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Bile acids (BAs) facilitate nutrient digestion and absorption and act as signaling molecules in a number of metabolic and inflammatory pathways. Expansion of the BA pool and increased exposure to microbial BA metabolites has been associated with increased colorectal cancer (CRC) risk. Bile acids (BAs) facilitate nutrient digestion and absorption and act as signaling molecules in a number of metabolic and inflammatory pathways. Expansion of the BA pool and increased exposure to microbial BA metabolites has been associated with increased colorectal cancer (CRC) risk. It is well established that diet influences systemic BA concentrations and microbial BA metabolism. Therefore, consumption of nutrients that reduce colonic exposure to BAs and microbial BA metabolites may be an effective method for reducing CRC risk, particularly in populations disproportionately burdened by CRC. Individuals who identify as Black/African American (AA/B) have the highest CRC incidence and death in the United States and are more likely to live in a food environment with an inequitable access to BA mitigating nutrients. Thus, this review discusses the current evidence supporting diet as a contributor to CRC disparities through BA-mediated mechanisms and relationships between these mechanisms and barriers to maintaining a low-risk diet.

Obesity remains one of the five leading global risks for mortality in both developed and developing countries. Changes in dietary approaches have recently emerged as an approach to combat and prevent the high prevalence of obesity, specifically for minority groups having higher obesity rates. However, little research has been conducted on specific obesity rates in the Native American adolescent population and its’ correlation to micronutrient intake. Our study chose a specific minority population of adolescents in order to contribute more academic research on obesity rates and micronutrient intake on Native American adolescents. Data was compiled using the Harvard School of Public Health Youth/Adolescent Questionnaire, which allowed significant results to be found among normal weight, overweight, and obese, male and female adolescents. This study used anthropometric measurements and dietary assessments to obtain baseline measurements and further determine the cause of the prevalence of obesity within Native American adolescent population. The majority of minerals featured significant results among various populations, more specifically among normal weight and obese males. Our finding indicates a relationship between a higher mineral intake and lower body weight in the male adolescent population. The data revealed an innovative correlation between micronutrient intake and obesity prevalence in Native American adolescents, which may provide a potential intervention to further prevent or combat obesity rates.

Sodium laser guide star (LGS) system has become one of the critical components in modern astronomical adaptive optics system (AOS), especially for the next-generation extremely large telescopes, such as the Thirty Meter Telescope and the European Extremely Large Telescope. Since the wavefront detection performance of AOS is directly related to the brightness of LGS, it is important for AOS to maximize its photon generation efficiency by all means. Sodium D2b line repumping is such a technique that can greatly increase the returned photons for either sodium continuous wave (CW) laser or pulsed laser. This technique has been studied theoretically and field tested with a 20 W CW laser by European Southern Observatory team. However, field test results of a 20 W class pulsed laser with D2b repumping have not been reported yet. In this paper, our latest field test results with theoretical comparison of D2b repumping with a 20 W quasi-continuous wave (QCW) pulsed laser will be presented. With a linearly polarized beam, approximate 40% photon return enhancement was achieved when 10% of laser power was detuned to D2b line, which agreed well with results from a rate equation-based Monte Carlo photon return simulation program. Both experiment and simulation results indicate that with a higher laser intensity projected at the sodium layer, the D2b repumping will be more effective.

Sodium laser guide star (LGS) system has become one of the critical components in modern astronomical adaptive optics system (AOS), especially for the next-generation extremely large telescopes, such as the Thirty Meter Telescope and the European Extremely Large Telescope. Since the wavefront detection performance of AOS is directly related to the brightness of LGS, it is important for AOS to maximize its photon generation efficiency by all means. Sodium D2b line repumping is such a technique that can greatly increase the returned photons for either sodium continuous wave (CW) laser or pulsed laser. This technique has been studied theoretically and field tested with a 20 W CW laser by European Southern Observatory team. However, field test results of a 20 W class pulsed laser with D2b repumping have not been reported yet. In this paper, our latest field test results with theoretical comparison of D2b repumping with a 20 W quasi-continuous wave (QCW) pulsed laser will be presented. With a linearly polarized beam, approximate 40% photon return enhancement was achieved when 10% of laser power was detuned to D2b line, which agreed well with results from a rate equation-based Monte Carlo photon return simulation program. Both experiment and simulation results indicate that with a higher laser intensity projected at the sodium layer, the D2b repumping will be more effective.