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In this research, a new triterpenoid, tirucalla-8,24-diene-3β,11β-diol-7-one (1), and eupha-8,24-diene-3β,11β-diol-7-one (2), which was isolated from Euphorbia kansui for the first time, together with twelve other known compounds (3–14), were isolated from the ethyl acetate extract of Euphorbia kansui. Their structures were elucidated based on High resolution electrospray ionization mass spectrometry (HR-ESI-MS), Infrared Spectroscopy (IR), 1D and 2D Nuclear Magnetic Resonance (NMR) data. Both constituents 1 and 2 exhibited moderate cytotoxicity against colon cancer HCT-116, gastric cancer MKN-45 and breast cancer MCF-7.

Increased arterial stiffness measured by brachial-ankle pulse wave velocity is associated with cardiovascular disease. However, the rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels are largely unknown. This study was based on the baseline data of a Chinese community-based atherosclerosis cohort which included 7402 individuals. Using generalized linear regression models, the relationship between blood glucose levels and brachial-ankle pulse wave velocity, and the relationship between blood pressure levels and brachial-ankle pulse wave velocity were examined. A marked interaction between hypertensive state and diabetic state was seen for brachial-ankle pulse wave velocity ( for interaction <0.001). The adjusted coefficient for subjects stratified by hypertensive groups and diabetic states showed that the highest brachial-ankle pulse wave velocity risk subjects were those who had both diabetes and hypertension (B=403.24; 95% CI: 372.43-434.05; <0.001). The participants with increased arterial stiffness demonstrate a high prevalence of higher blood pressure. When high blood glucose levels co-occur with high blood pressure levels, there is a remarkable increase in arterial stiffness.

The well-known Schwarzschild black hole was first obtained as a stationary, spherically symmetric solution of the Einstein's vacuum field equations. But until thirty years later, efforts were made for the analytic extension from the exterior area \\((r>2GM)\\) to the interior one \\((r<2GM)\\). As a contrast to its maximally extension in the Kruskal coordinates, we provide a comoving coordinate system from the view of the observers freely falling into the black hole in the radial direction. We find an interesting fact that the spatial part in this coordinate system is maximally symmetric \\((E_3)\\), i.e., along the world lines of these observers, the Schwarzschild black hole can be decomposed into a family of maximally symmetric subspaces.