b 0 baryon mass. The new state is consistent with the first radial excitation of the Λ b 0 baryon, the Λ b (2S) 0 resonance. Updated measurements of the masses and the upper limits on the natural widths of the previously observed Λ b (5912) 0 and Λ b (5920) 0 states are also reported.

Charmonium production cross-section in proton–proton collisions is measured at the centre-of-mass energy s = 13 TeV using decays to p p ¯ final state. The study is performed using a data sample corresponding to an integrated luminosity of 2.2 fb - 1 collected in 2018 with the LHCb detector. The production cross-section of the η c meson is measured in a rapidity range of 2.0 < y < 4.0 and in a transverse momentum range of 5.0 < p T < 20.0 GeV / c , which is extended compared with previous LHCb analyses. The differential cross-section is measured in bins of p T and, for the first time, of y . Upper limits, at 90% and 95% confidence levels, on the η c ( 2 S ) and h c ( 1 P ) prompt production cross-sections are determined for the first time.