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الترفيه مع الفن الغنائي والسردي الشفهي : الكيو يي الصينية
تتناول هذه السلسة مواضيع متنوعة ؛ كالشخصيات الصينية، والمسرح، والموسيقى، والرسم، وتنسيق الحدائق، والعمارة، والغناء الشعبي، والطب، والحرف التقليدية، والفنون القتالية، والعادات، والتقويم الشمسي، فضلا عن الملاحم والأساطير، والحلي والمجوهرات، والأدوات البرونزية، وفن الخط والأدب الصيني. لذا، لا بد تثري معارف القارئ المهتم بتاريخ الصين العريق وفي هذه السلسلة، سيبحر القارئ مستطلعا صورا مدهشة تتراكب بشكل متقن في كتب تصل به إلى قلب الحضارة الصينية وهو في مكانه.
BOOK
Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis
Background
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck. LSCC patients have seriously impaired vocal, respiratory, and swallowing functions with poor prognosis. Circular RNA (circRNA) has attracted great attention in cancer research. However, the expression patterns and roles of circRNAs in LSCC remain largely unknown.
Methods
RNA sequencing was performed on 57 pairs of LSCC and matched adjacent normal mucosa tissues to construct circRNA, miRNA, and mRNA expression profiles. RT-PCR, qPCR, Sanger sequencing, and FISH were undertaken to study the expression, localization, and clinical significance of
circCORO1C
in LSCC tissues and cells. The functions of
circCORO1C
in LSCC were investigated by RNAi-mediated knockdown, proliferation analysis, EdU staining, colony formation assay, Transwell assay, and apoptosis analysis. The regulatory mechanisms among
circCORO1C
,
let-7c-5p
, and
PBX3
were investigated by luciferase assay, RNA immunoprecipitation, western blotting, and immunohistochemistry.
Results
circCORO1C
was highly expressed in LSCC tissues and cells, and this high expression was closely associated with the malignant progression and poor prognosis of LSCC. Knockdown of
circCORO1C
inhibited the proliferation, migration, invasion, and in vivo tumorigenesis of LSCC cells. Mechanistic studies revealed that
circCORO1C
competitively bound to
let-7c-5p
and prevented it from decreasing the level of
PBX3
, which promoted the epithelial–mesenchymal transition and finally facilitated the malignant progression of LSCC.
Conclusions
circCORO1C
has an oncogenic role in LSCC progression and may serve as a novel target for LSCC therapy.
circCORO1C
expression has the potential to serve as a novel diagnostic and prognostic biomarker for LSCC detection.
Journal Article
Semantic enhancement and cross-modal interaction fusion for sentiment analysis in social media
The rapid development of social media has significantly impacted sentiment analysis, essential for understanding public opinion and predicting social trends. However, modality fusion in sentiment analysis can introduce a lot of noise because of the differences in semantic representations among various modalities, ultimately impacting the accuracy of classification results. Thus, this paper presents a Semantic Enhancement and Cross-Modal Interaction Fusion (SECIF) model for sentiment analysis to address these issues. Firstly, BERT and ResNet extract feature representations from text and images. Secondly, the GMHA mechanism is proposed to aggregate important semantic information and mitigate the influence of noise. Then, an ICN module is created to capture complex contextual dependencies and enhance the capability of text feature representations. Finally, a cross-modal interaction fusion module is implemented. Text features are considered primary, and image features are auxiliary, enabling the profound integration of textual and visual features. The model's performance is optimized by combining cross-entropy and KL divergence losses. The experiments are conducted using a dataset collected from public opinion events on Sina Weibo. The results demonstrate that the proposed model outperforms comparison models. The SECIF model improves by 11.19%, 82.27%, and 4.83% over the average accuracy of the text-only, image-only, and multimodal models, respectively. The proposed SECIF model is compared with ten baseline models on the publicly available datasets. The experimental results show that the SECIF model improves accuracy by 4.70% and F1 score by 6.56%. Through multimodal sentiment analysis, governments can better understand public emotions and opinion trends, facilitating more targeted and effective management strategies.
Journal Article
دراسات حول الفضاء العالمي و\الحزام والطريق\ : (مجلد السياحة)
إن استراتيجية \"الحزام والطريق\" هي عملية طويلة الأمد، ولا يمكن وصف دورها في تعزيز تنمية السياحة ببساطة. يحلل \"الفضاء العالمي و\"حزام واحد وطريق واحد\" حجم السياحة\" الوضع الحالي لتنمية السياحة العالمية في سياق استراتيجية \"حزام واحد وطريق واحد\"، ويقدم بالتفصيل تطور السياحة العالمية والخلفية السياحية. \"حزام وطريق\"، بما في ذلك نظرة عامة على صناعة السياحة العالمية، والاتجاهات الجديدة في تنمية السياحة العالمية ونمط السياحة العالمية، وما إلى ذلك، واستنادا إلى تحليل فرص وتحديات تنمية السياحة العالمية والصينية، والتأثير الترويجي لـ \"حزام واحد وطريق واحد\"، وتم تفسير استراتيجية \"الحزام والطريق\" لتنمية السياحة.
Book
Recent Progresses in the Treatment of Osteoporosis
Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and macrostructure of bone, leading to reduced bone mass and increased risk of fragile fractures. Anti-resorptive drugs, especially, bisphosphonates, are currently the treatment of choice in most developing countries. However, they do have limitations and adverse effects, which, to some extent, helped the development of anabolic drugs such as teriparatide and romosozumab. In patients with high or very high risk for fracture, sequential or combined therapies may be considered with the initial drugs being anabolic agents. Great endeavors have been made to find next generation drugs with maximal efficacy and minimal toxicity, and improved understanding of the role of different signaling pathways and their crosstalk in the pathogenesis of OP may help achieve this goal. Our review focused on recent progress with regards to the drug development by modification of Wnt pathway, while other pathways/molecules were also discussed briefly. In addition, new observations made in recent years in bone biology were summarized and discussed for the treatment of OP.
Journal Article
Birth Weight Reference Percentiles for Chinese
To develop a reference of population-based gestational age-specific birth weight percentiles for contemporary Chinese.
Birth weight data was collected by the China National Population-based Birth Defects Surveillance System. A total of 1,105,214 live singleton births aged ≥28 weeks of gestation without birth defects during 2006-2010 were included. The lambda-mu-sigma method was utilized to generate percentiles and curves.
Gestational age-specific birth weight percentiles for male and female infants were constructed separately. Significant differences were observed between the current reference and other references developed for Chinese or non-Chinese infants.
There have been moderate increases in birth weight percentiles for Chinese infants of both sexes and most gestational ages since 1980s, suggesting the importance of utilizing an updated national reference for both clinical and research purposes.
Journal Article
Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis
Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive destruction of articular cartilage. For a long time, OA has been considered as a degenerative disease, while recent observations indicate the mechanisms responsible for the pathogenesis of OA are multifaceted. Aging is a key factor in its development. Current treatments are palliative and no disease modifying anti-osteoarthritis drugs (DMOADs) are available. In addition to articular cartilage degradation, cellular senescence, synovial inflammation, and epigenetic alterations may all have a role in its formation. Accumulating data demonstrate a clear relationship between the senescence of articular chondrocytes and OA formation and progression. Inhibition of cell senescence may help identify new agents with the properties of DMOADs. Several anti-cellular senescence strategies have been proposed and these include sirtuin-activating compounds (STACs), senolytics, and senomorphics drugs. These agents may selectively remove senescent cells or ameliorate their harmful effects. The results from preclinical experiments and clinical trials are inspiring. However, more studies are warranted to confirm their efficacy, safety profiles and adverse effects of these agents.
Journal Article